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Searching for up to 100 curated homologs for Dsui_0083 FitnessBrowser__PS:Dsui_0083 (332 a.a.)

Found high-coverage hits (≥70%) to 46 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PSEB_CAMJE / Q0P8W4 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    57% identity, 97% coverage of query (374 bits)

PSEB_CAMJJ / Q5QKR8 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) (see 2 papers)
    57% identity, 96% coverage of query (374 bits)

2gn4A / O25511 Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADPH and udp-glcnac (see paper)
    55% identity, 97% coverage of query (360 bits)

pseB / O25511 UDP-N-acetylglucosamine 4,6-dehydratase subunit (EC 4.2.1.115) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 4 papers)
PSEB_HELPY / O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see 3 papers)
    55% identity, 97% coverage of query (360 bits)

2gnaA Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-gal
    55% identity, 97% coverage of query (360 bits)

2gn9A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glc
    55% identity, 97% coverage of query (360 bits)

2gn6A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glcnac
    55% identity, 97% coverage of query (360 bits)

2gn8A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp
    55% identity, 97% coverage of query (360 bits)

Q6VYQ5 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Helicobacter pylori (see paper)
    54% identity, 97% coverage of query (357 bits)

Q6VYQ6 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Helicobacter pylori (see paper)
    54% identity, 97% coverage of query (352 bits)

BC_3750 / Q81A42 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.135) from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see 5 papers)
Q81A42 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Bacillus cereus (see 2 papers)
    44% identity, 85% coverage of query (239 bits)

A0A0H3JPH0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Staphylococcus aureus (see paper)
    42% identity, 97% coverage of query (238 bits)

3w1vA / A0A0H3JPH0 Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
    43% identity, 95% coverage of query (237 bits)

4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product
    43% identity, 95% coverage of query (237 bits)

6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
    39% identity, 97% coverage of query (232 bits)

4j2oC / P37362 Crystal structure of NADP-bound wbjb from a. Baumannii community strain d1279779 (see paper)
    44% identity, 86% coverage of query (230 bits)

V5RBP5 UDP-glucose 4-epimerase (EC 5.1.3.2) from Acinetobacter baumannii (see paper)
    41% identity, 95% coverage of query (229 bits)

3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form
    43% identity, 95% coverage of query (229 bits)

wbvB / Q8L348 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Vibrio cholerae O37 (see 3 papers)
    39% identity, 100% coverage of query (223 bits)

wbjB / Q9KID0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Pseudomonas aeruginosa (see 2 papers)
    38% identity, 97% coverage of query (216 bits)

CAPD_RICPR / Q9ZDJ5 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
    38% identity, 97% coverage of query (213 bits)

3vvbA / A0A0H3JPH0 Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in apo form (see paper)
    37% identity, 95% coverage of query (182 bits)

G5CSR9 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Megavirus chiliensis (see paper)
    35% identity, 84% coverage of query (168 bits)

4tqgA / G5CSR9 Crystal structure of megavirus udp-glcnac 4,6-dehydratase, 5-epimerase mg534 (see paper)
    32% identity, 84% coverage of query (151 bits)

cpsE polysaccharide capsule synthesis protein CpsE from Streptococcus iniae (see paper)
    36% identity, 80% coverage of query (149 bits)

EPSC_BACSU / P71052 Probable polysaccharide biosynthesis protein EpsC from Bacillus subtilis (strain 168) (see paper)
    31% identity, 93% coverage of query (147 bits)

wbgZ / Q9F736 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Shigella sonnei (see paper)
    31% identity, 78% coverage of query (133 bits)

wbkD / Q2YMM0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Brucella abortus (strain 2308) (see 2 papers)
    31% identity, 82% coverage of query (133 bits)

wbpM / Q9KIC5 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Pseudomonas aeruginosa (see 6 papers)
    30% identity, 77% coverage of query (132 bits)

wbiI / GI|3135688 putative epimerase/dehydratase WbiI from Burkholderia pseudomallei (see paper)
    31% identity, 83% coverage of query (131 bits)

Build an alignment

Build an alignment for Dsui_0083 and 30 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

P72145 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Pseudomonas aeruginosa (see paper)
    29% identity, 77% coverage of query (130 bits)

RfbU / CAA69127.1 mannosyl-transferase from Vibrio cholerae (see paper)
    29% identity, 84% coverage of query (127 bits)

5bjuA / O86159 X-ray structure of the pglf dehydratase from campylobacter jejuni in complex with udp and NAD(h) (see paper)
    31% identity, 81% coverage of query (121 bits)

pglF / Q0P9D4 UDP-N-acetylglucosamine C-6 dehydratase (EC 4.2.1.135) from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 3 papers)
PGLF_CAMJE / Q0P9D4 UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase; UDP-GlcNAc C6 dehydratase; Protein glycosylation pathway protein F; UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining); EC 4.2.1.135 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    31% identity, 81% coverage of query (119 bits)

5bjvA X-ray structure of the pglf udp-n-acetylglucosamine 4,6-dehydratase from campylobacterjejuni, d396n/k397a variant in complex with udp-n- acrtylglucosamine
    30% identity, 81% coverage of query (117 bits)

ravE / D1H0J1 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces ravidus (see 2 papers)
    29% identity, 76% coverage of query (70.1 bits)

RHM1 / Q9SYM5 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM1 (EC 4.2.1.76) from Arabidopsis thaliana (see 3 papers)
RHM1_ARATH / Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    27% identity, 75% coverage of query (64.7 bits)

3pvzA / Q5E8L1 Udp-n-acetylglucosamine 4,6-dehydratase from vibrio fischeri
    26% identity, 86% coverage of query (63.9 bits)

RHM2 / Q9LPG6 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM2 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM2_ARATH / Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    27% identity, 74% coverage of query (58.2 bits)

Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
    27% identity, 70% coverage of query (57.0 bits)

8sk0A Crystal structure of evds6 decarboxylase in ligand bound state
    24% identity, 78% coverage of query (55.5 bits)

8sk0B / A0A1C5ADV9 Crystal structure of evds6 decarboxylase in ligand bound state (see paper)
    24% identity, 78% coverage of query (55.5 bits)

6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
    26% identity, 77% coverage of query (55.5 bits)

3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
    26% identity, 75% coverage of query (49.3 bits)

8v4hB / A0A0U3AP28 X-ray structure of the NADP-dependent reductase from campylobacter jejuni responsible for the synthesis of cdp-glucitol in the presence of cdp-glucitol
    22% identity, 74% coverage of query (45.8 bits)

8v4gA X-ray structure of the NADP-dependent reductase from campylobacter jejuni responsible for the synthesis of cdp-glucitol in the presence of cdp and NADP
    22% identity, 74% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory