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Searching for up to 100 curated homologs for Dsui_0982 FitnessBrowser__PS:Dsui_0982 (667 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MCCA_MOUSE / Q99MR8 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Mus musculus (Mouse) (see paper)
    49% identity, 100% coverage of query (663 bits)

MCCC1 / Q96RQ3 3-methylcrotonyl-CoA carboxylase α subunit (EC 6.4.1.4) from Homo sapiens (see 4 papers)
MCCA_HUMAN / Q96RQ3 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Homo sapiens (Human) (see 15 papers)
    48% identity, 100% coverage of query (652 bits)

Sama_1359 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Shewanella amazonensis SB2B
    54% identity, 99% coverage of query (644 bits)

MCCA_ORYSJ / Q2QMG2 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Oryza sativa subsp. japonica (Rice) (see paper)
    49% identity, 98% coverage of query (627 bits)

MCCA_ARATH / Q42523 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q42523 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) from Arabidopsis thaliana (see 2 papers)
    48% identity, 98% coverage of query (624 bits)

AO356_01595 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2C3
    53% identity, 99% coverage of query (614 bits)

liuD / Q9I299 methylcrotonyl-CoA carboxylase α-subunit (EC 6.4.1.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I299 methylcrotonoyl-CoA carboxylase (subunit 2/2) (EC 6.4.1.4) from Pseudomonas aeruginosa (see 3 papers)
    54% identity, 99% coverage of query (610 bits)

Pf1N1B4_3984 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N1B4
    51% identity, 99% coverage of query (610 bits)

Pf6N2E2_2194 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2E2
    52% identity, 99% coverage of query (609 bits)

SM_b21124 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Sinorhizobium meliloti 1021
    54% identity, 100% coverage of query (609 bits)

atuF / Q9HZV6 cis-geranyl-CoA carboxylase α-subunit (EC 6.4.1.5) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    48% identity, 100% coverage of query (564 bits)

8rthA / Q57YQ4 Trypanosoma brucei 3-methylcrotonyl-coa carboxylase (see paper)
    46% identity, 100% coverage of query (538 bits)

ACCA1_MYCTU / P9WPQ3 Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit; EC 6.3.4.14 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CAA79609.1 biotin carboxyl carrier protein from Mycobacterium tuberculosis (see paper)
    48% identity, 98% coverage of query (525 bits)

pccA / Q3J4D9 propionyl-CoA carboxylase α subunit (EC 6.4.1.3) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
    46% identity, 97% coverage of query (516 bits)

Dsui_0516 Propionyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.3) from Dechlorosoma suillum PS
    46% identity, 99% coverage of query (512 bits)

mccA 3-methylcrotonyl-CoA carboxylase biotin-containig subunit; EC 6.4.1.4 from Emericella nidulans (see paper)
mccA / AAR23110.1 3-methylcrotonyl-CoA carboxylase biotin-containing subunit from Aspergillus nidulans (see paper)
    45% identity, 96% coverage of query (511 bits)

PCCA_RUEPO / Q5LUF3 Propionyl-CoA carboxylase alpha chain; EC 6.4.1.3 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
Q5LUF3 propionyl-CoA carboxylase (EC 6.4.1.3) from Ruegeria pomeroyi (see paper)
    45% identity, 99% coverage of query (494 bits)

3n6rG / Q5LUF3 Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
    45% identity, 99% coverage of query (485 bits)

PCCA_PIG / P0DTA4 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Sus scrofa (Pig) (see paper)
    43% identity, 99% coverage of query (482 bits)

PCCA_CAEEL / Q19842 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Caenorhabditis elegans (see paper)
Q19842 propionyl-CoA carboxylase (subunit 2/2) (EC 6.4.1.3) from Caenorhabditis elegans (see paper)
    43% identity, 99% coverage of query (481 bits)

Pcca / P14882 propionyl-CoA carboxylase α subunit (EC 6.4.1.3) from Rattus norvegicus (see paper)
    43% identity, 99% coverage of query (470 bits)

8sgxX / A0A640KC69 Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
    49% identity, 71% coverage of query (446 bits)

7zyyA Cryo-em structure of lactococcus lactis pyruvate carboxylase with acetyl-coa
    38% identity, 84% coverage of query (348 bits)

5vyzA Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
    37% identity, 84% coverage of query (348 bits)

7zz3A Cryo-em structure of "bc react" conformation of lactococcus lactis pyruvate carboxylase with acetyl-coa
    38% identity, 84% coverage of query (347 bits)

3n6rA / Q5LUF3 Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
    37% identity, 99% coverage of query (301 bits)

P11029 Acetyl-CoA carboxylase; ACC; EC 6.4.1.2; EC 6.3.4.14 from Gallus gallus (Chicken)
    30% identity, 96% coverage of query (270 bits)

Build an alignment

Build an alignment for Dsui_0982 and 27 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

ACAC_YEAST / Q00955 Acetyl-CoA carboxylase; ACC; Fatty acid synthetase 3; mRNA transport-defective protein 7; EC 6.4.1.2; EC 6.3.4.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 13 papers)
Q00955 biotin carboxylase (EC 6.3.4.14); acetyl-CoA carboxylase (EC 6.4.1.2) from Saccharomyces cerevisiae (see 6 papers)
    29% identity, 96% coverage of query (265 bits)

ACC2 / O00763 Biotin carboxylase (EC 2.1.3.15; EC 6.4.1.2; EC 6.3.4.14) from Homo sapiens (see 6 papers)
ACACB_HUMAN / O00763 Acetyl-CoA carboxylase 2; ACC-beta; EC 6.4.1.2 from Homo sapiens (Human) (see 12 papers)
O00763 biotin carboxylase (EC 6.3.4.14); acetyl-CoA carboxylase (EC 6.4.1.2) from Homo sapiens (see 11 papers)
    33% identity, 71% coverage of query (256 bits)

5cslB / Q00955 Crystal structure of the 500 kd yeast acetyl-coa carboxylase holoenzyme dimer (see paper)
    29% identity, 95% coverage of query (256 bits)

5cslA / Q00955 Crystal structure of the 500 kd yeast acetyl-coa carboxylase holoenzyme dimer (see paper)
    29% identity, 96% coverage of query (244 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory