Sites on a Tree

 

Searching for up to 100 curated homologs for GFF1848 FitnessBrowser__Marino:GFF1848 (264 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YafR / b0212 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gloB / P0AC84 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli (strain K12) (see 9 papers)
GLO2_ECOLI / P0AC84 Hydroxyacylglutathione hydrolase GloB; Glyoxalase II; Glx II; EC 3.1.2.6 from Escherichia coli (strain K12) (see 2 papers)
6rz0A / P0AC84 Crystal structure of escherichia coli glyoxalase ii
gloB / MB|P0AC84 hydroxyacylglutathione hydrolase; EC 3.1.2.6 from Escherichia coli K12 (see 3 papers)
    45% identity, 100% coverage of query (214 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    44% identity, 100% coverage of query (213 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    44% identity, 100% coverage of query (213 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    44% identity, 100% coverage of query (213 bits)

8ewoA / Q9I2T1 Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
    45% identity, 100% coverage of query (197 bits)

GLO2C_ARATH / O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    37% identity, 100% coverage of query (174 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    36% identity, 100% coverage of query (174 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    36% identity, 100% coverage of query (173 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    36% identity, 100% coverage of query (170 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    35% identity, 100% coverage of query (156 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    35% identity, 100% coverage of query (156 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    34% identity, 100% coverage of query (156 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    35% identity, 100% coverage of query (156 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    35% identity, 100% coverage of query (156 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    37% identity, 85% coverage of query (152 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    41% identity, 85% coverage of query (149 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    40% identity, 85% coverage of query (144 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    34% identity, 84% coverage of query (124 bits)

GLO21_SCHPO / Q9UT36 Probable hydroxyacylglutathione hydrolase C824.07; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    34% identity, 81% coverage of query (117 bits)

GLO2 / Q05584 glyoxalase II (cytoplasmic) (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
GLO2_YEAST / Q05584 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Glyoxalase II; Glx II; EC 3.1.2.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
GLO2 / CAA71335.1 glyoxalase-II from Saccharomyces cerevisiae (see paper)
    33% identity, 85% coverage of query (117 bits)

Q6KF36 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
GLXII / GI|47604513 glyoxalase II from Trypanosoma brucei brucei (see paper)
glxII / CAD37800.1 glyoxalase II from Trypanosoma brucei brucei (see paper)
    34% identity, 88% coverage of query (114 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    30% identity, 88% coverage of query (111 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    30% identity, 88% coverage of query (108 bits)

GLO4 / Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (see paper)
GLO4 / CAA58065.1 glyoxalase-II from Saccharomyces cerevisiae (see 3 papers)
    32% identity, 83% coverage of query (102 bits)

Build an alignment

Build an alignment for GFF1848 and 24 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

ACTE_ASPCH / A0A7R7ZLL0 Atrochrysone carboxyl ACP thioesterase; AcTE; Physcion biosynthesis cluster thioesterase; EC 3.1.2.- from Aspergillus chevalieri (Eurotium chevalieri) (see paper)
    28% identity, 77% coverage of query (65.1 bits)

PK81A_PSEFD / M3ANL0 Atrochrysone carboxyl ACP thioesterase MYCFIDRAFT_190111; PKS8-1 gene cluster protein MYCFIDRAFT_190111; EC 3.1.2.- from Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis) (see 2 papers)
    26% identity, 79% coverage of query (61.2 bits)

TPCB_ASPFU / Q4WQZ6 Atrochrysone carboxyl ACP thioesterase; ACTE; Trypacidin synthesis protein B; EC 3.1.2.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    29% identity, 72% coverage of query (59.7 bits)

A0A1E7YQH3 persulfide dioxygenase (EC 1.13.11.18) from Acidithiobacillus caldus (see paper)
    28% identity, 94% coverage of query (56.6 bits)

Q581U6 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
    25% identity, 84% coverage of query (55.5 bits)

DMXR1_CRYX8 / A0A4P8DJU1 Atrochrysone carboxyl ACP thioesterase dmxR1; ACTE dmxR1; Dimeric xanthone biosynthesis cluster protein L; EC 3.1.2.- from Cryptosporiopsis sp. (strain 8999) (see paper)
    25% identity, 74% coverage of query (54.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory