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Searching for up to 100 curated homologs for Echvi_4213 FitnessBrowser__Cola:Echvi_4213 (263 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BT3719 glutamate 5-kinase (EC 2.7.2.11) from Bacteroides thetaiotaomicron VPI-5482
    39% identity, 92% coverage of query (185 bits)

CA265_RS20855 glutamate 5-kinase (EC 2.7.2.11) from Pedobacter sp. GW460-11-11-14-LB5
    41% identity, 96% coverage of query (185 bits)

Echvi_4033 glutamate 5-kinase (EC 2.7.2.11) from Echinicola vietnamensis KMM 6221, DSM 17526
    38% identity, 95% coverage of query (162 bits)

proB / BAA05044.1 gamma-glutamyl kinase from Bacillus subtilis (see paper)
    35% identity, 97% coverage of query (137 bits)

Q6E235 glutamate 5-kinase (EC 2.7.2.11) from Bacillus subtilis (see paper)
    35% identity, 97% coverage of query (131 bits)

ProB / b0242 glutamate 5-kinase (EC 2.7.2.11) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
proB / P0A7B5 glutamate 5-kinase (EC 2.7.2.11) from Escherichia coli (strain K12) (see 32 papers)
PROB_ECOLI / P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see 3 papers)
P0A7B5 glutamate 5-kinase (EC 2.7.2.11) from Escherichia coli (see 2 papers)
proB glutamate 5-kinase; EC 2.7.2.11 from Escherichia coli K12 (see 6 papers)
    32% identity, 95% coverage of query (125 bits)

2j5tD / P0A7B5 Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
    31% identity, 95% coverage of query (125 bits)

7wx3B / Q9VNW6 Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
    32% identity, 96% coverage of query (122 bits)

7f5xA / Q9VNW6 Gk domain of drosophila p5cs filament with glutamate (see paper)
    32% identity, 96% coverage of query (122 bits)

P5CS1_ORYSJ / O04226 Delta-1-pyrroline-5-carboxylate synthase 1; OsP5CS1; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice) (see paper)
    32% identity, 97% coverage of query (121 bits)

Build an alignment

Build an alignment for Echvi_4213 and 10 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

P5CS2_ORYSJ / Q941T1 Delta-1-pyrroline-5-carboxylate synthase 2; OsP5CS2; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice)
Q941T1 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Oryza sativa (see paper)
    29% identity, 96% coverage of query (119 bits)

p5cs / CAB40834.1 pyrroline-5-carboxylate synthetase from Vitis vinifera (see paper)
    30% identity, 96% coverage of query (115 bits)

2akoA / Q9PJ29 Crystal structure of glutamate 5-kinase from campylobacter jejuni
    31% identity, 95% coverage of query (112 bits)

G5K_LEIDO / A0A0R6Y3I5 Glutamate 5-kinase; LdG5K; Gamma-glutamyl kinase; EC 2.7.2.11 from Leishmania donovani (see paper)
A0A0R6Y3I5 glutamate 5-kinase (EC 2.7.2.11) from Leishmania donovani (see paper)
    31% identity, 92% coverage of query (110 bits)

proB glutamate 5-kinase; EC 2.7.2.11 from Campylobacter jejuni (see paper)
    31% identity, 95% coverage of query (109 bits)

ALDH18A1 / P54886 δ-1-pyrroline-5-carboxylate synthase (EC 1.2.1.41; EC 2.7.2.11) from Homo sapiens (see 4 papers)
P5CS_HUMAN / P54886 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Homo sapiens (Human) (see 8 papers)
    30% identity, 96% coverage of query (107 bits)

P5CS_MOUSE / Q9Z110 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Mus musculus (Mouse) (see paper)
Q9Z110 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Mus musculus (see paper)
    30% identity, 96% coverage of query (107 bits)

2j5vB / P0A7B5 Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
    28% identity, 95% coverage of query (104 bits)

YHJ3_YEAST / P38690 Uncharacterized protein YHR033W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    30% identity, 95% coverage of query (101 bits)

2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid
    28% identity, 95% coverage of query (101 bits)

P9WHU9 glutamate 5-kinase (EC 2.7.2.11) from Mycobacterium tuberculosis (see paper)
    35% identity, 83% coverage of query (98.6 bits)

PROB_YEAST / P32264 Glutamate 5-kinase; GK; Gamma-glutamyl kinase; EC 2.7.2.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32264 glutamate 5-kinase (EC 2.7.2.11) from Saccharomyces cerevisiae (see 5 papers)
    30% identity, 90% coverage of query (93.2 bits)

P5CS1 / P54887 δ1-pyrroline-5-carboxylate synthetase (EC 1.2.1.41; EC 2.7.2.11) from Arabidopsis thaliana (see 4 papers)
    31% identity, 97% coverage of query (88.2 bits)

Ga0059261_3512 glutamate 5-kinase (EC 2.7.2.11) from Sphingomonas koreensis DSMZ 15582
    30% identity, 88% coverage of query (83.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory