Searching for up to 100 curated homologs for CCNA_02487 FitnessBrowser__Caulo:CCNA_02487 (406 a.a.)
Found high-coverage hits (≥70%) to 56 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1pbcA Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate, 2,4-dihydroxybenzoate and 2-hydroxy- 4-aminobenzoate and of the try222ala mutant, complexed with 2- hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
61% identity, 96% coverage of query (497 bits)
PHHY_PSEAE / P20586 p-hydroxybenzoate hydroxylase; PHBH; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 7 papers)
1d7lA / P20586 Structure-function correlations of the reaction of reduced nicotinamide analogs with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins (see paper)
61% identity, 96% coverage of query (496 bits)
pobA / P00438 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas fluorescens (see 2 papers)
PHHY_PSEFL / P00438 p-hydroxybenzoate hydroxylase; PHBH; PHBHase; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas fluorescens (see 13 papers)
61% identity, 96% coverage of query (496 bits)
1iusA P-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate at ph 5.0
61% identity, 96% coverage of query (496 bits)
1dodA The mobil flavin of 4-oh benzoate hydroxylase: motion of a prosthetic group regulates catalysis
61% identity, 96% coverage of query (496 bits)
1bf3A P-hydroxybenzoate hydroxylase (phbh) mutant with cys 116 replaced by ser (c116s) and arg 42 replaced by lys (r42k), in complex with fad and 4-hydroxybenzoic acid
61% identity, 96% coverage of query (496 bits)
2phhA The coenzyme analogue adenosine 5-diphosphoribose displaces fad in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation
61% identity, 96% coverage of query (495 bits)
1pdhA Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified fad present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin
61% identity, 96% coverage of query (495 bits)
pobA / AAA73519.1 4-hydroxybenzoate hydroxylase from Rhizobium leguminosarum (see paper)
61% identity, 96% coverage of query (494 bits)
1k0lA Pseudomonas aeruginosa phbh r220q free of p-ohb
61% identity, 96% coverage of query (494 bits)
1k0jA Pseudomonas aeruginosa phbh r220q in complex with NADPH and free of p- ohb
61% identity, 96% coverage of query (494 bits)
1ykjB A45g p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound
61% identity, 96% coverage of query (487 bits)
6dllB / Q88H28 2.2 angstrom resolution crystal structure of p-hydroxybenzoate hydroxylase from pseudomonas putida in complex with fad. (see paper)
59% identity, 97% coverage of query (474 bits)
pobA / Q9R9T1 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas putida (see paper)
Q9R9T1 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas putida (see paper)
59% identity, 96% coverage of query (473 bits)
RR42_RS21940 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Cupriavidus basilensis FW507-4G11
59% identity, 96% coverage of query (451 bits)
Pf6N2E2_2914 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas fluorescens FW300-N2E2
56% identity, 96% coverage of query (444 bits)
pobA / F2JUE7 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) (see paper)
54% identity, 96% coverage of query (431 bits)
7on9A / C4TP09 Crystal structure of para-hydroxybenzoate-3-hydroxylase prai (see paper)
51% identity, 96% coverage of query (397 bits)
PRAI_PAESP / C4TP09 4-hydroxybenzoate 3-monooxygenase (NAD(P)H); 4-hydroxybenzoate 3-hydroxylase; 4HB 3-hydroxylase; EC 1.14.13.33 from Paenibacillus sp. (see paper)
praI / BAH79107.1 4-hydroxybenzoate 3-hydroxylase from Paenibacillus sp. JJ-1b (see paper)
51% identity, 96% coverage of query (397 bits)
8jqoA Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
46% identity, 96% coverage of query (371 bits)
8jqoD Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
40% identity, 96% coverage of query (267 bits)
Build an alignment for CCNA_02487 and 21 homologs with ≥ 30% identity
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stiL / CAD19095.1 cytochrome P450 dependent monooxygenase from Stigmatella aurantiaca (see paper)
27% identity, 75% coverage of query (74.3 bits)
tsdB / Q0SFL5 resorcinol 4-hydroxylase (NADH) (EC 1.14.13.220) from Rhodococcus jostii (strain RHA1) (see 2 papers)
TSDB_RHOJR / Q0SFL5 Probable NADH-specific resorcinol 4-hydroxylase; EC 1.14.13.220 from Rhodococcus jostii (strain RHA1) (see paper)
26% identity, 80% coverage of query (67.0 bits)
oxyE / L8EVI4 6-methylpretetramide 4-monooxygenase (EC 1.14.13.232) from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see 2 papers)
OXYE_STRRM / Q3S8R0 6-methylpretetramide 4-monooxygenase; EC 1.14.13.232 from Streptomyces rimosus (see paper)
Q3S8R0 6-methylpretetramide 4-monooxygenase (EC 1.14.13.232) from Streptomyces rimosus (see paper)
27% identity, 87% coverage of query (65.9 bits)
ctcN / Q53657 anhydrotetracycline 6-monooxygenase (EC 1.14.13.38) from Kitasatospora aureofaciens (see 2 papers)
cts8 / BAA07387.1 6-hydroxylation enzyme of tetracycline from Kitasatospora aureofaciens (see paper)
26% identity, 75% coverage of query (65.1 bits)
ROX_STRVP / F2R776 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
27% identity, 83% coverage of query (63.9 bits)
6brdA / F2R776 Crystal structure of rifampin monooxygenase from streptomyces venezuelae, complexed with rifampin and fad (see paper)
27% identity, 83% coverage of query (63.5 bits)
NTNA_NECSZ / A0A455LLV4 FAD-dependent monooxygenase ntnA; Nectripenoid biosynthesis cluster protein A; EC 1.-.-.- from Nectria sp. (see paper)
23% identity, 76% coverage of query (61.2 bits)
7yj0D Structural basis of oxepinone formation by a flavin-monooxygenase vibo
25% identity, 77% coverage of query (61.2 bits)
mtmOII / Q194R1 MtmOII from Streptomyces argillaceus (see 3 papers)
26% identity, 84% coverage of query (60.8 bits)
Cgl1158 / Q8NR94 resorcinol 4-hydroxylase (NADPH) (EC 1.14.13.219) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
RES4H_CORGL / Q8NR94 NADPH-dependent resorcinol 4-hydroxylase; Resorcinol hydroxylase; EC 1.14.13.219 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
25% identity, 76% coverage of query (60.8 bits)
nat2 / F8QPH2 ansamycin ring hydroxylase from Streptomyces sp. CS (see 5 papers)
26% identity, 81% coverage of query (60.5 bits)
8er0A / A0A316WTJ0 X-ray crystal structure of tet(x6) bound to anhydrotetracycline (see paper)
23% identity, 82% coverage of query (60.1 bits)
rif19 / Q9AE02 rifamycin ring hydroxylase from Amycolatopsis mediterranei (see 4 papers)
27% identity, 77% coverage of query (58.5 bits)
4k2xB / L8EUQ6 Oxys anhydrotetracycline hydroxylase from streptomyces rimosus (see paper)
27% identity, 84% coverage of query (57.8 bits)
PYRE3_STRRG / K7QRJ5 Dialkyldecalin synthase; FAD-dependent [4+2] cyclase; EC 5.5.1.- from Streptomyces rugosporus (see 2 papers)
25% identity, 82% coverage of query (57.4 bits)
5xgvA / K7QRJ5 The structure of diels-alderase pyre3 in the biosynthetic pathway of pyrroindomycins (see paper)
25% identity, 82% coverage of query (57.0 bits)
dntB / Q2PWU9 4-methyl-5-nitrocatechol monooxygenase (EC 1.14.13.210) from Burkholderia sp. (see 2 papers)
DNTB_BURSP / Q2PWU9 4-methyl-5-nitrocatechol 5-monooxygenase; 4M5NC monooxygenase; MNC monooxygenase; 4-methyl-5-nitrocatechol oxygenase; EC 1.14.13.210 from Burkholderia sp. (see 2 papers)
Q2PWU9 4-methyl-5-nitrocatechol 5-monooxygenase (EC 1.14.13.210) from Burkholderia sp. (see paper)
24% identity, 88% coverage of query (56.6 bits)
4x4jA / D7RFJ3 Structural and functional studies of bexe: insights into oxidation during be-7585a biosynthesis
28% identity, 76% coverage of query (56.2 bits)
6ui5A / Q1MX79 Tmn9 in complex with cofactor fad
25% identity, 77% coverage of query (56.2 bits)
DEP2_FUSLA / A0A0N0DCA8 FAD-dependent monooxygenase DEP2; Depudecin biosynthesis cluster protein 2; EC 1.-.-.- from Fusarium langsethiae (see 2 papers)
24% identity, 76% coverage of query (55.5 bits)
CH_124231 putative monooxygenase [Penicillium paxilli] from Magnaporthe grisea 70-15 (see paper)
24% identity, 72% coverage of query (55.5 bits)
8fhjC Crystal structure of a fad monooxygenease from methylocystis sp. Strain sb2 (see paper)
25% identity, 77% coverage of query (55.1 bits)
SDNN_SORAA / A0A1B4XBH7 FAD-dependent monooxygenase sdnN; Sordarin/hypoxysordarin biosynthesis cluster protein N; EC 1.-.-.- from Sordaria araneosa (Pleurage araneosa) (see paper)
22% identity, 80% coverage of query (54.7 bits)
DNRF_STREF / Q54530 Aklavinone 12-hydroxylase RdmE; Aklavinone 11-hydroxylase; EC 1.14.13.180 from Streptomyces purpurascens (see 2 papers)
Q54530 aklavinone 12-hydroxylase (EC 1.14.13.180) from Streptomyces purpurascens (see paper)
3ihgA / Q54530 Crystal structure of a ternary complex of aklavinone-11 hydroxylase with fad and aklavinone (see paper)
25% identity, 79% coverage of query (53.5 bits)
rebC / Q8KI25 flavin-dependent monooxygenase RebC (EC 1.13.12.17) from Lentzea aerocolonigenes (see 3 papers)
25% identity, 87% coverage of query (53.1 bits)
3eptA Structure of the rebeccamycin biosynthetic enzyme rebc with reduced flavin
25% identity, 86% coverage of query (52.8 bits)
6j0zC / Q6VMI4 Crystal structure of alpk (see paper)
26% identity, 80% coverage of query (52.4 bits)
5x68B / O15229 Crystal structure of human kmo (see paper)
20% identity, 77% coverage of query (52.4 bits)
NTNK_NECSZ / A0A455M7R7 FAD-dependent monooxygenase ntnK; Nectripenoid biosynthesis cluster protein K; EC 1.-.-.- from Nectria sp. (see paper)
23% identity, 77% coverage of query (51.2 bits)
5x6rA Crystal structure of saccharomyces cerevisiae kmo in complex with ro 61-8048
22% identity, 85% coverage of query (48.5 bits)
4j34B / P38169 Crystal structure of kynurenine 3-monooxygenase - truncated at position 394 plus his tag cleaved. (see paper)
21% identity, 87% coverage of query (48.1 bits)
KMO_YEAST / P38169 Kynurenine 3-monooxygenase; Biosynthesis of nicotinic acid protein 4; Kynurenine 3-hydroxylase; EC 1.14.13.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
P38169 kynurenine 3-monooxygenase (EC 1.14.13.9) from Saccharomyces cerevisiae (see paper)
22% identity, 79% coverage of query (47.8 bits)
DPMPE_MACPH / K2QVI4 FAD-dependent monooxygenase dpmpE; Diterpenoid pyrone biosynthesis cluster protein E; EC 1.-.-.- from Macrophomina phaseolina (strain MS6) (Charcoal rot fungus) (see paper)
20% identity, 83% coverage of query (47.4 bits)
4j36B Cocrystal structure of kynurenine 3-monooxygenase in complex with upf 648 inhibitor(kmo-394upf)
22% identity, 80% coverage of query (47.4 bits)
4eiqA Chromopyrrolic acid-soaked rebc-10x with bound 7-carboxy-k252c
23% identity, 87% coverage of query (43.9 bits)
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Lawrence Berkeley National Laboratory