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Searching for up to 100 curated homologs for CA265_RS12370 FitnessBrowser__Pedo557:CA265_RS12370 (291 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O73957 carboxylesterase (EC 3.1.1.1) from Sulfolobus acidocaldarius (see paper)
    31% identity, 91% coverage of query (91.3 bits)

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Build an alignment for CA265_RS12370 and 1 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    26% identity, 86% coverage of query (85.9 bits)

todF / P23133 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase (EC 3.7.1.25) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
TODF_PSEP1 / P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase; HOHH; EC 3.7.1.25 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see 2 papers)
    28% identity, 90% coverage of query (85.5 bits)

6eb3C Structural and enzymatic characterization of an esterase from a metagenomic library
    27% identity, 87% coverage of query (83.6 bits)

bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
    28% identity, 82% coverage of query (80.1 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    27% identity, 87% coverage of query (79.0 bits)

6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
    26% identity, 87% coverage of query (77.8 bits)

Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
    24% identity, 79% coverage of query (77.4 bits)

2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
    26% identity, 81% coverage of query (72.8 bits)

1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
    26% identity, 81% coverage of query (72.0 bits)

1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
    26% identity, 81% coverage of query (72.0 bits)

1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
    26% identity, 81% coverage of query (72.0 bits)

1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
    26% identity, 81% coverage of query (72.0 bits)

1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
    26% identity, 81% coverage of query (72.0 bits)

xylF / P23106 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas putida (see paper)
XYLF_PSEPU / P23106 2-hydroxymuconate semialdehyde hydrolase; HMSH; 2-hydroxymuconic semialdehyde hydrolase; EC 3.7.1.9 from Pseudomonas putida (Arthrobacter siderocapsulatus)
    25% identity, 90% coverage of query (67.4 bits)

bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
    24% identity, 87% coverage of query (66.2 bits)

hppC / AAB81313.1 2-hydroxy-6-ketonona-2,4-dienoate hydrolase from Rhodococcus globerulus (see paper)
    26% identity, 82% coverage of query (65.9 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    23% identity, 85% coverage of query (64.7 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    23% identity, 85% coverage of query (64.7 bits)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    23% identity, 85% coverage of query (64.3 bits)

bphD / BAA25612.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus erythropolis (see paper)
    26% identity, 84% coverage of query (61.2 bits)

hsaD / P9WNH5 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HSAD_MYCTU / P9WNH5 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17; EC 3.7.1.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WNH5 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Mycobacterium tuberculosis (see paper)
    26% identity, 80% coverage of query (60.5 bits)

5jzbA Crystal structure of hsad bound to 3,5-dichlorobenzene sulphonamide
    26% identity, 80% coverage of query (60.5 bits)

5jz9A / P9WNH5 Crystal structure of hsad bound to 3,5-dichloro-4- hydroxybenzenesulphonic acid (see paper)
    26% identity, 80% coverage of query (60.1 bits)

7zm4A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc31
    26% identity, 80% coverage of query (60.1 bits)

7zm3A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc17
    26% identity, 80% coverage of query (60.1 bits)

7zm2A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc8b
    26% identity, 80% coverage of query (60.1 bits)

7zm1A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc7b
    26% identity, 80% coverage of query (60.1 bits)

5jzsB Hsad bound to 3,5-dichloro-4-hydroxybenzoic acid
    26% identity, 80% coverage of query (60.1 bits)

2wufB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with 4,9dsha
    25% identity, 80% coverage of query (59.3 bits)

2wueB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopoda
    25% identity, 80% coverage of query (59.3 bits)

2wugA Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopda
    25% identity, 80% coverage of query (59.3 bits)

cpoL / PDB|1A88_A non-heme chloroperoxidase; EC 1.11.1.10 from Streptomyces lividans (see 2 papers)
cpoL / AAA18642.1 chloroperoxidase from Streptomyces lividans (see paper)
    25% identity, 78% coverage of query (56.6 bits)

ABH52_CAEEL / H2KZ86 Abhydrolase domain-containing protein abhd-5.2 from Caenorhabditis elegans (see paper)
    23% identity, 74% coverage of query (54.7 bits)

pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
    24% identity, 72% coverage of query (53.9 bits)

4g9eA Crystal structures of n-acyl homoserine lactonase aidh complexed with n-butanoyl homoserine
    22% identity, 83% coverage of query (52.4 bits)

4g8cA Crystal structures of n-acyl homoserine lactonase aidh e219g mutant complexed with n-hexanoyl homoserine
    22% identity, 83% coverage of query (51.2 bits)

4g8bA / D2J2T6 Crystal structures of n-acyl homoserine lactonase aidh s102g mutant complexed with n-hexanoyl homoserine lactone (see paper)
    22% identity, 83% coverage of query (50.8 bits)

5frdA / O28735 Structure of a thermophilic esterase (see paper)
    23% identity, 87% coverage of query (49.3 bits)

6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
    22% identity, 86% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory