Searching for up to 100 curated homologs for Echvi_0146 FitnessBrowser__Cola:Echvi_0146 (325 a.a.)
Found high-coverage hits (≥70%) to 68 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5z75A Artificial l-threonine 3-dehydrogenase designed by ancestral sequence reconstruction. (see paper)
65% identity, 94% coverage of query (434 bits)
7eprB Partial consensus l-threonine 3-dehydrogenase (c-change) (see paper)
59% identity, 96% coverage of query (400 bits)
7cgvA Full consensus l-threonine 3-dehydrogenase, fctdh-iiym (NAD+ bound form) (see paper)
62% identity, 94% coverage of query (399 bits)
7epsA Partial consensus l-threonine 3-dehydrogenase (e-change) (see paper)
58% identity, 95% coverage of query (385 bits)
RR42_RS28300 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus basilensis FW507-4G11
57% identity, 94% coverage of query (382 bits)
E5RQ20 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus necator (see paper)
56% identity, 96% coverage of query (380 bits)
2yy7A / Q8KZM4 Crystal structure of thermolabile l-threonine dehydrogenase from flavobacterium frigidimaris kuc-1 (see paper)
57% identity, 94% coverage of query (377 bits)
3wmwB / Q0K312 Gale-like l-threonine dehydrogenase from cupriavidus necator (apo form) (see paper)
53% identity, 94% coverage of query (341 bits)
5y1fA / D6PBM7 Monomeric l-threonine 3-dehydrogenase from metagenome database (NAD+ bound form) (see paper)
49% identity, 94% coverage of query (312 bits)
5y1gA Monomeric l-threonine 3-dehydrogenase from metagenome database (akb and nadh bound form)
49% identity, 94% coverage of query (312 bits)
D6PBM7 L-threonine 3-dehydrogenase (EC 1.1.1.103) from uncultured archaeon (see paper)
49% identity, 94% coverage of query (311 bits)
5y1eA Monomeric l-threonine 3-dehydrogenase from metagenome database (l-ser and NAD+ bound form)
49% identity, 94% coverage of query (311 bits)
E3PS87 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Acetoanaerobium sticklandii (see paper)
47% identity, 97% coverage of query (305 bits)
6jygD / D0N3N0 Crystal structure of l-threonine dehydrogenase from phytophthora infestans (see paper)
47% identity, 96% coverage of query (300 bits)
3a1nA / Q97BK3 Crystal structure of l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium (see paper)
44% identity, 96% coverage of query (289 bits)
Q97BK3 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Thermoplasma volcanium (see paper)
45% identity, 94% coverage of query (289 bits)
3a4vA Crystal structure of pyruvate bound l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium
45% identity, 94% coverage of query (289 bits)
3ajrA Crystal structure of l-3-hydroxynorvaline bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
44% identity, 96% coverage of query (288 bits)
3a9wA Crystal structure of l-threonine bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
44% identity, 96% coverage of query (288 bits)
TDH_PIG / Q8MIR0 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Sus scrofa (Pig) (see paper)
44% identity, 94% coverage of query (260 bits)
TDH_MOUSE / Q8K3F7 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Mus musculus (Mouse) (see paper)
43% identity, 94% coverage of query (260 bits)
D3ZN15 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Rattus norvegicus (see paper)
42% identity, 94% coverage of query (258 bits)
4yr9A / Q8K3F7 Mouse tdh with NAD+ bound (see paper)
43% identity, 94% coverage of query (254 bits)
8gjbA / Q4CU39 L-threonine 3-dehydrogenase from trypanosoma cruzi in complex with NAD and acetate
39% identity, 95% coverage of query (233 bits)
5k4wC / Q7YW97 Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to nadh and l-threonine refined to 1.72 angstroms (see paper)
38% identity, 96% coverage of query (226 bits)
5lc1A L-threonine dehydrogenase from trypanosoma brucei with NAD and the inhibitor pyruvate bound.
38% identity, 96% coverage of query (226 bits)
5k4qA Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ refined to 2.3 angstroms
38% identity, 96% coverage of query (226 bits)
Q7YW97 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Trypanosoma brucei (see paper)
38% identity, 95% coverage of query (225 bits)
5k50C Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ and l-allo-threonine refined to 2.23 angstroms
38% identity, 95% coverage of query (225 bits)
4yrbC / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
32% identity, 94% coverage of query (160 bits)
Build an alignment for Echvi_0146 and 30 homologs with ≥ 30% identity
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4yrbB / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
28% identity, 94% coverage of query (118 bits)
denD / P44094 D-erythronate 2-dehydrogenase (EC 1.1.1.410) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DEND_HAEIN / P44094 D-erythronate dehydrogenase; EC 1.1.1.410 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
25% identity, 87% coverage of query (84.0 bits)
Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
26% identity, 93% coverage of query (82.8 bits)
5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
27% identity, 78% coverage of query (79.7 bits)
5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
26% identity, 78% coverage of query (79.3 bits)
3sxpD / B5Z7L9 Crystal structure of helicobacter pylori adp-l-glycero-d-manno- heptose-6-epimerase (rfad, hp0859) (see paper)
25% identity, 96% coverage of query (69.7 bits)
GAE4 / O22141 subunit of UDP-GlcA 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
GAE4_ARATH / O22141 UDP-glucuronate 4-epimerase 4; UDP-glucuronic acid epimerase 4; AtUGlcAE1; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O22141 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 4 papers)
27% identity, 76% coverage of query (67.4 bits)
GAE3_ARATH / O81312 UDP-glucuronate 4-epimerase 3; UDP-glucuronic acid epimerase 3; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O81312 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
25% identity, 76% coverage of query (65.5 bits)
GAE2_ARATH / Q9LPC1 UDP-glucuronate 4-epimerase 2; UDP-glucuronic acid epimerase 2; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPC1 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see paper)
24% identity, 94% coverage of query (65.1 bits)
GAE6_ARATH / Q9LIS3 UDP-glucuronate 4-epimerase 6; UDP-glucuronic acid epimerase 6; AtUGlcAE2; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9LIS3 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 3 papers)
26% identity, 76% coverage of query (64.7 bits)
B5Z7L9 ADP-glyceromanno-heptose 6-epimerase (EC 5.1.3.20) from Helicobacter pylori (see paper)
25% identity, 82% coverage of query (61.2 bits)
GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
25% identity, 91% coverage of query (59.3 bits)
UGA4E_THEGP / F8C4X8 UDP-glucuronate 4-epimerase; UGA4E; TgUGAE; EC 5.1.3.6 from Thermodesulfobacterium geofontis (strain OPF15)
23% identity, 92% coverage of query (58.2 bits)
wbpP / Q9RHD6 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Pseudomonas aeruginosa (see 8 papers)
22% identity, 97% coverage of query (58.2 bits)
A0A1J0KK43 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Albuca bracteata (see paper)
24% identity, 76% coverage of query (57.0 bits)
2c20A / A0A6L8PTV5 Crystal structure of udp-glucose 4-epimerase
23% identity, 78% coverage of query (56.6 bits)
Echvi_1472 UDP-glucose 4-epimerase (EC 5.1.3.2) from Echinicola vietnamensis KMM 6221, DSM 17526
24% identity, 94% coverage of query (56.6 bits)
Q8KN66 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Pseudomonas aeruginosa (see paper)
1sb8A / Q8KN66 Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
22% identity, 97% coverage of query (55.5 bits)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose
22% identity, 97% coverage of query (55.5 bits)
3lu1A / Q7BJX9 Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
22% identity, 76% coverage of query (55.1 bits)
GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
26% identity, 94% coverage of query (55.1 bits)
wbgU / Q7BJX9 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Plesiomonas shigelloides (see paper)
GNE_PLESH / Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 3 papers)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Plesiomonas shigelloides (see 2 papers)
22% identity, 76% coverage of query (55.1 bits)
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
22% identity, 76% coverage of query (55.1 bits)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
22% identity, 76% coverage of query (55.1 bits)
7k3pA / Q0P9C3 The structure of the udp-glc/glcnac 4-epimerase from the human pathogen campylobacter jejuni
25% identity, 90% coverage of query (52.8 bits)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
22% identity, 75% coverage of query (52.4 bits)
6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
22% identity, 75% coverage of query (52.0 bits)
8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
25% identity, 74% coverage of query (52.0 bits)
1ek6A Structure of human udp-galactose 4-epimerase complexed with nadh and udp-glucose
22% identity, 94% coverage of query (52.0 bits)
GALE / Q14376 UDP-galactose 4-epimerase (EC 5.1.3.2; EC 5.1.3.7) from Homo sapiens (see 6 papers)
GALE_HUMAN / Q14376 UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; EC 5.1.3.2; EC 5.1.3.7 from Homo sapiens (Human) (see 12 papers)
Q14376 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Homo sapiens (see 4 papers)
22% identity, 94% coverage of query (52.0 bits)
wcaGNCTC / Q0P8I7 GDP-6-deoxy-4-keto-D-lyxo-heptose 4-reductase from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 3 papers)
GMHD_CAMJE / Q0P8I7 GDP-D-glycero-alpha-D-manno-heptose dehydrogenase; EC 1.1.98.- from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 2 papers)
23% identity, 97% coverage of query (50.4 bits)
6vo6D / Q0P8I7 Crystal structure of cj1427, an essential NAD-dependent dehydrogenase from campylobacter jejuni, in the presence of nadh and gdp (see paper)
23% identity, 97% coverage of query (50.4 bits)
1hzjA Human udp-galactose 4-epimerase: accommodation of udp-n- acetylglucosamine within the active site
22% identity, 94% coverage of query (50.4 bits)
1i3lA Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase
22% identity, 94% coverage of query (50.1 bits)
1i3kA / Q14376 Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase (see paper)
22% identity, 94% coverage of query (50.1 bits)
6vo8A X-ray structure of the cj1427 in the presence of nadh and gdp-d- glycero-d-mannoheptose, an essential NAD-dependent dehydrogenase from campylobacter jejuni
23% identity, 94% coverage of query (50.1 bits)
GALE_CAEEL / Q564Q1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; EC 5.1.3.2; EC 5.1.3.7 from Caenorhabditis elegans (see paper)
23% identity, 93% coverage of query (49.3 bits)
3m2pB / Q814Z6 The crystal structure of udp-n-acetylglucosamine 4-epimerase from bacillus cereus
22% identity, 81% coverage of query (45.4 bits)
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Lawrence Berkeley National Laboratory