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Searching for up to 100 curated homologs for CCNA_03541 FitnessBrowser__Caulo:CCNA_03541 (279 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4gieA / Q4DJ07 Crystal structure of prostaglandin f synthase from trypanosoma cruzi bound to NADP (see paper)
    46% identity, 91% coverage of query (211 bits)

Q4DJ07 prostaglandin-F synthase (EC 1.1.1.188) from Trypanosoma cruzi (see paper)
    46% identity, 91% coverage of query (211 bits)

4fziA Crystal structure of prostaglandin f synthase from trypanosoma cruzi
    46% identity, 91% coverage of query (211 bits)

PGFS_TRYBB / Q9GV41 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Trypanosoma brucei brucei (see paper)
    44% identity, 90% coverage of query (208 bits)

1vbjA / Q9GV41 The crystal structure of prostaglandin f synthase from trypanosoma brucei
    44% identity, 90% coverage of query (208 bits)

A0QV10 Aldo-keto reductase MSMEG_2408/MSMEI_2347; EC 1.1.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    45% identity, 88% coverage of query (207 bits)

A0A3P3ZE14 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania braziliensis (see paper)
    42% identity, 90% coverage of query (204 bits)

BN592_00768 / R7AF73 NAD(P)-dependent bile acid 3β-dehydrogenase (EC 1.1.1.391) from Eggerthella sp. CAG:298 (see 2 papers)
R7AF73 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) (EC 1.1.1.213); 3beta-hydroxysteroid 3-dehydrogenase (EC 1.1.1.270) from Eggerthella sp. CAG:298 (see paper)
    40% identity, 92% coverage of query (197 bits)

H9CWC0 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming) (EC 1.1.1.274) from Corynebacterium glutamicum (see paper)
    41% identity, 94% coverage of query (196 bits)

PGFS_LEIMA / P22045 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Leishmania major (see paper)
P22045 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania major (see paper)
    42% identity, 92% coverage of query (194 bits)

4g5dA / P22045 X-ray crystal structure of prostaglandin f synthase from leishmania major friedlin bound to NADPH (see paper)
    42% identity, 92% coverage of query (193 bits)

3d3fA / O32210 Crystal structure of yvgn and cofactor NADPH from bacillus subtilis (see paper)
    43% identity, 91% coverage of query (191 bits)

yvgN / O32210 glyoxal/methylglyoxal reductase (EC 1.1.1.283; EC 1.1.1.91) from Bacillus subtilis (strain 168) (see 3 papers)
GR_BACSU / O32210 Glyoxal reductase; GR; Methylglyoxal reductase; EC 1.1.1.-; EC 1.1.1.283 from Bacillus subtilis (strain 168) (see paper)
    43% identity, 91% coverage of query (191 bits)

DkgB / b0207 methylglyoxal reductase DkgB (EC 1.1.1.91; EC 1.1.1.346) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
dkgB / P30863 methylglyoxal reductase DkgB (EC 1.1.1.21; EC 1.1.1.91; EC 1.1.1.346) from Escherichia coli (strain K12) (see 5 papers)
dkgB / MB|P30863 2,5-diketo-D-gluconic acid reductase B; EC 1.1.1.274 from Escherichia coli K12 (see 5 papers)
    41% identity, 91% coverage of query (191 bits)

AK1A1_RAT / P51635 Aldo-keto reductase family 1 member A1; 3-DG-reducing enzyme; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Rattus norvegicus (Rat) (see 4 papers)
P51635 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Rattus norvegicus (see 2 papers)
    36% identity, 89% coverage of query (189 bits)

Akr1a4 / Q9JII6 alcohol dehydrogenase [NADP+] (EC 1.1.1.19) from Mus musculus (see 4 papers)
AK1A1_MOUSE / Q9JII6 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Mus musculus (Mouse) (see 5 papers)
Q540D7 aldehyde dehydrogenase (NADP+) (EC 1.2.1.4) from Mus musculus (see paper)
Q9JII6 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Mus musculus (see paper)
    36% identity, 89% coverage of query (187 bits)

Y2407_MYCS2 / A0QV09 Aldo-keto reductase MSMEG_2407/MSMEI_2346; AKR; AKR5H1; EC 1.1.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    40% identity, 90% coverage of query (185 bits)

2wzmA / A0QV09 Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form (see paper)
    40% identity, 90% coverage of query (185 bits)

AK1A1_HUMAN / P14550 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Homo sapiens (Human) (see 4 papers)
    36% identity, 89% coverage of query (184 bits)

DkgA / b3012 methylglyoxal reductase DkgA (EC 1.1.1.346) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
dkgA / Q46857 methylglyoxal reductase DkgA (EC 1.1.1.21; EC 1.1.1.346) from Escherichia coli (strain K12) (see 9 papers)
Q46857 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) (EC 1.1.1.346) from Escherichia coli (see paper)
    38% identity, 91% coverage of query (183 bits)

3cv7A Crystal structure of porcine aldehyde reductase ternary complex
    36% identity, 89% coverage of query (182 bits)

AKR1A1 / P50578 aldehyde reductase (EC 1.1.1.2) from Sus scrofa (see paper)
AK1A1_PIG / P50578 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Sus scrofa (Pig) (see paper)
P50578 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Sus scrofa (see 2 papers)
3fx4A / P50578 Porcine aldehyde reductase in ternary complex with inhibitor (see paper)
    36% identity, 89% coverage of query (181 bits)

Q5FT75 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans (see paper)
    35% identity, 96% coverage of query (181 bits)

3h4gA Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
    36% identity, 89% coverage of query (181 bits)

Y2996_MYCBO / Q7TXI6 Aldo-keto reductase BQ2027_MB2996; EC 1.1.1.- from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
    40% identity, 88% coverage of query (180 bits)

AKR1E2 / P82125 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Sus scrofa (see paper)
AKCL2_PIG / P82125 1,5-anhydro-D-fructose reductase; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member CL2; Aldo-keto reductase family 1 member E2; EC 1.1.1.263 from Sus scrofa (Pig) (see paper)
    38% identity, 89% coverage of query (180 bits)

Y2971_MYCTU / P9WQA5 Aldo-keto reductase Rv2971; AKR; EC 1.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    40% identity, 88% coverage of query (180 bits)

3wbwA / Q5FT75 Crystal structure of gox0644 in complex with NADPH
    36% identity, 91% coverage of query (179 bits)

AK1CA_RAT / D3ZF77 Aldo-keto reductase family 1 member C15; RAKc; EC 1.1.1.-; EC 1.1.1.216 from Rattus norvegicus (Rat) (see 4 papers)
    35% identity, 89% coverage of query (177 bits)

dkgA / P06632 2,5-diketo-D-gluconate reductase A monomer (EC 1.1.1.346) from Corynebacterium sp. (strain ATCC 31090) (see 4 papers)
DKGA_CORSC / P06632 2,5-diketo-D-gluconic acid reductase A; 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C; EC 1.1.1.346 from Corynebacterium sp. (strain ATCC 31090) (see 2 papers)
P06632 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) (EC 1.1.1.346) from Corynebacterium sp. (see paper)
    42% identity, 90% coverage of query (177 bits)

3h7uA / Q0PGJ6 Crystal structure of the plant stress-response enzyme akr4c9 (see paper)
    36% identity, 87% coverage of query (177 bits)

AKR4C9 / Q0PGJ6 aldo-keto reductase family 4 member C9 (EC 1.1.1.21; EC 1.1.1.210; EC 1.1.1.2; EC 1.1.1.54) from Arabidopsis thaliana (see 2 papers)
AKRC9_ARATH / Q0PGJ6 NADPH-dependent aldo-keto reductase, chloroplastic; AtChlAKR; Aldo-keto reductase family 4 member C9; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    36% identity, 87% coverage of query (177 bits)

1a80A / P06632 Native 2,5-diketo-d-gluconic acid reductase a from corynbacterium sp. Complexed with NADPH (see paper)
    42% identity, 90% coverage of query (177 bits)

Q5DD64 aldose reductase (EC 1.1.1.21) from Schistosoma japonicum (see paper)
    35% identity, 87% coverage of query (176 bits)

5jh2A / A2T1W7 Crystal structure of the holo form of akr4c7 from maize (see paper)
    37% identity, 87% coverage of query (176 bits)

E3W861 carbonyl reductase (NADPH) (EC 1.1.1.184) from Bacillus sp. (in: Bacteria) (see paper)
3b3dA / O34678 B.Subtilis ytbe (see paper)
    40% identity, 91% coverage of query (174 bits)

1m9hA Corynebacterium 2,5-dkgr a and phe 22 replaced with tyr (f22y), lys 232 replaced with gly (k232g), arg 238 replaced with his (r238h)and ala 272 replaced with gly (a272g)in presence of nadh cofactor
    42% identity, 90% coverage of query (174 bits)

A2T1W7 aldose reductase (EC 1.1.1.21) from Zea mays (see 2 papers)
    35% identity, 87% coverage of query (172 bits)

akr5f1 organophosphate reductase from Klebsiella sp. F51-1-2 (see paper)
    39% identity, 88% coverage of query (172 bits)

1vp5A / Q9X0A2 Crystal structure of 2,5-diketo-d-gluconic acid reductase (tm1009) from thermotoga maritima at 2.40 a resolution
    38% identity, 91% coverage of query (171 bits)

3h7rA / O80944 Crystal structure of the plant stress-response enzyme akr4c8 (see paper)
    35% identity, 85% coverage of query (169 bits)

AKR4C8 / O80944 aldo-keto reductase family 4 member C8 (EC 1.1.1.21; EC 1.1.1.210) from Arabidopsis thaliana (see paper)
AKRC8_ARATH / O80944 Aldo-keto reductase family 4 member C8; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    35% identity, 85% coverage of query (169 bits)

XYL1_CANTE / O74237 NAD(P)H-dependent D-xylose reductase; XR; EC 1.1.1.307 from Candida tenuis (Yeast) (Yamadazyma tenuis) (see 4 papers)
O74237 D-xylose reductase (EC 1.1.1.307) from Yamadazyma tenuis (see 5 papers)
    35% identity, 99% coverage of query (169 bits)

A0MTG4 D-xylose reductase (EC 1.1.1.307) from Scheffersomyces shehatae (see paper)
    35% identity, 91% coverage of query (169 bits)

D0VDT4 20alpha-hydroxysteroid dehydrogenase (EC 1.1.1.149) from Bos taurus (see paper)
    35% identity, 88% coverage of query (168 bits)

ALRA_DICDI / Q6IMN8 Aldose reductase A; ARA; Aldehyde reductase A; AlrA; EC 1.1.1.21 from Dictyostelium discoideum (Social amoeba) (see paper)
Q6IMN8 methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Dictyostelium discoideum (see paper)
    35% identity, 86% coverage of query (168 bits)

1k8cB / O74237 Crystal structure of dimeric xylose reductase in complex with NADP(h) (see paper)
    35% identity, 98% coverage of query (166 bits)

Q2TJA5 prostaglandin-F synthase (EC 1.1.1.188) from Sus scrofa (see paper)
    36% identity, 88% coverage of query (166 bits)

1mi3A 1.8 angstrom structure of xylose reductase from candida tenuis in complex with NAD
    35% identity, 98% coverage of query (166 bits)

S4WCW2 D-xylose reductase (EC 1.1.1.307) from Spathaspora passalidarum (see paper)
    34% identity, 88% coverage of query (165 bits)

3debr / Q9Y020 3-dehydroecdysone 3β-reductase from Spodoptera littoralis (see 3 papers)
    35% identity, 91% coverage of query (164 bits)

A0A455KZK8 D-xylose reductase (EC 1.1.1.307) from Thermomyces lanuginosus (see paper)
    36% identity, 89% coverage of query (164 bits)

YPR1_YEAST / Q12458 Putative reductase 1; EC 1.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    36% identity, 90% coverage of query (164 bits)

GRE3 putative uncharacterized protein GRE3 from Candida albicans (see paper)
    32% identity, 99% coverage of query (164 bits)

A9QVV8 D-xylose reductase (EC 1.1.1.307) from Candida tropicalis (see paper)
    32% identity, 94% coverage of query (164 bits)

AKR1E2 / Q96JD6 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Homo sapiens (see 7 papers)
AKCL2_HUMAN / Q96JD6 1,5-anhydro-D-fructose reductase; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2; LoopADR; Testis aldo-keto reductase; htAKR; Testis-specific protein; hTSP; EC 1.1.1.263 from Homo sapiens (Human) (see 2 papers)
    33% identity, 90% coverage of query (164 bits)

4gq0A / O60218 Crystal structure of akr1b10 complexed with NADP+ and caffeic acid phenethyl ester
    33% identity, 89% coverage of query (163 bits)

AK1BA_HUMAN / O60218 Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase; EC 1.1.1.300; EC 1.1.1.54 from Homo sapiens (Human) (see 7 papers)
O60218 aldose reductase (EC 1.1.1.21) from Homo sapiens (see 2 papers)
    33% identity, 89% coverage of query (163 bits)

4jiiX Crystal structure of akr1b10 complexed with NADP+ and zopolrestat
    33% identity, 89% coverage of query (163 bits)

4jihA Crystal structure of akr1b10 complexed with NADP+ and epalrestat
    33% identity, 89% coverage of query (163 bits)

4i5xA Crystal structure of akr1b10 complexed with NADP+ and flufenamic acid
    33% identity, 89% coverage of query (163 bits)

4gabA Human akr1b10 mutant v301l complexed with NADP+ and fidarestat
    33% identity, 89% coverage of query (163 bits)

4ga8A Human akr1b10 mutant v301l complexed with NADP+ and sorbinil
    33% identity, 89% coverage of query (163 bits)

5m2fX Crystal structure of human akr1b10 complexed with NADP+ and the synthetic retinoid uvi2008
    33% identity, 89% coverage of query (163 bits)

5liyX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk204
    33% identity, 89% coverage of query (163 bits)

5lixX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk184
    33% identity, 89% coverage of query (163 bits)

5liwX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk319
    33% identity, 89% coverage of query (163 bits)

5liuX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor idd388
    33% identity, 89% coverage of query (163 bits)

5likX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk181
    33% identity, 89% coverage of query (163 bits)

4xzlX Crystal structure of human akr1b10 complexed with NADP+ and jf0049
    33% identity, 89% coverage of query (163 bits)

4wevX Crystal structure of human akr1b10 complexed with NADP+ and sulindac
    33% identity, 89% coverage of query (163 bits)

4iccX Crystal structure of human akr1b10 complexed with NADP+ and jf0064
    33% identity, 89% coverage of query (163 bits)

5y7nA Crystal structure of akr1b10 in complex with NADP+ and androst-4-ene- 3-beta-6-alpha-diol
    33% identity, 89% coverage of query (163 bits)

GCY1_YEAST / P14065 Glycerol 2-dehydrogenase (NADP(+)); Galactose-inducible crystallin-like protein 1; EC 1.1.1.156 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 13 papers)
    35% identity, 90% coverage of query (162 bits)

P87039 D-xylose reductase (EC 1.1.1.307) from Candida tropicalis (see paper)
C1K8Y9 D-xylose reductase (EC 1.1.1.307) from Candida tropicalis (see paper)
    32% identity, 94% coverage of query (162 bits)

AKR1C4 / P17516 aldo-keto reductase family 1 member C4 (EC 1.1.1.213; EC 1.3.1.20; EC 1.1.1.225; EC 1.1.1.357) from Homo sapiens (see 9 papers)
AK1C4_HUMAN / P17516 Aldo-keto reductase family 1 member C4; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; 3alpha-hydroxysteroid 3-dehydrogenase; Chlordecone reductase; CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA; EC 1.1.1.-; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.1.1.357; EC 1.1.1.225 from Homo sapiens (Human) (see 11 papers)
P17516 3alpha-hydroxysteroid 3-dehydrogenase (EC 1.1.1.357) from Homo sapiens (see 4 papers)
    34% identity, 89% coverage of query (162 bits)

6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
    36% identity, 90% coverage of query (162 bits)

2fvlA / P17516 Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (akr1c4) complexed with NADP+
    34% identity, 89% coverage of query (162 bits)

Q9X265 carbonyl reductase (NADPH) (EC 1.1.1.184) from Thermotoga maritima (see 2 papers)
    36% identity, 90% coverage of query (162 bits)

1zuaX Crystal structure of akr1b10 complexed with NADP+ and tolrestat
    33% identity, 89% coverage of query (162 bits)

6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
    36% identity, 90% coverage of query (162 bits)

5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
    36% identity, 90% coverage of query (162 bits)

AK1C1_MACFU / Q95JH6 Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.149 from Macaca fuscata fuscata (Japanese macaque) (see paper)
    33% identity, 89% coverage of query (161 bits)

YBN4_SCHPO / O42888 Uncharacterized oxidoreductase C8E4.04; EC 1.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    33% identity, 88% coverage of query (160 bits)

GALUR / O49133 D-galacturonate reductase (EC 1.1.1.365) from Fragaria ananassa (see 2 papers)
GALUR_FRAAN / O49133 D-galacturonate reductase; FaGalUR; Aldo-keto reductase 2; EC 1.1.1.365 from Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana) (see 2 papers)
O49133 D-galacturonate reductase (EC 1.1.1.365) from Fragaria x ananassa (see paper)
    36% identity, 93% coverage of query (160 bits)

7s5fB / A0A1U9WT24 Crystal structure of mannose-6-phosphate reductase from celery (apium graveolens) leaves with NADP+ and mannonic acid bound (see paper)
    32% identity, 89% coverage of query (160 bits)

Q5FYA7 prostaglandin-F synthase (EC 1.1.1.188) from Canis lupus familiaris (see 2 papers)
    34% identity, 91% coverage of query (160 bits)

A0A0S2PJI4 D-xylose reductase (EC 1.1.1.307) from Spathaspora passalidarum (see paper)
    33% identity, 88% coverage of query (160 bits)

7f7kB / A0A5J6VLZ7 Crystal structure of akr4c17 bound with NADP+
    36% identity, 87% coverage of query (160 bits)

M6PR / P92923 mannose 6-phosphate reductase (EC 1.1.1.224) from Apium graveolens (see paper)
P92923 mannose-6-phosphate 6-reductase (EC 1.1.1.224) from Apium graveolens (see paper)
    32% identity, 89% coverage of query (160 bits)

AK1C1_MACFA / Q95JH7 Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.149 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
    33% identity, 89% coverage of query (160 bits)

7f7mA Akr4c17 in complex with NADP+ and glyphosate
    36% identity, 87% coverage of query (160 bits)

7f7lA Crystal structure of akr4c17 bound with NADPH
    36% identity, 87% coverage of query (160 bits)

AKR1C1 / Q04828 aldo-keto reductase family 1 member C1 (EC 1.1.1.149; EC 1.1.1.213; EC 1.1.1.112; EC 1.3.1.20) from Homo sapiens (see 13 papers)
AK1C1_HUMAN / Q04828 Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1; DD1; High-affinity hepatic bile acid-binding protein; HBAB; EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.149 from Homo sapiens (Human) (see 8 papers)
Q04828 20alpha-hydroxysteroid dehydrogenase (EC 1.1.1.149); 3beta-hydroxysteroid 3-dehydrogenase (EC 1.1.1.270); 3alpha-hydroxysteroid 3-dehydrogenase (EC 1.1.1.357); 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (EC 1.1.1.50); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Homo sapiens (see 13 papers)
    32% identity, 89% coverage of query (159 bits)

5z6tA / P31867 Crystal structure of d-xylose reductase from scheffersomyces stipitis in complex with NADPH (see paper)
    34% identity, 88% coverage of query (159 bits)

XYL1 / P31867 NAD(P)H-dependent D-xylose reductase (EC 1.1.1.21; EC 1.1.1.307) from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (see 3 papers)
XYL1_PICST / P31867 NAD(P)H-dependent D-xylose reductase; XR; EC 1.1.1.307 from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) (see paper)
P31867 D-xylose reductase (EC 1.1.1.307) from Scheffersomyces stipitis (see 8 papers)
xyl1 / CAA42072.1 Xylose reductase from Scheffersomyces stipitis (see paper)
    34% identity, 88% coverage of query (159 bits)

3c3uA Crystal structure of akr1c1 in complex with NADP and 3,5- dichlorosalicylic acid
    32% identity, 89% coverage of query (159 bits)

6ijxA Crystal structure of akr1c1 complexed with meclofenamic acid
    32% identity, 89% coverage of query (159 bits)

6a7aA Akr1c1 complexed with new inhibitor with novel scaffold
    32% identity, 89% coverage of query (159 bits)

4yvpA Crystal structure of akr1c1 complexed with glibenclamide
    32% identity, 89% coverage of query (159 bits)

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Build an alignment for CCNA_03541 and 100 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory