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Searching for up to 100 curated homologs for CCNA_03383 FitnessBrowser__Caulo:CCNA_03383 (617 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hcuC / BAC81752.1 hydrophobic compound transport factor from Pseudomonas aeruginosa (see paper)
    47% identity, 92% coverage of query (474 bits)

5ochE / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
    42% identity, 80% coverage of query (360 bits)

ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
    38% identity, 90% coverage of query (360 bits)

4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
    39% identity, 87% coverage of query (360 bits)

MITOS_HUMAN / Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 5 papers)
Q9NUT2 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
TC 3.A.1.201.22 / Q9NUT2 Mitochondrial ATP-binding cassette 1, ABCB8 from Homo sapiens
    42% identity, 80% coverage of query (359 bits)

MITOS_RAT / Q5RKI8 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Rattus norvegicus (Rat) (see paper)
    41% identity, 80% coverage of query (358 bits)

ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
    38% identity, 96% coverage of query (357 bits)

MITOS_MOUSE / Q9CXJ4 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Mus musculus (Mouse) (see paper)
    41% identity, 80% coverage of query (354 bits)

7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
    38% identity, 87% coverage of query (350 bits)

7ehlA Cryo-em structure of human abcb8 transporter in nucleotide binding state
    42% identity, 80% coverage of query (348 bits)

MDL1_SCHPO / Q9Y7M7 ATP-dependent permease MDL1, mitochondrial; ABC transporter mdl1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
mdl1 mitochondrial peptide-transporting ATPase from Schizosaccharomyces pombe (see 2 papers)
    37% identity, 90% coverage of query (344 bits)

4aywA Structure of the human mitochondrial abc transporter, abcb10 (plate form)
    38% identity, 87% coverage of query (342 bits)

ABCB5_MOUSE / B5X0E4 ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
    38% identity, 83% coverage of query (338 bits)

AB25B_ORYSJ / Q9FNU2 ABC transporter B family member 25; ABC transporter ABCB.25; OsABCB25; Protein ALS1 homolog; Protein ALUMINUM SENSITIVE 1; OsALS1 from Oryza sativa subsp. japonica (Rice) (see paper)
    40% identity, 82% coverage of query (338 bits)

TC 3.A.1.201.16 / I0DHH7 MDR efflux pump, ABCB4a from Strongylocentrotus purpuratus
    38% identity, 85% coverage of query (336 bits)

ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
    34% identity, 99% coverage of query (333 bits)

ABCB9_RAT / Q9QYJ4 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; TAP-like protein; TAPL; EC 7.4.2.6 from Rattus norvegicus (Rat) (see 3 papers)
    34% identity, 98% coverage of query (330 bits)

ABCB9_MOUSE / Q9JJ59 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; mABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Mus musculus (Mouse) (see paper)
    34% identity, 98% coverage of query (329 bits)

7v5cA / Q9JJ59 Cryo-em structure of the mouse abcb9 (adp.Bef3-bound) (see paper)
    35% identity, 90% coverage of query (329 bits)

7vfiA Cryo-em structure of the mouse tapl (9mer-peptide bound)
    35% identity, 90% coverage of query (329 bits)

5ochC / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
    40% identity, 80% coverage of query (327 bits)

msbA / Q2YJN8 lipid A-core oligosaccharide flippase (EC 7.5.2.6) from Brucella abortus (strain 2308) (see 2 papers)
    37% identity, 88% coverage of query (326 bits)

TAGA_DICDI / Q9GTN7 Serine protease/ABC transporter B family protein tagA; EC 3.4.21.- from Dictyostelium discoideum (Social amoeba) (see 3 papers)
    33% identity, 87% coverage of query (323 bits)

TC 3.A.1.201.12 / B2WTH9 California mussel ABCB/MDR multixenobiotic resistance efflux pump from Mytilus californianus (see paper)
    37% identity, 79% coverage of query (323 bits)

AB4B_ARATH / O80725 ABC transporter B family member 4; ABC transporter ABCB.4; AtABCB4; Multidrug resistance protein 4; P-glycoprotein 4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.7 / O80725 Auxin efflux pump Pgp4; AbcB4; MDR4; PGP4 (Lefèvre and Boutry 2018) of 1286 aas and 12 TMSs in a MCMC domain arrangement from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
MDR4 / RF|NP_182223.1 multidrug resistance protein 4; EC 3.6.3.44 from Arabidopsis thaliana (see paper)
    36% identity, 79% coverage of query (319 bits)

Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
    36% identity, 82% coverage of query (318 bits)

2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
    36% identity, 82% coverage of query (318 bits)

TC 3.A.1.201.15 / Q3T7C8 MDR efflux pump, ABCB1a from Strongylocentrotus purpuratus
    36% identity, 89% coverage of query (317 bits)

AB27B_ARATH / Q0WML0 ABC transporter B family member 27; ABC transporter ABCB.27; AtABCB27; Aluminum tolerance-related ATP-binding cassette transporter; Antigen peptide transporter-like 2; Transporter associated with antigen processing-like protein 2; AtTAP2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 3.A.1.201.8 / Q0WML0 The aluminum chelate (aluminum sensitivity (ALS1)) protein; expressed in root vacuoles half-type ABC transporter from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
TAP2 / RF|NP_198720.2 antigen peptide transporter-like 2 from Arabidopsis thaliana (see paper)
    39% identity, 82% coverage of query (315 bits)

MDR2_ASPFU / Q4WPP6 ABC multidrug transporter mdr2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 4 papers)
    36% identity, 88% coverage of query (315 bits)

P63359 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
    33% identity, 92% coverage of query (314 bits)

ABCB5_HUMAN / Q2M3G0 ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; EC 7.6.2.2 from Homo sapiens (Human) (see 11 papers)
Q2M3G0 ABC-type xenobiotic transporter (EC 7.6.2.2) from Homo sapiens (see 2 papers)
    35% identity, 92% coverage of query (314 bits)

3wmgA Crystal structure of an inward-facing eukaryotic abc multidrug transporter g277v/a278v/a279v mutant in complex with an cyclic peptide inhibitor, acap
    37% identity, 85% coverage of query (314 bits)

TC 3.A.1.201.23 / Q8T9W4 The cyclic AMP efflux pump of 1432 aas, ABCB3 from Dictyostelium discoideum
    36% identity, 79% coverage of query (312 bits)

MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
    33% identity, 92% coverage of query (312 bits)

6a6mA / M1VAN7 Crystal structure of an outward-open nucleotide-bound state of the eukaryotic abc multidrug transporter cmabcb1 (see paper)
    37% identity, 85% coverage of query (311 bits)

TC 3.A.1.201.21 / M1VAN7 Half sized ABCB1 drug (verapamil; rhodamine 6G) exporter of specificity similar to that of P-glycoprotein (3.A.1.201.1) from Cyanidioschyzon merolae strain 10D
    37% identity, 85% coverage of query (311 bits)

7fc9A Crystal structure of cmabcb1 in lipidic mesophase revealed by lcp-sfx
    37% identity, 84% coverage of query (310 bits)

7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
    33% identity, 92% coverage of query (310 bits)

8dmmA Structure of the vanadate-trapped msba bound to kdl
    33% identity, 92% coverage of query (310 bits)

7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
    33% identity, 92% coverage of query (307 bits)

7mewA E. Coli msba in complex with g247
    33% identity, 92% coverage of query (307 bits)

7bcwA Structure of msba in salipro with adp vanadate
    33% identity, 92% coverage of query (307 bits)

6bppA E. Coli msba in complex with lps and inhibitor g092
    33% identity, 92% coverage of query (307 bits)

6bplA E. Coli msba in complex with lps and inhibitor g907
    33% identity, 92% coverage of query (307 bits)

At3g28860 / AAN28720.2 MDR-like p-glycoprotein from Arabidopsis thaliana (see paper)
    36% identity, 89% coverage of query (306 bits)

AB19B_ARATH / Q9LJX0 ABC transporter B family member 19; ABC transporter ABCB.19; AtABCB19; Multidrug resistance protein 11; P-glycoprotein 19 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 3.A.1.201.6 / Q9LJX0 Auxin efflux pump Pgp19 (MDR11; ABCB19; ABCB21) (regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase (TC# 8.A.11.1.1) from Arabidopsis thaliana (Mouse-ear cress) (see 9 papers)
MDR11 / RF|NP_189528.1 multidrug resistance protein 11 from Arabidopsis thaliana (see paper)
    36% identity, 89% coverage of query (306 bits)

6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
    36% identity, 83% coverage of query (306 bits)

6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
    36% identity, 83% coverage of query (306 bits)

MDR1_CRIGR / P21448 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    36% identity, 83% coverage of query (305 bits)

TC 3.A.1.109.1 / P08716 α-Hemolysin exporter. HlyB has an (inactive?) N-terminal C39 peptidase-like domain from Escherichia coli (see 5 papers)
    36% identity, 89% coverage of query (305 bits)

MDR1A_MOUSE / P21447 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 1A; Multidrug resistance protein 3; P-glycoprotein 3; Phospholipid transporter ABCB1; EC 7.6.2.2; EC 7.6.2.1 from Mus musculus (Mouse) (see paper)
P21447 ABC-type xenobiotic transporter (EC 7.6.2.2) from Mus musculus (see paper)
    36% identity, 83% coverage of query (304 bits)

TC 3.A.1.106.14 / P73239 Lipid A exporter homologue of 593 aas and 6 TMSs (N-terminal with a C-terminal ATPase domain from Synechocystis sp. (strain PCC 6803 / Kazusa)
    35% identity, 83% coverage of query (304 bits)

4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
    36% identity, 83% coverage of query (304 bits)

4q9iA P-glycoprotein cocrystallised with qz-ala
    36% identity, 83% coverage of query (304 bits)

6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
    36% identity, 83% coverage of query (304 bits)

3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    36% identity, 83% coverage of query (304 bits)

3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    36% identity, 83% coverage of query (304 bits)

4xwkA P-glycoprotein co-crystallized with bde-100
    36% identity, 83% coverage of query (304 bits)

MDR3_RAT / Q08201 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; Multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3; EC 7.6.2.1 from Rattus norvegicus (Rat) (see 3 papers)
Q08201 ABC-type xenobiotic transporter (EC 7.6.2.2) from Rattus norvegicus (see paper)
    37% identity, 83% coverage of query (303 bits)

MDR3_MOUSE / P21440 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; Multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3; EC 7.6.2.1 from Mus musculus (Mouse) (see 14 papers)
    36% identity, 83% coverage of query (303 bits)

7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
    36% identity, 83% coverage of query (303 bits)

7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
    36% identity, 83% coverage of query (303 bits)

7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
    36% identity, 83% coverage of query (303 bits)

7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
    36% identity, 83% coverage of query (303 bits)

7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
    36% identity, 83% coverage of query (303 bits)

5koyA Mouse pgp 34 linker deleted bound with atp
    36% identity, 83% coverage of query (303 bits)

hlyB / CAD33760.1 hemolysin B from Escherichia coli (see paper)
hlyB / CAD42038.1 HlyB protein from Escherichia coli (see paper)
    35% identity, 92% coverage of query (302 bits)

7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
    35% identity, 92% coverage of query (302 bits)

AB1B_ARATH / Q9ZR72 ABC transporter B family member 1; ABC transporter ABCB.1; AtABCB1; Multidrug resistance protein 1; P-glycoprotein 1; AtPgp1 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
TC 3.A.1.201.5 / Q9ZR72 Auxin efflux pump Pgp1 (MDR1; ABCB1) (Carraro et al. 2012). Regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase; 8.A.11.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
MDR1 / RF|NP_181228.1 multidrug resistance protein 1 from Arabidopsis thaliana (see paper)
    38% identity, 79% coverage of query (302 bits)

TC 3.A.1.106.3 / Q8G7R7 Probable permease protein of ABC transporter system, component of The dimeric multidrug resistance exporter, ABC1/2 (exports the peptide antimicrobials, nisin and polymyxin; (Margolles et al., 2006) (both ABC1 and ABC2 also show striking similarity to family 3.A.1.117) from Bifidobacterium longum (see paper)
    34% identity, 85% coverage of query (301 bits)

7selA E. Coli msba in complex with lps and inhibitor g7090 (compound 3)
    33% identity, 92% coverage of query (301 bits)

ABCB1 / RF|NP_000918.2 multidrug resistance protein 1 from Homo sapiens
    35% identity, 83% coverage of query (299 bits)

ABCB1 / P08183 ATP-dependent translocase ABCB1 (EC 7.6.2.2) from Homo sapiens (see 39 papers)
MDR1_HUMAN / P08183 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Homo sapiens (Human) (see 8 papers)
P08183 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 10 papers)
TC 3.A.1.201.1 / P08183 Broad specificity multidrug resistance (MDR1; MDR-1; Pgp; P-gp; ABCB1; P-glycoprotein) efflux pump. It exports organic cations and amphiphilic compounds of unrelated chemical structure from Homo sapiens (Human) (see 19 papers)
    35% identity, 83% coverage of query (299 bits)

6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
    35% identity, 83% coverage of query (298 bits)

TC 3.A.1.201.25 / A5X7X7 MDR transporter, Crmdr1 of 1266 aas and 12 TMSs from Catharanthus roseus
    34% identity, 91% coverage of query (298 bits)

Q9HUG8 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Pseudomonas aeruginosa (see paper)
    38% identity, 81% coverage of query (298 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    35% identity, 83% coverage of query (298 bits)

AAA66476.1 SMDR1 from Schistosoma mansoni (see paper)
    36% identity, 84% coverage of query (298 bits)

7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
    35% identity, 83% coverage of query (298 bits)

7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
    35% identity, 83% coverage of query (298 bits)

7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
    35% identity, 83% coverage of query (298 bits)

7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
    35% identity, 83% coverage of query (298 bits)

7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
    35% identity, 83% coverage of query (298 bits)

PGP1_CAEEL / P34712 Multidrug resistance protein pgp-1; P-glycoprotein A; P-glycoprotein-related protein 1; EC 7.6.2.2 from Caenorhabditis elegans (see paper)
P34712 ABC-type xenobiotic transporter (EC 7.6.2.2) from Caenorhabditis elegans (see paper)
TC 3.A.1.201.14 / P34712 P-glycoprotein-1 MDR exporter from Caenorhabditis elegans
    34% identity, 98% coverage of query (297 bits)

6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
    35% identity, 83% coverage of query (297 bits)

TC 3.A.1.210.9 / Q1LRE9 The Ni2+/Co2+ exporter AtmA from Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    34% identity, 94% coverage of query (296 bits)

YWJA_BACSU / P45861 Uncharacterized ABC transporter ATP-binding protein YwjA from Bacillus subtilis (strain 168) (see 2 papers)
    33% identity, 90% coverage of query (296 bits)

MDL1_YEAST / P33310 ATP-dependent permease MDL1, mitochondrial; ABC transporter MDL1; Multidrug resistance-like protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 3.A.1.212.1 / P33310 The mitochondrial peptide exporter, Mdl1p (exports peptides of 6-21 amino acyl residues from the mitochondrial matrix as well as degradation products of misassembled respiratory chain complexes) (Janas et al., 2003; van der Does et al., 2006; Gompf et al., 2007). A leaderless Mdl1p targets to the ER membrane instead of to the mitochondria from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
MDL1 / RF|NP_013289.1 ATP-dependent permease MDL1, mitochondrial; EC 3.6.3.43 from Saccharomyces cerevisiae (see paper)
    35% identity, 84% coverage of query (296 bits)

MDR1_CRYGR / A0A095C325 ABC multidrug transporter MDR1 from Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii) (Cryptococcus bacillisporus) (see 2 papers)
    37% identity, 83% coverage of query (296 bits)

MDR2_TRIRC / F2T1C4 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus) (see 3 papers)
    36% identity, 83% coverage of query (296 bits)

MDR2_TRIIM / A0A059JJ46 ABC multidrug transporter MDR2; Multidrug resistance protein 2 from Trichophyton interdigitale (strain MR816) (see 4 papers)
    36% identity, 83% coverage of query (296 bits)

8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
    35% identity, 91% coverage of query (296 bits)

4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
    38% identity, 80% coverage of query (294 bits)

6s7pA Nucleotide bound abcb4
    35% identity, 83% coverage of query (293 bits)

7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
    35% identity, 83% coverage of query (293 bits)

7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
    36% identity, 80% coverage of query (291 bits)

7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
    35% identity, 83% coverage of query (291 bits)

BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
    34% identity, 87% coverage of query (290 bits)

TAP2_RAT / P36372 Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; EC 7.4.2.14 from Rattus norvegicus (Rat) (see paper)
P36372 ABC-type antigen peptide transporter (subunit 1/2) (EC 7.4.2.14) from Rattus norvegicus (see 6 papers)
    38% identity, 79% coverage of query (288 bits)

Build an alignment

Build an alignment for CCNA_03383 and 100 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory