Searching for up to 100 curated homologs for Dsui_0724 FitnessBrowser__PS:Dsui_0724 (307 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
56% identity, 94% coverage of query (325 bits)
TC 3.A.1.102.1 / P50332 NodI, component of Lipooligosaccharide exporter (nodulation proteins, NodIJ) from Rhizobium galegae (see paper)
54% identity, 99% coverage of query (315 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
40% identity, 97% coverage of query (204 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
36% identity, 97% coverage of query (197 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
37% identity, 98% coverage of query (192 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
43% identity, 72% coverage of query (180 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
35% identity, 97% coverage of query (180 bits)
TC 3.A.1.105.4 / Q4VWC9 PltI, component of The pyoluteorin (a chlorinated polyketide) efflux pump, PltHIJKN (see 2 papers)
45% identity, 72% coverage of query (172 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
35% identity, 97% coverage of query (169 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
37% identity, 79% coverage of query (164 bits)
YadG / b0127 putative ABC transporter ATP-binding protein YadG from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YADG_ECOLI / P36879 Uncharacterized ABC transporter ATP-binding protein YadG from Escherichia coli (strain K12) (see paper)
yadG / MB|P36879 uncharacterized ABC transporter ATP-binding protein yadG from Escherichia coli K12 (see paper)
39% identity, 72% coverage of query (159 bits)
ABCA3_RAT / A0A0G2K1Q8 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Rattus norvegicus (Rat) (see paper)
36% identity, 88% coverage of query (157 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
36% identity, 88% coverage of query (156 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
37% identity, 93% coverage of query (155 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
36% identity, 88% coverage of query (154 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
41% identity, 71% coverage of query (153 bits)
ABCA7_HUMAN / Q8IZY2 Phospholipid-transporting ATPase ABCA7; ABCA-SSN; ATP-binding cassette sub-family A member 7; Autoantigen SS-N; Macrophage ABC transporter; EC 7.6.2.1 from Homo sapiens (Human) (see 12 papers)
TC 3.A.1.211.10 / Q8IZY2 ABCA7. Regulates cellular efflux of phospholipids but not cholesterol, to apo A-1 from Homo sapiens (see 10 papers)
41% identity, 71% coverage of query (153 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
40% identity, 73% coverage of query (153 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
42% identity, 71% coverage of query (152 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
41% identity, 71% coverage of query (152 bits)
ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
40% identity, 70% coverage of query (150 bits)
ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
40% identity, 70% coverage of query (149 bits)
TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
40% identity, 70% coverage of query (148 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
40% identity, 70% coverage of query (148 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
39% identity, 71% coverage of query (146 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
38% identity, 71% coverage of query (145 bits)
ABCAH_MOUSE / E9PX95 ATP-binding cassette sub-family A member 17 from Mus musculus (Mouse) (see 2 papers)
37% identity, 71% coverage of query (145 bits)
METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
34% identity, 72% coverage of query (144 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
35% identity, 71% coverage of query (136 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 71% coverage of query (123 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
32% identity, 71% coverage of query (120 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 75% coverage of query (119 bits)
YhiG / b3486 ribosome-associated ATPase from Escherichia coli K-12 substr. MG1655 (see 13 papers)
RBBA_ECOLI / P37624 Ribosome-associated ATPase; Ribosomal bound ATPase from Escherichia coli (strain K12) (see 5 papers)
yhiH / RF|YP_026225 uncharacterized ABC transporter ATP-binding protein yhiH from Escherichia coli K12 (see paper)
33% identity, 74% coverage of query (118 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
33% identity, 71% coverage of query (115 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
35% identity, 75% coverage of query (115 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
34% identity, 72% coverage of query (113 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
34% identity, 72% coverage of query (113 bits)
Build an alignment for Dsui_0724 and 37 homologs with ≥ 30% identity
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1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
29% identity, 74% coverage of query (112 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
33% identity, 71% coverage of query (112 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 76% coverage of query (111 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 76% coverage of query (111 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 76% coverage of query (111 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
32% identity, 71% coverage of query (110 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
29% identity, 74% coverage of query (110 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
31% identity, 72% coverage of query (110 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
31% identity, 72% coverage of query (110 bits)
2olkA Abc protein artp in complex with adp-beta-s
31% identity, 72% coverage of query (110 bits)
2oljA Abc protein artp in complex with adp/mg2+
31% identity, 72% coverage of query (110 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
35% identity, 72% coverage of query (107 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
34% identity, 71% coverage of query (106 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
34% identity, 70% coverage of query (106 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
34% identity, 71% coverage of query (105 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
32% identity, 76% coverage of query (104 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
33% identity, 71% coverage of query (103 bits)
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
33% identity, 71% coverage of query (103 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
33% identity, 71% coverage of query (103 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
33% identity, 71% coverage of query (103 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
33% identity, 71% coverage of query (103 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
33% identity, 71% coverage of query (103 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
32% identity, 76% coverage of query (102 bits)
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
31% identity, 72% coverage of query (101 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
36% identity, 71% coverage of query (101 bits)
7ahhC Opua inhibited inward-facing, sbd docked
32% identity, 70% coverage of query (100 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
32% identity, 70% coverage of query (100 bits)
7ahdC Opua (e190q) occluded
31% identity, 70% coverage of query (99.4 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
31% identity, 70% coverage of query (97.4 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
31% identity, 70% coverage of query (97.4 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
31% identity, 70% coverage of query (97.4 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
31% identity, 70% coverage of query (97.4 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
31% identity, 70% coverage of query (97.4 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
31% identity, 70% coverage of query (97.4 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
31% identity, 70% coverage of query (97.4 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
31% identity, 74% coverage of query (97.1 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
31% identity, 74% coverage of query (97.1 bits)
4hluC / Q9X1Z1 Structure of the ecfa-a' heterodimer bound to adp (see paper)
32% identity, 72% coverage of query (95.5 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
27% identity, 70% coverage of query (92.8 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
27% identity, 70% coverage of query (92.8 bits)
6tejB / A0A100XE85 Structure of apo irtab devoid sid in complex with sybody syb_nl5 (see paper)
34% identity, 75% coverage of query (92.0 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
27% identity, 70% coverage of query (91.7 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
27% identity, 70% coverage of query (91.7 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
27% identity, 70% coverage of query (90.5 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
27% identity, 70% coverage of query (88.2 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
27% identity, 75% coverage of query (88.2 bits)
4zirB Crystal structure of ecfaa' heterodimer bound to amppnp
31% identity, 72% coverage of query (88.2 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
31% identity, 70% coverage of query (87.0 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
31% identity, 70% coverage of query (87.0 bits)
6qv0A Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
31% identity, 72% coverage of query (87.0 bits)
6quzA Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35
31% identity, 72% coverage of query (86.7 bits)
4q4aA / Q9WYC3 Improved model of amp-pnp bound tm287/288 (see paper)
31% identity, 72% coverage of query (86.7 bits)
8hprD Lpqy-sugabc in state 4
30% identity, 72% coverage of query (85.9 bits)
8hprC Lpqy-sugabc in state 4
30% identity, 72% coverage of query (85.9 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
31% identity, 70% coverage of query (85.9 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
30% identity, 71% coverage of query (85.1 bits)
7metB / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
29% identity, 71% coverage of query (84.0 bits)
7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
29% identity, 71% coverage of query (84.0 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
29% identity, 72% coverage of query (82.8 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
26% identity, 73% coverage of query (81.3 bits)
ABCG2_HUMAN / Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338 antigen; EC 7.6.2.2 from Homo sapiens (Human) (see 29 papers)
Q9UNQ0 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 11 papers)
TC 3.A.1.204.2 / Q9UNQ0 Drug resistance transporter, ABCG2 (MXR; ABCP) (human breast cancer resistance protein, BCRP) (Moitra et al., 2011). It exports urate and haem in haempoietic cells (Latunde-Dada et al., 2006) as well as cytotoxic agents (mitoxantrone, flavopiridol, methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, topotecan, rosurvastatin, and resveratrol), fluorescent dyes (Hoechst 33342) and other toxic substances (PhIP and pheophorbide a) (Özvegy-Laczka et al., 2005; Nigam 2015). It also transports folate and sterols: estradiol, and probably cholesterol, progesterone, testosterone and tamoxifen (Janvilisri et al., 2003; Breedveld et al., 2007). It is a homotetramer (Xu et al., 2004). It forms a homodimer bound via a disulfide bond at Cys-603 which stabilizes the protein against ubiquitin-mediated degradation in proteosomes (Wakabayashi et al., 2007), and can for dodecamers with 12 subunits (Xu et al. 2007). It has 6 established TMSs with the N- and C- termini inside (Wang et al., 2008). The following drugs are exported from human breast cancer cell line MCF-7: miloxantrone, daunorubicin, doxorubicin and rhodamine123). Also transports reduced folates and mono-, di- and tri-glutamate derivatives of folic acid and methotrexate (Assaraf et al., 2006). It is an active glutathione efflux pump (Brechbuhl et al., 2010). Mutations in ABCG2 cause hyperuricemia and gout , which led to the identification of urate as a physiological subsrate for ABCG2; it catalyzes elimination of urate across the renal tubular apical membrane (see 17 papers)
ABCG2 / GB|ABI97388.1 ATP-binding cassette sub-family G member 2 from Homo sapiens (see paper)
30% identity, 71% coverage of query (81.3 bits)
6hijA Cryo-em structure of the human abcg2-mz29-fab complex with cholesterol and pe lipids docked
29% identity, 76% coverage of query (80.9 bits)
7nezA Structure of topotecan-bound abcg2
29% identity, 76% coverage of query (80.5 bits)
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Lawrence Berkeley National Laboratory