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Searching for up to 100 curated homologs for GFF1016 FitnessBrowser__Marino:GFF1016 (247 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YehW / b2128 glycine betaine ABC transporter membrane subunit YehW from Escherichia coli K-12 substr. MG1655 (see 3 papers)
yehW / P33359 glycine betaine ABC transporter membrane subunit YehW from Escherichia coli (strain K12) (see 2 papers)
YEHW_ECOLI / P33359 Glycine betaine uptake system permease protein YehW from Escherichia coli (strain K12) (see 3 papers)
    54% identity, 91% coverage of query (216 bits)

OSMY_SALTY / Q8ZPK1 Osmoprotectant import permease protein OsmY from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.12.14 / Q8ZPK1 ABC-type transport system protein, component of OsmU (OsmVWXY) transporter for glycine betaine and choline-O-sulfate uptake. Induced by osmotic stress (0.3M NaCl) (Frossard et al., 2012). Also called OpuCA/CB1/CB2/CC from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    41% identity, 83% coverage of query (139 bits)

EGTUB_STAA3 / A0A0H2XK79 Probable ergothioneine transporter EgtUBC from Staphylococcus aureus (strain USA300) (see paper)
    38% identity, 83% coverage of query (122 bits)

OPUBB_BACSU / Q45461 Choline transport system permease protein OpuBB from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.12.3 / Q45461 OPBB aka OpuBB aka PROW, component of Choline porter from Bacillus subtilis (see 3 papers)
    35% identity, 86% coverage of query (119 bits)

U5LHK3 ABC-type quaternary amine transporter (subunit 2/3) (EC 7.6.2.9) from Bacillus infantis (see paper)
    39% identity, 78% coverage of query (119 bits)

OPUCD_LISM4 / G2JZ41 Carnitine transport permease protein OpuCD from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
OPUCD_LISMN / Q9KHT6 Carnitine transport permease protein OpuCD from Listeria monocytogenes (see paper)
    36% identity, 87% coverage of query (118 bits)

OPUCB_LISM4 / G2JZ43 Carnitine transport permease protein OpuCB from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
OPUCB_LISMN / Q9KHT8 Carnitine transport permease protein OpuCB from Listeria monocytogenes (see paper)
    37% identity, 83% coverage of query (114 bits)

OPUCB_BACSU / O34878 Glycine betaine/carnitine/choline transport system permease protein OpuCB from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.12.4 / O34878 OPCB aka OpuCB, component of Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate from Bacillus subtilis (see 2 papers)
    36% identity, 78% coverage of query (112 bits)

OPUBD_BACSU / P39775 Choline transport system permease protein OpuBD from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.12.3 / P39775 OPBD aka OpuBD aka PROZ, component of Choline porter from Bacillus subtilis (see 4 papers)
    36% identity, 87% coverage of query (107 bits)

OPUCD_BACSU / O34742 Glycine betaine/carnitine/choline transport system permease protein OpuCD from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.12.4 / O34742 OPCD aka OpuCD, component of Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate from Bacillus subtilis (see 2 papers)
    36% identity, 79% coverage of query (105 bits)

U5LFB4 ABC-type quaternary amine transporter (subunit 3/3) (EC 7.6.2.9) from Bacillus infantis (see paper)
    39% identity, 73% coverage of query (104 bits)

TC 3.A.1.12.10 / Q87WH4 OpuC aka PSPTO4576, component of The OpuC transporter selective for glycine betaine > choline, acetylcholine, carnitine and proline betaine (contains tandem cystathionine-β-synthase (CBS) domains in the ABC component of OpuC that are required for osmoregulatory function (Chen and Beattie, 2007)) from Pseudomonas syringae pv. tomato (see paper)
    39% identity, 75% coverage of query (102 bits)

EGTUB_LISMO / Q8Y775 Probable ergothioneine transporter EgtUBC from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) (see 2 papers)
    38% identity, 80% coverage of query (101 bits)

TC 3.A.1.12.8 / Q93A34 BilEB aka OpuBB protein, component of A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) from Listeria monocytogenes (see paper)
    38% identity, 80% coverage of query (101 bits)

TC 3.A.1.12.11 / Q8Q043 Glycine betaine transport system, permease protein, component of The glycine betaine uptake porter, GbpABCD from Methanosarcina mazei (see paper)
    34% identity, 79% coverage of query (98.6 bits)

EGTUB_ENTFA / Q837Z8 Probable ergothioneine transporter EgtUBC from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
    34% identity, 81% coverage of query (88.6 bits)

TC 3.A.1.12.6 / Q9KKE2 HutW aka HISW, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
    32% identity, 74% coverage of query (82.0 bits)

YehY / b2130 glycine betaine ABC transporter membrane subunit YehY from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yehY / P33361 glycine betaine ABC transporter membrane subunit YehY from Escherichia coli (strain K12) (see 2 papers)
YEHY_ECOLI / P33361 Glycine betaine uptake system permease protein YehY from Escherichia coli (strain K12) (see 3 papers)
    33% identity, 77% coverage of query (79.3 bits)

Build an alignment

Build an alignment for GFF1016 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

AO356_09615 ABC transporter for L-Histidine, permease component from Pseudomonas fluorescens FW300-N2C3
    29% identity, 76% coverage of query (75.1 bits)

TC 3.A.1.12.7 / Q92N36 ChoW, component of High affinity (3 μM) choline-specific uptake system from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
    30% identity, 75% coverage of query (71.2 bits)

OPUAB_BACSU / P46921 Glycine betaine transport system permease protein OpuAB from Bacillus subtilis (strain 168) (see 2 papers)
P46921 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see 2 papers)
TC 3.A.1.12.2 / P46921 OPAB aka OpuAB, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 3 papers)
    26% identity, 92% coverage of query (70.9 bits)

TC 3.A.1.12.11 / Q8Q042 Glycine betaine transport system, permease protein, component of The glycine betaine uptake porter, GbpABCD from Methanosarcina mazei (see paper)
    29% identity, 77% coverage of query (68.9 bits)

TC 3.A.1.12.9 / Q8U4S4 OtaB, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see paper)
    29% identity, 72% coverage of query (68.6 bits)

EGTU_HELPG / B5Z7I3 Ergothioneine transport permease/ergothioneine binding protein EgtU from Helicobacter pylori (strain G27) (see paper)
    36% identity, 75% coverage of query (67.8 bits)

Pf6N2E2_4682 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2E2
    26% identity, 80% coverage of query (58.2 bits)

AO356_13810 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2C3
    26% identity, 80% coverage of query (58.2 bits)

AO353_07785 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2E3
    25% identity, 80% coverage of query (57.8 bits)

TC 3.A.1.12.12 / Q9HTI7 Probable permease of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity from Pseudomonas aeruginosa (see paper)
    28% identity, 71% coverage of query (55.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory