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Searching for up to 100 curated homologs for GFF1132 FitnessBrowser__Marino:GFF1132 (290 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

xylE / P06622 subunit of catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas putida (see 2 papers)
P06622 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas putida (see 3 papers)
Q7BH44 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas sp. (see paper)
T1WIF8 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas sp. HA14 (see paper)
1mpyA / P06622 Structure of catechol 2,3-dioxygenase (metapyrocatechase) from pseudomonas putida mt-2 (see paper)
    79% identity, 100% coverage of query (491 bits)

T1WJ05 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas sp. HA12 (see paper)
    79% identity, 100% coverage of query (490 bits)

Q8KLV4 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas stutzeri (see paper)
cdo / CAD43168.1 catechol 2,3-dioxygenase from Pseudomonas stutzeri (see paper)
    79% identity, 100% coverage of query (486 bits)

phlH / CAA56747.1 catechol 2,3-dioxygenase from Pseudomonas putida (see 2 papers)
    78% identity, 100% coverage of query (475 bits)

E7DDG2 catechol 2,3-dioxygenase (EC 1.13.11.2) from Planococcus sp. S5 (see 2 papers)
    76% identity, 100% coverage of query (471 bits)

bphE / AAA20982.1 catechol 2,3-dioxygenase from Pseudomonas sp (see paper)
    75% identity, 100% coverage of query (471 bits)

nahH / BAE92167.1 catechol-2, 3-dioxygenase NahH from Pseudomonas putida (see 2 papers)
    76% identity, 100% coverage of query (471 bits)

T1T0J4 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas sp. HA10 (see paper)
    78% identity, 95% coverage of query (459 bits)

nahH / CAE46794.1 NahH protein, partial from Pseudomonas stutzeri (see paper)
    78% identity, 88% coverage of query (427 bits)

Q7WYF5 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas sp. (see paper)
    50% identity, 100% coverage of query (299 bits)

3hpvA / Q7WYF5 Crystal structure analysis of the 2,3-dioxygenase lapb from pseudomonas sp. Kl28 (see paper)
    49% identity, 96% coverage of query (287 bits)

3hq0B Crystal structure analysis of the 2,3-dioxygenase lapb from pseudomonas in complex with a product
    50% identity, 93% coverage of query (283 bits)

3hpyA Crystal structure analysis of the 2,3-dioxygenase lapb from pseudomonas in the complex with 4-methylcatechol
    50% identity, 93% coverage of query (283 bits)

Q842G7 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas putida (see paper)
    49% identity, 100% coverage of query (280 bits)

catE / AAB03075.1 catechol 2,3-dioxygenase from Sphingomonas agrestis (see paper)
cmpE / CAB06613.1 catechol 2,3-dioxygenase from Sphingomonas sp (see 2 papers)
    47% identity, 100% coverage of query (279 bits)

xylE / AAB03690.1 catechol 2,3-dioxygenase from Sphingobium yanoikuyae (see paper)
    46% identity, 100% coverage of query (273 bits)

xylE / AXM44144.1 catechol 2,3-dioxygenase from Sphingobium scionense (see paper)
    46% identity, 100% coverage of query (273 bits)

5znhA / A0A4V8GZK8 Catechol 2,3-dioxygenase with 4-methyl catechol from diaphorobacter sp ds2
    43% identity, 100% coverage of query (233 bits)

alnE / BAB18933.1 catechol 2,3-dioxygenase from Pseudomonas sp. Y-2 (see paper)
    42% identity, 100% coverage of query (233 bits)

5zsxA Catechol 2,3-dioxygenase with 3-fluorocatechol from diaphorobacter sp ds2
    43% identity, 100% coverage of query (233 bits)

Q52264 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas putida (see paper)
    41% identity, 99% coverage of query (218 bits)

cbzE / Q9Z417 chlorocatechol 2,3-dioxygenase monomer from Pseudomonas putida (see 4 papers)
Q9Z417 catechol 2,3-dioxygenase (EC 1.13.11.2) from Pseudomonas putida (see paper)
cbzE / AAX38581.1 CbzE from Pseudomonas putida (see paper)
    40% identity, 100% coverage of query (211 bits)

Build an alignment

Build an alignment for GFF1132 and 22 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

BPHC_GEOG3 / Q8GR45 Manganese-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase; Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase; Mn(II)-dependent 23OHBP oxygenase; EC 1.13.11.39 from Geobacillus genomosp. 3 (see paper)
Q8GR45 biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) from Bacillus sp. (in: Bacteria) (see 2 papers)
bphC / BAC23089.1 2,3-dihydroxybiphenyl 1,2-dioxygenase from Geobacillus genomosp. 3 (see paper)
    27% identity, 96% coverage of query (121 bits)

Q4J6K0 catechol 2,3-dioxygenase (EC 1.13.11.2) from Sulfolobus acidocaldarius (see paper)
    30% identity, 99% coverage of query (106 bits)

7q2aB / Q0S9X1 Crystal structure of aphc in complex with 4-ethylcatechol (see paper)
    28% identity, 92% coverage of query (103 bits)

3lm4A Crystal structure of 2,3-dihydroxy biphenyl dioxygenase from rhodococcus sp. (Strain rha1)
    28% identity, 92% coverage of query (103 bits)

V5W6K5 catechol 2,3-dioxygenase (EC 1.13.11.2) from Saccharolobus solfataricus (see 3 papers)
    27% identity, 98% coverage of query (97.4 bits)

1f1uA / Q44048 Crystal structure of homoprotocatechuate 2,3-dioxygenase from arthrobacter globiformis (native, low temperature) (see paper)
    25% identity, 91% coverage of query (80.9 bits)

1f1vA Anaerobic substrate complex of homoprotocatechuate 2,3-dioxygenase from arthrobacter globiformis. (Complex with 3,4- dihydroxyphenylacetate)
    25% identity, 91% coverage of query (80.9 bits)

Q45135 3,4-dihydroxyphenylacetate 2,3-dioxygenase (EC 1.13.11.15) from Brevibacterium fuscum (see 4 papers)
    24% identity, 89% coverage of query (79.7 bits)

3eckC Structure of e323l homoprotocatechuate 2,3-dioxygenase from brevibacterium fuscum in complex with putative o-o bond cleavage intermediate formed via in crystallo reaction with 4-sulfonyl catechol at low oxygen concentrations
    24% identity, 89% coverage of query (79.7 bits)

1q0cA Anerobic substrate complex of homoprotocatechuate 2,3-dioxygenase from brevibacterium fuscum. (Complex with 3,4-dihydroxyphenylacetate)
    24% identity, 90% coverage of query (79.7 bits)

1f1xA Crystal structure of homoprotocatechuate 2,3-dioxygenase from brevibacterium fuscum
    24% identity, 90% coverage of query (79.7 bits)

3ojkA Structure of co-substituted homoprotocatechuate 2,3-dioxygenase in complex with 4-nitrocatechol at 1.68 ang resolution
    24% identity, 89% coverage of query (79.7 bits)

3ojjA Structure of co-substituted homoprotocatechuate 2,3-dioxygenase from b.Fuscum at 1.72 ang resolution
    24% identity, 89% coverage of query (79.7 bits)

3bzaA Structure of mn-substituted homoprotocatechuate 2,3-dioxygenase from b.Fuscum at 1.7 ang resolution
    24% identity, 89% coverage of query (79.7 bits)

2igaC Structure of homoprotocatechuate 2,3-dioxygenase from b. Fuscum in complex with reactive intermediates formed via in crystallo reaction with 4-nitrocatechol at low oxygen concentrations.
    24% identity, 89% coverage of query (79.7 bits)

2igaB Structure of homoprotocatechuate 2,3-dioxygenase from b. Fuscum in complex with reactive intermediates formed via in crystallo reaction with 4-nitrocatechol at low oxygen concentrations.
    24% identity, 89% coverage of query (79.7 bits)

2igaA Structure of homoprotocatechuate 2,3-dioxygenase from b. Fuscum in complex with reactive intermediates formed via in crystallo reaction with 4-nitrocatechol at low oxygen concentrations.
    24% identity, 89% coverage of query (79.7 bits)

2ig9B Structure of a full-length homoprotocatechuate 2,3-dioxygenase from b. Fuscum in a new spacegroup.
    24% identity, 89% coverage of query (79.7 bits)

4ghcC / Q45135 Structure of y257f variant of homoprotocatechuate 2,3-dioxygenase from b.Fuscum at 1.55 ang resolution (see paper)
    24% identity, 89% coverage of query (77.8 bits)

4z6rC Structure of h200e variant of homoprotocatechuate 2,3-dioxygenase from b.Fuscum in complex with 4-sulfonyl catechol at 1.70 ang resolution
    24% identity, 89% coverage of query (76.6 bits)

3b59A / Q2GAG3 Crystal structure of the mn(ii)-bound glyoxalase from novosphingobium aromaticivorans
    26% identity, 82% coverage of query (65.9 bits)

cmtC / Q51976 2,3-dihydroxy-p-cumate 3,4-dioxygenase (EC 1.13.11.14) from Pseudomonas putida (see 4 papers)
cmtC / AAB62287.1 2,3-dihydroxy-p-cumate-3,4-dioxygenase from Pseudomonas putida (see 3 papers)
    23% identity, 88% coverage of query (51.2 bits)

A9QT35 biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) from Dyella ginsengisoli (see paper)
    26% identity, 81% coverage of query (50.4 bits)

bphC1 / BAA25603.1 2,3-dihydroxybiphenyl 1,2-dioxygenase from Rhodococcus erythropolis (see paper)
    26% identity, 80% coverage of query (49.7 bits)

bphC / A0A097SRG2 biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) from Cupriavidus sp. WS (see paper)
    26% identity, 83% coverage of query (48.5 bits)

bphC3 / BAA25608.1 2,3-dihydroxybiphenyl 1,2-dioxygenase from Rhodococcus erythropolis (see paper)
bpdE / AAB07755.1 2,3-dihydroxybiphenyl 1,2-dioxygenase from Rhodococcus sp. M5 (see paper)
    25% identity, 81% coverage of query (47.0 bits)

1kmyA / P47228 Crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase complexed with 2,3-dihydroxybiphenyl under anaerobic condition (see paper)
    25% identity, 83% coverage of query (46.2 bits)

BPHC_PARXL / P47228 Biphenyl-2,3-diol 1,2-dioxygenase; 2,3-dihydroxybiphenyl dioxygenase; DHBD; 23OHBP oxygenase; EC 1.13.11.39 from Paraburkholderia xenovorans (strain LB400) (see paper)
B3VTK1 biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) from Achromobacter sp. (see paper)
bphC / GB|ABE37053.1 biphenyl-2,3-diol 1,2-dioxygenase; EC 1.13.11.39 from Burkholderia xenovorans LB400 (see 5 papers)
BphC / CAA46910.1 Biphenyl-2,3-diol-1,2 dioxygenase from Pseudomonas sp (see paper)
    25% identity, 81% coverage of query (46.2 bits)

1lkdA Crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase (dhbd) complexed with 2',6'-dicl dihydroxybiphenyl (dhb)
    25% identity, 83% coverage of query (46.2 bits)

1lgtA Crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase (dhbd) complexed with 2'-cl dihydroxybiphenyl (dhb)
    25% identity, 83% coverage of query (46.2 bits)

1knfA Crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase complexed with 3-methyl catechol under anaerobic condition
    25% identity, 83% coverage of query (46.2 bits)

1kndA Crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase complexed with catechol under anaerobic condition
    25% identity, 83% coverage of query (46.2 bits)

1hanA Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a pcb-degrading pseudomonad
    25% identity, 83% coverage of query (46.2 bits)

F2X5L9 biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) from uncultured bacterium (see paper)
    25% identity, 81% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory