Searching for up to 100 curated homologs for Echvi_3886 FitnessBrowser__Cola:Echvi_3886 (547 a.a.)
Found high-coverage hits (≥70%) to 28 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
DLAT / P10515 pyruvate dehydrogenase E2 component from Homo sapiens (see 5 papers)
ODP2_HUMAN / P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Homo sapiens (Human) (see 10 papers)
P10515 pyruvate dehydrogenase system (subunit 2/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
38% identity, 100% coverage of query (339 bits)
ODP2_RAT / P08461 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Rattus norvegicus (Rat) (see paper)
39% identity, 100% coverage of query (337 bits)
ODP2_BOVIN / P11180 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Bos taurus (Bovine) (see 3 papers)
39% identity, 100% coverage of query (331 bits)
ODP23_ARATH / Q5M729 Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 3 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 3; PDC-E2 3; PDCE2 3; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
43% identity, 77% coverage of query (323 bits)
ODP21_ARATH / Q0WQF7 Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 1 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 1; PDC-E2 1; PDCE2 1; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q0WQF7 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104) from Arabidopsis thaliana (see paper)
38% identity, 100% coverage of query (322 bits)
ODP22_ARATH / Q8RWN9 Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 2 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 2; PDC-E2 2; PDCE2 2; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8RWN9 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104) from Arabidopsis thaliana (see paper)
43% identity, 81% coverage of query (321 bits)
ODP2_MESAU / P86197 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Mesocricetus auratus (Golden hamster) (see paper)
34% identity, 100% coverage of query (291 bits)
acoC TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12 from Clostridium magnum (see paper)
AAA21747.1 dihydrolipoamide acetyltransferase from Clostridium magnum (see paper)
35% identity, 78% coverage of query (273 bits)
pdhA putative dihydrolipoamide S-acetyltransferase from Emericella nidulans (see 3 papers)
38% identity, 78% coverage of query (270 bits)
ODP2_FUSO4 / A0A0D2Y5A7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; FoDLAT; DLAT; EC 2.3.1.12 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) (see paper)
38% identity, 78% coverage of query (262 bits)
A6ZS09 dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) from Saccharomyces cerevisiae (see paper)
36% identity, 78% coverage of query (252 bits)
ODP2_YEAST / P12695 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
35% identity, 78% coverage of query (252 bits)
ODP2_CHATD / G0S4X6 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; MRP3; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 3 papers)
39% identity, 78% coverage of query (251 bits)
PDHX / O00330 pyruvate dehydrogenase complex E3-binding protein component from Homo sapiens (see 9 papers)
ODPX_HUMAN / O00330 Pyruvate dehydrogenase protein X component, mitochondrial; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; proX from Homo sapiens (Human) (see 8 papers)
O00330 pyruvate dehydrogenase system (subunit 3/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
33% identity, 77% coverage of query (250 bits)
ODPX_BOVIN / P22439 Pyruvate dehydrogenase protein X component; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; proX from Bos taurus (Bovine) (see paper)
34% identity, 77% coverage of query (250 bits)
pdhC / AAC24934.1 dihydrolipoamide acetyltransferase E2 from Bacillus subtilis (see 3 papers)
34% identity, 77% coverage of query (246 bits)
P20285 pyruvate dehydrogenase system (EC 1.2.1.104) from Neurospora crassa (see paper)
37% identity, 78% coverage of query (246 bits)
P21883 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; S complex, 48 kDa subunit; EC 2.3.1.12 from Bacillus subtilis (strain 168)
34% identity, 77% coverage of query (246 bits)
P16263 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bacillus subtilis (see paper)
36% identity, 77% coverage of query (228 bits)
ODP24_ARATH / Q9SQI8 Dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic; Dihydrolipoamide S-acetyltransferase component 4 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 4; PDC-E2 4; PDCE2 4; plE2; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
35% identity, 76% coverage of query (213 bits)
P11961 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
33% identity, 77% coverage of query (212 bits)
E2(o) subunit / b0727 dihydrolipoyltranssuccinylase (EC 2.3.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
sucB / P0AFG6 2-oxoglutarate dehydrogenase E2 subunit (EC 2.3.1.61) from Escherichia coli (strain K12) (see paper)
ODO2_ECOLI / P0AFG6 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli (strain K12) (see 3 papers)
P0AFG6 2-oxoglutarate dehydrogenase system (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Escherichia coli (see 6 papers)
SucB-lipoate / ECOCYC|SUCB-LIPOATE dihydrolipoyltranssuccinase from Escherichia coli K12 (see 3 papers)
sucB / PDB|1PMR dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli K12 (see 14 papers)
32% identity, 77% coverage of query (208 bits)
Q9RH46 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Coxiella burnetii (see paper)
33% identity, 77% coverage of query (202 bits)
Q6FYD4 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella quintana (see paper)
33% identity, 77% coverage of query (202 bits)
Q8GCY1 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella vinsonii (see paper)
31% identity, 77% coverage of query (186 bits)
Build an alignment for Echvi_3886 and 25 homologs with ≥ 30% identity
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P06959 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Escherichia coli (strain K12)
28% identity, 98% coverage of query (147 bits)
ODB2_BOVIN / P11181 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Bos taurus (Bovine) (see 2 papers)
26% identity, 80% coverage of query (137 bits)
DBT / P11182 branched-chain α-keto acid dehydrogenase complex E2 component subunit (EC 2.3.1.168) from Homo sapiens (see 9 papers)
ODB2_HUMAN / P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; BCKDH-E2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Homo sapiens (Human) (see 9 papers)
P11182 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 3 papers)
26% identity, 81% coverage of query (137 bits)
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Lawrence Berkeley National Laboratory