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Searching for up to 100 curated homologs for Echvi_4481 Echvi_4481 mercuric reductase (647 a.a.)

Found high-coverage hits (≥70%) to 86 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

T1RLH3 mercury(II) reductase (EC 1.16.1.1) from Flavobacterium sp. SOK62 (see paper)
    56% identity, 84% coverage of query (621 bits)

MERA_LYSSH / D9J041 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Lysinibacillus sphaericus (Bacillus sphaericus) (see paper)
D9J041 mercury(II) reductase (EC 1.16.1.1) from Lysinibacillus sphaericus (see 2 papers)
    39% identity, 83% coverage of query (400 bits)

P16171 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Bacillus cereus
    34% identity, 96% coverage of query (386 bits)

Q93UN8 mercury(II) reductase (EC 1.16.1.1) from Escherichia coli (see paper)
    42% identity, 83% coverage of query (357 bits)

MERA_PSEAI / P00392 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Pseudomonas aeruginosa (see 2 papers)
    41% identity, 83% coverage of query (348 bits)

E0XF09 mercury(II) reductase (EC 1.16.1.1) from Serratia marcescens (see paper)
    41% identity, 83% coverage of query (347 bits)

MERA_STRLI / P30341 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Streptomyces lividans (see paper)
    42% identity, 71% coverage of query (331 bits)

4k7zA / P00392 Crystal structure of the c136(42)a/c141(47)a double mutant of tn501 mera in complex with NADP and hg2+
    45% identity, 70% coverage of query (330 bits)

4k8dA Crystal structure of the c558(464)a/c559(465)a double mutant of tn501 mera in complex with NADPH and hg2+
    45% identity, 70% coverage of query (329 bits)

A8UT36 mercury(II) reductase (EC 1.16.1.1) from Hydrogenivirga sp. 128-5-R1-1 (see paper)
    35% identity, 84% coverage of query (323 bits)

V5TDP2 mercury(II) reductase (EC 1.16.1.1) from uncultured bacterium (see paper)
    37% identity, 83% coverage of query (311 bits)

A4YG49 mercury(II) reductase (EC 1.16.1.1) from Metallosphaera sedula (see paper)
    35% identity, 71% coverage of query (276 bits)

Q97VD9 mercury(II) reductase (EC 1.16.1.1) from Saccharolobus solfataricus (see paper)
merA / ABL96630.1 MerA from Saccharolobus solfataricus (see 2 papers)
    33% identity, 71% coverage of query (272 bits)

B4U9T7 mercury(II) reductase (EC 1.16.1.1) from Hydrogenobaculum sp. Y04AAS1 (see paper)
    38% identity, 71% coverage of query (266 bits)

4ywoA / A4YG49 Mercuric reductase from metallosphaera sedula (see paper)
    34% identity, 70% coverage of query (262 bits)

DLDH_PEA / P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
P31023 pyruvate dehydrogenase system (subunit 1/3) (EC 1.2.1.104); glycine cleavage system (subunit 4/4) (EC 1.4.1.27) from Pisum sativum (see 2 papers)
    33% identity, 70% coverage of query (239 bits)

1dxlA / P31023 Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
    33% identity, 70% coverage of query (239 bits)

LPD1 / Q9M5K3 glycine cleavage system L protein 1 from Arabidopsis thaliana (see 3 papers)
DLDH1_ARATH / Q9M5K3 Dihydrolipoyl dehydrogenase 1, mitochondrial; AtmLPD1; mtLPD1; Dihydrolipoamide dehydrogenase 1; Glycine cleavage system L protein 1; Pyruvate dehydrogenase complex E3 subunit 1; E3-1; PDC-E3 1; EC 1.8.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9M5K3 glycine cleavage system (subunit 5/5) (EC 1.4.1.27) from Arabidopsis thaliana (see paper)
    32% identity, 70% coverage of query (223 bits)

DLDH_CHATD / G0SB20 Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex E3 component; EC 1.8.1.4 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 2 papers)
    31% identity, 71% coverage of query (222 bits)

4jdrA / P0A9P0 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
    30% identity, 70% coverage of query (211 bits)

Lpd / b0116 lipoamide dehydrogenase (EC 1.8.1.4) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
lpd / P0A9P0 lipoamide dehydrogenase (EC 1.8.1.4) from Escherichia coli (strain K12) (see 19 papers)
DLDH_ECOLI / P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see paper)
P0A9P0 pyruvate dehydrogenase system (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 1/3) (EC 1.2.1.105); glycine cleavage system (EC 1.4.1.27); dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Escherichia coli (see 4 papers)
lpd / SP|P0A9P1 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Escherichia coli K12 (see 10 papers)
    30% identity, 70% coverage of query (211 bits)

P42770 glutathione-disulfide reductase (EC 1.8.1.7) from Arabidopsis thaliana (see 2 papers)
    33% identity, 70% coverage of query (208 bits)

GSHRP_PEA / P27456 Glutathione reductase, chloroplastic/mitochondrial; GR; GRase; GOR1; EC 1.8.1.7 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
    31% identity, 72% coverage of query (204 bits)

acoL TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Clostridium magnum (see paper)
AAA21748.1 dihydrolipoamide dehydrogenase from Clostridium magnum (see paper)
    30% identity, 71% coverage of query (202 bits)

Build an alignment

Build an alignment for Echvi_4481 and 24 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

1zmdA Crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh
    27% identity, 70% coverage of query (187 bits)

1zmcA Crystal structure of human dihydrolipoamide dehydrogenase complexed to NAD+
    27% identity, 70% coverage of query (187 bits)

DLD / P09622 dihydrolipoyl dehydrogenase monomer from Homo sapiens (see 11 papers)
DLDH_HUMAN / P09622 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; EC 1.8.1.4 from Homo sapiens (Human) (see 18 papers)
A0A024R713 2-oxoglutarate dehydrogenase system (subunit 3/3) (EC 1.2.1.105) from Homo sapiens (see paper)
P09622 pyruvate dehydrogenase system (subunit 1/5) (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 1/3) (EC 1.2.1.105); glycine cleavage system (subunit 1/4) (EC 1.4.1.27); dihydrolipoyl dehydrogenase (EC 1.8.1.4); dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 16 papers)
    27% identity, 70% coverage of query (186 bits)

6hg8B / P09622 Crystal structure of the r460g disease-causing mutant of the human dihydrolipoamide dehydrogenase.
    27% identity, 70% coverage of query (184 bits)

LPDA_MYCTU / P9WHH7 NAD(P)H dehydrogenase (quinone); NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; EC 1.6.5.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    28% identity, 71% coverage of query (162 bits)

TRXR1_EMIHU / B9A1H3 Thioredoxin reductase SEP1; EhSEP1; EC 1.8.1.9 from Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi) (see paper)
B9A1H3 thioredoxin-disulfide reductase (EC 1.8.1.9) from Emiliania huxleyi (see paper)
    28% identity, 71% coverage of query (140 bits)

TRXR1_DROME / P91938 Thioredoxin reductase 1, mitochondrial; EC 1.8.1.9 from Drosophila melanogaster (Fruit fly) (see 8 papers)
P91938 thioredoxin-disulfide reductase (EC 1.8.1.9) from Drosophila melanogaster (see 3 papers)
    28% identity, 71% coverage of query (138 bits)

7mgnA Crystal structure of f501h/h506e variant of 2-ketopropyl coenzyme m oxidoreductase/carboxylase (2-kpcc) from xanthobacter autotrophicus
    25% identity, 70% coverage of query (133 bits)

3q6jA Structural basis for carbon dioxide binding by 2-ketopropyl coenzyme m oxidoreductase/carboxylase
    25% identity, 70% coverage of query (132 bits)

2c3cA / Q56839 2.01 angstrom x-ray crystal structure of a mixed disulfide between coenzyme m and NADPH-dependent oxidoreductase 2-ketopropyl coenzyme m carboxylase (see paper)
    25% identity, 70% coverage of query (132 bits)

1mo9A NADPH dependent 2-ketopropyl coenzyme m oxidoreductase/carboxylase complexed with 2-ketopropyl coenzyme m
    25% identity, 70% coverage of query (132 bits)

xecC / Q56839 2-oxopropyl-CoM reductase subunit (EC 1.8.1.5) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 3 papers)
XECC_XANP2 / Q56839 2-oxopropyl-CoM reductase, carboxylating; 2-ketopropyl-coenzyme M oxidoreductase/carboxylase; Aliphatic epoxide carboxylation component II; Epoxide carboxylase component II; NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase; 2-KPCC; EC 1.8.1.5 from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 5 papers)
Q56839 2-oxopropyl-CoM reductase (carboxylating) (EC 1.8.1.5) from Xanthobacter autotrophicus (see 5 papers)
    25% identity, 70% coverage of query (132 bits)

8a1rA / Q962Y6 Cryo-em structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor (see paper)
    25% identity, 77% coverage of query (130 bits)

7b02A Thioredoxin glutathione reductase from schistosoma mansoni in complex with 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid
    25% identity, 77% coverage of query (130 bits)

8plmA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 23.
    26% identity, 76% coverage of query (129 bits)

8pluA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 31.
    26% identity, 76% coverage of query (129 bits)

8ploA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 25.
    26% identity, 76% coverage of query (129 bits)

8pliA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 19.
    26% identity, 76% coverage of query (129 bits)

8plhA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 18.
    26% identity, 76% coverage of query (129 bits)

8plgA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 17.
    26% identity, 76% coverage of query (129 bits)

8pllA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 22.
    26% identity, 76% coverage of query (128 bits)

8plkA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 21.
    26% identity, 76% coverage of query (128 bits)

8plfA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 16.
    26% identity, 76% coverage of query (128 bits)

8pl1A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 2.
    26% identity, 76% coverage of query (127 bits)

8plwA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 33.
    26% identity, 76% coverage of query (127 bits)

8plyB Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 35.
    25% identity, 76% coverage of query (127 bits)

8plxA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 34.
    25% identity, 76% coverage of query (127 bits)

8pltA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 30.
    25% identity, 76% coverage of query (127 bits)

8plsA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 29.
    25% identity, 76% coverage of query (127 bits)

8plrA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 28.
    25% identity, 76% coverage of query (127 bits)

8plqB Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 27.
    25% identity, 76% coverage of query (127 bits)

8plpA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 26.
    25% identity, 76% coverage of query (127 bits)

8plnA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 24.
    25% identity, 76% coverage of query (127 bits)

8pljA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 20.
    25% identity, 76% coverage of query (127 bits)

8pleA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 15.
    25% identity, 76% coverage of query (127 bits)

8pldA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 14.
    25% identity, 76% coverage of query (127 bits)

8plcA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 13.
    25% identity, 76% coverage of query (127 bits)

8plbA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 12.
    25% identity, 76% coverage of query (127 bits)

8plaA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 11.
    25% identity, 76% coverage of query (127 bits)

8pl9A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 10.
    25% identity, 76% coverage of query (127 bits)

8pl8A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 9.
    25% identity, 76% coverage of query (127 bits)

8pl7A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 8.
    25% identity, 76% coverage of query (127 bits)

8pl6A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 7.
    25% identity, 76% coverage of query (127 bits)

8pl5A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 6.
    25% identity, 76% coverage of query (127 bits)

8pl4A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 5.
    25% identity, 76% coverage of query (127 bits)

8pl3A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 4.
    25% identity, 76% coverage of query (127 bits)

8pl2B Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 3.
    25% identity, 76% coverage of query (127 bits)

8pddA Thioredoxin glutathione reductase of schistosoma mansoni at 1.25a resolution.
    25% identity, 76% coverage of query (127 bits)

6zp3A Thioredoxin glutathione reductase from schistosoma mansoni in complex with 2-methylindole-3-acetic acid
    25% identity, 76% coverage of query (127 bits)

6zlpA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 4-aminopiazthiole
    25% identity, 76% coverage of query (127 bits)

6rtjA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 1 hour of soaking
    25% identity, 76% coverage of query (127 bits)

6fmzA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1,4-bis(2-hydroxyethyl)piperazine
    25% identity, 76% coverage of query (127 bits)

6fmuA Thioredoxin glutathione reductase from schistosome mansoni in complex with 2-[4-(4-amino-butyl)-piperazin-1-yl]-ethanol
    25% identity, 76% coverage of query (127 bits)

3h4kA Crystal structure of the wild type thioredoxin glutatione reductase from schistosoma mansoni in complex with auranofin
    25% identity, 76% coverage of query (127 bits)

2x8hA Thioredoxin glutathione reductase from schistosoma mansoni in complex with gsh
    25% identity, 76% coverage of query (127 bits)

6zstA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid
    25% identity, 76% coverage of query (127 bits)

6rtmA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 2 hour of soaking
    25% identity, 76% coverage of query (127 bits)

8pl0A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 1.
    25% identity, 76% coverage of query (127 bits)

6zlbA Thioredoxin glutathione reductase from schistosoma mansoni in complex with indole-3-carbinol
    25% identity, 76% coverage of query (127 bits)

6fp4A Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1,8-naphthyridine-2-carboxylic acid
    25% identity, 76% coverage of query (127 bits)

2x99A Thioredoxin glutathione reductase from schistosoma mansoni in complex with NADPH
    25% identity, 76% coverage of query (127 bits)

8plvA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 32.
    26% identity, 73% coverage of query (126 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory