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Searching for up to 100 curated homologs for Echvi_0794 FitnessBrowser__Cola:Echvi_0794 (529 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

tmaT / A0A0B5RUB0 trimethylamine transporter from Myroides profundi (see paper)
TMAT_MYRPR / A0A0B5RUB0 Trimethylamine transporter; TMA transporter; TMA-specific transporter from Myroides profundi (see paper)
    51% identity, 99% coverage of query (536 bits)

Q0PCR9 ABC-type quaternary amine transporter (EC 7.6.2.9) from Aphanothece halophytica (see paper)
    56% identity, 96% coverage of query (528 bits)

BETS_RHIML / G3XCN6 Glycine betaine/proline betaine transporter BetS from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
TC 2.A.15.1.5 / Q92WM0 Glycine-betaine/proline-betaine:Na+ symporter, BetS; BetT, OpuD (see 2 papers)
    50% identity, 94% coverage of query (497 bits)

BCCT2_VIBPA / Q87NZ5 Glycine betaine/proline/choline transporter VP1723 from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (see paper)
    46% identity, 95% coverage of query (451 bits)

GBTR_ACIAD / Q6F754 Glycine betaine transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
TC 2.A.15.1.9 / Q6F754 High affinity glycine betaine uptake system from Acinetobacter sp. (strain ADP1) (see paper)
    44% identity, 95% coverage of query (445 bits)

BCCT1_VIBPA / Q87PP5 Glycine betaine/proline/choline/ectoine transporter VP1456 from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (see paper)
    48% identity, 93% coverage of query (439 bits)

BCCT3_VIBPA / Q87NG3 Glycine betaine transporter 1 from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (see paper)
    48% identity, 93% coverage of query (439 bits)

BETL_LISMN / Q9X4A5 Glycine betaine transporter BetL; Glycine betaine-Na(+) symporter from Listeria monocytogenes (see 4 papers)
TC 2.A.15.1.11 / Q9X4A5 Glycine betaine transporter BetL (Glycine betaine-Na(+) symporter) from Listeria monocytogenes (see 4 papers)
    44% identity, 95% coverage of query (425 bits)

OPUD_BACSU / P54417 Glycine betaine transporter OpuD from Bacillus subtilis (strain 168) (see paper)
TC 2.A.15.1.1 / P54417 Glycine betaine:Na+ symporter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 3 papers)
    44% identity, 95% coverage of query (414 bits)

GBT_DESHY / Q24SP9 Probable glycine betaine transporter from Desulfitobacterium hafniense (strain Y51) (see paper)
    41% identity, 92% coverage of query (411 bits)

BETT2_ACIAD / Q6FDF5 Osmo-dependent choline transporter BetT2 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    38% identity, 96% coverage of query (392 bits)

BetT / b0314 choline:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
BetT / P0ABC9 choline:H+ symporter from Escherichia coli (strain K12) (see 5 papers)
BETT_ECOLI / P0ABC9 High-affinity choline transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.15.1.4 / P0ABC9 The high-affinity, proton- or sodium-driven, secondary symporter, BetT from Escherichia coli (see 4 papers)
    38% identity, 97% coverage of query (392 bits)

TC 2.A.15.1.3 / Q4ZLW8 Low affinity (0.9 mM), high efficiency, choline/glycine betaine:H+ symporter, BetT from Pseudomonas syringae pv. syringae (strain B728a) (see paper)
    41% identity, 93% coverage of query (389 bits)

ECTP_CORGL / Q79VE0 Ectoine/glycine betaine/proline transporter EctP from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
TC 2.A.15.1.2 / Q79VE0 Ectosine/glycine betaine/proline:Na+ symporter (see 2 papers)
ectP / CAA04760.1 EctP protein from Corynebacterium glutamicum (see paper)
    38% identity, 96% coverage of query (369 bits)

BETT1_ACIAD / Q6FDF6 Osmo-independent choline transporter BetT1 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    40% identity, 92% coverage of query (350 bits)

ECTT_VIRPA / Q93AK1 Ectoine/hydroxyectoine transporter from Virgibacillus pantothenticus (see paper)
TC 2.A.15.1.8 / Q93AK1 The ectoine/hydroxyectoine:Na+ symporter, EctT from Virgibacillus pantothenticus
    40% identity, 94% coverage of query (350 bits)

BETP_CORGL / P54582 Glycine betaine transporter BetP; Glycine betaine permease from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 17 papers)
TC 2.A.15.1.10 / P54582 Glycine betaine transporter, BetP. The x-ray structure is known (3PO3; 2WIT; Ressl et al., 2009). Regulatory crosstalk in the trimeric BetP has been reported (Gärtner et al., 2011). An extracellular K+ -dependent interaction site modulates betaine-binding (Ge et al., 2011). The porter is trimeric and exhibits structural asymmetry (Tsai et al., 2011). The C-terminal domain is involved in osmosensing and is trimeric like wild-type BetP from Corynebacterium glutamicum (see paper)
    38% identity, 98% coverage of query (333 bits)

4llhA / P54582 Substrate bound outward-open state of the symporter betp (see paper)
    40% identity, 90% coverage of query (329 bits)

3p03C Crystal structure of betp-g153d with choline bound
    41% identity, 87% coverage of query (329 bits)

LCOP_CORGL / Q8NN75 Betaine/ectoine transporter LcoP; Low capacity osmoregulated permease from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
TC 2.A.15.1.7 / Q8NN75 The ectoine/glycine:Na+ symporter, LcoP from Corynebacterium glutamicum (see paper)
    34% identity, 96% coverage of query (281 bits)

TC 2.A.15.1.6 / D0U567 The glycine betaine, dimethylsulfoniopropionate:Na+ symporter from Psychrobacter sp. J466 (see paper)
    33% identity, 93% coverage of query (267 bits)

BCCT4_VIBPA / Q87J97 Glycine betaine transporter 2 from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (see paper)
    32% identity, 95% coverage of query (251 bits)

Build an alignment

Build an alignment for Echvi_0794 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

2wswA / B4EY22 Crystal structure of carnitine transporter from proteus mirabilis (see paper)
    29% identity, 92% coverage of query (195 bits)

4m8jA Crystal structure of cait r262e bound to gamma-butyrobetaine
    29% identity, 91% coverage of query (195 bits)

CAIT_PROMH / B4EY22 L-carnitine/gamma-butyrobetaine antiporter from Proteus mirabilis (strain HI4320) (see 2 papers)
TC 2.A.15.2.2 / B4EY22 The L-carnitine:γ-butyrobetaine antiporter, CaiT from Proteus mirabilis (strain HI4320) (see 2 papers)
    28% identity, 96% coverage of query (194 bits)

YaaP / b0040 L-carnitine:γ-butyrobetaine antiporter from Escherichia coli K-12 substr. MG1655 (see paper)
caiT / P31553 L-carnitine:γ-butyrobetaine antiporter from Escherichia coli (strain K12) (see 4 papers)
CAIT_ECOLI / P31553 L-carnitine/gamma-butyrobetaine antiporter from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.15.2.1 / P31553 Carnitine:γ-butyrobetaine antiporter from Escherichia coli (see 7 papers)
    28% identity, 93% coverage of query (193 bits)

3hfxA Crystal structure of carnitine transporter
    28% identity, 91% coverage of query (191 bits)

YeaV / b1801 putative transporter YeaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
YEAV_ECOLI / P0ABD1 Uncharacterized transporter YeaV from Escherichia coli (strain K12) (see paper)
    30% identity, 87% coverage of query (190 bits)

2wsxA / P31553 Crystal structure of carnitine transporter from escherichia coli (see paper)
    28% identity, 92% coverage of query (189 bits)

CARNT_ACIB2 / D0C9N4 Carnitine transporter from Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81) (see paper)
    28% identity, 86% coverage of query (178 bits)

gbuE / A0A415DZ18 γ-butyrobetaine transporter from Emergencia timonensis (see paper)
    30% identity, 85% coverage of query (172 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory