Sites on a Tree

 

Searching for up to 100 curated homologs for CCNA_01841 FitnessBrowser__Caulo:CCNA_01841 (539 a.a.)

Found high-coverage hits (≥70%) to 44 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ACEA_HYPME / O50078 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Hyphomicrobium methylovorum (see paper)
    81% identity, 100% coverage of query (924 bits)

A8C781 isocitrate lyase (EC 4.1.3.1) from Azotobacter vinelandii (see paper)
    60% identity, 93% coverage of query (620 bits)

Q9I0K4 isocitrate lyase (EC 4.1.3.1) from Pseudomonas aeruginosa (see 2 papers)
    60% identity, 93% coverage of query (616 bits)

Psest_2014 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas stutzeri RCH2
    59% identity, 96% coverage of query (616 bits)

A8C5K8 isocitrate lyase (EC 4.1.3.1) from Colwellia psychrerythraea (see paper)
    56% identity, 96% coverage of query (566 bits)

6g1oA / Q9I0K4 Structure of pseudomonas aeruginosa isocitrate lyase, icl (see paper)
    60% identity, 85% coverage of query (561 bits)

Q93R40 isocitrate lyase (EC 4.1.3.1) from Colwellia maris (see paper)
    55% identity, 95% coverage of query (559 bits)

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
    31% identity, 83% coverage of query (162 bits)

icl / CAA82555.1 isocitrate lyase from Rhodococcus fascians (see paper)
    30% identity, 84% coverage of query (160 bits)

A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii (see paper)
    30% identity, 90% coverage of query (159 bits)

Build an alignment

Build an alignment for CCNA_01841 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

7cmyC / Q81GQ9 Isocitrate lyase from bacillus cereus atcc 14579 in complex with magnessium ion, glyoxylate, and succinate
    28% identity, 91% coverage of query (157 bits)

6c4aA / P9WKK7 Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis with pyruvate (see paper)
    30% identity, 80% coverage of query (156 bits)

icl / P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see 3 papers)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis (see 4 papers)
    30% identity, 80% coverage of query (156 bits)

6xppA Crystal structure of itaconate modified mycobaterium tuberculosis isocitrate lyase
    30% identity, 80% coverage of query (156 bits)

7rb1A Isocitrate lyase-1 from mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-d-isocitric acid
    30% identity, 80% coverage of query (156 bits)

6wsiA Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium tuberculosis
    30% identity, 80% coverage of query (156 bits)

6vb9A Covalent adduct of cis-2,3-epoxysuccinic acid with isocitrate lyase-1 from mycobacterium tuberculosis
    30% identity, 80% coverage of query (156 bits)

5dqlA Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis
    30% identity, 80% coverage of query (156 bits)

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
    30% identity, 85% coverage of query (153 bits)

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus (see paper)
    30% identity, 83% coverage of query (153 bits)

1f8iA Crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
    30% identity, 80% coverage of query (152 bits)

Icl / b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655 (see paper)
aceA / P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12) (see 25 papers)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12) (see 7 papers)
    29% identity, 90% coverage of query (149 bits)

7rbxC / Q2YQA0 Crystal structure of isocitrate lyase and phosphorylmutase:isocitrate lyase from brucella melitensis biovar abortus 2308 bound to itaconic acid (see paper)
    28% identity, 84% coverage of query (149 bits)

1igwC / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    29% identity, 90% coverage of query (148 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    29% identity, 84% coverage of query (147 bits)

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
    29% identity, 84% coverage of query (145 bits)

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
    28% identity, 87% coverage of query (145 bits)

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
    28% identity, 84% coverage of query (144 bits)

Ac3H11_2831 Isocitrate lyase (EC 4.1.3.1) from Acidovorax sp. GW101-3H11
    28% identity, 78% coverage of query (144 bits)

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
    27% identity, 90% coverage of query (143 bits)

6lrtA / A9WDE7 Crystal structure of isocitrate lyase (caur_3889) from chloroflexus aurantiacus in complex with isocitrate and manganese ion
    27% identity, 84% coverage of query (141 bits)

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus (see paper)
    28% identity, 85% coverage of query (135 bits)

5e9gD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    27% identity, 85% coverage of query (114 bits)

1igwA / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
    27% identity, 90% coverage of query (112 bits)

5e9gC Structural insights of isocitrate lyases from magnaporthe oryzae
    27% identity, 84% coverage of query (108 bits)

Q5YLB6 isocitrate lyase (EC 4.1.3.1) from Paracoccidioides brasiliensis (see paper)
    25% identity, 88% coverage of query (107 bits)

icl / P28297 isocitrate lyase (EC 4.1.3.1) from Arabidopsis thaliana (see paper)
ACEA_ARATH / P28297 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    26% identity, 81% coverage of query (102 bits)

ACEA_BRANA / P25248 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Brassica napus (Rape) (see paper)
    26% identity, 81% coverage of query (101 bits)

ACEB_YARLI / Q6BZP5 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) (see paper)
    24% identity, 88% coverage of query (100 bits)

5e9fD / P0CT06 Structural insights of isocitrate lyases from magnaporthe oryzae (see paper)
    27% identity, 84% coverage of query (99.8 bits)

icl / CAB37065.1 isocitrate lyase from Eremothecium gossypii (see paper)
    23% identity, 94% coverage of query (87.4 bits)

ACEB_YEAST / Q12031 Mitochondrial 2-methylisocitrate lyase ICL2; Methylisocitrate lyase; EC 4.1.3.30 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    23% identity, 81% coverage of query (82.0 bits)

GI|61657961 methylisocitrate lyase precursor; EC 4.1.3.30 from Emericella nidulans (see paper)
mclA methylisocitrate lyase; EC 4.1.3.30 from Emericella nidulans (see 2 papers)
mclA / CAI65406.1 methylisocitrate lyase precursor from Aspergillus nidulans (see paper)
    26% identity, 80% coverage of query (81.3 bits)

ACEB_EMENI / C8V9Y5 Methylisocitrate lyase, mitochondrial; 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
    26% identity, 80% coverage of query (81.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory