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Searching for up to 100 curated homologs for Dsui_1113 FitnessBrowser__PS:Dsui_1113 (278 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
    45% identity, 84% coverage of query (213 bits)

TC 3.A.1.4.10 / Q8DQH7 ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    45% identity, 87% coverage of query (209 bits)

HSERO_RS00900 L-proline ABC transporter, ATPase component 2 from Herbaspirillum seropedicae SmR1
    44% identity, 87% coverage of query (201 bits)

AZOBR_RS08250 L-proline and D-alanine ABC transporter, ATPase component 2 from Azospirillum brasilense Sp245
    44% identity, 86% coverage of query (196 bits)

Ac3H11_1692 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, ATPase component 2 from Acidovorax sp. GW101-3H11
    43% identity, 86% coverage of query (194 bits)

braG / CAB75552.1 ATPase from Rhizobium leguminosarum bv. viciae (see 2 papers)
    42% identity, 86% coverage of query (186 bits)

TC 3.A.1.4.6 / Q8YT15 NatE, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    42% identity, 86% coverage of query (182 bits)

TC 3.A.1.4.11 / Q6N8W2 Branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    46% identity, 87% coverage of query (182 bits)

LivF / b3454 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
LivF / P22731 branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.4.1 / P22731 LivF aka B3454, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 4 papers)
livF / GB|AAC76479.2 high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF from Escherichia coli K12 (see 5 papers)
    41% identity, 86% coverage of query (178 bits)

TC 3.A.1.4.9 / Q0S720 ABC branched-chain amino acid transporter, ATP-binding component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
    42% identity, 86% coverage of query (177 bits)

Pf6N2E2_2926 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 2 LivF from Pseudomonas fluorescens FW300-N2E2
    43% identity, 86% coverage of query (175 bits)

TC 3.A.1.4.8 / P21630 High-affinity branched-chain amino acid transport ATP-binding protein BraG, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    44% identity, 86% coverage of query (172 bits)

TC 3.A.1.4.2 / P73650 NatE aka LivF aka SLR1881, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    38% identity, 87% coverage of query (150 bits)

TC 3.A.1.4.7 / Q92TN4 Putative branched-chain amino acid uptake ABC transporter ATP-binding protein, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
    35% identity, 89% coverage of query (132 bits)

1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
    33% identity, 81% coverage of query (126 bits)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
    33% identity, 81% coverage of query (126 bits)

TC 3.A.1.4.4 / Q9L3S2 UrtE, component of The high-affinity (<1 μM) urea porter (see paper)
    34% identity, 81% coverage of query (125 bits)

TC 3.A.1.4.5 / Q8NRV7 UrtE, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    36% identity, 85% coverage of query (122 bits)

TC 3.A.1.4.6 / Q7A2H0 NatA, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    30% identity, 79% coverage of query (119 bits)

Build an alignment

Build an alignment for Dsui_1113 and 19 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.4.2 / Q55164 NatA aka BRAF aka SLR0467, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    29% identity, 83% coverage of query (110 bits)

A0A071L2Z5 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Pseudomonas aeruginosa (see paper)
TC 3.A.1.152.1 / Q9HVV6 Probable ATP-binding component of ABC transporter, component of LPS export system, LptF (M), LptG (M) and LptB (C) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
    32% identity, 81% coverage of query (110 bits)

E6MYT4 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Neisseria meningitidis serogroup B / serotype 15 (see 2 papers)
    32% identity, 85% coverage of query (109 bits)

6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
    33% identity, 81% coverage of query (108 bits)

lptB / Q2YP14 lipopolysaccharide transport system ATP-binding protein (EC 7.5.2.5) from Brucella abortus (strain 2308) (see paper)
    32% identity, 81% coverage of query (108 bits)

lptB / O25417 lipopolysaccharide transport system ATP-binding protein LptB (EC 7.5.2.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
    34% identity, 81% coverage of query (105 bits)

TC 3.A.1.4.11 / Q6N8W1 Putative branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    32% identity, 82% coverage of query (103 bits)

TC 3.A.1.4.8 / P21629 High-affinity branched-chain amino acid transport ATP-binding protein BraF, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    24% identity, 82% coverage of query (102 bits)

TcyN / b1917 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
tcyN / P37774 cystine ABC transporter ATP binding subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 7 papers)
TCYN_ECOLI / P37774 L-cystine transport system ATP-binding protein TcyN; EC 7.4.2.12 from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P37774 YECC aka CysZ aka B1917, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 5 papers)
    30% identity, 78% coverage of query (101 bits)

ARTM_BACSU / P54537 Arginine transport ATP-binding protein ArtM from Bacillus subtilis (strain 168) (see paper)
    31% identity, 77% coverage of query (101 bits)

Pf6N2E2_2925 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, ATPase component 1 LivG from Pseudomonas fluorescens FW300-N2E2
    25% identity, 82% coverage of query (101 bits)

lptB / Q7CPN9 LPS export ABC transporter ATP-binding protein (EC 7.5.2.5) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 9 papers)
    31% identity, 81% coverage of query (100 bits)

PHNT_SALTY / P96063 Putative 2-aminoethylphosphonate import ATP-binding protein PhnT from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.11.5 / P96063 PhnT aka STM0428, component of 2-aminoethyl phosphonate porter from Salmonella typhimurium (see 2 papers)
    31% identity, 91% coverage of query (99.8 bits)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
    31% identity, 81% coverage of query (97.4 bits)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
    31% identity, 81% coverage of query (97.4 bits)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
    31% identity, 81% coverage of query (97.4 bits)

4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
    32% identity, 80% coverage of query (96.7 bits)

6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
    31% identity, 81% coverage of query (96.3 bits)

6b89A E. Coli lptb in complex with adp and novobiocin
    31% identity, 81% coverage of query (95.5 bits)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
    31% identity, 81% coverage of query (95.5 bits)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative
    31% identity, 80% coverage of query (93.6 bits)

MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
    29% identity, 83% coverage of query (90.9 bits)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
    29% identity, 84% coverage of query (90.1 bits)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
    29% identity, 84% coverage of query (90.1 bits)

6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
    29% identity, 84% coverage of query (90.1 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    29% identity, 86% coverage of query (88.6 bits)

4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
    29% identity, 77% coverage of query (87.8 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    28% identity, 86% coverage of query (85.5 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    28% identity, 86% coverage of query (85.5 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    28% identity, 86% coverage of query (85.5 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    28% identity, 86% coverage of query (85.5 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    28% identity, 86% coverage of query (85.5 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    28% identity, 86% coverage of query (85.5 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    28% identity, 86% coverage of query (85.5 bits)

4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
    29% identity, 76% coverage of query (84.3 bits)

ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
    30% identity, 79% coverage of query (84.0 bits)

8fhkC / O07550 Heterodimeric abc transporter bmrcd in the occluded conformation bound to atp: bmrcd_oc-atp (see paper)
    27% identity, 81% coverage of query (82.4 bits)

7m33C The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342 and atp
    27% identity, 81% coverage of query (82.4 bits)

8t1pC Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
    27% identity, 81% coverage of query (82.4 bits)

6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
    29% identity, 77% coverage of query (80.5 bits)

6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
    29% identity, 79% coverage of query (80.5 bits)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
    29% identity, 77% coverage of query (80.5 bits)

3c4jA Abc protein artp in complex with atp-gamma-s
    26% identity, 77% coverage of query (80.5 bits)

3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
    26% identity, 77% coverage of query (80.5 bits)

2olkA Abc protein artp in complex with adp-beta-s
    26% identity, 77% coverage of query (80.5 bits)

2oljA Abc protein artp in complex with adp/mg2+
    26% identity, 77% coverage of query (80.5 bits)

4q9iA P-glycoprotein cocrystallised with qz-ala
    27% identity, 85% coverage of query (80.1 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    28% identity, 91% coverage of query (79.7 bits)

6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
    29% identity, 79% coverage of query (79.3 bits)

3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    29% identity, 79% coverage of query (79.3 bits)

3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    29% identity, 79% coverage of query (79.3 bits)

7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
    29% identity, 79% coverage of query (79.3 bits)

4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
    29% identity, 79% coverage of query (79.3 bits)

4xwkA P-glycoprotein co-crystallized with bde-100
    29% identity, 79% coverage of query (79.3 bits)

7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
    29% identity, 79% coverage of query (79.0 bits)

7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
    25% identity, 85% coverage of query (79.0 bits)

7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
    29% identity, 79% coverage of query (79.0 bits)

7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
    29% identity, 79% coverage of query (79.0 bits)

7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
    29% identity, 79% coverage of query (79.0 bits)

6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
    25% identity, 85% coverage of query (79.0 bits)

IRTA_MYCT3 / G7CBF5 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
    27% identity, 94% coverage of query (79.0 bits)

6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
    28% identity, 79% coverage of query (78.2 bits)

5koyA Mouse pgp 34 linker deleted bound with atp
    28% identity, 79% coverage of query (78.2 bits)

6s7pA Nucleotide bound abcb4
    28% identity, 87% coverage of query (77.8 bits)

7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
    25% identity, 85% coverage of query (77.8 bits)

7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
    28% identity, 87% coverage of query (77.8 bits)

5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
    29% identity, 77% coverage of query (77.4 bits)

ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
    28% identity, 88% coverage of query (77.4 bits)

8t3kC / O07550 Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to atp: bmrcd_if-atp2 (see paper)
    26% identity, 81% coverage of query (77.4 bits)

5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
    26% identity, 83% coverage of query (77.0 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    28% identity, 77% coverage of query (77.0 bits)

8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
    27% identity, 81% coverage of query (77.0 bits)

6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
    27% identity, 82% coverage of query (75.9 bits)

7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
    27% identity, 82% coverage of query (75.9 bits)

7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
    27% identity, 82% coverage of query (75.9 bits)

7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
    27% identity, 82% coverage of query (75.9 bits)

7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
    27% identity, 82% coverage of query (75.9 bits)

7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
    27% identity, 82% coverage of query (75.5 bits)

8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
    26% identity, 81% coverage of query (75.5 bits)

7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
    27% identity, 77% coverage of query (75.5 bits)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
    27% identity, 86% coverage of query (75.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory