Searching for up to 100 curated homologs for Dsui_2863 FitnessBrowser__PS:Dsui_2863 (500 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
4ex5A / Q2SXD6 Crystal structure of lysyl-tRNA synthetase lysrs from burkholderia thailandensis bound to lysine (see paper)
65% identity, 98% coverage of query (667 bits)
HerC / b2890 lysine—tRNA ligase, constitutive (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 53 papers)
lysS / P0A8N3 lysine—tRNA ligase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 53 papers)
lysS lysine--tRNA ligase; EC 6.1.1.6 from Escherichia coli K12 (see paper)
61% identity, 99% coverage of query (616 bits)
LysU / b4129 lysine—tRNA ligase/Ap4A synthetase/Ap3A synthetase (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 70 papers)
lysU / P0A8N5 lysyl-tRNA synthetase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 73 papers)
P0A8N5 lysine-tRNA ligase (EC 6.1.1.6) from Escherichia coli (see paper)
lysU / RF|NP_418553 lysyl-tRNA synthetase, heat inducible; EC 6.1.1.6 from Escherichia coli K12 (see 10 papers)
60% identity, 100% coverage of query (615 bits)
P0A8N5 Lysine--tRNA ligase, heat inducible; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Escherichia coli (strain K12)
60% identity, 100% coverage of query (615 bits)
1e1tA / P0A8N5 Lysyl-tRNA synthetase (lysu) hexagonal form complexed with the lysyl_adenylate intermediate (see paper)
60% identity, 98% coverage of query (596 bits)
1e24A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and atp and mn2+
60% identity, 98% coverage of query (596 bits)
1e22A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and the non-hydrolysable atp analogue amp-pcp
60% identity, 98% coverage of query (596 bits)
1bbuA / P0A8N3 Lysyl-tRNA synthetase (lyss) complexed with lysine (see paper)
61% identity, 98% coverage of query (595 bits)
5yzxA Crystal structure of e.Coli lysu t146d mutant
60% identity, 98% coverage of query (595 bits)
1e1oA Lysyl-tRNA synthetase (lysu) hexagonal form, complexed with lysine
60% identity, 98% coverage of query (589 bits)
6wbdB / B2FQ84 Crystal structure of lysyl-tRNA synthetase from stenotrophomonas maltophilia with bound l-lysine
59% identity, 98% coverage of query (584 bits)
Q9RHV9 lysine-tRNA ligase (EC 6.1.1.6) from Geobacillus stearothermophilus (see 3 papers)
56% identity, 97% coverage of query (535 bits)
3a74A / Q9RHV9 Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with diadenosine tetraphosphate (ap4a)
55% identity, 97% coverage of query (521 bits)
3e9iA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysine hydroxamate-amp
55% identity, 97% coverage of query (521 bits)
3e9hA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysylsulfamoyl adenosine
55% identity, 97% coverage of query (521 bits)
SYK_STAAU / Q53638 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Staphylococcus aureus (see paper)
53% identity, 98% coverage of query (513 bits)
Q1D380 lysine-tRNA ligase (EC 6.1.1.6) from Myxococcus xanthus (see 2 papers)
51% identity, 97% coverage of query (512 bits)
Q04LI2 lysine-tRNA ligase (EC 6.1.1.6) from Streptococcus pneumoniae (see paper)
49% identity, 99% coverage of query (470 bits)
SYKM_ARATH / Q9LJE2 Lysine--tRNA ligase, chloroplastic/mitochondrial; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 2; AtKRS-2; Protein OVULE ABORTION 5; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
43% identity, 96% coverage of query (407 bits)
SYK_MOUSE / Q99MN1 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Mus musculus (Mouse) (see paper)
Q99MN1 lysine-tRNA ligase (EC 6.1.1.6) from Mus musculus (see paper)
44% identity, 98% coverage of query (386 bits)
SYK_RAT / Q5XIM7 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Rattus norvegicus (Rat) (see 5 papers)
43% identity, 98% coverage of query (382 bits)
SYK_CRIGR / P37879 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
43% identity, 98% coverage of query (380 bits)
SYK_HUMAN / Q15046 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Homo sapiens (Human) (see 25 papers)
Q15046 lysine-tRNA ligase (EC 6.1.1.6) from Homo sapiens (see 12 papers)
43% identity, 98% coverage of query (379 bits)
6chdA / Q15046 Crystal structure of human lysyl-tRNA synthetase complexed with l- lysylsulfamoyl adenosine
43% identity, 98% coverage of query (376 bits)
4ycuA Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase
43% identity, 98% coverage of query (376 bits)
3bjuA Crystal structure of tetrameric form of human lysyl-tRNA synthetase
43% identity, 98% coverage of query (370 bits)
4dpgA Crystal structure of human lysrs: p38/aimp2 complex i
43% identity, 98% coverage of query (369 bits)
P15180 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
41% identity, 98% coverage of query (368 bits)
CLA4_CLACD / A0A120HYZ1 Lysine--tRNA ligase cla4; Cladosporin biosynthesis cluster protein 4; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Cladosporium cladosporioides (see paper)
40% identity, 100% coverage of query (367 bits)
6ildB Crystal structure of human lysrs: p38/aimp2 complex ii
42% identity, 98% coverage of query (367 bits)
4ycwA Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant
43% identity, 98% coverage of query (366 bits)
7f6wA / P15180 Crystal structure of saccharomyces cerevisiae lysyl-tRNA synthetase (see paper)
40% identity, 98% coverage of query (361 bits)
4up7A / C4M7X2 Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate (see paper)
41% identity, 98% coverage of query (361 bits)
SYK_CAEEL / Q22099 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Caenorhabditis elegans (see paper)
43% identity, 99% coverage of query (359 bits)
4up9A Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with atp
41% identity, 98% coverage of query (348 bits)
J5K1T7 lysine-tRNA ligase (EC 6.1.1.6) from Beauveria bassiana (see paper)
40% identity, 98% coverage of query (347 bits)
4upaA Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with amppnp
41% identity, 98% coverage of query (347 bits)
Q580G3 lysine-tRNA ligase (EC 6.1.1.6) from Trypanosoma brucei (see paper)
40% identity, 94% coverage of query (345 bits)
Q8IDJ8 lysine-tRNA ligase (EC 6.1.1.6) from Plasmodium falciparum (see 2 papers)
40% identity, 97% coverage of query (339 bits)
6agtB / Q8IDJ8 Crystal structure of pfkrs complexed with chromone inhibitor (see paper)
40% identity, 97% coverage of query (338 bits)
6bniA / Q5CR27 Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and adenosine
42% identity, 87% coverage of query (338 bits)
6kbfA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
40% identity, 97% coverage of query (338 bits)
6kctA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5
40% identity, 97% coverage of query (338 bits)
6kabA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2
40% identity, 97% coverage of query (338 bits)
6hcwA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and a difluoro cyclohexyl chromone ligand
42% identity, 87% coverage of query (338 bits)
6c86A Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysylsulfamoyl adenosine
42% identity, 87% coverage of query (338 bits)
5eloA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and cladosporin
42% identity, 87% coverage of query (338 bits)
A0QHC4 lysyltransferase (EC 2.3.2.3) from Mycobacterium avium (see paper)
41% identity, 86% coverage of query (333 bits)
6kcnA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
40% identity, 97% coverage of query (332 bits)
5hgqB Loa loa lysyl-tRNA synthetase in complex with cladosporin. (see paper)
42% identity, 97% coverage of query (330 bits)
SYKC_ARATH / Q9ZPI1 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 1; AtKRS-1; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
39% identity, 98% coverage of query (330 bits)
A0R577 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
40% identity, 99% coverage of query (329 bits)
6aqgC / A0PV47 Crystal structure of lysyl-tRNA synthetase from mycobacterium ulcerans complexed with l-lysine and cladosporin
41% identity, 96% coverage of query (325 bits)
6nrzA / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
6nrzB / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
42% identity, 87% coverage of query (324 bits)
6o3fA Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis with complexed with l-lysine and a difluoro cyclohexyl chromone ligand
42% identity, 87% coverage of query (324 bits)
6ns0A Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and cladosporin
42% identity, 87% coverage of query (324 bits)
6m0tA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and cladosporin derivative (cl-2)
39% identity, 97% coverage of query (324 bits)
C4M7X2 lysine-tRNA ligase (EC 6.1.1.6) from Entamoeba histolytica (see paper)
37% identity, 98% coverage of query (323 bits)
6l4qA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-b
39% identity, 97% coverage of query (323 bits)
7zogA Crystal structure of cryptosporidium parvum -plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
41% identity, 87% coverage of query (322 bits)
A0QYV1 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
42% identity, 86% coverage of query (318 bits)
6aqhB / G7CF12 Crystal structure of lysyl-tRNA synthetase from mycobacterium thermoresistibile complexed with l-lysine and cladosporin
41% identity, 96% coverage of query (318 bits)
6ka6A Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
39% identity, 97% coverage of query (318 bits)
4pg3A Crystal structure of krs complexed with inhibitor
39% identity, 97% coverage of query (318 bits)
LYSX_MYCTU / P9WFU7 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; EC 6.1.1.6; EC 2.3.2.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
A5U2Z7 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see paper)
P9WFU7 lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see 2 papers)
40% identity, 86% coverage of query (313 bits)
5zh4A Crystal structure of pfkrs with inhibitor clado-7
38% identity, 97% coverage of query (311 bits)
6hcuA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
39% identity, 97% coverage of query (311 bits)
7bt5A Crystal structure of plasmodium lysrs complexing with an antitumor compound
39% identity, 97% coverage of query (311 bits)
6l3yA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-c
39% identity, 97% coverage of query (309 bits)
5zh5A Crystal structure of pfkrs with inhibitor clado-2
38% identity, 97% coverage of query (306 bits)
5zh2A / W7JP72 Crystal structure of pfkrs with inhibitor clado-5 (see paper)
39% identity, 97% coverage of query (304 bits)
5zh3B Crystal structure of pfkrs with inhibitor clado-6
38% identity, 97% coverage of query (304 bits)
7qi8A Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and inhibitor
39% identity, 95% coverage of query (302 bits)
5zh4B Crystal structure of pfkrs with inhibitor clado-7
38% identity, 97% coverage of query (301 bits)
6hcvA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with a chromone ligand
38% identity, 97% coverage of query (300 bits)
5zh3A Crystal structure of pfkrs with inhibitor clado-6
37% identity, 97% coverage of query (297 bits)
7qh8A / P9WFU9 Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine (see paper)
40% identity, 95% coverage of query (294 bits)
7qhnA Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and an inhibitor
40% identity, 86% coverage of query (284 bits)
SYKM_SCHPO / O74858 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
35% identity, 88% coverage of query (250 bits)
SYKM_YEAST / P32048 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P32048 lysine-tRNA ligase (EC 6.1.1.6) from Saccharomyces cerevisiae (see paper)
31% identity, 86% coverage of query (180 bits)
Build an alignment for Dsui_2863 and 80 homologs with ≥ 30% identity
Or download the sequences
SYDND_METMA / Q8Q0R2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) (see paper)
27% identity, 87% coverage of query (136 bits)
SYDND_HALSA / O07683 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
O07683 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Halobacterium salinarum (see paper)
28% identity, 86% coverage of query (131 bits)
1b8aA / Q52428 Aspartyl-tRNA synthetase (see paper)
27% identity, 90% coverage of query (124 bits)
SYD_THEKO / Q52428 Aspartate--tRNA(Asp) ligase; Aspartyl-tRNA synthetase; AspRS; Discriminating aspartyl-tRNA synthetase; D-AspRS; EC 6.1.1.12 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 4 papers)
Q52428 aspartate-tRNA ligase (EC 6.1.1.12) from Thermococcus kodakarensis (see 4 papers)
27% identity, 90% coverage of query (124 bits)
3nemB Aspartyl-tRNA synthetase complexed with aspartyl adenylate
27% identity, 90% coverage of query (124 bits)
3nemA Aspartyl-tRNA synthetase complexed with aspartyl adenylate
27% identity, 90% coverage of query (124 bits)
3nelA Aspartyl-tRNA synthetase complexed with aspartic acid
27% identity, 90% coverage of query (124 bits)
SYDND_METTH / O26328 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
O26328 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Methanothermobacter thermautotrophicus (see paper)
26% identity, 90% coverage of query (114 bits)
Q8I2B1 aspartate-tRNA ligase (EC 6.1.1.12) from Plasmodium falciparum (see paper)
24% identity, 73% coverage of query (102 bits)
4o2dB / A0QWN3 Crystal structure of aspartyl-tRNA synthetase from mycobacterium smegmatis with bound aspartic acid (see paper)
24% identity, 87% coverage of query (93.6 bits)
SYDND_THET8 / Q5SIC2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 4 papers)
Q5SIC2 aspartate-tRNA ligase (EC 6.1.1.12) from Thermus thermophilus (see paper)
27% identity, 87% coverage of query (91.3 bits)
Q585M3 aspartate-tRNA ligase (EC 6.1.1.12) from Trypanosoma brucei (see paper)
24% identity, 86% coverage of query (90.9 bits)
SYDC_MOUSE / Q922B2 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Mus musculus (Mouse) (see paper)
Q922B2 aspartate-tRNA ligase (EC 6.1.1.12) from Mus musculus (see paper)
25% identity, 86% coverage of query (89.4 bits)
SYDC_RAT / P15178 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Rattus norvegicus (Rat) (see paper)
25% identity, 86% coverage of query (89.0 bits)
SYDC_HUMAN / P14868 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing gene 40 protein; EC 6.1.1.12 from Homo sapiens (Human) (see 4 papers)
P14868 aspartate-tRNA ligase (EC 6.1.1.12) from Homo sapiens (see 2 papers)
24% identity, 86% coverage of query (88.2 bits)
SYNC_YEAST / P38707 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 86% coverage of query (85.5 bits)
1x55A Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
24% identity, 90% coverage of query (75.9 bits)
1x54A / O57980 Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate (see paper)
24% identity, 90% coverage of query (75.9 bits)
aspS2 / Q9RVH4 aspartyl-tRNA synthetase, non-discriminating (EC 6.1.1.23) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
SYDND_DEIRA / Q9RVH4 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
24% identity, 87% coverage of query (75.1 bits)
3kfuC / Q5SIC2 Crystal structure of the transamidosome (see paper)
26% identity, 86% coverage of query (75.1 bits)
Or start over
Lawrence Berkeley National Laboratory