Searching for up to 100 curated homologs for Dsui_2735 FitnessBrowser__PS:Dsui_2735 (363 a.a.)
Found high-coverage hits (≥70%) to 51 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GcvT / b2905 aminomethyltransferase (EC 2.1.2.10) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gcvT / P27248 aminomethyltransferase (EC 2.1.2.10) from Escherichia coli (strain K12) (see 8 papers)
GCST_ECOLI / P27248 Aminomethyltransferase; Glycine cleavage system T protein; EC 2.1.2.10 from Escherichia coli (strain K12) (see paper)
P27248 glycine cleavage system (subunit 3/3) (EC 1.4.1.27) from Escherichia coli (see paper)
gcvT aminomethyltransferase; EC 2.1.2.10 from Escherichia coli K12 (see 5 papers)
54% identity, 100% coverage of query (388 bits)
BWI76_RS23880 Aminomethyltransferase (EC 2.1.2.10) from Klebsiella michiganensis M5al
55% identity, 100% coverage of query (386 bits)
3a8iA / P27248 Crystal structure of et-ehred-5-ch3-thf complex (see paper)
54% identity, 99% coverage of query (385 bits)
Q5NHP0 glycine cleavage system (EC 1.4.1.27) from Francisella tularensis subsp. tularensis (see paper)
50% identity, 99% coverage of query (347 bits)
gcvT / P54261 glycine cleavage system T-protein (EC 1.4.1.27) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
P54261 glycine cleavage system (subunit 1/2) (EC 1.4.1.27) from Synechocystis sp. PCC 6803 (see paper)
42% identity, 94% coverage of query (254 bits)
Q9WY54 glycine cleavage system (EC 1.4.1.27) from Thermotoga maritima (see paper)
43% identity, 98% coverage of query (252 bits)
1wooA / Q9WY54 Crystal structure of t-protein of the glycine cleavage system (see paper)
43% identity, 98% coverage of query (252 bits)
1worA Crystal structure of t-protein of the glycine cleavage system
43% identity, 98% coverage of query (252 bits)
1wopA Crystal structure of t-protein of the glycine cleavage system
43% identity, 98% coverage of query (252 bits)
P49364 glycine cleavage system (subunit 1/4) (EC 1.4.1.27) from Pisum sativum (see paper)
36% identity, 97% coverage of query (198 bits)
O65396 glycine cleavage system (subunit 1/5) (EC 1.4.1.27) from Arabidopsis thaliana (see paper)
36% identity, 97% coverage of query (197 bits)
AMT / P28337 aminomethyltransferase (EC 2.1.2.10) from Gallus gallus (see 5 papers)
GCST_CHICK / P28337 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Gallus gallus (Chicken) (see paper)
P28337 glycine cleavage system (subunit 1/3) (EC 1.4.1.27) from Gallus gallus (see paper)
37% identity, 97% coverage of query (193 bits)
Pf6N2E2_5556 Aminomethyltransferase (EC 2.1.2.10) from Pseudomonas fluorescens FW300-N2E2
37% identity, 97% coverage of query (193 bits)
PS417_22370 Aminomethyltransferase (EC 2.1.2.10) from Pseudomonas simiae WCS417
36% identity, 97% coverage of query (186 bits)
AMT / P48728 aminomethyltransferase (EC 2.1.2.10) from Homo sapiens (see 2 papers)
GCST_HUMAN / P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 8 papers)
P48728 glycine cleavage system (subunit 2/4) (EC 1.4.1.27) from Homo sapiens (see 2 papers)
35% identity, 97% coverage of query (185 bits)
1wsvA / P48728 Crystal structure of human t-protein of glycine cleavage system (see paper)
35% identity, 97% coverage of query (185 bits)
GCST_YEAST / P48015 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; Glycine decarboxylase complex subunit T; EC 2.1.2.10 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
36% identity, 98% coverage of query (183 bits)
O58888 glycine cleavage system (EC 1.4.1.27) from Pyrococcus horikoshii (see paper)
34% identity, 98% coverage of query (182 bits)
B0F460 glycine cleavage system (subunit 1/5) (EC 1.4.1.27) from Paratrimastix pyriformis (see paper)
33% identity, 100% coverage of query (176 bits)
PfGW456L13_1866 Aminomethyltransferase (EC 2.1.2.10) from Pseudomonas fluorescens GW456-L13
35% identity, 97% coverage of query (173 bits)
tdm / Q5LT52 trimethylamine-oxide aldolase (EC 4.1.2.32) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (see 2 papers)
TDM_RUEPO / Q5LT52 Trimethylamine-oxide aldolase; Trimethylamine N-oxide demethylase; TMAO demethylase; Tdm; EC 4.1.2.32 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
31% identity, 90% coverage of query (140 bits)
Build an alignment for Dsui_2735 and 21 homologs with ≥ 30% identity
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A0A122IGX3 glycine cleavage system (EC 1.4.1.27) from Plasmodium berghei (see paper)
27% identity, 98% coverage of query (139 bits)
3ad7A / Q50LF0 Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
30% identity, 96% coverage of query (123 bits)
TSOXA_CORS9 / Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 5 papers)
Q50LF0 sarcosine oxidase (subunit 4/4) (EC 1.5.3.1) from Corynebacterium sp. U-96 (see paper)
30% identity, 96% coverage of query (123 bits)
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid
30% identity, 96% coverage of query (123 bits)
2gagA / Q3ZDQ8 Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
28% identity, 97% coverage of query (118 bits)
soxA / Q46337 sarcosine oxidase α subunit (EC 1.5.3.24) from Corynebacterium sp. (strain P-1) (see 3 papers)
TSOXA_CORS1 / Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 5 papers)
28% identity, 95% coverage of query (117 bits)
TSOXA_ARTSP / Q9AGP1 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Arthrobacter sp.
30% identity, 95% coverage of query (115 bits)
mgdC / D7R616 N-methyl glutamate dehydrogenase γ subunit (EC 1.5.99.5) from Methyloversatilis universalis (see 2 papers)
28% identity, 97% coverage of query (109 bits)
dmg1 / Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see 7 papers)
DMGO_ARTGO / Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 4 papers)
Q9AGP8 dimethylglycine oxidase (EC 1.5.3.10) from Arthrobacter globiformis (see paper)
26% identity, 95% coverage of query (100 bits)
1pj6A / Q9AGP8 Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
26% identity, 95% coverage of query (100 bits)
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid
26% identity, 95% coverage of query (100 bits)
Dmgdh / Q63342 dimethylglycine dehydrogenase, mitochondrial (EC 1.5.8.4) from Rattus norvegicus (see 9 papers)
M2GD_RAT / Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 3 papers)
Q63342 dimethylglycine dehydrogenase (EC 1.5.8.4) from Rattus norvegicus (see 3 papers)
27% identity, 91% coverage of query (99.0 bits)
4pabB / Q63342 Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
27% identity, 91% coverage of query (99.0 bits)
Q5RKL4 dimethylglycine dehydrogenase (EC 1.5.8.4) from Rattus norvegicus (see paper)
27% identity, 91% coverage of query (97.4 bits)
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate
26% identity, 95% coverage of query (97.4 bits)
Q9DBT9 dimethylglycine dehydrogenase (EC 1.5.8.4) from Mus musculus (see paper)
25% identity, 91% coverage of query (97.1 bits)
DMGDH / Q9UI17 dimethylglycine dehydrogenase (EC 1.5.8.4) from Homo sapiens (see 6 papers)
M2GD_HUMAN / Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 2 papers)
Q9UI17 dimethylglycine dehydrogenase (EC 1.5.8.4) from Homo sapiens (see 2 papers)
27% identity, 91% coverage of query (96.7 bits)
SARDH / Q9UL12 sarcosine dehydrogenase (EC 1.5.8.3) from Homo sapiens (see 5 papers)
SARDH_HUMAN / Q9UL12 Sarcosine dehydrogenase, mitochondrial; SarDH; BPR-2; EC 1.5.8.3 from Homo sapiens (Human) (see 2 papers)
28% identity, 78% coverage of query (91.3 bits)
mabO / Q8GAI3 4-methylaminobutyrate oxidase (demethylating) (EC 1.5.3.19) from Paenarthrobacter nicotinovorans (see 2 papers)
MABO1_PAENI / Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
26% identity, 88% coverage of query (88.2 bits)
SarDH / Q64380 sarcosine dehydrogenase (EC 1.5.8.3) from Rattus norvegicus (see 10 papers)
SARDH_RAT / Q64380 Sarcosine dehydrogenase, mitochondrial; SarDH; EC 1.5.8.3 from Rattus norvegicus (Rat) (see 2 papers)
27% identity, 77% coverage of query (84.7 bits)
DMDA_PELUB / Q4FP21 Dimethylsulfonioproprionate demethylase DmdA; EC 2.1.1.269 from Pelagibacter ubique (strain HTCC1062) (see 3 papers)
Q4FP21 dimethylsulfoniopropionate demethylase (EC 2.1.1.269) from Candidatus Pelagibacter ubique (see 4 papers)
3tfiA / Q4FP21 Dmsp-dependent demethylase from p. Ubique - with substrate dmsp (see paper)
22% identity, 83% coverage of query (82.4 bits)
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf
22% identity, 83% coverage of query (82.4 bits)
Q8NCN5 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) from Homo sapiens (see paper)
23% identity, 77% coverage of query (73.2 bits)
PDPR_BOVIN / O46504 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr from Bos taurus (Bovine) (see 2 papers)
23% identity, 77% coverage of query (71.2 bits)
DESA_SPHSK / G2IJ05 Syringate O-demethylase; Tetrahydrofolate-dependent syringate O-demethylase; H(4)folate-dependent syringate O-demethylase; EC 2.1.1.- from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
25% identity, 93% coverage of query (66.6 bits)
ligM / BAD61059.1 vanillate/3-O-methylgallate O-demethylase from Sphingomonas paucimobilis (see 3 papers)
27% identity, 72% coverage of query (48.9 bits)
LIGM_SPHSK / G2IQS7 Vanillate/3-O-methylgallate O-demethylase; Vanillate/3MGA O-demethylase; EC 2.1.1.341 from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see 3 papers)
G2IQS7 vanillate/3-O-methylgallate O-demethylase (EC 2.1.1.341) from Sphingobium sp. (see paper)
27% identity, 72% coverage of query (48.9 bits)
5x1jA Vanillate/3-o-methylgallate o-demethylase, ligm, vanillate complex form
27% identity, 72% coverage of query (48.9 bits)
5x1kA Vanillate/3-o-methylgallate o-demethylase, ligm, 3-o-methylgallate complex form
27% identity, 72% coverage of query (48.9 bits)
5x1nA / G2IQS7 Vanillate/3-o-methylgallate o-demethylase, ligm, protocatechuate- tetrahydrofolate complex form (see paper)
27% identity, 72% coverage of query (45.8 bits)
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Lawrence Berkeley National Laboratory