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Searching for up to 100 curated homologs for Echvi_3106 FitnessBrowser__Cola:Echvi_3106 (441 a.a.)

Found high-coverage hits (≥70%) to 54 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf1N1B4_5129 D-galacturonate transporter ExuT from Pseudomonas fluorescens FW300-N1B4
    31% identity, 98% coverage of query (244 bits)

CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
    33% identity, 97% coverage of query (241 bits)

BT4105 D-galacturonate transporter ExuT from Bacteroides thetaiotaomicron VPI-5482
    30% identity, 97% coverage of query (211 bits)

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    31% identity, 91% coverage of query (204 bits)

TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
    31% identity, 95% coverage of query (187 bits)

ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
    31% identity, 95% coverage of query (187 bits)

EXUT_DICCH / P94774 Galacturonate transporter from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 3 papers)
TC 2.A.1.14.41 / P94774 The Aldohexuronate (glucuronate, galacturonate) uptake porter from Dickeya chrysanthemi
exuT / AAB70881.1 exuT from Dickeya chrysanthemi (see paper)
    31% identity, 79% coverage of query (160 bits)

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Build an alignment for Echvi_3106 and 7 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    28% identity, 99% coverage of query (155 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    28% identity, 96% coverage of query (154 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    27% identity, 87% coverage of query (143 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    27% identity, 87% coverage of query (143 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    28% identity, 91% coverage of query (140 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    27% identity, 96% coverage of query (139 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    27% identity, 91% coverage of query (133 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    26% identity, 91% coverage of query (132 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    27% identity, 95% coverage of query (130 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    27% identity, 95% coverage of query (122 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    26% identity, 93% coverage of query (117 bits)

ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
    26% identity, 95% coverage of query (109 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    27% identity, 94% coverage of query (102 bits)

ANTR4_ARATH / Q66GI9 Probable anion transporter 4, chloroplastic; Phosphate transporter PHT4;3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    28% identity, 76% coverage of query (96.7 bits)

ANTR5_ARATH / Q9FKV1 Probable anion transporter 5; Phosphate transporter PHT4;6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    24% identity, 92% coverage of query (91.3 bits)

ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    26% identity, 89% coverage of query (85.9 bits)

ANTR3_ARATH / Q7XJR2 Probable anion transporter 3, chloroplastic; Phosphate transporter PHT4;2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q7XJR2 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see paper)
    24% identity, 80% coverage of query (83.2 bits)

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
    24% identity, 90% coverage of query (77.0 bits)

Q9HTV5 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Pseudomonas aeruginosa (see paper)
    23% identity, 99% coverage of query (75.5 bits)

S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
    24% identity, 80% coverage of query (75.1 bits)

S17A9_RAT / P0DX21 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Rattus norvegicus (Rat) (see 2 papers)
    24% identity, 81% coverage of query (73.9 bits)

NPT1_HUMAN / Q14916 Sodium-dependent phosphate transport protein 1; Na(+)/PI cotransporter 1; Na/Pi-4; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.1.14.27 / Q14916 Voltage-driven Na+:phosphate cotransporter; solute carrier family 17, member 1 from Homo sapiens (see 7 papers)
    25% identity, 90% coverage of query (73.2 bits)

S17A9_MOUSE / Q8VCL5 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Mus musculus (Mouse) (see 5 papers)
    23% identity, 81% coverage of query (70.9 bits)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    24% identity, 88% coverage of query (69.3 bits)

VGL2B_DANRE / Q5W8I7 Vesicular glutamate transporter 2.2; Solute carrier family 17 member 6-A; Vesicular glutamate transporter 2-B from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
    24% identity, 80% coverage of query (68.9 bits)

VGLU2_HUMAN / Q9P2U8 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.14.31 / Q9P2U8 Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) from Homo sapiens (see 5 papers)
    25% identity, 80% coverage of query (68.6 bits)

VGLU2_RAT / Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 10 papers)
TC 2.A.1.14.16 / Q9JI12 The broad specificity brain synaptic vesicle anion transporter (transports glutamate in a Δψ-dependent fashion requiring Cl- but phosphate by a Na+-dependent mechanism via a different pathway/mechanism from Rattus norvegicus (see 8 papers)
    25% identity, 80% coverage of query (68.2 bits)

VGLU2_MOUSE / Q8BLE7 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Mus musculus (Mouse) (see 9 papers)
    25% identity, 80% coverage of query (68.2 bits)

GLPT1_ARATH / Q9C5L3 Putative glycerol-3-phosphate transporter 1; G-3-P transporter 1; Glycerol-3-phosphate permease 1; AtG3Pp1; G-3-P permease 1; Protein PHOSPHATE STARVATION-INDUCED GENE 3; AtPS3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9C5L3 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Arabidopsis thaliana (see paper)
    24% identity, 83% coverage of query (67.4 bits)

G6PT3_MOUSE / Q9WU81 Glucose-6-phosphate exchanger SLC37A2; Solute carrier family 37 member 2; cAMP-inducible protein 2 from Mus musculus (Mouse) (see paper)
    23% identity, 96% coverage of query (67.4 bits)

7t3nA / Q9JI12 R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
    24% identity, 80% coverage of query (66.6 bits)

VGLU1_MOUSE / Q3TXX4 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Mus musculus (Mouse) (see 11 papers)
    24% identity, 80% coverage of query (66.2 bits)

VGLU1_RAT / Q62634 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Rattus norvegicus (Rat) (see 13 papers)
TC 2.A.1.14.13 / Q62634 Broad specificity brain synaptic vesicle anion:Na+ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities from Rattus norvegicus (Rat) (see 10 papers)
    24% identity, 80% coverage of query (66.2 bits)

VGL2A_DANRE / Q5W8I8 Vesicular glutamate transporter 2.1; Protein blumenkohl; Solute carrier family 17 member 6-B; Vesicular glutamate transporter 2-A from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
    24% identity, 80% coverage of query (65.9 bits)

VGLU1_HUMAN / Q9P2U7 Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 from Homo sapiens (Human) (see paper)
TC 2.A.1.14.30 / Q9P2U7 Vesicular glutamate transporter 1, VGluT1 or PNP1 of 560 aas and 12 TMSs. Brain-specific Na+-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7). Several proteins must be retrieved to the synaptic vesicle before it can export neurotransmitters, and cargo retrieval is a collective cargo-driven process, dependent on VGluT1 from Homo sapiens (see 2 papers)
    24% identity, 80% coverage of query (65.5 bits)

NPT1_RABIT / Q28722 Sodium-dependent phosphate transport protein 1; NAPI-1; Na(+)/PI cotransporter 1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
    22% identity, 93% coverage of query (65.5 bits)

GlpT / b2240 sn-glycerol 3-phosphate:phosphate antiporter from Escherichia coli K-12 substr. MG1655 (see 24 papers)
glpT / P08194 sn-glycerol 3-phosphate:phosphate antiporter from Escherichia coli (strain K12) (see 48 papers)
TC 2.A.1.4.3 / P08194 Glycerol-P:Pi antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007) from Escherichia coli (see 7 papers)
    23% identity, 99% coverage of query (65.5 bits)

TC 2.A.1.4.2 / P12681 P-glycerate:Pi antiporter, Pgt from Salmonella typhimurium (see 2 papers)
    26% identity, 91% coverage of query (63.5 bits)

TC 2.A.1.14.15 / Q7YQJ7 Apical membrane renal proximal tubule. Voltage-driven but Na+-independent organic anion transporter, OATv1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) from Sus scrofa (Pig) (see paper)
    23% identity, 94% coverage of query (63.5 bits)

NPT3_HUMAN / O00624 Sodium-dependent phosphate transport protein 3; Na(+)/PI cotransporter 3; Sodium/phosphate cotransporter 3; Solute carrier family 17 member 2 from Homo sapiens (Human) (see paper)
TC 2.A.1.14.29 / O00624 Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2) from Homo sapiens (see 3 papers)
    25% identity, 78% coverage of query (62.4 bits)

Q9SA71 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Arabidopsis thaliana (see paper)
    22% identity, 83% coverage of query (61.2 bits)

genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    25% identity, 77% coverage of query (60.5 bits)

EAT4_CAEEL / P34644 Probable vesicular glutamate transporter eat-4; Abnormal pharyngeal pumping eat-4 from Caenorhabditis elegans (see 9 papers)
TC 2.A.1.14.42 / P34644 Vesicular glutamate transporter, EAT-4/VGLUT of 576 aas from Caenorhabditis elegans
    22% identity, 79% coverage of query (59.7 bits)

TC 2.A.1.53.2 / Q5ZUB4 The valine uptake permease, PhtJ (required for maximal growth in macrophages and Acanthamoeba castellanii) (see paper)
    21% identity, 83% coverage of query (59.7 bits)

VGLU3_HUMAN / Q8NDX2 Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.14.32 / Q8NDX2 Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8). Loss in mice produces circadian-dependent hyperdopaminergia and amiliorates motor disfunction and dopa-mediated dyskinesias in a model of Parkinson's Disease (Divito et al. 2015). VGLUT3 is expressed selectively in the inner hair cells (IHCs) and transports the neurotransmitter glutamate into synaptic vesicles. Mutation of the SLC17A8 gene is associated with DFNA25 (deafness, autosomal dominant 25), a non-syndromic hearing loss (ADNSHL) in humans (Ryu et al. 2016). Glut3 contributes to stress response and related psychopathologies from Homo sapiens (see 4 papers)
    23% identity, 76% coverage of query (59.7 bits)

PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    23% identity, 90% coverage of query (59.3 bits)

PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
    23% identity, 91% coverage of query (52.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory