Searching for up to 100 curated homologs for GFF1388 FitnessBrowser__psRCH2:GFF1388 (233 a.a.)
Found high-coverage hits (≥70%) to 52 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
acoC TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12 from Clostridium magnum (see paper)
AAA21747.1 dihydrolipoamide acetyltransferase from Clostridium magnum (see paper)
35% identity, 93% coverage of query (124 bits)
P20708 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Azotobacter vinelandii (see paper)
33% identity, 91% coverage of query (114 bits)
AF123459 / Q9XYS5 dihydrolipoyl dehydrogenase-binding protein (EC 1.2.1.104) from Ascaris suum (see 12 papers)
33% identity, 97% coverage of query (112 bits)
SMc03203 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Sinorhizobium meliloti 1021
36% identity, 95% coverage of query (112 bits)
E2(o) subunit / b0727 dihydrolipoyltranssuccinylase (EC 2.3.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
sucB / P0AFG6 2-oxoglutarate dehydrogenase E2 subunit (EC 2.3.1.61) from Escherichia coli (strain K12) (see paper)
ODO2_ECOLI / P0AFG6 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli (strain K12) (see 3 papers)
P0AFG6 2-oxoglutarate dehydrogenase system (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Escherichia coli (see 6 papers)
SucB-lipoate / ECOCYC|SUCB-LIPOATE dihydrolipoyltranssuccinase from Escherichia coli K12 (see 3 papers)
sucB / PDB|1PMR dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli K12 (see 14 papers)
32% identity, 91% coverage of query (111 bits)
ODP2_MYCTU / P9WIS7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
36% identity, 91% coverage of query (110 bits)
6zzmB / A0A0G3H170 Crystal structure of the catalytic domain of corynebacterium mustelae predicted acetyltransferase acef (e2p). (see paper)
33% identity, 90% coverage of query (108 bits)
acoC / Q3A7N9 dihydrolipoamide acetyltransferase subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
33% identity, 94% coverage of query (107 bits)
pdhA putative dihydrolipoamide S-acetyltransferase from Emericella nidulans (see 3 papers)
33% identity, 94% coverage of query (107 bits)
ODP2_CORGL / Q8NNJ2 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
Q8NNJ2 pyruvate dehydrogenase system (subunit 2/3) (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 2/3) (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Corynebacterium glutamicum (see 3 papers)
32% identity, 94% coverage of query (107 bits)
Q9RH46 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Coxiella burnetii (see paper)
32% identity, 91% coverage of query (107 bits)
P20285 pyruvate dehydrogenase system (EC 1.2.1.104) from Neurospora crassa (see paper)
33% identity, 92% coverage of query (106 bits)
ODP2_FUSO4 / A0A0D2Y5A7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; FoDLAT; DLAT; EC 2.3.1.12 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) (see paper)
32% identity, 94% coverage of query (106 bits)
ODO2A_ARATH / Q9FLQ4 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2-1; OGDC-E2-1; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1; E2K-1; EC 2.3.1.61 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
31% identity, 97% coverage of query (105 bits)
ODP2_CHATD / G0S4X6 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; MRP3; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 3 papers)
32% identity, 93% coverage of query (105 bits)
6zzkB / Q8NNJ2 Crystal structure of the catalytic domain of c. Glutamicum acef (e2p) in ternary complex with coa and dihydrolipoamide. (see paper)
32% identity, 90% coverage of query (105 bits)
6zzkA Crystal structure of the catalytic domain of c. Glutamicum acef (e2p) in ternary complex with coa and dihydrolipoamide.
32% identity, 90% coverage of query (105 bits)
6zzjA Crystal structure of the catalytic domain of corynebacterium glutamicum acetyltransferase acef (e2p) in complex with oxidized coa.
32% identity, 90% coverage of query (105 bits)
ODP2_BOVIN / P11180 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Bos taurus (Bovine) (see 3 papers)
30% identity, 93% coverage of query (104 bits)
acoC / AAA18917.1 dihydrolipoamide acetyltransferase from Pelobacter carbinolicus (see paper)
32% identity, 94% coverage of query (103 bits)
DLAT / P10515 pyruvate dehydrogenase E2 component from Homo sapiens (see 5 papers)
ODP2_HUMAN / P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Homo sapiens (Human) (see 10 papers)
P10515 pyruvate dehydrogenase system (subunit 2/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
31% identity, 93% coverage of query (102 bits)
sucB_1 / O84058 dihydrolipoyllysine succinyltransferase (EC 2.3.1.61) from Chlamydia trachomatis (strain D/UW-3/Cx) (see 4 papers)
30% identity, 93% coverage of query (102 bits)
odhB / CAA62981.1 dihydrolipoamide S-succinyltransferase (E2) from Cupriavidus necator (see paper)
33% identity, 91% coverage of query (102 bits)
ODP2_RAT / P08461 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Rattus norvegicus (Rat) (see paper)
30% identity, 93% coverage of query (101 bits)
ODO2_YEAST / P19262 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; DLST; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; OGDHC subunit E2; Alpha-ketoglutarate dehydrogenase subunit E2; alpha-KGDHC subunit E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P19262 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Saccharomyces cerevisiae (see paper)
32% identity, 95% coverage of query (101 bits)
ODP2_MESAU / P86197 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Mesocricetus auratus (Golden hamster) (see paper)
30% identity, 93% coverage of query (101 bits)
ODPX_BOVIN / P22439 Pyruvate dehydrogenase protein X component; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; proX from Bos taurus (Bovine) (see paper)
30% identity, 93% coverage of query (101 bits)
P11961 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
32% identity, 92% coverage of query (101 bits)
Pf6N2E2_479 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens FW300-N2E2
34% identity, 94% coverage of query (100 bits)
ODO2B_ARATH / Q8H107 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2-2; OGDC-E2-2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2; E2K-2; EC 2.3.1.61 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 97% coverage of query (99.4 bits)
pdhC / AAC24934.1 dihydrolipoamide acetyltransferase E2 from Bacillus subtilis (see 3 papers)
33% identity, 92% coverage of query (98.6 bits)
P21883 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; S complex, 48 kDa subunit; EC 2.3.1.12 from Bacillus subtilis (strain 168)
33% identity, 92% coverage of query (98.6 bits)
Q6C5L8 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Yarrowia lipolytica (see paper)
31% identity, 95% coverage of query (98.2 bits)
Build an alignment for GFF1388 and 33 homologs with ≥ 30% identity
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ODP22_ARATH / Q8RWN9 Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide S-acetyltransferase component 2 of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 2; PDC-E2 2; PDCE2 2; EC 2.3.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8RWN9 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104) from Arabidopsis thaliana (see paper)
29% identity, 92% coverage of query (97.8 bits)
PDHX / O00330 pyruvate dehydrogenase complex E3-binding protein component from Homo sapiens (see 9 papers)
ODPX_HUMAN / O00330 Pyruvate dehydrogenase protein X component, mitochondrial; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; proX from Homo sapiens (Human) (see 8 papers)
O00330 pyruvate dehydrogenase system (subunit 3/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
30% identity, 93% coverage of query (97.4 bits)
DLST / P36957 2-oxoglutarate dehydrogenase complex, dihydrolipoamide succinyltransferase component (EC 2.3.1.61) from Homo sapiens (see 5 papers)
ODO2_HUMAN / P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; EC 2.3.1.61 from Homo sapiens (Human) (see 3 papers)
P36957 2-oxoglutarate dehydrogenase system (subunit 2/3) (EC 1.2.1.105) from Homo sapiens (see paper)
29% identity, 95% coverage of query (92.0 bits)
ODO2_PIG / Q9N0F1 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; E2o; PE2o; EC 2.3.1.61 from Sus scrofa (Pig) (see paper)
29% identity, 95% coverage of query (90.9 bits)
ODO2_BOVIN / P11179 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; EC 2.3.1.61 from Bos taurus (Bovine) (see 2 papers)
30% identity, 95% coverage of query (89.4 bits)
1eafA / P10802 Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex (see paper)
32% identity, 89% coverage of query (81.6 bits)
P06959 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Escherichia coli (strain K12)
28% identity, 90% coverage of query (77.8 bits)
ODO12_CORGL / Q8NRC3 2-oxoglutarate dehydrogenase E1/E2 component; ODH E1/E2 component; EC 1.2.4.2; EC 2.3.1.61 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 5 papers)
Q8NRC3 2-oxoglutarate dehydrogenase system (subunit 3/3) (EC 1.2.1.105); oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) from Corynebacterium glutamicum (see paper)
28% identity, 94% coverage of query (77.4 bits)
8p5sA / Q8NRC3 Crystal structure of the homohexameric 2-oxoglutarate dehydrogenase odha from corynebacterium glutamicum (see paper)
27% identity, 92% coverage of query (77.4 bits)
8p5wA Single particle cryo-em structure of homohexameric 2-oxoglutarate dehydrogenase odha from corynebacterium glutamicum following reaction with the 2-oxoglutarate analogue succinyl phosphonate
27% identity, 92% coverage of query (76.3 bits)
8p5uA Single particle cryo-em structure of homohexameric 2-oxoglutarate dehydrogenase odha from corynebacterium glutamicum with coenzyme a bound to the e2o domain
27% identity, 92% coverage of query (76.3 bits)
8p5vA / Q8NRC3 Single particle cryo-em structure of homohexameric 2-oxoglutarate dehydrogenase odha from corynebacterium glutamicum in complex with the product succinyl-coa (see paper)
27% identity, 92% coverage of query (76.3 bits)
DBT / P11182 branched-chain α-keto acid dehydrogenase complex E2 component subunit (EC 2.3.1.168) from Homo sapiens (see 9 papers)
ODB2_HUMAN / P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; BCKDH-E2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Homo sapiens (Human) (see 9 papers)
P11182 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 3 papers)
27% identity, 88% coverage of query (72.0 bits)
ODB2_BOVIN / P11181 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Bos taurus (Bovine) (see 2 papers)
27% identity, 88% coverage of query (69.7 bits)
2ii5A Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (e2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (bckdc), isobutyryl-coenzyme a-bound form
27% identity, 88% coverage of query (69.7 bits)
2ii4A Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (e2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (bckdc), coenzyme a-bound form
27% identity, 88% coverage of query (69.7 bits)
2ii3A / P11181 Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (e2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (bckdc), oxidized coenzyme a-bound form (see paper)
27% identity, 88% coverage of query (69.7 bits)
KGD_MYCS2 / A0R2B1 Multifunctional 2-oxoglutarate metabolism enzyme; 2-hydroxy-3-oxoadipate synthase; HOA synthase; HOAS; 2-oxoglutarate carboxy-lyase; 2-oxoglutarate decarboxylase; Alpha-ketoglutarate decarboxylase; KG decarboxylase; KGD; Alpha-ketoglutarate-glyoxylate carboligase; EC 2.2.1.5; EC 4.1.1.71; EC 1.2.4.2; EC 2.3.1.61 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
A0R2B1 oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2); 2-oxoglutarate decarboxylase (EC 4.1.1.71) from Mycolicibacterium smegmatis (see 2 papers)
27% identity, 92% coverage of query (60.8 bits)
8p5rC / A0R2B1 Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase kgd from mycobacterium smegmatis in complex with gara (see paper)
28% identity, 71% coverage of query (60.5 bits)
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