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Searching for up to 100 curated homologs for CCNA_02572 FitnessBrowser__Caulo:CCNA_02572 (436 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PUR8_BACSU / P12047 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; Glutamyl--tRNA ligase regulatory factor; EC 4.3.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
P12047 adenylosuccinate lyase (EC 4.3.2.2) from Bacillus subtilis (see paper)
purB / GI|143366 (glutamyl-trna synthetase regulatory factor); EC 4.3.2.2 from Bacillus subtilis (see 4 papers)
    50% identity, 99% coverage of query (453 bits)

PUR8_STAAW / Q7A0G9 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Staphylococcus aureus (strain MW2) (see paper)
Q7A0G9 adenylosuccinate lyase (EC 4.3.2.2) from Staphylococcus aureus (see paper)
    47% identity, 99% coverage of query (432 bits)

PUR8_THEMA / Q9X0I0 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    49% identity, 99% coverage of query (427 bits)

2x75A / Q7A0G9 Staphylococcus aureus adenylosuccinate lyase (see paper)
    47% identity, 98% coverage of query (423 bits)

MJ0929 / Q58339 adenylosuccinate lyase (EC 4.3.2.2) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
    38% identity, 95% coverage of query (299 bits)

4eeiB / Q5NIQ1 Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with amp and succinate
    37% identity, 100% coverage of query (263 bits)

5hw2A Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
    40% identity, 87% coverage of query (263 bits)

toyF / B6CWI9 succinylo-toyocamycin phosphate lyase from Streptomyces rimosus (see paper)
    39% identity, 95% coverage of query (255 bits)

2SL_DICD3 / E0SKP1 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    32% identity, 95% coverage of query (217 bits)

2SL_ENTI1 / E6LDH5 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5) (see paper)
    33% identity, 96% coverage of query (207 bits)

Q8ZY28 adenylosuccinate lyase (EC 4.3.2.2) from Pyrobaculum aerophilum (see paper)
    36% identity, 85% coverage of query (192 bits)

Build an alignment

Build an alignment for CCNA_02572 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

YBN5_SCHPO / O42889 Uncharacterized protein C8E4.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 94% coverage of query (166 bits)

TAD1 / A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
TAD1_USTMD / A0A0U2UYC4 Trans-aconitate decarboxylase 1; Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein TAD1; EC 4.1.1.113 from Ustilago maydis (Corn smut fungus) (see 2 papers)
A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
    29% identity, 98% coverage of query (165 bits)

pcaB2 / Q2HNY9 3-carboxymuconate lactonizing enzyme type 2 (EC 5.5.1.2) from Hydrogenophaga intermedia (see 2 papers)
    31% identity, 88% coverage of query (145 bits)

A0R4I6 adenylosuccinate lyase (EC 4.3.2.2) from Mycolicibacterium smegmatis (see paper)
    30% identity, 92% coverage of query (138 bits)

CREDH_STRDJ / K4R6W4 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768) (see paper)
    31% identity, 94% coverage of query (133 bits)

pcaB / AAC37149.1 beta-carboxy-cis,cis-muconate cycloisomerase from Acinetobacter baylyi (see 11 papers)
    27% identity, 99% coverage of query (131 bits)

RR42_RS32055 3-carboxymuconate cycloisomerase PcaB (EC 5.5.1.2) from Cupriavidus basilensis FW507-4G11
    30% identity, 85% coverage of query (130 bits)

5nx9D / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
    26% identity, 100% coverage of query (126 bits)

ade13 / Q05911 Ade13 (EC 4.3.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
    27% identity, 86% coverage of query (125 bits)

Q05911 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    27% identity, 86% coverage of query (125 bits)

ADSL / P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 3 papers)
PUR8_HUMAN / P30566 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Homo sapiens (Human) (see 14 papers)
P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 5 papers)
    26% identity, 100% coverage of query (124 bits)

ade8 / RF|NP_596735.1 adenylosuccinate lyase Ade8; EC 4.3.2.2 from Schizosaccharomyces pombe (see paper)
    26% identity, 95% coverage of query (120 bits)

ADE13 enzyme of adenine biosynthesis from Candida albicans (see paper)
    27% identity, 86% coverage of query (119 bits)

PUR8_CHICK / P21265 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Gallus gallus (Chicken) (see paper)
    26% identity, 92% coverage of query (113 bits)

5eytA / G4VQX9 Crystal structure of adenylosuccinate lyase from schistosoma mansoni in complex with amp (see paper)
    27% identity, 83% coverage of query (108 bits)

B2LS18 adenylosuccinate lyase (EC 4.3.2.2) from Ctenopharyngodon idella (see paper)
    25% identity, 95% coverage of query (108 bits)

5vkwB / A0A1D8PT56 Crystal structure of adenylosuccinate lyase ade13 from candida albicans
    25% identity, 86% coverage of query (103 bits)

D3ZW08 adenylosuccinate lyase (EC 4.3.2.2) from Rattus norvegicus (see paper)
    24% identity, 95% coverage of query (100 bits)

5nxaA Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
    24% identity, 100% coverage of query (100 bits)

creD / A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
CRED_STRCM / A0A0K2JL82 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces cremeus (see 3 papers)
A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
    31% identity, 70% coverage of query (98.6 bits)

5nxaB Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
    25% identity, 79% coverage of query (98.2 bits)

5nx9C / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
    24% identity, 100% coverage of query (96.3 bits)

5nxaC / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate (see paper)
    25% identity, 83% coverage of query (94.0 bits)

5xnzA / A0A0K2JL82 Crystal structure of cred complex with fumarate (see paper)
    31% identity, 70% coverage of query (86.7 bits)

purB / AAA92731.1 adenylosuccinate lyase from Escherichia coli (see paper)
    28% identity, 75% coverage of query (86.3 bits)

Ade / b1131 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
purB / P0AB89 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli (strain K12) (see 8 papers)
PUR8_ECOLI / P0AB89 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Escherichia coli (strain K12) (see 3 papers)
purB / MB|P0AB89 adenylosuccinate lyase from Escherichia coli K12 (see 2 papers)
    28% identity, 75% coverage of query (85.5 bits)

Q8X737 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli (see paper)
    28% identity, 75% coverage of query (85.5 bits)

2ptqA Crystal structure of escherichia coli adenylosuccinate lyase mutant h171n with bound amp and fumarate
    28% identity, 75% coverage of query (84.0 bits)

2ptrA Crystal structure of escherichia coli adenylosuccinate lyase mutant h171a with bound adenylosuccinate substrate
    28% identity, 75% coverage of query (82.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory