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Searching for up to 100 curated homologs for Dsui_2116 FitnessBrowser__PS:Dsui_2116 (382 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1vljB / Q9WZS7 Crystal structure of nadh-dependent butanol dehydrogenase a (tm0820) from thermotoga maritima at 1.78 a resolution
    48% identity, 93% coverage of query (351 bits)

7w9yA Crystal structure of bacillus subtilis yugj in complex with NADP and nickel (see paper)
    39% identity, 100% coverage of query (295 bits)

ADH2_GEOTN / A4ISB9 Long-chain-alcohol dehydrogenase 2; Alcohol dehydrogenase 2; ADH2; Fatty alcohol oxidoreductase 2; EC 1.1.1.192 from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
A4ISB9 long-chain-alcohol dehydrogenase (EC 1.1.1.192); alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Geobacillus thermodenitrificans (see paper)
    40% identity, 100% coverage of query (286 bits)

7w9zA Crystal structure of bacillus subtilis yugj in complex with NADP and nitrate
    39% identity, 99% coverage of query (285 bits)

B0KB53 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermoanaerobacter pseudethanolicus (see paper)
    41% identity, 91% coverage of query (272 bits)

bdhA / Q04944 BdhA from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 2 papers)
bdhA / GI|15026377 NADH-dependent butanol dehydrogenase A from Clostridium acetobutylicum ATCC 824 (see paper)
bdhA NADH-dependent butanol dehydrogenase A; EC 1.1.1.- from Clostridium acetobutylicum (see paper)
    36% identity, 91% coverage of query (244 bits)

bdhB / Q04945 BdhB from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 5 papers)
    36% identity, 91% coverage of query (244 bits)

7fjgA / Q8R612 Crystal structure of butanol dehydrogenase a (yqdh) in complex with partial nadh from fusobacterium nucleatum
    34% identity, 99% coverage of query (243 bits)

8i29A Crystal structure of butanol dehydrogenase a (yqdh) in complex with nadh from fusobacterium nucleatum
    34% identity, 99% coverage of query (243 bits)

A7LGK0 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see paper)
    35% identity, 92% coverage of query (218 bits)

YqhD / b3011 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 35 papers)
yqhD / Q46856 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.21; EC 1.1.1.2) from Escherichia coli (strain K12) (see 38 papers)
YQHD_ECOLI / Q46856 Alcohol dehydrogenase YqhD; EC 1.1.1.2 from Escherichia coli (strain K12) (see paper)
Q46856 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Escherichia coli (see paper)
yqhD / RF|NP_417484 alcohol dehydrogenase yqhD; EC 1.1.1.- from Escherichia coli K12 (see 5 papers)
    34% identity, 92% coverage of query (211 bits)

1oj7A / Q46856 Structural genomics, unknown function crystal structure of e. Coli k-12 yqhd (see paper)
    34% identity, 92% coverage of query (208 bits)

1oj7B Structural genomics, unknown function crystal structure of e. Coli k-12 yqhd
    34% identity, 92% coverage of query (208 bits)

U6CL97 alcohol dehydrogenase (NADP+) (EC 1.1.1.2); alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Pectobacterium atrosepticum (see paper)
    32% identity, 92% coverage of query (200 bits)

Build an alignment

Build an alignment for Dsui_2116 and 14 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ADH3_ENTH1 / Q24857 NADP-dependent alcohol dehydrogenase 3; ADH; EC 1.1.1.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
    29% identity, 94% coverage of query (172 bits)

Q59477 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 2 papers)
    29% identity, 99% coverage of query (143 bits)

Q7WRJ3 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 3 papers)
    28% identity, 99% coverage of query (140 bits)

3bfjA / Q7WRJ3 Crystal structure analysis of 1,3-propanediol oxidoreductase (see paper)
    28% identity, 99% coverage of query (140 bits)

DHAT_CITFR / P45513 1,3-propanediol dehydrogenase; 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase; EC 1.1.1.202 from Citrobacter freundii (see paper)
P45513 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Citrobacter freundii (see paper)
dhaT / GB|AAB48848.1 1,3-propanediol dehydrogenase; EC 1.1.1.202 from Citrobacter freundii (see paper)
dhaT / AAB48848.1 1,3-propanediol dehydrogenase from Citrobacter freundii (see 4 papers)
    27% identity, 99% coverage of query (138 bits)

hpfD / A0A374P995 3-hydroxypropane-1-sulfonate dehydrogenase from Hungatella hathewayi (see paper)
    27% identity, 93% coverage of query (135 bits)

YiaY / b3589 L-threonine dehydrogenase (EC 1.1.1.103) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yiaY / P37686 L-threonine dehydrogenase (EC 1.1.1.103) from Escherichia coli (strain K12) (see 5 papers)
    28% identity, 94% coverage of query (134 bits)

adhB / P0DJA2 alcohol dehydrogenase II monomer (EC 1.1.1.1) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 8 papers)
ADH2_ZYMMO / P0DJA2 Alcohol dehydrogenase 2; Alcohol dehydrogenase II; ADH II; EC 1.1.1.1 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 2 papers)
P0DJA2 alcohol dehydrogenase (EC 1.1.1.1) from Zymomonas mobilis subsp. mobilis (see paper)
    28% identity, 97% coverage of query (132 bits)

3owoA / P0DJA2 Structures of iron-dependent alcohol dehydrogenase 2 from zymomonas mobilis zm4 with and without NAD cofactor (see paper)
    28% identity, 96% coverage of query (131 bits)

3ox4A Structures of iron-dependent alcohol dehydrogenase 2 from zymomonas mobilis zm4 complexed with NAD cofactor
    28% identity, 96% coverage of query (131 bits)

A3RL85 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see paper)
    27% identity, 99% coverage of query (130 bits)

ADH4_SCHPO / Q09669 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; EC 1.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
Q09669 alcohol dehydrogenase (EC 1.1.1.1) from Schizosaccharomyces pombe (see paper)
adh4 / RF|NP_592819.1 alcohol dehydrogenase Adh4; EC 1.1.1.1 from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 99% coverage of query (127 bits)

I3E949 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see 2 papers)
    28% identity, 99% coverage of query (126 bits)

I3DX19 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    27% identity, 100% coverage of query (125 bits)

B1HX72 methanol dehydrogenase (EC 1.1.1.244) from Lysinibacillus sphaericus (see paper)
    27% identity, 99% coverage of query (123 bits)

I3DVX6 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    27% identity, 99% coverage of query (123 bits)

A0NIJ1 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Oenococcus oeni (see paper)
    27% identity, 96% coverage of query (122 bits)

I3DTP7 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
    27% identity, 100% coverage of query (122 bits)

C1IWT4 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermococcus sp. (see paper)
    29% identity, 86% coverage of query (121 bits)

A0A0C1Q6R1 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Levilactobacillus brevis (see paper)
    27% identity, 99% coverage of query (121 bits)

I3E2P9 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see 4 papers)
    27% identity, 99% coverage of query (120 bits)

ADHA_THEET / Q9F282 Long-chain primary alcohol dehydrogenase AdhA; EC 1.1.1.2 from Thermoanaerobacter ethanolicus (Clostridium thermohydrosulfuricum) (see paper)
B0K3U7 alcohol dehydrogenase (EC 1.1.1.1); alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermoanaerobacter sp. (see paper)
    27% identity, 94% coverage of query (120 bits)

ADH4 / P10127 alcohol dehydrogenase IV (EC 1.1.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 11 papers)
ADH4_YEAST / P10127 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; ADHIV; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
    25% identity, 98% coverage of query (118 bits)

A0A1D3TV27 alcohol dehydrogenase (EC 1.1.1.1) from Anaerobium acetethylicum (see paper)
    25% identity, 99% coverage of query (118 bits)

gbsB / P71017 choline dehydrogenase from Bacillus subtilis (strain 168) (see paper)
GBSB_BACSU / P71017 Choline dehydrogenase; Alcohol dehydrogenase; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 2 papers)
gbsB alcohol dehydrogenase; EC 1.1.1.1 from Bacillus subtilis (see 3 papers)
    29% identity, 98% coverage of query (114 bits)

mdh / P31005 NAD-dependent methanol dehydrogenase monomer (EC 1.1.1.244) from Bacillus methanolicus (see paper)
MEDH_BACMT / P31005 NAD-dependent methanol dehydrogenase; MDH; MEDH; Type 3 alcohol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see 6 papers)
P31005 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
mdh methanol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see paper)
    28% identity, 99% coverage of query (112 bits)

F8GNE5 methanol dehydrogenase (EC 1.1.1.244) from Cupriavidus necator (see paper)
    27% identity, 90% coverage of query (111 bits)

B7FWP2 hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) from Phaeodactylum tricornutum (see paper)
    27% identity, 100% coverage of query (107 bits)

7qlqAAA Lactaldehyde reductase
    25% identity, 88% coverage of query (107 bits)

FucO / b2799 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli K-12 substr. MG1655 (see 22 papers)
fucO / P0A9S1 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli (strain K12) (see 23 papers)
FUCO_ECOLI / P0A9S1 Lactaldehyde reductase; Propanediol oxidoreductase; EC 1.1.1.77 from Escherichia coli (strain K12) (see paper)
    25% identity, 92% coverage of query (106 bits)

7qlgAAA Lactaldehyde reductase
    25% identity, 88% coverage of query (106 bits)

2bi4A Lactaldehyde:1,2-propanediol oxidoreductase of escherichia coli
    25% identity, 92% coverage of query (106 bits)

fucO / RF|NP_417279 propanediol oxidoreductase from Escherichia coli K12 (see 5 papers)
    25% identity, 92% coverage of query (105 bits)

5br4A / P0A9S1 E. Coli lactaldehyde reductase (fuco) m185c mutant (see paper)
    25% identity, 92% coverage of query (105 bits)

1rrmA Crystal structure of lactaldehyde reductase
    25% identity, 92% coverage of query (105 bits)

5yvmA / A0A133UP32 Crystal structure of the archaeal halo-thermophilic red sea brine pool alcohol dehydrogenase adh/d1 bound to nzq (see paper)
    25% identity, 96% coverage of query (100 bits)

BT3767 L-lactaldehyde reductase FucO (EC 1.1.1.77) from Bacteroides thetaiotaomicron VPI-5482
    26% identity, 88% coverage of query (99.0 bits)

O58517 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Pyrococcus horikoshii (see paper)
    27% identity, 92% coverage of query (98.6 bits)

HP15_3135 ethanol oxidation regulatory protein ercA from Marinobacter adhaerens HP15
    25% identity, 90% coverage of query (98.2 bits)

6jkpA Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense in complex with NAD+
    26% identity, 90% coverage of query (97.1 bits)

6jkoA / A0A0A7I0A5 Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense (see paper)
    26% identity, 90% coverage of query (97.1 bits)

5yvrA Crystal structure of the h277a mutant of adh/d1, an archaeal halo- thermophilic red sea brine pool alcohol dehydrogenase
    24% identity, 96% coverage of query (96.7 bits)

3jzdA / Q46TQ1 Crystal structure of putative alcohol dehedrogenase (yp_298327.1) from ralstonia eutropha jmp134 at 2.10 a resolution
    26% identity, 91% coverage of query (87.4 bits)

3zdrA Structure of the alcohol dehydrogenase (adh) domain of a bifunctional adhe dehydrogenase from geobacillus thermoglucosidasius ncimb 11955 (see paper)
    25% identity, 75% coverage of query (86.7 bits)

1vhdA / Q9X022 Crystal structure of an iron containing alcohol dehydrogenase (see paper)
    25% identity, 86% coverage of query (85.9 bits)

1o2dA Crystal structure of alcohol dehydrogenase, iron-containing (tm0920) from thermotoga maritima at 1.30 a resolution
    25% identity, 86% coverage of query (85.9 bits)

6c75B Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form
    25% identity, 98% coverage of query (82.0 bits)

A0A0Q2QQL1 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermococcus thioreducens (see paper)
6c75A / A0A0Q2QQL1 Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form (see paper)
    25% identity, 98% coverage of query (82.0 bits)

4HBDH_CUPNE / Q59104 4-hydroxybutyrate dehydrogenase; 4HbD; Gamma-hydroxybutyrate dehydrogenase; GHBDH; EC 1.1.1.61 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see 2 papers)
Q59104 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Cupriavidus necator (see paper)
gbd / PRF|2104199G 4-hydroxybutyrate dehydrogenase; EC 1.1.1.61 from Cupriavidus necator (see paper)
    25% identity, 87% coverage of query (80.1 bits)

7bvpA / P0A9Q7 Adhe spirosome in extended conformation (see paper)
    22% identity, 82% coverage of query (77.8 bits)

6tqmA Escherichia coli adhe structure in its compact conformation
    22% identity, 82% coverage of query (77.8 bits)

AdhE / b1241 fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (EC 1.1.1.1; EC 1.2.1.10) from Escherichia coli K-12 substr. MG1655 (see 62 papers)
adhE / P0A9Q7 fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (EC 1.1.1.1; EC 1.2.1.10) from Escherichia coli (strain K12) (see 64 papers)
ADHE_ECOLI / P0A9Q7 Bifunctional aldehyde-alcohol dehydrogenase AdhE; Alcohol dehydrogenase E; EC 1.2.1.10; EC 1.1.1.1 from Escherichia coli (strain K12) (see 13 papers)
ADHE_ECO57 / P0A9Q8 Bifunctional aldehyde-alcohol dehydrogenase AdhE; Alcohol dehydrogenase E; EC 1.2.1.10; EC 1.1.1.1 from Escherichia coli O157:H7 (see 2 papers)
P0A9Q7 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Escherichia coli (see paper)
adhE / MB|P0A9Q7 aldehyde-alcohol dehydrogenase; EC 1.1.1.1; EC 1.2.1.10 from Escherichia coli K12 (see 12 papers)
    22% identity, 82% coverage of query (77.4 bits)

6scgA Structure of adhe form 1
    22% identity, 82% coverage of query (77.4 bits)

ADH_THEBA / A0A0S1X9S7 Alcohol dehydrogenase; EC 1.1.1.1 from Thermococcus barophilus (see paper)
    23% identity, 86% coverage of query (72.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory