Searching for up to 100 curated homologs for Echvi_0300 FitnessBrowser__Cola:Echvi_0300 (305 a.a.)
Found high-coverage hits (≥70%) to 94 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.132.1 / O30489 GldA, component of The GldAFG putative ABC transporter required for ratchet-type gliding motility; may function in secretion of a macromolecule such as an exopolysaccharide. (Agarwal et al., 1997; Hunnicutt et al., 2002; McBride and Zhu 2013). Soluble GldG homologues (no TMSs) are found in eukaryotes (e.g. intraflagellar protein transporter, IPT52 of Chlamydomonas reinhardtii; XP_001692161) from Cytophaga johnsonae (Flavobacterium johnsoniae) (see paper)
50% identity, 99% coverage of query (315 bits)
natA / P46903 Na+ ABC efflux transporter ATP-binding protein (EC 7.2.2.4) from Bacillus subtilis (strain 168) (see paper)
NATA_BACSU / P46903 ABC transporter ATP-binding protein NatA; ABC-type Na(+) transporter; EC 7.2.2.4 from Bacillus subtilis (strain 168) (see 2 papers)
P46903 ABC-type Na+ transporter (EC 7.2.2.4) from Bacillus subtilis (see 2 papers)
TC 3.A.1.115.1 / P46903 NatA; ATP-binding transport protein (Na(+) ABC transporter), component of Na+ efflux pump NatAB from Bacillus subtilis (see 3 papers)
natA / GB|BAA22236.1 sodium extrusion ABC transporter, ATP-binding protein NatA from Bacillus subtilis (see paper)
40% identity, 70% coverage of query (169 bits)
YXLF_BACSU / P94374 Uncharacterized ABC transporter ATP-binding protein YxlF; EC 7.-.-.- from Bacillus subtilis (strain 168) (see paper)
36% identity, 78% coverage of query (161 bits)
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
32% identity, 98% coverage of query (161 bits)
TC 3.A.1.131.1 / P42332 BcrA, component of The 2 or 3 component bacitracin-resistance efflex pump, BcrAB or BcrABC (Podlesek et al., 1995; Bernard et al., 2003) (BcrA is most similar to SpaF (3.A.1.124.2), but BcrB (5-6 TMSs) is only distantly related to other ABC2-type membrane proteins (Wang et al., 2009). BcrC is not sufficiently similar to detect similarity in BLAST searches. BcrC (5TMSs) belongs to the PAP2 phosphatase superfamily and may not be a contituent of the BcrAB transporter. Transcription is regulated by BcrR, a one-component transmembrane signal transduction system from Bacillus licheniformis (see paper)
bcrA / GB|AAA99504.1 bacitracin ABC transporter, ATP-binding protein BcrA from Bacillus licheniformis (see paper)
32% identity, 98% coverage of query (159 bits)
TC 3.A.1.148.1 / W2ET84 ABC transporter ATP binding domain, component of ABC lantibiotic NAI-107 immunity exporter, MlbYZ from Microbispora sp. ATCC PTA-5024
36% identity, 72% coverage of query (152 bits)
TC 3.A.1.126.1 / Q8RME1 BerA, component of Exporter of β-exotoxin I, BerAB from Bacillus thuringiensis serovar thuringiensis (see 2 papers)
33% identity, 90% coverage of query (146 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
35% identity, 73% coverage of query (146 bits)
TC 3.A.1.146.1 / Q9ZBX4 ABC transporter ATP-binding protein, component of The probable actinorhodin (ACT) and undecylprodigiosin (RED) exporter (Lee et al. 2012), AreABCD (Sco3956-9) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
31% identity, 98% coverage of query (143 bits)
TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
30% identity, 98% coverage of query (141 bits)
TC 3.A.1.124.2 / Q45404 SpaF, component of The 3-component subtilin immunity exporter, SpaEFG from Bacillus subtilis (see paper)
38% identity, 78% coverage of query (141 bits)
TC 3.A.1.105.3 / Q70J75 CmrA, component of The 4A-4E-O-dideacetyl-chromomycin A3 (biosynthetic precursor of chromomycin) exporter (may also export chromomycin and mithramycin from Streptomyces griseus subsp. griseus
32% identity, 98% coverage of query (140 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
35% identity, 74% coverage of query (137 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
30% identity, 99% coverage of query (134 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
30% identity, 99% coverage of query (133 bits)
Build an alignment for Echvi_0300 and 15 homologs with ≥ 30% identity
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BCRA_ENTFL / Q5WNX0 Bacitracin transport ATP-binding protein BcrA from Enterococcus faecalis (Streptococcus faecalis) (see 2 papers)
27% identity, 98% coverage of query (133 bits)
TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
28% identity, 99% coverage of query (130 bits)
MEATP_MYCTU / O86311 Multidrug efflux system ATP-binding protein Rv1218c; EC 7.6.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
37% identity, 72% coverage of query (129 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
35% identity, 79% coverage of query (121 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
32% identity, 71% coverage of query (121 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
30% identity, 77% coverage of query (120 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
35% identity, 79% coverage of query (120 bits)
TC 3.A.1.105.4 / Q4VWC9 PltI, component of The pyoluteorin (a chlorinated polyketide) efflux pump, PltHIJKN (see 2 papers)
30% identity, 90% coverage of query (119 bits)
6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
29% identity, 77% coverage of query (118 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
29% identity, 71% coverage of query (115 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
32% identity, 72% coverage of query (114 bits)
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
31% identity, 75% coverage of query (114 bits)
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
31% identity, 75% coverage of query (114 bits)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
31% identity, 75% coverage of query (114 bits)
6b89A E. Coli lptb in complex with adp and novobiocin
31% identity, 75% coverage of query (114 bits)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium
31% identity, 75% coverage of query (114 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
30% identity, 77% coverage of query (114 bits)
6xjhC Pmtcd abc exporter without the basket domain at c2 symmetry
30% identity, 72% coverage of query (111 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
31% identity, 72% coverage of query (108 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
31% identity, 72% coverage of query (108 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
31% identity, 72% coverage of query (108 bits)
7lkpA Structure of atp-free human abca4
31% identity, 72% coverage of query (108 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
33% identity, 77% coverage of query (108 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 72% coverage of query (107 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
31% identity, 72% coverage of query (107 bits)
7lkzA Structure of atp-bound human abca4
31% identity, 72% coverage of query (107 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
29% identity, 75% coverage of query (105 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
31% identity, 74% coverage of query (100 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
30% identity, 74% coverage of query (99.8 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
30% identity, 74% coverage of query (99.8 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
30% identity, 74% coverage of query (99.8 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
30% identity, 71% coverage of query (98.2 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
27% identity, 77% coverage of query (97.1 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
31% identity, 70% coverage of query (94.0 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
31% identity, 70% coverage of query (94.0 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
31% identity, 70% coverage of query (94.0 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
30% identity, 74% coverage of query (92.8 bits)
7r8eA / P45844 The structure of human abcg1 e242q complexed with atp (see paper)
29% identity, 72% coverage of query (87.8 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
29% identity, 72% coverage of query (85.5 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
28% identity, 72% coverage of query (85.1 bits)
7oz1A Cryo-em structure of abcg1 e242q mutant with atp and cholesteryl hemisuccinate bound
29% identity, 72% coverage of query (84.3 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
24% identity, 99% coverage of query (84.0 bits)
8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
26% identity, 83% coverage of query (83.2 bits)
8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
26% identity, 83% coverage of query (83.2 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
27% identity, 79% coverage of query (80.9 bits)
8hf4A / A0A0H2ZPI8 Cryo-em structure of nucleotide-bound coma at outward-facing state with ec gate closed conformation (see paper)
30% identity, 70% coverage of query (80.1 bits)
8k7aA Cryo-em structure of nucleotide-bound coma e647q mutant with mg2+
29% identity, 70% coverage of query (79.0 bits)
8hf6A Cryo-em structure of nucleotide-bound coma e647q mutant
29% identity, 70% coverage of query (79.0 bits)
8hf7B Cryo-em structure of coma bound to its mature substrate csp peptide
29% identity, 70% coverage of query (79.0 bits)
CFTR_RAT / P34158 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Rattus norvegicus (Rat) (see 5 papers)
29% identity, 76% coverage of query (78.2 bits)
CFTR_MOUSE / P26361 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Mus musculus (Mouse) (see 12 papers)
P26361 adenylate kinase (EC 2.7.4.3); channel-conductance-controlling ATPase (EC 5.6.1.6) from Mus musculus (see 2 papers)
29% identity, 76% coverage of query (77.4 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
28% identity, 70% coverage of query (75.5 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
27% identity, 70% coverage of query (74.3 bits)
8ipsA / P23886 Cryo-em structure of heme transporter cyddc from escherichia coli in the inward facing heme loading state (see paper)
25% identity, 72% coverage of query (74.3 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
27% identity, 71% coverage of query (73.9 bits)
CFTR / P13569 cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) from Homo sapiens (see 23 papers)
CFTR_HUMAN / P13569 Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Homo sapiens (Human) (see 120 papers)
P13569 adenylate kinase (EC 2.7.4.3); channel-conductance-controlling ATPase (EC 5.6.1.6) from Homo sapiens (see 17 papers)
TC 3.A.1.202.1 / P13569 Cystic fibrosis transmembrane conductance regulator (CFTR) (also called ABCC7); cyclic AMP-dependent chloride channel; also catalyzes nucleotide (ATP-ADP)-dependent glutathione and glutathione-conjugate flux (Kogan et al., 2003) (may also activate inward rectifying K+ channels). The underlying mechanism by which ATP hydrolysis controls channel opening is described by Gadsby et al., 2006. The most common cause of cystic fibrosis (CF) is defective folding of a cystic fibrosis transmembrane conductance regulator (CFTR) mutant lacking Phe508 (DeltaF508)(Riordan, 2008). The DeltaF508 protein appears to be trapped in a prefolded state with incomplete packing of the transmembrane segments, a defect that can be repaired by direct interaction with correctors such as corr-4a, VRT-325, and VRT-532 (Wang et al., 2007). CFTR interacts directly with MRP4 (3.A.1.208.7) to control Cl- secretion (Li et al., 2007). It has intrinsic adenylate kinase activity that may be of functional importance (Randak and Welsh, 2007). The intact CFTR protein mediates ATPase rather than adenylate kinase activity (Ramjeesingh et al., 2008). Regulated by Na+/H+ exchange regulatory cofactors (NHERF; O14745; TC #8.A.24.1.1) (Seidler et al., 2009). Regulated by protein kinase A and C phosphorylation (Csanády et al., 2010). It is also activated by membrane stretch induced by negative pressures (Zhang et al., 2010). TMS6 plays roles in gating and permeation (Bai et al., 2010; 2011). The 3-D structure revealed the probable location of the channel gate (Rosenberg et al., 2011). Conformational changes opening the CFTR chloride channel pore, coupled to ATP-dependent gating, have been studied (Wang and Linsdell, 2012). Alternating access to the transmembrane domain of CFTR has been demonstrated from Homo sapiens (Human) (see 71 papers)
CFTR / RF|NP_000483.3 cystic fibrosis transmembrane conductance regulator from Homo sapiens (see paper)
27% identity, 73% coverage of query (73.6 bits)
5uakA / P13569 Dephosphorylated, atp-free human cystic fibrosis transmembra conductance regulator (cftr) (see paper)
27% identity, 73% coverage of query (73.2 bits)
7svrA The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) and lumacaftor (vx-809)
27% identity, 73% coverage of query (73.2 bits)
CFTR_DANRE / Q1LX78 Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; EC 5.6.1.6 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 6 papers)
Q1LX78 channel-conductance-controlling ATPase (EC 5.6.1.6) from Danio rerio (see paper)
26% identity, 77% coverage of query (72.8 bits)
6d3rA Thermostablilized dephosphorylated chicken cftr (see paper)
26% identity, 73% coverage of query (72.4 bits)
7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2)
25% identity, 72% coverage of query (72.4 bits)
7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8)
25% identity, 72% coverage of query (72.0 bits)
7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4)
25% identity, 72% coverage of query (72.0 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
25% identity, 75% coverage of query (72.0 bits)
7svdA The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with atp/mg and lumacaftor (vx-809)
27% identity, 73% coverage of query (72.0 bits)
7sv7A The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with atp/mg and tezacaftor (vx-661)
27% identity, 73% coverage of query (72.0 bits)
6o2pA Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (cftr)
27% identity, 73% coverage of query (72.0 bits)
6o1vA Complex of human cystic fibrosis transmembrane conductance regulator (cftr) and glpg1837
27% identity, 73% coverage of query (72.0 bits)
6msmA / P13569 Phosphorylated, atp-bound human cystic fibrosis transmembrane conductance regulator (cftr) (see paper)
27% identity, 73% coverage of query (72.0 bits)
8ubrA Cystic fibrosis transmembrane conductance regulator
27% identity, 73% coverage of query (71.6 bits)
5w81A / Q1LX78 Phosphorylated, atp-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (cftr) (see paper)
26% identity, 77% coverage of query (71.6 bits)
7ahdC Opua (e190q) occluded
22% identity, 71% coverage of query (71.6 bits)
7ahhC Opua inhibited inward-facing, sbd docked
22% identity, 71% coverage of query (71.6 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
22% identity, 71% coverage of query (71.6 bits)
MRP4_HUMAN / O15439 ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; Multidrug resistance-associated protein 4; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3 from Homo sapiens (Human) (see 14 papers)
O15439 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 4 papers)
TC 3.A.1.208.7 / O15439 MRP4 (ABCC4); exporter of cyclic nucleotides (cAMP, cGMP and other nucleotide analogues, particularly purine analogues, methotrexate, bile acids, prostaglandins E1 and E2, reduced folates, 9-(2-phosphonylmethyoxyethyl)adenine, leukotrienes, estradiol 17-β-D-glucuronide) and drug sulfate conjugates (inhibited by nonsteroidal antiinflammatory drugs Reid et al., 2003; Rius et al., 2008)). When overexpressed, it can lower the intracellular concentration of nucleoside/nucleotide analogs, such as the antiviral compounds PMEA (9-(2-phosphonylmethoxyethyl)adenine), adefovir, or ganciclovir (Nigam 2015), and of anticancer nucleobase analogs, such as 6-mercaptopurine, after their conversion into the respective nucleotides. MRP4 interacts directly with CFTR (3.A.1.202.1) to control Cl- secretion (Li et al., 2007). It also functions in urate elimination across the renal tubule apical membrane (Prestin et al. 2014). Thus, MRP4 is a broad specificity organic anion exporter (Ritter et al., 2005). MRP4 and CFTR together function in the regulation of cAMP and beta-adrenergic contraction in cardiac myocytes (Sellers et al., 2012). Amino acid changes can alter the uptake of drugs such as 6-mercaptopurine (6-MP) and 9-(2-phosphonyl methoxyethyl) adenine (PMEA) (see 8 papers)
ABCC4 / RF|NP_001098985.1 multidrug resistance-associated protein 4 from Homo sapiens (see paper)
28% identity, 73% coverage of query (71.2 bits)
8i39A Cryo-em structure of abscisic acid transporter atabcg25 with aba
26% identity, 72% coverage of query (71.2 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
26% identity, 71% coverage of query (71.2 bits)
7zdtC Occ(apo/return) conformation of cyddc mutant (e500q.C) in atp(cydc) bound state (dataset-18)
25% identity, 72% coverage of query (70.9 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
24% identity, 75% coverage of query (70.9 bits)
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Lawrence Berkeley National Laboratory