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Searching for up to 100 curated homologs for CCNA_02459 FitnessBrowser__Caulo:CCNA_02459 (714 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

mutB / AAA03041.1 methylmalonyl-CoA large subunit from Streptomyces cinnamonensis (see paper)
    76% identity, 96% coverage of query (1088 bits)

Q84FZ1 methylmalonyl-CoA mutase (EC 5.4.99.2) from Methylorubrum extorquens (see paper)
    75% identity, 100% coverage of query (1069 bits)

6oxdA / P9WJK5 Structure of mycobacterium tuberculosis methylmalonyl-coa mutase with adenosyl cobalamin (see paper)
    74% identity, 97% coverage of query (1032 bits)

mutB / P11653 methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) from Propionibacterium freudenreichii subsp. shermanii (see 8 papers)
MUTB_PROFR / P11653 Methylmalonyl-CoA mutase large subunit; MCM-alpha; EC 5.4.99.2 from Propionibacterium freudenreichii subsp. shermanii (see 4 papers)
P11653 methylmalonyl-CoA mutase (EC 5.4.99.2) from Propionibacterium freudenreichii subsp. shermanii (see paper)
    69% identity, 99% coverage of query (1022 bits)

6reqA Methylmalonyl-coa mutase, 3-carboxypropyl-coa inhibitor complex
    69% identity, 99% coverage of query (1019 bits)

4reqA Methylmalonyl-coa mutase substrate complex
    69% identity, 99% coverage of query (1018 bits)

7reqA Methylmalonyl-coa mutase, 2-carboxypropyl-coa inhibitor complex
    69% identity, 99% coverage of query (1016 bits)

3reqA Methylmalonyl-coa mutase, substrate-free state (poor quality structure)
    69% identity, 99% coverage of query (1016 bits)

2reqA Methylmalonyl-coa mutase, non-productive coa complex, in open conformation representing substrate-free state
    69% identity, 99% coverage of query (1016 bits)

1e1cA / P11653 Methylmalonyl-coa mutase h244a mutant (see paper)
    69% identity, 99% coverage of query (1015 bits)

5reqA Methylmalonyl-coa mutase, y89f mutant, substrate complex
    69% identity, 99% coverage of query (1014 bits)

Caur_2508 / A9WI23 methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    68% identity, 99% coverage of query (997 bits)

MUTA_MOUSE / P16332 Methylmalonyl-CoA mutase, mitochondrial; MCM; Methylmalonyl-CoA isomerase; EC 5.4.99.2 from Mus musculus (Mouse) (see paper)
    63% identity, 97% coverage of query (926 bits)

Q23381 methylmalonyl-CoA mutase (EC 5.4.99.2) from Caenorhabditis elegans (see paper)
    65% identity, 96% coverage of query (923 bits)

MUT / P22033 Methylmalonyl-CoA mutase, mitochondrial (EC 5.4.99.2) from Homo sapiens (see 4 papers)
MUTA_HUMAN / P22033 Methylmalonyl-CoA mutase, mitochondrial; MCM; Methylmalonyl-CoA isomerase; EC 5.4.99.2 from Homo sapiens (Human) (see 31 papers)
P22033 methylmalonyl-CoA mutase (EC 5.4.99.2) from Homo sapiens (see 6 papers)
    63% identity, 97% coverage of query (920 bits)

2xiqA / P22033 Crystal structure of human methylmalonyl-coa mutase in complex with adenosylcobalamin and malonyl-coa (see paper)
    63% identity, 97% coverage of query (920 bits)

8dyjB Crystal structure of human methylmalonyl-coa mutase in complex with adp and cob(ii)alamin
    63% identity, 96% coverage of query (920 bits)

mcm / CAJ91090.1 methylmalonyl-CoA mutase from Sorangium cellulosum (see paper)
    67% identity, 96% coverage of query (912 bits)

Dsui_0519 Methylmalonyl-CoA mutase (EC 5.4.99.2) from Dechlorosoma suillum PS
    64% identity, 96% coverage of query (904 bits)

F1KUP0 methylmalonyl-CoA mutase subunit (EC 5.4.99.2) from Ascaris suum (see paper)
    63% identity, 96% coverage of query (901 bits)

Q8MI68 methylmalonyl-CoA mutase (EC 5.4.99.2) from Sus scrofa (see paper)
    62% identity, 97% coverage of query (897 bits)

mcmA / Q3J4D7 methylmalonyl-CoA mutase (EC 5.4.99.2) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
MCM_CERS4 / Q3J4D7 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see 2 papers)
    66% identity, 96% coverage of query (894 bits)

8gjuJ / P22033 Crystal structure of human methylmalonyl-coa mutase (mmut) in complex with methylmalonic acidemia type a protein (mmaa), coenzyme a, and gdp (see paper)
    62% identity, 97% coverage of query (884 bits)

MCM_RHIME / O86028 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
    61% identity, 98% coverage of query (837 bits)

YliK / b2917 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
scpA / P27253 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli (strain K12) (see 4 papers)
SCPA_ECOLI / P27253 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Escherichia coli (strain K12) (see 3 papers)
    61% identity, 95% coverage of query (828 bits)

O74009 methylmalonyl-CoA mutase (subunit 2/2) (EC 5.4.99.2) from Pyrococcus horikoshii (see paper)
    50% identity, 74% coverage of query (528 bits)

A4YEG1 methylmalonyl-CoA mutase (subunit 2/2) (EC 5.4.99.2) from Metallosphaera sedula (see paper)
    46% identity, 73% coverage of query (463 bits)

hcmA / I3VE77 2-hydroxyisobutanoyl-CoA mutase large subunit (EC 5.4.99.64) from Aquincola tertiaricarbonis (see 3 papers)
HCMA_AQUTE / I3VE77 2-hydroxyisobutanoyl-CoA mutase large subunit; 2-hydroxyisobutyryl-CoA mutase large subunit; HCM large subunit; EC 5.4.99.64 from Aquincola tertiaricarbonis (see 2 papers)
I3VE77 2-hydroxyisobutanoyl-CoA mutase (subunit 2/2) (EC 5.4.99.64) from Aquincola tertiaricarbonis (see 3 papers)
    43% identity, 74% coverage of query (422 bits)

4r3uA / I3VE77 Crystal structure of 2-hydroxyisobutyryl-coa mutase (see paper)
    43% identity, 74% coverage of query (422 bits)

ECM_METEA / Q49115 Ethylmalonyl-CoA mutase; EC 5.4.99.63 from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) (see 3 papers)
    37% identity, 87% coverage of query (392 bits)

C7C6S9 ethylmalonyl-CoA mutase (EC 5.4.99.63) from Methylorubrum extorquens (see paper)
    37% identity, 87% coverage of query (391 bits)

D5WTR7 2-hydroxyisobutanoyl-CoA mutase (subunit 2/2) (EC 5.4.99.64) from Kyrpidia tusciae DSM 2912 (see paper)
    40% identity, 73% coverage of query (390 bits)

ECM_CERS4 / Q3IZ90 Ethylmalonyl-CoA mutase; EC 5.4.99.63 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
Q3IZ90 ethylmalonyl-CoA mutase (EC 5.4.99.63) from Cereibacter sphaeroides (see paper)
    38% identity, 87% coverage of query (360 bits)

PCMA_XANP2 / A7IQE5 Pivalyl-CoA mutase large subunit; PCM large subunit; Pivalyl-CoA mutase, substrate-binding subunit; EC 5.4.99.- from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see paper)
    35% identity, 71% coverage of query (272 bits)

Caur_2509 / A9WI24 methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    33% identity, 82% coverage of query (248 bits)

Q8Y2U5 methylmalonyl-CoA mutase (EC 5.4.99.2) from Ralstonia solanacearum (see paper)
    34% identity, 75% coverage of query (243 bits)

ICMF_GEOKA / Q5KUG0 Fused isobutyryl-CoA mutase; EC 5.4.99.13; EC 3.6.5.- from Geobacillus kaustophilus (strain HTA426) (see 2 papers)
    32% identity, 72% coverage of query (233 bits)

Build an alignment

Build an alignment for CCNA_02459 and 37 homologs with ≥ 30% identity

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory