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Searching for up to 100 curated homologs for Echvi_1876 FitnessBrowser__Cola:Echvi_1876 (437 a.a.)

Found high-coverage hits (≥70%) to 69 curated proteins.

Removed hits that are identical to the query, leaving 68

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8A9M2 xylose isomerase (EC 5.3.1.5) from Bacteroides thetaiotaomicron (see paper)
    69% identity, 100% coverage of query (626 bits)

4xkmA / Q8A9M2 Crystal structure of xylose isomerase from an human intestinal tract microbe bacteroides thetaiotaomicron
    69% identity, 100% coverage of query (625 bits)

Q9P8C9 xylose isomerase (EC 5.3.1.5) from Piromyces sp. E2 (see paper)
    65% identity, 100% coverage of query (609 bits)

5nh4A / Q9P8C9 Crystal structure of xylose isomerase from piromyces e2 in complex with one mg2+ ions and glycerol (see paper)
    65% identity, 100% coverage of query (607 bits)

B7SLY1 xylose isomerase (EC 5.3.1.5) from Orpinomyces sp. (see 2 papers)
    65% identity, 100% coverage of query (607 bits)

5nhcA Crystal structure of xylose isomerase from piromyces e2 in complex with two co2+ ions and xylulose
    65% identity, 100% coverage of query (607 bits)

5nhaA Crystal structure of xylose isomerase from piromyces sp. E2 in complex with two mn2+ ions and sorbitol
    65% identity, 100% coverage of query (607 bits)

5nh9A Crystal structure of xylose isomerase from piromyces e2 in complex with two mn2+ ions and xylose
    65% identity, 100% coverage of query (607 bits)

5nh7A Crystal structure of xylose isomerase from piromyces e2 in complex with two mg2+ ions and xylose
    65% identity, 100% coverage of query (607 bits)

5nh6A Crystal structure of xylose isomerase from piromyces e2 complexed with one mg2+ ion and xylitol
    65% identity, 100% coverage of query (607 bits)

5nh5A Crystal structure of native xylose isomerase from piromyces e2
    65% identity, 100% coverage of query (607 bits)

5yn3A Crystal structure of xylose isomerase from piromyces sp. E2
    65% identity, 99% coverage of query (606 bits)

BPHYT_RS32825 Xylose isomerase (EC 5.3.1.5) from Burkholderia phytofirmans PsJN
    53% identity, 99% coverage of query (485 bits)

BWI76_RS27025 Xylose isomerase (EC 5.3.1.5) from Klebsiella michiganensis M5al
    51% identity, 100% coverage of query (478 bits)

XylA / b3565 xylose isomerase (EC 5.3.1.5) from Escherichia coli K-12 substr. MG1655 (see 38 papers)
xylA / P00944 xylose isomerase (EC 5.3.1.5) from Escherichia coli (strain K12) (see 36 papers)
XYLA_ECOLI / P00944 Xylose isomerase; D-xylulose keto-isomerase; EC 5.3.1.5 from Escherichia coli (strain K12) (see 2 papers)
xylA / GB|AAC76589.1 xylose isomerase; EC 5.3.1.5 from Escherichia coli K12 (see 2 papers)
    51% identity, 100% coverage of query (472 bits)

D9SR73 xylose isomerase (EC 5.3.1.5) from Clostridium cellulovorans (see paper)
    51% identity, 100% coverage of query (471 bits)

C7G532 xylose isomerase (EC 5.3.1.5) from Vibrio sp. (see paper)
    53% identity, 99% coverage of query (469 bits)

PS417_10945 Xylose isomerase (EC 5.3.1.5) from Pseudomonas simiae WCS417
    51% identity, 99% coverage of query (468 bits)

SMc03163 Xylose isomerase (EC 5.3.1.5) from Sinorhizobium meliloti 1021
    52% identity, 100% coverage of query (462 bits)

1a0cA / P19148 Xylose isomerase from thermoanaerobacterium thermosulfurigenes
    50% identity, 99% coverage of query (456 bits)

xylA / AAB06798.1 xylose isomerase from Thermotoga neapolitana (see paper)
    50% identity, 99% coverage of query (453 bits)

1a0eA / P45687 Xylose isomerase from thermotoga neapolitana
    50% identity, 99% coverage of query (453 bits)

XYLA_THESA / P30435 Xylose isomerase; EC 5.3.1.5 from Thermoanaerobacterium saccharolyticum (see paper)
AAA03088.1 xylose isomerase from Thermoanaerobacterium saccharolyticum (see paper)
    50% identity, 99% coverage of query (452 bits)

AO356_28500 Xylose isomerase (EC 5.3.1.5) from Pseudomonas fluorescens FW300-N2C3
    51% identity, 99% coverage of query (451 bits)

D2DK62 xylose isomerase (EC 5.3.1.5) from Thermoanaerobacter ethanolicus (see paper)
    49% identity, 99% coverage of query (450 bits)

xylA / AAC44473.1 xylose isomerase from Thermoanaerobacterium sp (see paper)
    49% identity, 99% coverage of query (444 bits)

xylA / AAA99461.1 xylose isomerase from Bacillus sp. (see paper)
    50% identity, 99% coverage of query (432 bits)

1a0dA / P54273 Xylose isomerase from bacillus stearothermophilus
    50% identity, 99% coverage of query (431 bits)

PGA1_c14000 Xylose isomerase (EC 5.3.1.5) from Phaeobacter inhibens BS107
    48% identity, 99% coverage of query (427 bits)

xylA / G2TH70 xylA (EC 5.3.1.5) from Weizmannia coagulans 36D1 (see paper)
    48% identity, 99% coverage of query (420 bits)

XYLA_LEVBR / P29443 Xylose isomerase; EC 5.3.1.5 from Levilactobacillus brevis (Lactobacillus brevis) (see paper)
    46% identity, 100% coverage of query (405 bits)

6intA / A0A4V8H014 Xylose isomerase from paenibacillus sp. R4 (see paper)
    46% identity, 99% coverage of query (400 bits)

A1A0H0 xylose isomerase (EC 5.3.1.5) from Bifidobacterium adolescentis (see paper)
    46% identity, 98% coverage of query (391 bits)

P24300 xylose isomerase (EC 5.3.1.5) from Streptomyces rubiginosus (see 8 papers)
4duoA / P24300 Room-temperature x-ray structure of d-xylose isomerase in complex with 2mg2+ ions and xylitol at ph 7.7 (see paper)
    31% identity, 73% coverage of query (120 bits)

1gw9A Tri-iodide derivative of xylose isomerase from streptomyces rubiginosus
    31% identity, 73% coverage of query (120 bits)

1xiiA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase
    31% identity, 73% coverage of query (120 bits)

1xihA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase
    31% identity, 73% coverage of query (120 bits)

1xicA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase
    31% identity, 73% coverage of query (120 bits)

9xiaA X-ray analysis of d-xylose isomerase at 1.9 angstroms: native enzyme in complex with substrate and with a mechanism-designed inactivator
    31% identity, 73% coverage of query (120 bits)

1xieA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase
    31% identity, 73% coverage of query (120 bits)

1xidA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase
    31% identity, 73% coverage of query (120 bits)

5y4iA Crystal structure of glucose isomerase in complex with glycerol in one metal binding mode
    31% identity, 73% coverage of query (120 bits)

4j4kA Crystal structure of glucose isomerase
    31% identity, 73% coverage of query (120 bits)

4e3vA Crystal structure of xylose isomerase from streptomyces rubiginosus cryoprotected in proline
    31% identity, 73% coverage of query (120 bits)

3xisA A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 angstroms streptomyces rubiginosus structures with xylitol and d-xylose
    31% identity, 73% coverage of query (120 bits)

8awsA Millisecond cryo-trapping by the spitrobot crystal plunger, xylose isomerase with glucose at 50ms
    31% identity, 73% coverage of query (120 bits)

3u3hA X-ray crystallographic analysis of d-xylose isomerase-catalyzed isomerization of (r)-glyceraldehyde
    31% identity, 73% coverage of query (120 bits)

2g4jA Anomalous substructure of glucose isomerase
    31% identity, 73% coverage of query (120 bits)

1oadA Glucose isomerase from streptomyces rubiginosus in p21212 crystal form
    31% identity, 73% coverage of query (120 bits)

8awyA Millisecond cryo-trapping by the spitrobot crystal plunger, serial measurement xylose isomerase with 2,3-butanediol at 50ms
    31% identity, 73% coverage of query (120 bits)

4zb0A A dehydrated form of glucose isomerase collected at room temperature.
    31% identity, 73% coverage of query (120 bits)

4qehA Room temperature x-ray structure of d-xylose isomerase in complex with two mg2+ ions and l-ribose
    31% identity, 73% coverage of query (120 bits)

4qeeA Room temperature x-ray structure of d-xylose isomerase in complex with two ni2+ ions and l-ribose
    31% identity, 73% coverage of query (120 bits)

4qe4A Room temperature x-ray structure of d-xylose isomerase in complex with two ni2+ ions and l-ribulose
    31% identity, 73% coverage of query (120 bits)

4qe1A Room temperature x-ray structure of d-xylose isomerase in complex with two cd2+ ions and l-ribulose
    31% identity, 73% coverage of query (120 bits)

4qdwA Joint x-ray and neutron structure of streptomyces rubiginosus d-xylose isomerase in complex with two ni2+ ions and linear l-arabinose
    31% identity, 73% coverage of query (120 bits)

4qdpA Joint x-ray and neutron structure of streptomyces rubiginosus d-xylose isomerase in complex with two cd2+ ions and cyclic beta-l-arabinose
    31% identity, 73% coverage of query (120 bits)

3qzaA Joint neutron and x-ray structure of apo-d-xylose isomerase at ph=5.9
    31% identity, 73% coverage of query (120 bits)

3kbnA Room temperature structure of d-xylose isomerase in complex with 2ni(2+) co-factors and d12-d-glucose in the linear form
    31% identity, 73% coverage of query (120 bits)

3kbmA Room temperature x-ray structure of d-xylose isomerase complexed with 2cd(2+) co-factors and d12-d-alpha-glucose in the cyclic form
    31% identity, 73% coverage of query (120 bits)

1xycA X-ray crystallographic structures of d-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis
    31% identity, 71% coverage of query (116 bits)

1xybA X-ray crystallographic structures of d-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis
    31% identity, 71% coverage of query (116 bits)

1s5mA Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift
    31% identity, 71% coverage of query (115 bits)

1muwA The 0.86 angstrom structure of xylose isomerase
    31% identity, 71% coverage of query (115 bits)

2gyiA Design, synthesis, and characterization of a potent xylose isomerase inhibitor, d-threonohydroxamic acid, and high-resolution x-ray crystallographic structure of the enzyme-inhibitor complex
    30% identity, 73% coverage of query (115 bits)

1clkA Crystal structure of streptomyces diastaticus no.7 strain m1033 xylose isomerase at 1.9 a resolution with pseudo-i222 space group
    30% identity, 81% coverage of query (115 bits)

P26997 xylose isomerase (EC 5.3.1.5) from Thermus thermophilus (see paper)
    31% identity, 70% coverage of query (114 bits)

Build an alignment

Build an alignment for Echvi_1876 and 67 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

6n98A / A0A1K2FZ20 Xylose isomerase 1f1 variant from streptomyces sp. F-1 (see paper)
    28% identity, 80% coverage of query (94.7 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory