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Searching for up to 100 curated homologs for Echvi_4679 FitnessBrowser__Cola:Echvi_4679 (337 a.a.)

Found high-coverage hits (≥70%) to 35 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.14.7 / Q9X665 FhuC aka FhuA, component of Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2) (see 2 papers)
    36% identity, 74% coverage of query (156 bits)

FPUD_BACAN / Q81V82 Petrobactin import ATP-binding protein FpuD; EC 7.2.2.- from Bacillus anthracis (see paper)
    33% identity, 70% coverage of query (136 bits)

TC 3.A.1.14.19 / Q93SS1 Hemin import ATP-binding protein hmuV, component of Heme uptake porter, HugBCD (Villarreal et al., 2008); also called HmuTUV from Plesiomonas shigelloides (see paper)
    31% identity, 71% coverage of query (120 bits)

STE6_YEAST / P12866 Alpha-factor-transporting ATPase; Mating factor A secretion protein STE6; Multiple drug resistance protein homolog; P-glycoprotein; EC 7.4.2.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P12866 ABC-type alpha-factor-pheromone transporter (EC 7.4.2.7) from Saccharomyces cerevisiae (see paper)
TC 3.A.1.206.1 / P12866 a-Factor sex pheromone (a hydrophobic isoprenylated (farnesylated) carboxymethylated peptide) exporter, Ste6 from Saccharomyces cerevisiae (Baker's yeast) (see 9 papers)
STE6 / RF|NP_012713.1 alpha-factor-transporting ATPase from Saccharomyces cerevisiae
    30% identity, 70% coverage of query (99.0 bits)

Build an alignment

Build an alignment for Echvi_4679 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

5yv5A Crystal structure of the complex of archaeal ribosomal stalk protein ap1 and archaeal ribosome recycling factor aabce1.
    28% identity, 71% coverage of query (84.3 bits)

1yqtA Rnase-l inhibitor
    28% identity, 71% coverage of query (84.3 bits)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide
    26% identity, 71% coverage of query (80.5 bits)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp
    26% identity, 71% coverage of query (80.5 bits)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter
    26% identity, 71% coverage of query (80.5 bits)

3bk7A / Q9UZA4 Structure of the complete abce1/rnaase-l inhibitor protein from pyrococcus abysii (see paper)
    26% identity, 71% coverage of query (80.5 bits)

5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
    31% identity, 70% coverage of query (80.1 bits)

6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
    26% identity, 71% coverage of query (79.0 bits)

RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
    29% identity, 70% coverage of query (78.6 bits)

6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
    25% identity, 72% coverage of query (77.0 bits)

6bppA E. Coli msba in complex with lps and inhibitor g092
    27% identity, 70% coverage of query (66.2 bits)

6bplA E. Coli msba in complex with lps and inhibitor g907
    27% identity, 70% coverage of query (66.2 bits)

IRTA_MYCTU / P9WQJ9 Mycobactin import ATP-binding/permease protein IrtA; Iron-regulated transporter A; EC 7.2.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
TC 3.A.1.21.2 / P63391 IrtA, component of The Fe3+-carboxymycobactin transporter, IrtAB (Rodriguez and Smith, 2006). IrtA contains an FAD-binding domain (see 2 papers)
    28% identity, 71% coverage of query (66.2 bits)

7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
    27% identity, 70% coverage of query (66.2 bits)

MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
    27% identity, 70% coverage of query (66.2 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    26% identity, 72% coverage of query (66.2 bits)

7mewA E. Coli msba in complex with g247
    27% identity, 70% coverage of query (66.2 bits)

8dmmA Structure of the vanadate-trapped msba bound to kdl
    27% identity, 70% coverage of query (66.2 bits)

7bcwA Structure of msba in salipro with adp vanadate
    27% identity, 70% coverage of query (66.2 bits)

7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
    27% identity, 70% coverage of query (66.2 bits)

RLI1_YEAST / Q03195 Translation initiation factor RLI1; ATP-binding cassette sub-family E member RLI1; RNase L inhibitor from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
4crmP / Q03195 Cryo-em of a pre-recycling complex with erf1 and abce1 (see paper)
    27% identity, 72% coverage of query (65.9 bits)

3j16B Models of ribosome-bound dom34p and rli1p and their ribosomal binding partners
    27% identity, 72% coverage of query (65.9 bits)

ABCE1_DROME / Q9VSS1 Protein Pixie; ATP-binding cassette sub-family E member 1 from Drosophila melanogaster (Fruit fly) (see 5 papers)
    24% identity, 72% coverage of query (65.9 bits)

5ll6h Structure of the 40s abce1 post-splitting complex in ribosome recycling and translation initiation
    27% identity, 72% coverage of query (65.9 bits)

8cask / Q03195 Cryo-em structure of native otu2-bound ubiquitinated 48s initiation complex (partial) (see paper)
    27% identity, 72% coverage of query (65.9 bits)

7wixA Cryo-em structure of mycobacterium tuberculosis irtab in complex with adp
    28% identity, 71% coverage of query (65.1 bits)

7wivA / P9WQJ9 Cryo-em structure of mycobacterium tuberculosis irtab in complex with an amp-pnp
    28% identity, 71% coverage of query (65.1 bits)

6zvj1 of a human ABCE1-bound 43S pre-initiation complex - State II
    25% identity, 74% coverage of query (63.2 bits)

7o80Bz / G1SG72 7o80Bz (see paper)
    25% identity, 74% coverage of query (63.2 bits)

ABCE1_HUMAN / P61221 ATP-binding cassette sub-family E member 1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I; EC 3.6.5.- from Homo sapiens (Human) (see 8 papers)
ABCE1_MOUSE / P61222 ATP-binding cassette sub-family E member 1; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I; EC 3.6.5.- from Mus musculus (Mouse) (see paper)
    25% identity, 74% coverage of query (63.2 bits)

3jagjj of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon
    25% identity, 73% coverage of query (63.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory