Searching for up to 100 curated homologs for CA265_RS15335 FitnessBrowser__Pedo557:CA265_RS15335 (314 a.a.)
Found high-coverage hits (≥70%) to 64 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5z75A Artificial l-threonine 3-dehydrogenase designed by ancestral sequence reconstruction. (see paper)
68% identity, 98% coverage of query (439 bits)
7cgvA Full consensus l-threonine 3-dehydrogenase, fctdh-iiym (NAD+ bound form) (see paper)
63% identity, 99% coverage of query (413 bits)
7eprB Partial consensus l-threonine 3-dehydrogenase (c-change) (see paper)
60% identity, 99% coverage of query (392 bits)
2yy7A / Q8KZM4 Crystal structure of thermolabile l-threonine dehydrogenase from flavobacterium frigidimaris kuc-1 (see paper)
59% identity, 99% coverage of query (392 bits)
7epsA Partial consensus l-threonine 3-dehydrogenase (e-change) (see paper)
55% identity, 99% coverage of query (347 bits)
RR42_RS28300 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus basilensis FW507-4G11
54% identity, 98% coverage of query (345 bits)
E5RQ20 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus necator (see paper)
53% identity, 99% coverage of query (339 bits)
E3PS87 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Acetoanaerobium sticklandii (see paper)
50% identity, 99% coverage of query (328 bits)
5y1gA Monomeric l-threonine 3-dehydrogenase from metagenome database (akb and nadh bound form)
50% identity, 99% coverage of query (313 bits)
5y1fA / D6PBM7 Monomeric l-threonine 3-dehydrogenase from metagenome database (NAD+ bound form) (see paper)
50% identity, 99% coverage of query (312 bits)
D6PBM7 L-threonine 3-dehydrogenase (EC 1.1.1.103) from uncultured archaeon (see paper)
50% identity, 99% coverage of query (312 bits)
5y1eA Monomeric l-threonine 3-dehydrogenase from metagenome database (l-ser and NAD+ bound form)
50% identity, 99% coverage of query (312 bits)
3wmwB / Q0K312 Gale-like l-threonine dehydrogenase from cupriavidus necator (apo form) (see paper)
51% identity, 99% coverage of query (301 bits)
TDH_MOUSE / Q8K3F7 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Mus musculus (Mouse) (see paper)
49% identity, 92% coverage of query (297 bits)
D3ZN15 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Rattus norvegicus (see paper)
49% identity, 92% coverage of query (296 bits)
4yr9A / Q8K3F7 Mouse tdh with NAD+ bound (see paper)
49% identity, 92% coverage of query (291 bits)
6jygD / D0N3N0 Crystal structure of l-threonine dehydrogenase from phytophthora infestans (see paper)
48% identity, 98% coverage of query (291 bits)
TDH_PIG / Q8MIR0 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Sus scrofa (Pig) (see paper)
47% identity, 98% coverage of query (290 bits)
3a1nA / Q97BK3 Crystal structure of l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium (see paper)
42% identity, 99% coverage of query (271 bits)
Q97BK3 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Thermoplasma volcanium (see paper)
42% identity, 99% coverage of query (270 bits)
3a4vA Crystal structure of pyruvate bound l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium
42% identity, 99% coverage of query (270 bits)
3ajrA Crystal structure of l-3-hydroxynorvaline bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
42% identity, 99% coverage of query (269 bits)
3a9wA Crystal structure of l-threonine bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
42% identity, 99% coverage of query (269 bits)
Q7YW97 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Trypanosoma brucei (see paper)
37% identity, 98% coverage of query (222 bits)
5k4wC / Q7YW97 Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to nadh and l-threonine refined to 1.72 angstroms (see paper)
37% identity, 98% coverage of query (221 bits)
5k50C Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ and l-allo-threonine refined to 2.23 angstroms
37% identity, 98% coverage of query (221 bits)
5lc1A L-threonine dehydrogenase from trypanosoma brucei with NAD and the inhibitor pyruvate bound.
37% identity, 98% coverage of query (221 bits)
5k4qA Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ refined to 2.3 angstroms
37% identity, 98% coverage of query (221 bits)
4yrbC / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
38% identity, 92% coverage of query (195 bits)
4yrbB / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
33% identity, 92% coverage of query (150 bits)
Build an alignment for CA265_RS15335 and 30 homologs with ≥ 30% identity
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Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
25% identity, 97% coverage of query (72.4 bits)
denD / P44094 D-erythronate 2-dehydrogenase (EC 1.1.1.410) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DEND_HAEIN / P44094 D-erythronate dehydrogenase; EC 1.1.1.410 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
22% identity, 93% coverage of query (63.2 bits)
GAE4 / O22141 subunit of UDP-GlcA 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
GAE4_ARATH / O22141 UDP-glucuronate 4-epimerase 4; UDP-glucuronic acid epimerase 4; AtUGlcAE1; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O22141 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 4 papers)
27% identity, 71% coverage of query (60.8 bits)
GAE5_ARATH / Q9STI6 UDP-glucuronate 4-epimerase 5; UDP-glucuronic acid epimerase 5; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9STI6 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 2 papers)
28% identity, 71% coverage of query (58.2 bits)
GAE6_ARATH / Q9LIS3 UDP-glucuronate 4-epimerase 6; UDP-glucuronic acid epimerase 6; AtUGlcAE2; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LIS3 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 3 papers)
23% identity, 95% coverage of query (57.8 bits)
5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
24% identity, 72% coverage of query (55.8 bits)
GAE1_ARATH / Q9M0B6 UDP-glucuronate 4-epimerase 1; UDP-glucuronic acid epimerase 1; AtUGlcAE3; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9M0B6 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 3 papers)
26% identity, 71% coverage of query (55.8 bits)
UGA4E_THEGP / F8C4X8 UDP-glucuronate 4-epimerase; UGA4E; TgUGAE; EC 5.1.3.6 from Thermodesulfobacterium geofontis (strain OPF15)
24% identity, 87% coverage of query (55.5 bits)
GAE2_ARATH / Q9LPC1 UDP-glucuronate 4-epimerase 2; UDP-glucuronic acid epimerase 2; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPC1 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
28% identity, 71% coverage of query (55.1 bits)
GAE3_ARATH / O81312 UDP-glucuronate 4-epimerase 3; UDP-glucuronic acid epimerase 3; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O81312 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
25% identity, 71% coverage of query (54.7 bits)
gla / P96481 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Streptococcus pneumoniae (see 2 papers)
23% identity, 74% coverage of query (54.3 bits)
5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
24% identity, 72% coverage of query (54.3 bits)
galE / CAB44218.1 UDP-galactose 4-epimerase from Lactococcus lactis (see paper)
23% identity, 96% coverage of query (53.9 bits)
GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
23% identity, 99% coverage of query (53.1 bits)
O73960 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrococcus horikoshii (see paper)
22% identity, 98% coverage of query (53.1 bits)
8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
26% identity, 77% coverage of query (52.0 bits)
8v4hB / A0A0U3AP28 X-ray structure of the NADP-dependent reductase from campylobacter jejuni responsible for the synthesis of cdp-glucitol in the presence of cdp-glucitol
22% identity, 99% coverage of query (51.6 bits)
3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
24% identity, 99% coverage of query (51.2 bits)
1bsvA / P32055 Gdp-fucose synthetase from escherichia coli complex with NADPH (see paper)
23% identity, 96% coverage of query (51.2 bits)
YefB / b2052 GDP-L-fucose synthase (EC 1.1.1.271) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
fcl / P32055 GDP-L-fucose synthase (EC 1.1.1.271) from Escherichia coli (strain K12) (see 11 papers)
FCL_ECOLI / P32055 GDP-L-fucose synthase; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; EC 1.1.1.271 from Escherichia coli (strain K12) (see 5 papers)
P32055 GDP-L-fucose synthase (EC 1.1.1.271) from Escherichia coli (see 2 papers)
23% identity, 96% coverage of query (51.2 bits)
A0A1J0KK43 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Albuca bracteata (see paper)
25% identity, 71% coverage of query (50.8 bits)
1e6uA Gdp 4-keto-6-deoxy-d-mannose epimerase reductase
23% identity, 96% coverage of query (50.8 bits)
Q6K9M5 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Oryza sativa (see paper)
26% identity, 71% coverage of query (50.4 bits)
Q304Y2 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Zea mays (see paper)
26% identity, 71% coverage of query (50.1 bits)
A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
24% identity, 99% coverage of query (50.1 bits)
8v4gA X-ray structure of the NADP-dependent reductase from campylobacter jejuni responsible for the synthesis of cdp-glucitol in the presence of cdp and NADP
22% identity, 99% coverage of query (50.1 bits)
2c20A / A0A6L8PTV5 Crystal structure of udp-glucose 4-epimerase
24% identity, 94% coverage of query (49.3 bits)
2c59A / Q93VR3 Gdp-mannose-3', 5' -epimerase (arabidopsis thaliana), with gdp-alpha- d-mannose and gdp-beta-l-galactose bound in the active site. (see paper)
21% identity, 96% coverage of query (48.1 bits)
GME / Q93VR3 GDP-D-mannose-3,5-epimerase (EC 5.1.3.18) from Arabidopsis thaliana (see paper)
GME_ARATH / Q93VR3 GDP-mannose 3,5-epimerase; GDP-Man 3,5-epimerase; EC 5.1.3.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
21% identity, 96% coverage of query (47.8 bits)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
23% identity, 77% coverage of query (47.4 bits)
2c54A Gdp-mannose-3', 5' -epimerase (arabidopsis thaliana),k178r, with gdp- beta-l-gulose and gdp-4-keto-beta-l-gulose bound in active site.
20% identity, 96% coverage of query (47.4 bits)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
23% identity, 77% coverage of query (47.0 bits)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
23% identity, 77% coverage of query (47.0 bits)
6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
23% identity, 77% coverage of query (45.8 bits)
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Lawrence Berkeley National Laboratory