Sites on a Tree

 

Searching for up to 100 curated homologs for Echvi_4660 FitnessBrowser__Cola:Echvi_4660 (456 a.a.)

Found high-coverage hits (≥70%) to 36 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9EYM7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Streptomyces venezuelae (see paper)
    46% identity, 100% coverage of query (380 bits)

Y1077_MYCTU / P9WP51 Probable cystathionine beta-synthase Rv1077; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    44% identity, 100% coverage of query (351 bits)

7xnzB / P9WP51 Native cystathionine beta-synthase of mycobacterium tuberculosis. (see paper)
    44% identity, 100% coverage of query (350 bits)

7xoyA Cystathionine beta-synthase of mycobacterium tuberculosis in the presence of s-adenosylmethionine and serine.
    44% identity, 100% coverage of query (350 bits)

7qgtA / P35520 Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa. (see paper)
    38% identity, 99% coverage of query (305 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    39% identity, 97% coverage of query (305 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    38% identity, 99% coverage of query (305 bits)

Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
    39% identity, 95% coverage of query (302 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    38% identity, 98% coverage of query (295 bits)

uptG / AAK53485.1 cystathionine beta-lyase from Xanthomonas campestris pv. campestris (see 4 papers)
    35% identity, 100% coverage of query (294 bits)

CYS4 / P32582 Cys4 (EC 4.2.1.22) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
CBS_YEAST / P32582 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4; EC 4.2.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32582 cystathionine beta-synthase (EC 4.2.1.22) from Saccharomyces cerevisiae (see 3 papers)
    37% identity, 98% coverage of query (290 bits)

CBS / A0A563XPB1 cystathionine β-synthase (EC 4.2.1.22) from Gallus gallus (see 7 papers)
    39% identity, 97% coverage of query (282 bits)

CBS_APIME / Q2V0C9 Cystathionine beta-synthase; EC 4.2.1.22 from Apis mellifera (Honeybee) (see paper)
Q2V0C9 cystathionine beta-synthase (EC 4.2.1.22) from Apis mellifera (see paper)
    40% identity, 100% coverage of query (281 bits)

3pc3A / Q9VRD9 Full length structure of cystathionine beta-synthase from drosophila in complex with aminoacrylate (see paper)
    38% identity, 95% coverage of query (280 bits)

3pc4A Full length structure of cystathionine beta-synthase from drosophila in complex with serine
    38% identity, 95% coverage of query (280 bits)

3pc2A Full length structure of cystathionine beta-synthase from drosophila
    38% identity, 95% coverage of query (279 bits)

Q9VRD9 cystathionine beta-synthase (EC 4.2.1.22) from Drosophila melanogaster (see paper)
    38% identity, 95% coverage of query (278 bits)

5ohxA / Q2V0C9 Structure of active cystathionine b-synthase from apis mellifera (see paper)
    40% identity, 100% coverage of query (277 bits)

mecA cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans (see 2 papers)
    36% identity, 98% coverage of query (270 bits)

6c4pA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the pmp complex
    44% identity, 71% coverage of query (269 bits)

6c2hA / P32582 Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the catalytic core (see paper)
    44% identity, 71% coverage of query (268 bits)

6c2zA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the plp-aminoacrylate intermediate
    44% identity, 71% coverage of query (268 bits)

6c2qA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the plp-l-serine intermediate
    44% identity, 71% coverage of query (268 bits)

6xwlC / A0A125YSJ9 Cystathionine beta-synthase from toxoplasma gondii (see paper)
    35% identity, 98% coverage of query (259 bits)

6xylA Crystal structure of delta466-491 cystathionine beta-synthase from toxoplasma gondii with l-serine
    36% identity, 98% coverage of query (255 bits)

6vjuB / Q5ZRD1 Crystal structure of cystathionine beta synthase from legionella pneumophila with llp, plp, and homocysteine
    47% identity, 71% coverage of query (252 bits)

CYSK_EMENI / P50867 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
cysB / GB|AAC06128.1 cysteine synthase; EC 2.5.1.47 from Emericella nidulans (see 3 papers)
    40% identity, 70% coverage of query (236 bits)

CBS2_CAEEL / Q9N4K2 Putative cystathionine beta-synthase cbs-2; EC 4.2.1.22 from Caenorhabditis elegans (see 2 papers)
    43% identity, 71% coverage of query (234 bits)

CYSK_SCHPO / O59701 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 3 papers)
cys11 / RF|NP_595332.1 cysteine synthase from Schizosaccharomyces pombe (see 2 papers)
    42% identity, 70% coverage of query (232 bits)

CBS1_CAEEL / G5EFH8 Cystathionine beta-synthase cbs-1; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Caenorhabditis elegans (see 2 papers)
    42% identity, 71% coverage of query (228 bits)

CYSK_NEUCR / Q7RYW6 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
    39% identity, 71% coverage of query (215 bits)

2isqA / P47998 Crystal structure of o-acetylserine sulfhydrylase from arabidopsis thaliana in complex with c-terminal peptide from arabidopsis serine acetyltransferase (see paper)
    40% identity, 72% coverage of query (202 bits)

OASA1 / P47998 O-acetylserine (thiol) lyase (EC 2.5.1.47) from Arabidopsis thaliana (see 3 papers)
CYSK1_ARATH / P47998 Cysteine synthase 1; At.OAS.5-8; Beta-substituted Ala synthase 1;1; ARAth-Bsas1;1; CSase A; AtCS-A; Cys-3A; O-acetylserine (thiol)-lyase 1; OAS-TL A; O-acetylserine sulfhydrylase; Protein ONSET OF LEAF DEATH 3; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    40% identity, 72% coverage of query (202 bits)

1z7yA Crystal structure of the arabidopsis thaliana o-acetylserine sulfhydrylase k46a mutant
    39% identity, 72% coverage of query (200 bits)

5z5cB / Q8REP3 Crystal structure of hydrogen sulfide-producing enzyme (fn1055) from fusobacterium nucleatum: lysine-dimethylated form (see paper)
    32% identity, 70% coverage of query (120 bits)

5b55A Crystal structure of hydrogen sulfide-producing enzyme (fn1055) d232n mutant in complexed with alpha-aminoacrylate intermediate: lysine- dimethylated form
    32% identity, 70% coverage of query (120 bits)

Build an alignment

Build an alignment for Echvi_4660 and 36 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory