Searching for up to 100 curated homologs for Dsui_0694 FitnessBrowser__PS:Dsui_0694 (251 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (169 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (169 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
44% identity, 96% coverage of query (167 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
44% identity, 95% coverage of query (167 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
44% identity, 95% coverage of query (167 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
44% identity, 95% coverage of query (167 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
44% identity, 95% coverage of query (167 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
44% identity, 95% coverage of query (167 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
44% identity, 95% coverage of query (167 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
44% identity, 95% coverage of query (167 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
44% identity, 95% coverage of query (166 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
44% identity, 95% coverage of query (166 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
44% identity, 95% coverage of query (166 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
44% identity, 95% coverage of query (166 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
44% identity, 95% coverage of query (166 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
44% identity, 95% coverage of query (166 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (166 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (166 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
44% identity, 95% coverage of query (166 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
44% identity, 95% coverage of query (166 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
44% identity, 95% coverage of query (166 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
44% identity, 95% coverage of query (166 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
44% identity, 95% coverage of query (166 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
44% identity, 95% coverage of query (166 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
44% identity, 95% coverage of query (166 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
44% identity, 95% coverage of query (166 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
44% identity, 95% coverage of query (166 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
44% identity, 95% coverage of query (166 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
44% identity, 95% coverage of query (166 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
44% identity, 95% coverage of query (166 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
44% identity, 95% coverage of query (166 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
44% identity, 95% coverage of query (166 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
44% identity, 95% coverage of query (166 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
43% identity, 96% coverage of query (166 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
43% identity, 96% coverage of query (166 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
44% identity, 95% coverage of query (166 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
44% identity, 95% coverage of query (166 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
44% identity, 95% coverage of query (166 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
44% identity, 95% coverage of query (166 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (166 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (166 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (166 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
44% identity, 95% coverage of query (166 bits)
2c7vC / O76290 Structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate (see paper)
42% identity, 95% coverage of query (165 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (165 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (165 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (165 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (165 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
44% identity, 95% coverage of query (165 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
43% identity, 95% coverage of query (165 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
43% identity, 93% coverage of query (165 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (165 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
43% identity, 95% coverage of query (165 bits)
2yhuA Trypanosoma brucei ptr1 in complex with inhibitor whf30
43% identity, 95% coverage of query (165 bits)
2x9gA High resolution structure of tbptr1 in complex with pemetrexed
43% identity, 95% coverage of query (165 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (164 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
43% identity, 95% coverage of query (164 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
43% identity, 95% coverage of query (164 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
43% identity, 95% coverage of query (164 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
43% identity, 95% coverage of query (164 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
43% identity, 95% coverage of query (164 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
43% identity, 95% coverage of query (163 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
44% identity, 95% coverage of query (163 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
44% identity, 95% coverage of query (163 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
44% identity, 95% coverage of query (163 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
44% identity, 95% coverage of query (163 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
44% identity, 95% coverage of query (163 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
42% identity, 95% coverage of query (163 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
43% identity, 93% coverage of query (163 bits)
3gn1C Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00067116)
44% identity, 95% coverage of query (163 bits)
3jq7C Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
44% identity, 94% coverage of query (161 bits)
5k6aC Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
43% identity, 95% coverage of query (161 bits)
7pxxC The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
43% identity, 93% coverage of query (161 bits)
5l4nA Leishmania major pteridine reductase 1 (ptr1) in complex with compound 1
43% identity, 93% coverage of query (161 bits)
6rxcA Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
43% identity, 93% coverage of query (160 bits)
O09352 pteridine reductase (EC 1.5.1.33) from Leishmania amazonensis (see paper)
42% identity, 93% coverage of query (159 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
44% identity, 95% coverage of query (159 bits)
2bfmA Leishmania major pteridine reductase 1 in complex with NADP and trimethoprim
42% identity, 93% coverage of query (159 bits)
1e92A Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
42% identity, 93% coverage of query (159 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
42% identity, 93% coverage of query (159 bits)
2qhxA Structure of pteridine reductase from leishmania major complexed with a ligand
42% identity, 93% coverage of query (159 bits)
5l42A Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
42% identity, 93% coverage of query (159 bits)
2bfaC Leishmania major pteridine reductase 1 in complex with NADP and cb3717
42% identity, 93% coverage of query (157 bits)
2bfpA Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin
42% identity, 93% coverage of query (157 bits)
1e7wA One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
42% identity, 93% coverage of query (157 bits)
1w0cD Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex.
42% identity, 93% coverage of query (157 bits)
1e92D Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
42% identity, 93% coverage of query (157 bits)
6tbxC Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
43% identity, 95% coverage of query (157 bits)
5l42C Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
42% identity, 93% coverage of query (157 bits)
2bfpD / Q01782 Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin (see paper)
42% identity, 93% coverage of query (156 bits)
1p33B / P42556 Pteridine reductase from leishmania tarentolae complex with NADPH and mtx (see paper)
42% identity, 93% coverage of query (156 bits)
A4I067 pteridine reductase (EC 1.5.1.33) from Leishmania infantum (see paper)
41% identity, 93% coverage of query (156 bits)
Build an alignment for Dsui_0694 and 100 homologs with ≥ 30% identity
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Lawrence Berkeley National Laboratory