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Searching for up to 100 curated homologs for Dsui_1232 FitnessBrowser__PS:Dsui_1232 (362 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2hzlB / Q3J1R2 Crystal structures of a sodium-alpha-keto acid binding subunit from a trap transporter in its closed forms (see paper)
    56% identity, 91% coverage of query (406 bits)

TAKP_CERS4 / Q3J1R2 Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
    54% identity, 100% coverage of query (405 bits)

TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    56% identity, 99% coverage of query (400 bits)

TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
    52% identity, 95% coverage of query (380 bits)

4yicA / A0A0J9X284 Crystal structure of a trap transporter solute binding protein (ipr025997) from bordetella bronchiseptica rb50 (bb0280, target efi- 500035) with bound picolinic acid
    54% identity, 91% coverage of query (377 bits)

7ug8B / Q0I6F8 Crystal structure of a solute receptor from synechococcus cc9311 in complex with alpha-ketovaleric and calcium
    51% identity, 90% coverage of query (364 bits)

5cm6A Crystal structure of a trap periplasmic solute binding protein from pseudoalteromonas atlantica t6c(patl_2292, target efi-510180) with bound sodium and pyruvate
    40% identity, 88% coverage of query (248 bits)

4petA / Q48AL6 Crystal structure of a trap periplasmic solute binding protein from colwellia psychrerythraea (cps_0129, target efi-510097) with bound calcium and pyruvate (see paper)
    38% identity, 89% coverage of query (243 bits)

Build an alignment

Build an alignment for Dsui_1232 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TLBP_THET8 / Q5SK82 Lactate-binding periplasmic protein TTHA0766; ABC transporter, solute-binding protein; Extracytoplasmic solute receptor protein TTHA0766; TRAP transporter lactate-binding subunit P from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    28% identity, 94% coverage of query (124 bits)

2zzvA / Q5SK82 Crystal structure of a periplasmic substrate binding protein in complex with calcium and lactate (see paper)
    28% identity, 79% coverage of query (113 bits)

2zzwA Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
    28% identity, 79% coverage of query (113 bits)

4xf5A / Q1QZR9 Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound (s)-(+)-2-amino-1-propanol.
    25% identity, 85% coverage of query (89.4 bits)

4uabA Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound ethanolamine
    24% identity, 85% coverage of query (86.3 bits)

4p8bA / Q0KC03 Crystal structure of a trap periplasmic solute binding protein from ralstonia eutropha h16 (h16_a1328), target efi-510189, with bound (s)-2-hydroxy-2-methyl-3-oxobutanoate ((s)-2-acetolactate) (see paper)
    25% identity, 74% coverage of query (70.9 bits)

PP_1169 D-glucuronate / D-galacturonate TRAP transporter, solute receptor component from Pseudomonas putida KT2440
    26% identity, 78% coverage of query (69.3 bits)

DCTP_VEREI / A1WPV4 Solute-binding protein Veis_3954 from Verminephrobacter eiseniae (strain EF01-2) (see paper)
    25% identity, 73% coverage of query (64.7 bits)

4p9kA Crystal structure of a trap periplasmic solute binding protein from verminephrobacter eiseniae ef01-2 (veis_3954, target efi-510324) a nephridial symbiont of the earthworm eisenia foetida, bound to d- erythronate with residual density suggestive of superposition with copurified alternative ligand.
    25% identity, 73% coverage of query (64.7 bits)

4pakA / A1WPV4 Crystal structure of a trap periplasmic solute binding protein from verminephrobacter eiseniae ef01-2 (veis_3954, target efi-510324) a nephridial symbiont of the earthworm eisenia foetida, bound to (r)- pantoic acid (see paper)
    25% identity, 73% coverage of query (64.3 bits)

6wgmA / G5ZWD6 Crystal structure of a marine metagenome trap solute binding protein specific for pyroglutamate (sorcerer ii global ocean sampling expedition, unidentified microbe, scf7180008839099) in complex with co-purified pyroglutamate
    23% identity, 70% coverage of query (57.4 bits)

4nq8B / A0A0H3LPK2 Crystal structure of a trap periplasmic solute binding protein from bordetella bronchispeptica (bb3421), target efi-510039, with density modeled as pantoate (see paper)
    21% identity, 83% coverage of query (56.2 bits)

DCTP_OLEA2 / Q312S0 Isethionate-binding periplasmic protein DctP; TRAP transporter, DctP solute-binding subunit from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see paper)
    25% identity, 75% coverage of query (56.2 bits)

Psest_2125 D-gluconate TRAP transporter, periplasmic component from Pseudomonas stutzeri RCH2
    23% identity, 79% coverage of query (56.2 bits)

DCTP_SULSN / A3T0D1 Solute-binding protein NAS141_03721 from Sulfitobacter sp. (strain NAS-14.1) (see paper)
    25% identity, 83% coverage of query (54.3 bits)

DCTP_CHRSD / Q1QUN2 Solute-binding protein Csal_2479 from Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) (see paper)
    23% identity, 93% coverage of query (51.6 bits)

DCTP_RHOCA / P37735 C4-dicarboxylate-binding periplasmic protein DctP from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see 3 papers)
TC 2.A.56.1.1 / P37735 DctP, component of Tripartite dicarboxylate:H+ symporter (substrates include: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate and mesaconate) from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
    26% identity, 72% coverage of query (49.7 bits)

4ovrA / A7IKQ4 Crystal structure of a trap periplasmic solute binding protein from xanthobacter autotrophicus py2, target efi-510329, with bound beta-d- galacturonate (see paper)
    22% identity, 77% coverage of query (48.1 bits)

AZOBR_RS15915 gluconate TRAP transporter, periplasmic solute-binding component from Azospirillum brasilense Sp245
    22% identity, 77% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory