Sites on a Tree

 

Searching for up to 100 curated homologs for CCNA_03203 FitnessBrowser__Caulo:CCNA_03203 (325 a.a.)

Found high-coverage hits (≥70%) to 84 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
    45% identity, 98% coverage of query (263 bits)

LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    44% identity, 99% coverage of query (260 bits)

L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
    44% identity, 98% coverage of query (255 bits)

SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
    39% identity, 97% coverage of query (238 bits)

2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
    39% identity, 97% coverage of query (238 bits)

2zr8A Crystal structure of modified serine racemase complexed with serine
    39% identity, 97% coverage of query (238 bits)

1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
    39% identity, 97% coverage of query (238 bits)

1v71A Crystal structure of s.Pombe serine racemase
    39% identity, 97% coverage of query (238 bits)

Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
    37% identity, 99% coverage of query (219 bits)

TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    39% identity, 98% coverage of query (214 bits)

Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
    41% identity, 99% coverage of query (205 bits)

SRR_ORYSJ / Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q7XSN8 serine racemase (EC 5.1.1.18) from Oryza sativa (see paper)
    36% identity, 98% coverage of query (203 bits)

BHCB_PARDP / A1B8Z2 beta-hydroxyaspartate dehydratase; EC 4.2.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
    37% identity, 95% coverage of query (199 bits)

sr / Q2PGG3 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Arabidopsis thaliana (see paper)
SRR_ARATH / Q2PGG3 Serine racemase; AtSR; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q2PGG3 serine racemase (EC 5.1.1.18) from Arabidopsis thaliana (see paper)
    38% identity, 95% coverage of query (199 bits)

sr / A5HUN0 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Hordeum vulgare (see paper)
A5HUN0 serine racemase (EC 5.1.1.18) from Hordeum vulgare (see paper)
    38% identity, 95% coverage of query (197 bits)

F7ZG00 serine racemase (EC 5.1.1.18) from Roseobacter litoralis (see paper)
    36% identity, 98% coverage of query (193 bits)

5cvcA / F5CAQ9 Structure of maize serine racemase (see paper)
    37% identity, 97% coverage of query (193 bits)

F5CAQ9 serine racemase (EC 5.1.1.18) from Zea mays (see paper)
    37% identity, 97% coverage of query (192 bits)

B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
    36% identity, 98% coverage of query (191 bits)

SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 3 papers)
    35% identity, 96% coverage of query (188 bits)

7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
    35% identity, 96% coverage of query (188 bits)

7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    35% identity, 96% coverage of query (188 bits)

7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
    35% identity, 96% coverage of query (188 bits)

7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
    35% identity, 96% coverage of query (188 bits)

7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
    35% identity, 96% coverage of query (188 bits)

7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
    35% identity, 96% coverage of query (187 bits)

7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    35% identity, 96% coverage of query (187 bits)

6zspAAA serine racemase bound to atp and malonate.
    35% identity, 96% coverage of query (187 bits)

3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
    35% identity, 96% coverage of query (187 bits)

FSDH_RALPI / Q10725 Phenylserine dehydratase; EC 4.2.1.- from Ralstonia pickettii (Burkholderia pickettii) (see 2 papers)
    38% identity, 99% coverage of query (185 bits)

A0A0U4MRI4 serine racemase (EC 5.1.1.18) from Penaeus monodon (see paper)
    37% identity, 96% coverage of query (184 bits)

A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
    33% identity, 96% coverage of query (181 bits)

1ve5A / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    43% identity, 95% coverage of query (179 bits)

Tdc / b3117 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
tdcB / P0AGF6 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli (strain K12) (see 25 papers)
TDCB_ECOLI / P0AGF6 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Escherichia coli (strain K12) (see 4 papers)
tdcB / RF|NP_417587 threonine ammonia-lyase; EC 4.3.1.19 from Escherichia coli K12 (see 7 papers)
    37% identity, 99% coverage of query (178 bits)

A0QY48 L-serine ammonia-lyase (EC 4.3.1.17) from Mycolicibacterium smegmatis (see paper)
    41% identity, 99% coverage of query (177 bits)

SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 5 papers)
    36% identity, 96% coverage of query (175 bits)

TD2_SOLLC / P25306 Threonine dehydratase 2 biosynthetic, chloroplastic; SlTD2; Threonine deaminase 2; EC 4.3.1.17; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 5 papers)
    37% identity, 85% coverage of query (174 bits)

TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens (see paper)
    41% identity, 94% coverage of query (173 bits)

TDCB_SALTY / P11954 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    36% identity, 99% coverage of query (172 bits)

2gn2A / P11954 Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
    36% identity, 99% coverage of query (172 bits)

CCNA_03750 threonine deaminase (EC 4.3.1.19) from Caulobacter crescentus NA1000
    38% identity, 99% coverage of query (172 bits)

CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
    34% identity, 96% coverage of query (170 bits)

ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
    35% identity, 90% coverage of query (169 bits)

TD_NICAT / Q9AXU4 Threonine dehydratase; Threonine deaminase; EC 4.3.1.19 from Nicotiana attenuata (Coyote tobacco) (see 2 papers)
Q9AXU4 threonine ammonia-lyase (EC 4.3.1.19) from Nicotiana attenuata (see paper)
    32% identity, 94% coverage of query (169 bits)

K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
    35% identity, 96% coverage of query (168 bits)

A0A0U5A554 aspartate racemase (EC 5.1.1.13) from Penaeus monodon (see paper)
    35% identity, 96% coverage of query (168 bits)

AKS11_ALTAL / V5Y0V0 Threonine dehydratase-like protein AKTS1-1; AK-toxin biosynthesis protein S1-1; EC 4.3.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
    35% identity, 92% coverage of query (167 bits)

SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 2 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
    35% identity, 96% coverage of query (167 bits)

3hmkA Crystal structure of serine racemase
    35% identity, 96% coverage of query (167 bits)

ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
    34% identity, 90% coverage of query (164 bits)

1ve5D / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    41% identity, 95% coverage of query (162 bits)

THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    36% identity, 90% coverage of query (162 bits)

CH_124219 threonine deaminase [Arxula adeninivorans] from Magnaporthe grisea 70-15 (see paper)
    37% identity, 90% coverage of query (152 bits)

Asr / BAE78960.1 aspartate racemase from Scapharca broughtonii (see paper)
    32% identity, 96% coverage of query (151 bits)

ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
    34% identity, 98% coverage of query (150 bits)

Q2V0H1 serine racemase (EC 5.1.1.18) from Pyrobaculum islandicum (see paper)
    36% identity, 94% coverage of query (150 bits)

1tdjA / P04968 Threonine deaminase (biosynthetic) from e. Coli (see paper)
    35% identity, 90% coverage of query (150 bits)

Ile / b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ilvA / P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12) (see 21 papers)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see 4 papers)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli (see paper)
    35% identity, 90% coverage of query (150 bits)

THDH_YEAST / P00927 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    34% identity, 90% coverage of query (149 bits)

V6QU65 threonine ammonia-lyase (EC 4.3.1.19) from Fusarium graminearum (see paper)
    34% identity, 94% coverage of query (149 bits)

TD1_SOLLC / A0FKE6 Threonine dehydratase 1 biosynthetic, chloroplastic; SlTD1; Threonine deaminase 1; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 2 papers)
    35% identity, 91% coverage of query (146 bits)

A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
    33% identity, 98% coverage of query (145 bits)

Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
    31% identity, 96% coverage of query (145 bits)

Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
    33% identity, 97% coverage of query (135 bits)

Build an alignment

Build an alignment for CCNA_03203 and 64 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

STDH_YEAST / P25379 Catabolic L-serine/threonine dehydratase; EC 4.3.1.17; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    27% identity, 85% coverage of query (79.0 bits)

DPAL_SALTY / P40817 Diaminopropionate ammonia-lyase; DAPAL; 2,3-diaminopropionate ammonia-lyase; Alpha,beta-diaminopropionate ammonia-lyase; Diaminopropionatase; EC 4.3.1.15 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
P40817 Diaminopropionate ammonia-lyase (EC 4.3.1.15) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    27% identity, 81% coverage of query (75.5 bits)

5ygrB / P40817 Crystal structure of plp bound diaminopropionate ammonia lyase from salmonella typhimurium (see paper)
    28% identity, 81% coverage of query (69.7 bits)

5ygrD / P40817 Crystal structure of plp bound diaminopropionate ammonia lyase from salmonella typhimurium (see paper)
    27% identity, 81% coverage of query (69.3 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    25% identity, 90% coverage of query (63.2 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    25% identity, 90% coverage of query (62.8 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    25% identity, 90% coverage of query (62.8 bits)

A0A0X1KHE6 L-serine ammonia-lyase (EC 4.3.1.17) from Rhizomucor miehei (see paper)
    26% identity, 91% coverage of query (60.8 bits)

5c3uA / A0A0X1KHE6 Crystal structure of a fungal l-serine ammonia-lyase from rhizomucor miehei (see paper)
    26% identity, 90% coverage of query (59.7 bits)

YgeX / b2871 2,3-diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
ygeX / P66899 2,3-diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli (strain K12) (see 5 papers)
DPAL_ECOLI / P66899 Diaminopropionate ammonia-lyase; DAPAL; 2,3-diaminopropionate ammonia-lyase; Alpha,beta-diaminopropionate ammonia-lyase; Diaminopropionatase; EC 4.3.1.15 from Escherichia coli (strain K12) (see 4 papers)
P66899 Diaminopropionate ammonia-lyase (EC 4.3.1.15) from Escherichia coli (see 3 papers)
    27% identity, 77% coverage of query (59.7 bits)

A0A0U3SCD8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Pieris rapae (see paper)
    27% identity, 81% coverage of query (57.4 bits)

thrC / CAA82669.1 threonine synthase from Bacillus sp. (see paper)
    26% identity, 91% coverage of query (57.4 bits)

4d9mA Crystal structure of diaminopropionate ammonia lyase from escherichia coli in complex with aminoacrylate-plp azomethine reaction intermediate
    28% identity, 77% coverage of query (55.8 bits)

4d9nA / P66899 Crystal structure of diaminopropionate ammonia lyase from escherichia coli in complex with d-serine (see paper)
    27% identity, 77% coverage of query (53.5 bits)

A0A220K8D2 L-3-cyanoalanine synthase (EC 4.4.1.9) from Aporia crataegi (see paper)
    24% identity, 81% coverage of query (52.8 bits)

A0A220K8B9 L-3-cyanoalanine synthase (EC 4.4.1.9) from Plutella xylostella (see paper)
    27% identity, 81% coverage of query (52.8 bits)

8eh0A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with quinoline n-oxide
    26% identity, 89% coverage of query (48.5 bits)

8egyA Engineered holo tyrosine synthase (tmtyrs1) derived from t. Maritima trpb
    26% identity, 89% coverage of query (48.5 bits)

8egzB / P50909 Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate
    26% identity, 89% coverage of query (48.5 bits)

A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    25% identity, 90% coverage of query (46.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory