Searching for up to 100 curated homologs for GFF1270 FitnessBrowser__Phaeo:GFF1270 (279 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_2560 ABC transporter for L-Histidine, ATPase component from Acidovorax sp. GW101-3H11
44% identity, 86% coverage of query (197 bits)
TC 3.A.1.17.5 / C0LZR9 OphH, component of The phthalate uptake system, OphFGH from Burkholderia cepacia
46% identity, 79% coverage of query (196 bits)
TC 3.A.1.17.4 / Q2BM69 Putative taurin uptake ABC transporter ATP-binding protein, component of The taurine uptake system, TauABC from Neptuniibacter caesariensis
40% identity, 82% coverage of query (177 bits)
OPUCA_LISM4 / G2JZ44 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
OPUCA_LISMN / Q9KHT9 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes (see paper)
44% identity, 71% coverage of query (176 bits)
TC 3.A.1.16.2 / O05347 CynD, component of Bispecific cyanate/nitrite transporter
42% identity, 87% coverage of query (174 bits)
Q6RH47 taurine dehydrogenase (EC 1.4.99.2) from Paracoccus pantotrophus (see paper)
41% identity, 82% coverage of query (172 bits)
OPUBA_BACSU / Q45460 Choline transport ATP-binding protein OpuBA from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.12.3 / Q45460 OPBA aka OpuBA aka PROV, component of Choline porter from Bacillus subtilis (see 3 papers)
41% identity, 73% coverage of query (168 bits)
TauB / b0366 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TauB / Q47538 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli (strain K12) (see 3 papers)
TAUB_ECOLI / Q47538 Taurine import ATP-binding protein TauB; EC 7.6.2.7 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.17.1 / Q47538 TauB aka SSIB aka B0366, component of Taurine (2-aminoethane sulfonate) porter from Escherichia coli (see 4 papers)
43% identity, 70% coverage of query (167 bits)
NRTD_SYNE7 / P38046 Nitrate import ATP-binding protein NrtD; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.1 / P38046 NrtD, component of Four component nitrate/nitrite porter (see paper)
39% identity, 88% coverage of query (167 bits)
SSUB_BACSU / P97027 Aliphatic sulfonates import ATP-binding protein SsuB; EC 7.6.2.14 from Bacillus subtilis (strain 168) (see paper)
39% identity, 81% coverage of query (167 bits)
TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
42% identity, 80% coverage of query (166 bits)
OPUCA_BACSU / O34992 Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA from Bacillus subtilis (strain 168) (see 4 papers)
TC 3.A.1.12.4 / O34992 OPCA aka OpuCA, component of Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate from Bacillus subtilis (see 2 papers)
40% identity, 73% coverage of query (165 bits)
NRTC_SYNE7 / P38045 Nitrate import ATP-binding protein NrtC; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see 2 papers)
TC 3.A.1.16.1 / P38045 NrtC, component of Four component nitrate/nitrite porter (see paper)
39% identity, 84% coverage of query (162 bits)
TC 3.A.1.16.4 / Q8YRV8 Nitrate transport ATP-binding protein of ABC transporter, component of Nitrate uptake system, NrtABCD from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
39% identity, 89% coverage of query (162 bits)
TMOW_RUEPO / Q5LT65 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
37% identity, 75% coverage of query (159 bits)
TC 3.A.1.12.12 / Q9HTI8 Probable ATP-binding component of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity from Pseudomonas aeruginosa (see paper)
41% identity, 72% coverage of query (159 bits)
AO353_07790 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E3
40% identity, 81% coverage of query (158 bits)
CMPC_SYNE7 / Q55107 Bicarbonate transport ATP-binding protein CmpC; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55107 CmpC, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
40% identity, 81% coverage of query (158 bits)
TC 3.A.1.6.7 / Q6QJE1 Chloroplast ATP-binding protein, component of The chloroplast sulfate transporter, SulP/SulP2/Sabc/Sbp from Chlamydomonas reinhardtii (see 2 papers)
42% identity, 75% coverage of query (156 bits)
Pf6N2E2_4681 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E2
40% identity, 81% coverage of query (156 bits)
AO356_13805 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2C3
40% identity, 81% coverage of query (156 bits)
OSMV_SALTY / Q8ZPK4 Osmoprotectant import ATP-binding protein OsmV; EC 7.6.2.- from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.12.14 / Q8ZPK4 ABC-type proline/glycine betaine transport system, component of OsmU (OsmVWXY) transporter for glycine betaine and choline-O-sulfate uptake. Induced by osmotic stress (0.3M NaCl) (Frossard et al., 2012). Also called OpuCA/CB1/CB2/CC from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
39% identity, 77% coverage of query (155 bits)
CMPD_SYNE7 / Q55108 Bicarbonate transport ATP-binding protein CmpD; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55108 CmpD, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
34% identity, 92% coverage of query (153 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
37% identity, 81% coverage of query (153 bits)
7ahhC Opua inhibited inward-facing, sbd docked
37% identity, 81% coverage of query (153 bits)
TC 3.A.1.12.5 / Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see paper)
39% identity, 73% coverage of query (152 bits)
7ahdC Opua (e190q) occluded
38% identity, 73% coverage of query (150 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
40% identity, 73% coverage of query (145 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
40% identity, 73% coverage of query (145 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
40% identity, 73% coverage of query (145 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
40% identity, 73% coverage of query (145 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
40% identity, 73% coverage of query (145 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
40% identity, 73% coverage of query (145 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
40% identity, 73% coverage of query (145 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
40% identity, 73% coverage of query (145 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
38% identity, 70% coverage of query (139 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
39% identity, 72% coverage of query (132 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
36% identity, 76% coverage of query (132 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
39% identity, 72% coverage of query (131 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
38% identity, 84% coverage of query (131 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
38% identity, 71% coverage of query (130 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
35% identity, 80% coverage of query (127 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
35% identity, 80% coverage of query (127 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
35% identity, 80% coverage of query (127 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
38% identity, 75% coverage of query (127 bits)
5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
36% identity, 74% coverage of query (124 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
35% identity, 75% coverage of query (122 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
35% identity, 75% coverage of query (121 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
35% identity, 75% coverage of query (121 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
35% identity, 75% coverage of query (121 bits)
8g4cB / O34697 Bceabs atpgs high res tm (see paper)
33% identity, 74% coverage of query (119 bits)
7tchB Bceab e169q variant atp-bound conformation
33% identity, 74% coverage of query (117 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
33% identity, 80% coverage of query (113 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
33% identity, 80% coverage of query (113 bits)
2olkA Abc protein artp in complex with adp-beta-s
33% identity, 80% coverage of query (113 bits)
2oljA Abc protein artp in complex with adp/mg2+
33% identity, 80% coverage of query (113 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
33% identity, 75% coverage of query (112 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
33% identity, 75% coverage of query (112 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
33% identity, 75% coverage of query (112 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
32% identity, 82% coverage of query (110 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
34% identity, 74% coverage of query (102 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
30% identity, 75% coverage of query (97.8 bits)
8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
34% identity, 72% coverage of query (97.8 bits)
FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
34% identity, 72% coverage of query (97.8 bits)
8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
33% identity, 72% coverage of query (96.7 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
34% identity, 75% coverage of query (96.7 bits)
7arlD Lolcde in complex with lipoprotein and adp
30% identity, 77% coverage of query (96.3 bits)
7mdyC Lolcde nucleotide-bound
30% identity, 77% coverage of query (95.9 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
30% identity, 77% coverage of query (95.9 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
30% identity, 77% coverage of query (94.7 bits)
7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
30% identity, 72% coverage of query (94.7 bits)
7w79A Heme exporter hrtba in complex with mn-amppnp
31% identity, 72% coverage of query (92.4 bits)
7w78A / Q6NEF2 Heme exporter hrtba in complex with mg-amppnp (see paper)
31% identity, 72% coverage of query (92.0 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
32% identity, 73% coverage of query (91.3 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
30% identity, 78% coverage of query (89.0 bits)
Build an alignment for GFF1270 and 75 homologs with ≥ 30% identity
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ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
29% identity, 80% coverage of query (88.2 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
31% identity, 75% coverage of query (87.4 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
31% identity, 75% coverage of query (87.4 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
26% identity, 81% coverage of query (86.3 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
27% identity, 75% coverage of query (84.0 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
25% identity, 81% coverage of query (82.8 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
30% identity, 75% coverage of query (82.8 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
30% identity, 78% coverage of query (82.8 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
30% identity, 78% coverage of query (82.0 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
31% identity, 74% coverage of query (80.9 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
29% identity, 78% coverage of query (80.5 bits)
7lkzA Structure of atp-bound human abca4
29% identity, 78% coverage of query (80.5 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 78% coverage of query (79.0 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
30% identity, 71% coverage of query (78.6 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
30% identity, 76% coverage of query (78.2 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
26% identity, 75% coverage of query (77.8 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
31% identity, 80% coverage of query (77.8 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
31% identity, 80% coverage of query (77.4 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
28% identity, 75% coverage of query (76.3 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
31% identity, 80% coverage of query (76.3 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
27% identity, 81% coverage of query (75.9 bits)
IRTA_MYCT3 / G7CBF5 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
31% identity, 75% coverage of query (75.1 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
27% identity, 75% coverage of query (75.1 bits)
ABCAD_MOUSE / Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
29% identity, 70% coverage of query (74.3 bits)
7t55A / A3DCU1 Cryo-em structure of pcat1 in the inward-facing wide conformation under atp turnover condition (see paper)
28% identity, 71% coverage of query (72.8 bits)
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Lawrence Berkeley National Laboratory