Searching for up to 100 curated homologs for CA265_RS15855 CA265_RS15855 2-isopropylmalate synthase (386 a.a.)
Found high-coverage hits (≥70%) to 81 curated proteins.
Removed hits that are identical to the query, leaving 80
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
70% identity, 94% coverage of query (530 bits)
Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
65% identity, 98% coverage of query (519 bits)
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
54% identity, 97% coverage of query (411 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
54% identity, 97% coverage of query (395 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
51% identity, 99% coverage of query (391 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
50% identity, 99% coverage of query (391 bits)
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
50% identity, 99% coverage of query (387 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
52% identity, 97% coverage of query (384 bits)
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
50% identity, 99% coverage of query (382 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
49% identity, 99% coverage of query (379 bits)
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
49% identity, 99% coverage of query (379 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
50% identity, 98% coverage of query (378 bits)
MAM1 / Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 2 papers)
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 7 papers)
48% identity, 98% coverage of query (365 bits)
K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
49% identity, 98% coverage of query (364 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
49% identity, 97% coverage of query (363 bits)
6e1jA / C5J4P1 Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
47% identity, 99% coverage of query (361 bits)
MAM2_ARATH / Q8VX04 Methylthioalkylmalate synthase 2, chloroplastic; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8VX04 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see paper)
47% identity, 98% coverage of query (360 bits)
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
47% identity, 99% coverage of query (355 bits)
MAM3 / Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see paper)
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 4 papers)
45% identity, 97% coverage of query (349 bits)
LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida) (see paper)
46% identity, 99% coverage of query (346 bits)
A0A0G2T6D7 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum pennellii (see paper)
51% identity, 84% coverage of query (330 bits)
A0A0B5GPY2 methylthioalkylmalate synthase (EC 2.3.3.17) from Brassica oleracea (see paper)
46% identity, 87% coverage of query (315 bits)
3rmjB / Q9JZG1 Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
50% identity, 82% coverage of query (314 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
45% identity, 98% coverage of query (313 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
47% identity, 97% coverage of query (294 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
45% identity, 97% coverage of query (288 bits)
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
41% identity, 98% coverage of query (236 bits)
6ktqA / Q4J989 Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
38% identity, 91% coverage of query (213 bits)
HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
38% identity, 91% coverage of query (213 bits)
B0SN40 2-isopropylmalate synthase (EC 2.3.3.13) from Leptospira biflexa (see paper)
36% identity, 90% coverage of query (203 bits)
HOSA_SULTO / Q971S5 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
36% identity, 92% coverage of query (202 bits)
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
37% identity, 97% coverage of query (198 bits)
4ov9A / B0SN40 Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
36% identity, 90% coverage of query (197 bits)
4ov4A Isopropylmalate synthase binding with ketoisovalerate
36% identity, 90% coverage of query (197 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
34% identity, 89% coverage of query (180 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
34% identity, 89% coverage of query (174 bits)
LEU12_LEPIN / Q8F8T4 2-isopropylmalate synthase 2; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
34% identity, 86% coverage of query (173 bits)
frbC / Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215) (see 2 papers)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215) (see paper)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (see paper)
33% identity, 89% coverage of query (172 bits)
A0A1Y6KBA1 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. ORS 285 (see 2 papers)
33% identity, 88% coverage of query (162 bits)
CIMA_SULAC / Q4J6H1 (R)-citramalate synthase; Citramalate synthase; CMS; EC 2.3.3.21 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
33% identity, 89% coverage of query (152 bits)
3ivtB / Q9Y823 Homocitrate synthase lys4 bound to 2-og (see paper)
30% identity, 88% coverage of query (145 bits)
Build an alignment for CA265_RS15855 and 41 homologs with ≥ 30% identity
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3ivsA Homocitrate synthase lys4
29% identity, 93% coverage of query (145 bits)
HOSM_SCHPO / Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
lys4 / RF|NP_596458.1 homocitrate synthase (predicted); EC 2.3.3.14 from Schizosaccharomyces pombe (see 2 papers)
30% identity, 88% coverage of query (144 bits)
LYS20 / P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSC_YEAST / P48570 Homocitrate synthase, cytosolic isozyme; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see 2 papers)
28% identity, 97% coverage of query (142 bits)
M1U949 homocitrate synthase (EC 2.3.3.14) from Flammulina velutipes (see paper)
28% identity, 95% coverage of query (142 bits)
3mi3A Homocitrate synthase lys4 bound to lysine
30% identity, 88% coverage of query (142 bits)
LYS21 / Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSM_YEAST / Q12122 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see paper)
28% identity, 96% coverage of query (141 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
31% identity, 90% coverage of query (140 bits)
hcs / O87198 homocitrate synthase (EC 2.3.3.14) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
HOSA_THET2 / O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
30% identity, 96% coverage of query (137 bits)
DVU1914 (R)-citramalate synthase (EC 2.3.3.21) from Desulfovibrio vulgaris Hildenborough JW710
31% identity, 90% coverage of query (135 bits)
CIRSY_DEHMC / P0DO96 Citrate (Re)-synthase; Re face-specific citrate synthase; Re-citrate synthase; EC 2.3.3.3 from Dehalococcoides mccartyi (strain CBDB1) (see paper)
P0DO96 citrate (Re)-synthase (EC 2.3.3.3) from Dehalococcoides sp. (see paper)
30% identity, 90% coverage of query (135 bits)
BT1858 (R)-citramalate synthase (EC 2.3.1.182) from Bacteroides thetaiotaomicron VPI-5482
29% identity, 96% coverage of query (134 bits)
cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
32% identity, 85% coverage of query (132 bits)
C7C437 homocitrate synthase (EC 2.3.3.14) from Aspergillus fumigatus (see paper)
27% identity, 96% coverage of query (130 bits)
LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
27% identity, 91% coverage of query (127 bits)
LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
28% identity, 91% coverage of query (124 bits)
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate
31% identity, 83% coverage of query (120 bits)
3a9iA / O87198 Crystal structure of homocitrate synthase from thermus thermophilus complexed with lys (see paper)
31% identity, 81% coverage of query (119 bits)
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate
31% identity, 83% coverage of query (119 bits)
cimA / Q8F3Q1 (R)-citramalate synthase subunit (EC 2.3.3.21) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
CIMA_LEPIN / Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 3 papers)
27% identity, 98% coverage of query (118 bits)
LEU4 putative 2-isopropylmalalate synthase from Candida albicans (see paper)
27% identity, 90% coverage of query (114 bits)
CH_124190 2-isopropylmalate synthase 2 from Magnaporthe grisea 70-15 (see paper)
27% identity, 88% coverage of query (107 bits)
AMT7_ALTAL / C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
27% identity, 79% coverage of query (103 bits)
3bliA / Q8F3Q1 Crystal structure of the catalytic domain of licms in complexed with pyruvate and acetyl-coa (see paper)
27% identity, 77% coverage of query (100 bits)
3figB / P9WQB3 Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
27% identity, 76% coverage of query (91.7 bits)
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
27% identity, 76% coverage of query (91.7 bits)
1sr9A Crystal structure of leua from mycobacterium tuberculosis
27% identity, 76% coverage of query (91.7 bits)
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
27% identity, 76% coverage of query (91.7 bits)
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
27% identity, 76% coverage of query (91.3 bits)
LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis (see 6 papers)
26% identity, 90% coverage of query (90.1 bits)
4lrsA / D1A3K8 Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
27% identity, 76% coverage of query (72.0 bits)
hsaF / P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HOA_MYCTU / P9WMK5 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.43; EC 4.1.3.39 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis (see paper)
26% identity, 87% coverage of query (63.9 bits)
4jn6C / P9WMK5 Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37 (see paper)
26% identity, 86% coverage of query (63.5 bits)
HMGC2_HUMAN / Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; HMGCL-like 1; Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase; er-cHL; EC 4.1.3.4 from Homo sapiens (Human) (see 2 papers)
24% identity, 72% coverage of query (55.8 bits)
3mp3B Crystal structure of human lyase in complex with inhibitor hg-coa
24% identity, 72% coverage of query (53.5 bits)
2cw6A / P35914 Crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria (see paper)
24% identity, 72% coverage of query (53.5 bits)
HMGCL / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) from Homo sapiens (see 9 papers)
HMGCL_HUMAN / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Homo sapiens (Human) (see 18 papers)
P35914 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Homo sapiens (see 4 papers)
24% identity, 72% coverage of query (53.1 bits)
3mp5B Crystal structure of human lyase r41m in complex with hmg-coa
23% identity, 72% coverage of query (50.8 bits)
dmpG / P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600) (see paper)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600) (see 3 papers)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (see paper)
dmpG / CAA43227.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas sp. CF600 (see paper)
22% identity, 81% coverage of query (43.9 bits)
1nvmA / P51016 Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate (see paper)
22% identity, 79% coverage of query (43.5 bits)
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