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Searching for up to 100 curated homologs for Echvi_2939 FitnessBrowser__Cola:Echvi_2939 (285 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
    57% identity, 98% coverage of query (327 bits)

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
    53% identity, 98% coverage of query (295 bits)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) (see paper)
    52% identity, 100% coverage of query (289 bits)

HSERO_RS06355 2,4-diketo-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Herbaspirillum seropedicae SmR1
    50% identity, 99% coverage of query (285 bits)

lra6 / Q1NEI7 L-2,4-diketo-3-deoxyrhamnonate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
    47% identity, 100% coverage of query (259 bits)

8gsrA / Q1NEI7 Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
    46% identity, 99% coverage of query (255 bits)

8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form)
    46% identity, 99% coverage of query (255 bits)

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate
    48% identity, 75% coverage of query (200 bits)

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    48% identity, 75% coverage of query (200 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    48% identity, 75% coverage of query (200 bits)

dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
    43% identity, 75% coverage of query (179 bits)

6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
    41% identity, 81% coverage of query (179 bits)

6iymA / K0A9N9 Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
    37% identity, 96% coverage of query (174 bits)

Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    43% identity, 75% coverage of query (169 bits)

3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
    41% identity, 75% coverage of query (165 bits)

6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
    35% identity, 93% coverage of query (164 bits)

6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
    35% identity, 93% coverage of query (164 bits)

FAHD1_ARATH / Q93ZE5 Probable acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    43% identity, 72% coverage of query (160 bits)

3qdfA / B2HIH3 Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
    42% identity, 75% coverage of query (155 bits)

FAHD1_MOUSE / Q8R0F8 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; EC 3.7.1.5; EC 4.1.1.112 from Mus musculus (Mouse) (see 2 papers)
    40% identity, 72% coverage of query (155 bits)

6sbiA / Q8R0F8 X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
    40% identity, 72% coverage of query (155 bits)

FAHD2_ARATH / Q9LUR3 Probable acylpyruvase FAHD2, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2; FAH domain-containing protein 2; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    42% identity, 72% coverage of query (146 bits)

hbzF / Q0QFQ3 maleylpyruvate hydrolase monomer (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
HBZF_PSEAC / Q0QFQ3 Maleylpyruvate hydrolase; MPH11; EC 3.7.1.23 from Pseudomonas alcaligenes (see 3 papers)
Q0QFQ3 maleylpyruvate hydrolase (EC 3.7.1.23) from Pseudomonas alcaligenes (see paper)
    37% identity, 73% coverage of query (144 bits)

4dbhA / Q8NQY2 Crystal structure of cg1458 with inhibitor (see paper)
    37% identity, 74% coverage of query (137 bits)

6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
    36% identity, 78% coverage of query (127 bits)

6j5yA / Q9I111 Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
    30% identity, 75% coverage of query (110 bits)

naaD / F8QQ75 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Bradyrhizobium sp. JS329 (see paper)
    32% identity, 72% coverage of query (109 bits)

Build an alignment

Build an alignment for Echvi_2939 and 27 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SO1670 fumarylacetoacetate hydrolase (EC 3.7.1.2) from Shewanella oneidensis MR-1
    28% identity, 82% coverage of query (73.2 bits)

xacE / D4GP28 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43; EC 4.2.1.141) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
KDXD_HALVD / D4GP28 Probable 2-keto-3-deoxyxylonate dehydratase; KDXD; EC 4.2.1.141 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    28% identity, 71% coverage of query (68.6 bits)

2q1dX 2-keto-3-deoxy-d-arabinonate dehydratase complexed with magnesium and 2,5-dioxopentanoate
    28% identity, 75% coverage of query (59.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory