Searching for up to 100 curated homologs for CA265_RS13115 FitnessBrowser__Pedo557:CA265_RS13115 (286 a.a.)

Found high-coverage hits (≥70%) to 22 curated proteins.

Removed hits that are identical to the query, leaving 21

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HMGC2_RAT / D4A5C3 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; EC 4.1.3.4 from Rattus norvegicus (Rat) (see paper)
    34% identity, 95% coverage of query (153 bits)

HMGC2_HUMAN / Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; HMGCL-like 1; Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase; er-cHL; EC 4.1.3.4 from Homo sapiens (Human) (see 2 papers)
    33% identity, 95% coverage of query (148 bits)

HMGCL_BACSU / O34873 Hydroxymethylglutaryl-CoA lyase YngG; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Bacillus subtilis (strain 168) (see paper)
    33% identity, 93% coverage of query (142 bits)

HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse) (see paper)
    32% identity, 96% coverage of query (142 bits)

HMGCL_RAT / P97519 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Rattus norvegicus (Rat) (see paper)
P97519 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Rattus norvegicus (see paper)
    31% identity, 96% coverage of query (137 bits)

HMGCL / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) from Homo sapiens (see 9 papers)
HMGCL_HUMAN / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Homo sapiens (Human) (see 18 papers)
P35914 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Homo sapiens (see 4 papers)
    32% identity, 95% coverage of query (134 bits)

2cw6A / P35914 Crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria (see paper)
    32% identity, 95% coverage of query (134 bits)

3mp3B Crystal structure of human lyase in complex with inhibitor hg-coa
    32% identity, 95% coverage of query (134 bits)

3mp5B Crystal structure of human lyase r41m in complex with hmg-coa
    31% identity, 95% coverage of query (130 bits)

6ndsA / A0A0D5YK08 Structure of an hmg-coa lyase from acenitobacter baumannii in complex with coenzyme a and 3-methylmalate
    32% identity, 91% coverage of query (128 bits)

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Additional hits (identity < 30%)

hlyA 3-hydroxy-3-methylglutaryl-coenzyme A lyase/3-methylglutaconyl-coenzyme A hydratase; EC 4.1.3.4; EC 4.2.1.18 from Emericella nidulans (see paper)
    29% identity, 96% coverage of query (128 bits)

liuE / Q9I2A0 hydroxymethylglutaryl-CoA lyase subunit (EC 4.1.3.26; EC 4.1.3.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
LIUE_PSEAE / Q9I2A0 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase; HIHG-CoA lyase; HMG-CoA lyase; (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase; EC 4.1.3.26; EC 4.1.3.4 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I2A0 3-Hydroxy-3-isohexenylglutaryl-CoA lyase (EC 4.1.3.26) from Pseudomonas aeruginosa PAO1 (see paper)
    33% identity, 89% coverage of query (126 bits)

HMGCL_ARATH / O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 93% coverage of query (125 bits)

SM_b21125 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Sinorhizobium meliloti 1021
    29% identity, 98% coverage of query (125 bits)

1ydnA / Q8YEF2 Crystal structure of the hmg-coa lyase from brucella melitensis, northeast structural genomics target lr35. (see paper)
    28% identity, 93% coverage of query (118 bits)

CCL_CHLAA / A9WGE2 (R)-citramalyl-CoA lyase; EC 4.1.3.46 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    27% identity, 91% coverage of query (112 bits)

mvaB / P13703 hydroxymethylglutaryl-CoA lyase monomer (EC 4.1.3.4) from Pseudomonas mevalonii (see 8 papers)
mvaB / GB|AAA25895.1 hydroxymethylglutaryl-CoA lyase; EC 4.1.3.4 from Pseudomonas mevalonii (see paper)
    30% identity, 85% coverage of query (112 bits)

P13703 Hydroxymethylglutaryl-CoA lyase; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Pseudomonas mevalonii
    30% identity, 85% coverage of query (112 bits)

LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
    22% identity, 94% coverage of query (48.1 bits)

B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
    23% identity, 79% coverage of query (48.1 bits)

LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
    22% identity, 94% coverage of query (45.8 bits)

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