Searching for up to 100 curated homologs for GFF1649 FitnessBrowser__Phaeo:GFF1649 (383 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
mdeA / P13254 MdeA from Pseudomonas putida (see 6 papers)
MEGL_PSEPU / P13254 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methioninase; EC 4.4.1.11; EC 4.4.1.2 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 5 papers)
1pg8A / P13254 Crystal structure of l-methionine alpha-, gamma-lyase
BAA13642.1 L-methionine gamma-lyase from Pseudomonas putida (see paper)
37% identity, 96% coverage of query (233 bits)
3vk3A Crystal structure of l-methionine gamma-lyase from pseudomonas putida c116h mutant complexed with l-methionine
37% identity, 96% coverage of query (233 bits)
5x30C Crystal structure of pseudomonas putida methionine gamma-lyase c116h mutant with l-homocysteine intermediates.
37% identity, 96% coverage of query (233 bits)
5x2xA Crystal structure of pseudomonas putida methionine gamma-lyase wild type with l-homocysteine intermediates
37% identity, 96% coverage of query (233 bits)
5x2wA Crystal structure of pseudomonas putida methionine gamma-lyase wild type with l-methionine intermediates
37% identity, 96% coverage of query (233 bits)
ALGLR_THEMA / Q9X0Z7 L-alanine/L-glutamate racemase; EC 5.1.1.1; EC 5.1.1.3 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9X0Z7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1); glutamate racemase (EC 5.1.1.3) from Thermotoga maritima (see paper)
35% identity, 93% coverage of query (228 bits)
MEGL_FUSNN / Q8RDT4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-cysteine desulfidase; EC 4.4.1.11; EC 4.4.1.2; EC 4.4.1.28 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see paper)
Q8RDT4 methionine gamma-lyase (EC 4.4.1.11) from Fusobacterium nucleatum subsp. nucleatum (see paper)
36% identity, 98% coverage of query (226 bits)
megL / A0A0J6G7P5 methionine γ-lyase (EC 4.4.1.11) from Pseudomonas deceptionensis (see paper)
MEGL_PSEDM / A0A0J6G7P5 L-methionine gamma-lyase; MGL; EC 4.4.1.11 from Pseudomonas deceptionensis (see paper)
39% identity, 95% coverage of query (223 bits)
A0A1L7H888 methionine gamma-lyase (EC 4.4.1.11) from Clostridium tetani (see paper)
36% identity, 94% coverage of query (222 bits)
MEGL_FUSNP / Q8L0X4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Fusobacterium nucleatum subsp. polymorphum (Fusobacterium polymorphum) (see paper)
34% identity, 98% coverage of query (218 bits)
7d7oB / Q818A3 Crystal structure of cystathionine gamma-lyase from bacillus cereus atcc 14579 (see paper)
33% identity, 96% coverage of query (216 bits)
MCCB_BACSU / O05394 Cystathionine gamma-lyase; Gamma-cystathionase; Homocysteine gamma-lyase; EC 4.4.1.1; EC 4.4.1.2 from Bacillus subtilis (strain 168) (see paper)
O05394 cystathionine beta-synthase (O-acetyl-L-serine) (EC 2.5.1.134) from Bacillus subtilis (see paper)
34% identity, 95% coverage of query (213 bits)
O15564 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis (see paper)
mgl1 / CAA04124.1 methionine gamma-lyase from Trichomonas vaginalis (see paper)
33% identity, 97% coverage of query (211 bits)
O15565 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis (see paper)
mgl2 / CAA04125.1 methionine gamma-lyase from Trichomonas vaginalis (see paper)
34% identity, 97% coverage of query (211 bits)
5m3zA Crystal structure of citrobacter freundii methionine gamma-lyase with c115h replacement in the complex with l-norleucine
33% identity, 99% coverage of query (211 bits)
A2RM21 cystathionine gamma-lyase (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lactococcus lactis (see 2 papers)
metC / RF|YP_001033049.1 cystathionine beta-lyase; EC 4.4.1.8 from Lactococcus lactis subsp. cremoris MG1363 (see 3 papers)
35% identity, 94% coverage of query (210 bits)
1e5eA / A2FEV4 Methionine gamma-lyase (mgl) from trichomonas vaginalis in complex with propargylglycine
33% identity, 97% coverage of query (210 bits)
4omaA The crystal structure of methionine gamma-lyase from citrobacter freundii in complex with l-cycloserine pyridoxal-5'-phosphate
33% identity, 99% coverage of query (210 bits)
3jwbA Crystal structure of l-methionine gamma-lyase from citrobacter freundii with norleucine
33% identity, 99% coverage of query (210 bits)
3jwaA Crystal structure of l-methionine gamma-lyase from citrobacter freundii with methionine phosphinate
33% identity, 99% coverage of query (210 bits)
3jw9A Crystal structure of l-methionine gamma-lyase from citrobacter freundii with s-ethyl-cysteine
33% identity, 99% coverage of query (210 bits)
1e5fA Methionine gamma-lyase (mgl) from trichomonas vaginalis
33% identity, 97% coverage of query (210 bits)
4hf8A Crystal structure of l-methionine gamma-lyase from citrobacter freundii with glycine
33% identity, 99% coverage of query (210 bits)
6egrA / A0A0A5P8W7 Crystal structure of citrobacter freundii methionine gamma-lyase with v358y replacement (see paper)
33% identity, 99% coverage of query (209 bits)
SO1812 Methionine gamma-lyase (EC 4.4.1.11) from Shewanella oneidensis MR-1
35% identity, 94% coverage of query (209 bits)
C3VMV9 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis (see paper)
34% identity, 99% coverage of query (208 bits)
Q84AR1 methionine gamma-lyase (EC 4.4.1.11); alliin lyase (EC 4.4.1.4) from Citrobacter freundii (see 11 papers)
33% identity, 99% coverage of query (208 bits)
MEGL_PORGI / Q7MX71 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Porphyromonas gingivalis (strain ATCC BAA-308 / W83) (see paper)
Q7MX71 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis (see paper)
34% identity, 99% coverage of query (208 bits)
7mcbH / X5E0F1 Crystal structure of staphylococcus aureus cystathionine gamma lyase holoenzyme (see paper)
33% identity, 95% coverage of query (202 bits)
7mcyH Crystal structure of staphylococcus aureus cystathionine gamma lyase, holoenzyme with bound nl3
33% identity, 95% coverage of query (202 bits)
7mcuH Crystal structure of staphylococcus aureus cystathionine gamma lyase, holoenzyme with bound nl2
33% identity, 95% coverage of query (202 bits)
7mctH Crystal structure of staphylococcus aureus cystathionine gamma lyase, holoenzyme with bound nl1
33% identity, 95% coverage of query (202 bits)
7mcqA Crystal structure of staphylococcus aureus cystathionine gamma lyase, aoaa-bound enzyme in dimeric form
33% identity, 95% coverage of query (202 bits)
5dx5A / J7TA22 Crystal structure of methionine gamma-lyase from clostridium sporogenes (see paper)
33% identity, 94% coverage of query (201 bits)
MEGL_TREDE / Q73KL7 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) (see paper)
Q73KL7 methionine gamma-lyase (EC 4.4.1.11) from Treponema denticola (see paper)
33% identity, 96% coverage of query (201 bits)
J7TA22 methionine gamma-lyase (EC 4.4.1.11) from Clostridium sporogenes (see 2 papers)
33% identity, 94% coverage of query (201 bits)
GB|AAF14695.1 cystathionine beta-lyase; EC 4.4.1.8 from Austrochilidae (see paper)
34% identity, 94% coverage of query (200 bits)
B3TNN8 cystathionine gamma-lyase (subunit 2/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei (see paper)
34% identity, 97% coverage of query (200 bits)
4l0oH / P56069 Structure determination of cystathionine gamma-synthase from helicobacter pylori
33% identity, 97% coverage of query (197 bits)
metB / P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
33% identity, 97% coverage of query (197 bits)
METB_HELPX / Q1M0P5 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Helicobacter pylori (Campylobacter pylori) (see paper)
Q1M0P5 cystathionine gamma-synthase (EC 2.5.1.48) from Helicobacter pylori (see paper)
33% identity, 97% coverage of query (196 bits)
3mkjA Methionine gamma-lyase from citrobacter freundii with pyridoximine-5'- phosphate
32% identity, 99% coverage of query (196 bits)
Q86D28 methionine gamma-lyase (EC 4.4.1.11) from Entamoeba histolytica (see 3 papers)
metg / BAC75877.2 methionine gamma-lyase from Entamoeba histolytica (see paper)
33% identity, 92% coverage of query (195 bits)
6ld8A / Q5H1U9 Crystal structure of cystathionine gamma synthase from xanthomonas oryzae pv. Oryzae in complex with aminoacrylate and cysteine
35% identity, 94% coverage of query (194 bits)
3aejA / Q86D28 Reaction intermediate structure of entamoeba histolytica methionine gamma-lyase 1 tetramer containing michaelis complex and methionine- pyridoxal-5'-phosphate
33% identity, 92% coverage of query (194 bits)
6lgoA Crystal structure of cystathionine gamma synthase from xanthomonas oryzae pv. Oryzae in complex with homolanthionine
35% identity, 94% coverage of query (194 bits)
3aeoA Reaction intermediate structure of entamoeba histolytica methionine gamma-lyase 1 containing methionine alpha, beta-enamine-pyridoxamine- 5'-phosphate
33% identity, 92% coverage of query (194 bits)
3aelA Reaction intermediate structure of entamoeba histolytica methionine gamma-lyase 1 containing methionine imine-pyridoxamine-5'-phosphate and alpha-amino-alpha, beta-butenoic acid-pyridoxal-5'-phosphate
33% identity, 92% coverage of query (194 bits)
3aejC Reaction intermediate structure of entamoeba histolytica methionine gamma-lyase 1 tetramer containing michaelis complex and methionine- pyridoxal-5'-phosphate
33% identity, 92% coverage of query (194 bits)
6ld9A Crystal structure of cystathionine gamma synthase from xanthomonas oryzae pv. Oryzae in complex with cystathionine
35% identity, 94% coverage of query (193 bits)
B3TNN9 cystathionine gamma-lyase (subunit 1/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei (see paper)
34% identity, 97% coverage of query (192 bits)
CGS1 / P55217 cystathionine γ-synthase (EC 2.5.1.48) from Arabidopsis thaliana (see 2 papers)
CGS1_ARATH / P55217 Cystathionine gamma-synthase 1, chloroplastic; AtCGS1; METHIONINE OVERACCUMULATION 1; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
33% identity, 93% coverage of query (190 bits)
METI_BACSU / O31631 Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.- from Bacillus subtilis (strain 168) (see paper)
33% identity, 94% coverage of query (188 bits)
CGL_DICDI / Q55DV9 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Dictyostelium discoideum (Social amoeba) (see paper)
34% identity, 85% coverage of query (187 bits)
6ldoA / F9UT53 Crystal structure of cystathionine gamma-lyase from lactobacillus plantarum complexed with l-serine (see paper)
33% identity, 97% coverage of query (184 bits)
METC_BACSU / O31632 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase MetC; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13 from Bacillus subtilis (strain 168) (see 2 papers)
32% identity, 95% coverage of query (184 bits)
METC_COXBU / Q83A83 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I) (see paper)
33% identity, 94% coverage of query (184 bits)
1qgnA / Q9ZPL5 Cystathionine gamma-synthase from nicotiana tabacum (see paper)
33% identity, 93% coverage of query (184 bits)
6le4A Crystal structure of cystathionine gamma-lyase from lactobacillus plantarum complexed with cystathionine
33% identity, 97% coverage of query (184 bits)
1i48A Cystathionine gamma-synthase in complex with the inhibitor ctcpo
33% identity, 93% coverage of query (183 bits)
1i43A Cystathionine gamma-synthase in complex with the inhibitor ppca
33% identity, 93% coverage of query (183 bits)
1i41A Cystathionine gamma-synthase in complex with the inhibitor appa
33% identity, 93% coverage of query (183 bits)
ALGLR_WOLPM / Q73GL9 L-alanine/L-glutamate racemase; EC 5.1.1.1; EC 5.1.1.3 from Wolbachia pipientis wMel (see paper)
Q73GL9 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1); glutamate racemase (EC 5.1.1.3) from Wolbachia pipientis (see paper)
30% identity, 95% coverage of query (182 bits)
6k1lA / B4SII9 E53a mutant of a putative cystathionine gamma-lyase (see paper)
34% identity, 94% coverage of query (180 bits)
6k1lB E53a mutant of a putative cystathionine gamma-lyase
34% identity, 94% coverage of query (180 bits)
4iyoD / Q5H4T8 Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates (see paper)
33% identity, 94% coverage of query (179 bits)
Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae (see paper)
33% identity, 94% coverage of query (179 bits)
4iyoB Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates
33% identity, 94% coverage of query (179 bits)
4iy7B Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates
33% identity, 94% coverage of query (179 bits)
4iy7A Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates
33% identity, 94% coverage of query (179 bits)
4ixzA Native structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae at ph 9.0
33% identity, 94% coverage of query (179 bits)
L0EK12 cystathionine gamma-synthase (EC 2.5.1.48) from Cicer arietinum (see paper)
32% identity, 96% coverage of query (178 bits)
B2LXT6 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus nidulans (see paper)
mecB cystathionine gamma-lyase; EC 4.4.1.1 from Emericella nidulans (see paper)
32% identity, 97% coverage of query (176 bits)
L0EKR2 cystathionine gamma-synthase (EC 2.5.1.48) from Lens culinaris (see paper)
32% identity, 93% coverage of query (175 bits)
6cjaA / Q5ZX43 Crystal structure of cystathionine beta-lyase from legionella pneumophila philadelphia 1 in complex with alanyl-plp and serine
34% identity, 94% coverage of query (175 bits)
7ba4A / A0A509J8D5 Structure of cystathionine gamma-lyase from pseudomonas aeruginosa
33% identity, 94% coverage of query (172 bits)
MetC / b3008 cystathionine β-lyase / L-cysteine desulfhydrase / alanine racemase (EC 4.4.1.13; EC 4.4.1.1; EC 4.4.1.28; EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
metC / P06721 cystathionine β-lyase / L-cysteine desulfhydrase / alanine racemase (EC 4.4.1.13; EC 4.4.1.1; EC 5.1.1.10) from Escherichia coli (strain K12) (see 48 papers)
METC_ECOLI / P06721 Cystathionine beta-lyase MetC; CBL; CL; Beta-cystathionase MetC; Cysteine desulfhydrase MetC; CD; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13; EC 4.4.1.28 from Escherichia coli (strain K12) (see 8 papers)
P06721 alanine racemase (EC 5.1.1.1) from Escherichia coli (see paper)
31% identity, 94% coverage of query (172 bits)
1cl1B / P06721 Cystathionine beta-lyase (cbl) from escherichia coli (see paper)
31% identity, 94% coverage of query (172 bits)
4itxA P113s mutant of e. Coli cystathionine beta-lyase metc inhibited by reaction with l-ala-p
31% identity, 94% coverage of query (172 bits)
4ixsB Native structure of xometc at ph 5.2
32% identity, 94% coverage of query (172 bits)
2gqnA Cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-nitro-benzamide
31% identity, 94% coverage of query (172 bits)
2fq6A Cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-trifluoromethyl-benzamide
31% identity, 94% coverage of query (172 bits)
1cl2A Cystathionine beta-lyase (cbl) from escherichia coli in complex with aminoethoxyvinylglycine
31% identity, 94% coverage of query (172 bits)
uptH / AAK53484.1 cystathionine gamma-synthase from Xanthomonas campestris pv. campestris (see 4 papers)
32% identity, 95% coverage of query (170 bits)
1ibjA / P53780 Crystal structure of cystathionine beta-lyase from arabidopsis thaliana (see paper)
33% identity, 94% coverage of query (170 bits)
CBL1 / P53780 cystathionine β-lyase monomer (EC 4.4.1.13) from Arabidopsis thaliana (see 3 papers)
METC_ARATH / P53780 Cystathionine beta-lyase, chloroplastic; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
33% identity, 94% coverage of query (170 bits)
METC_BORAV / Q07703 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Osteotoxin; EC 4.4.1.13 from Bordetella avium (see paper)
metC / AAA22978.1 cystathionine beta-lyase from Bordetella avium (see paper)
32% identity, 95% coverage of query (169 bits)
A8CEI3 mimosinase (EC 3.5.1.61) from Leucaena leucocephala (see 2 papers)
30% identity, 97% coverage of query (169 bits)
METC_STAHJ / Q4L332 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Staphylococcus haemolyticus (strain JCSC1435) (see paper)
31% identity, 93% coverage of query (169 bits)
Build an alignment for GFF1649 and 89 homologs with ≥ 30% identity
Or download the sequences
AB823649.2 / U6BYK3 mimosinase (EC 4.3.3.8) from Mimosa pudica (see 5 papers)
U6BYK3 mimosinase (EC 3.5.1.61) from Mimosa pudica (see paper)
29% identity, 95% coverage of query (169 bits)
8j6nA / Q9EQS4 Crystal structure of cystathionine gamma-lyase in complex with compound 1 (see paper)
31% identity, 94% coverage of query (169 bits)
8sadA / A0A0H3FMF8 Crystal structure of cystathionine beta lyase from klebsiella aerogenes, plp/malonate complex (c2 form)
31% identity, 94% coverage of query (169 bits)
8u99A Crystal structure of cystathionine beta lyase from klebsiella aerogenes (plp-serine adduct)
31% identity, 94% coverage of query (169 bits)
8u98A Crystal structure of cystathionine beta lyase from klebsiella aerogenes (plp-glycine adduct)
31% identity, 94% coverage of query (169 bits)
8sa9A Crystal structure of cystathionine beta lyase from klebsiella aerogenes, plp-oxamate adduct (c2 form)
31% identity, 94% coverage of query (169 bits)
8sabA Crystal structure of cystathionine beta lyase from klebsiella aerogenes, plp adduct with alanine (c2 form)
31% identity, 94% coverage of query (169 bits)
Cth / P18757 cystathionine γ-lyase subunit (EC 4.4.1.1) from Rattus norvegicus (see 15 papers)
CGL_RAT / P18757 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; Probasin-related antigen; PRB-RA; EC 4.4.1.1; EC 4.4.1.2 from Rattus norvegicus (Rat) (see paper)
31% identity, 94% coverage of query (167 bits)
Q4FME3 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1) from Candidatus Pelagibacter ubique (see paper)
29% identity, 85% coverage of query (167 bits)
Q4WCI1 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus fumigatus (see paper)
34% identity, 85% coverage of query (167 bits)
METB_MYCTU / P9WGB7 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
31% identity, 94% coverage of query (167 bits)
Or start over
Lawrence Berkeley National Laboratory