Searching for up to 100 curated homologs for Echvi_4539 FitnessBrowser__Cola:Echvi_4539 (322 a.a.)
Found high-coverage hits (≥70%) to 73 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.124.4 / A6MER5 McdF, component of The macedocin exporter, McdEFG from Streptococcus macedonicus (see paper)
36% identity, 96% coverage of query (173 bits)
TC 3.A.1.124.3 / Q75V15 NukF, component of The lantibiotic Nukacin ISK-1 (TC# 1.C.21.1.5)/NukH (BAD01013; 92aas) exporter, NukEFG from Staphylococcus warneri (see paper)
35% identity, 95% coverage of query (173 bits)
BCRA_ENTFL / Q5WNX0 Bacitracin transport ATP-binding protein BcrA from Enterococcus faecalis (Streptococcus faecalis) (see 2 papers)
35% identity, 95% coverage of query (166 bits)
TC 3.A.1.124.5 / Q09II0 SboF, component of The salivaricin exporter, SboEFG from Streptococcus salivarius (see paper)
40% identity, 70% coverage of query (162 bits)
YXLF_BACSU / P94374 Uncharacterized ABC transporter ATP-binding protein YxlF; EC 7.-.-.- from Bacillus subtilis (strain 168) (see paper)
34% identity, 94% coverage of query (160 bits)
TC 3.A.1.126.1 / Q8RME1 BerA, component of Exporter of β-exotoxin I, BerAB from Bacillus thuringiensis serovar thuringiensis (see 2 papers)
30% identity, 97% coverage of query (151 bits)
nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
33% identity, 96% coverage of query (151 bits)
Build an alignment for Echvi_4539 and 7 homologs with ≥ 30% identity
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TC 3.A.1.132.1 / O30489 GldA, component of The GldAFG putative ABC transporter required for ratchet-type gliding motility; may function in secretion of a macromolecule such as an exopolysaccharide. (Agarwal et al., 1997; Hunnicutt et al., 2002; McBride and Zhu 2013). Soluble GldG homologues (no TMSs) are found in eukaryotes (e.g. intraflagellar protein transporter, IPT52 of Chlamydomonas reinhardtii; XP_001692161) from Cytophaga johnsonae (Flavobacterium johnsoniae) (see paper)
29% identity, 94% coverage of query (150 bits)
TC 3.A.1.124.6 / Q18BL2 ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein, component of CprABC antimicrobial peptide resistance ABC exporter from Peptoclostridium difficile (strain 630)
39% identity, 72% coverage of query (150 bits)
sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
31% identity, 98% coverage of query (149 bits)
NOSF_STUST / P19844 Probable ABC transporter ATP-binding protein NosF from Stutzerimonas stutzeri (Pseudomonas stutzeri) (see 2 papers)
nosF / CAA37716.1 NosF ATPase from Pseudomonas stutzeri (see 13 papers)
38% identity, 73% coverage of query (149 bits)
7o12B / P19844 Abc transporter nosdfy, amppnp-bound in gdn (see paper)
38% identity, 73% coverage of query (149 bits)
7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc
38% identity, 73% coverage of query (147 bits)
YbhF / b0794 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
ybhF / P0A9U1 ABC exporter ATP binding subunit YbhF (EC 7.6.2.2) from Escherichia coli (strain K12) (see 6 papers)
YBHF_ECOLI / P0A9U1 Probable multidrug ABC transporter ATP-binding protein YbhF from Escherichia coli (strain K12) (see paper)
ybhF / MB|P0A9U1 uncharacterized ABC transporter ATP-binding protein ybhF from Escherichia coli K12 (see paper)
33% identity, 89% coverage of query (145 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
37% identity, 76% coverage of query (144 bits)
ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
38% identity, 75% coverage of query (141 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
37% identity, 76% coverage of query (139 bits)
ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
38% identity, 75% coverage of query (139 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
35% identity, 97% coverage of query (138 bits)
ABCA4_MOUSE / O35600 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Mus musculus (Mouse) (see 4 papers)
38% identity, 78% coverage of query (137 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
39% identity, 74% coverage of query (137 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
39% identity, 74% coverage of query (137 bits)
7lkpA Structure of atp-free human abca4
39% identity, 74% coverage of query (137 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
37% identity, 78% coverage of query (137 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
38% identity, 75% coverage of query (136 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
38% identity, 75% coverage of query (136 bits)
7lkzA Structure of atp-bound human abca4
38% identity, 74% coverage of query (136 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
35% identity, 76% coverage of query (131 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
36% identity, 71% coverage of query (131 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
36% identity, 71% coverage of query (130 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
35% identity, 71% coverage of query (129 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
33% identity, 78% coverage of query (128 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
32% identity, 79% coverage of query (124 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
33% identity, 74% coverage of query (123 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
32% identity, 74% coverage of query (122 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
33% identity, 74% coverage of query (122 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
31% identity, 83% coverage of query (122 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
30% identity, 81% coverage of query (119 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 81% coverage of query (118 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
29% identity, 81% coverage of query (118 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
29% identity, 81% coverage of query (118 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
34% identity, 74% coverage of query (117 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
29% identity, 89% coverage of query (115 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
31% identity, 71% coverage of query (113 bits)
6xjiC / X5EJW5 Pmtcd abc exporter at c1 symmetry (see paper)
29% identity, 86% coverage of query (112 bits)
YhiG / b3486 ribosome-associated ATPase from Escherichia coli K-12 substr. MG1655 (see 13 papers)
RBBA_ECOLI / P37624 Ribosome-associated ATPase; Ribosomal bound ATPase from Escherichia coli (strain K12) (see 5 papers)
yhiH / RF|YP_026225 uncharacterized ABC transporter ATP-binding protein yhiH from Escherichia coli K12 (see paper)
27% identity, 89% coverage of query (108 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
26% identity, 77% coverage of query (83.2 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
26% identity, 77% coverage of query (83.2 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
26% identity, 77% coverage of query (83.2 bits)
8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
28% identity, 72% coverage of query (81.6 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
28% identity, 72% coverage of query (81.6 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
27% identity, 77% coverage of query (81.3 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
24% identity, 83% coverage of query (79.0 bits)
P59852 Lactococcin-G-processing and transport ATP-binding protein LagD; EC 3.4.22.-; EC 7.-.-.- from Lactococcus lactis subsp. lactis (Streptococcus lactis)
26% identity, 70% coverage of query (73.9 bits)
7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
26% identity, 72% coverage of query (72.0 bits)
4s0fA Crystal structure of the peptidase-containing abc transporter pcat1 e648q mutant complexed with atpgs in an occluded conformation
26% identity, 72% coverage of query (70.9 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
25% identity, 72% coverage of query (68.9 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
24% identity, 74% coverage of query (67.8 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
25% identity, 71% coverage of query (65.9 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
25% identity, 71% coverage of query (65.9 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
25% identity, 71% coverage of query (65.9 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
24% identity, 72% coverage of query (65.1 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
25% identity, 71% coverage of query (64.3 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
25% identity, 71% coverage of query (64.3 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
25% identity, 71% coverage of query (64.3 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
25% identity, 71% coverage of query (64.3 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
24% identity, 74% coverage of query (63.2 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
26% identity, 71% coverage of query (62.8 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
25% identity, 71% coverage of query (62.4 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
25% identity, 71% coverage of query (62.4 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
25% identity, 71% coverage of query (62.4 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
25% identity, 71% coverage of query (62.4 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
24% identity, 71% coverage of query (61.2 bits)
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Lawrence Berkeley National Laboratory