Searching for up to 100 curated homologs for GFF1975 FitnessBrowser__Marino:GFF1975 (295 a.a.)
Found high-coverage hits (≥70%) to 67 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PRPB_SHEON / Q8EJW1 2-methylisocitrate lyase; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Shewanella oneidensis (strain MR-1) (see paper)
70% identity, 98% coverage of query (420 bits)
Pf6N2E2_6061 Methylisocitrate lyase (EC 4.1.3.30) from Pseudomonas fluorescens FW300-N2E2
66% identity, 100% coverage of query (399 bits)
prpB / Q0KAG5 2-methylcitrate lyase (EC 4.1.3.30) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
66% identity, 98% coverage of query (397 bits)
PRPB_CUPNE / Q937P0 2-methylisocitrate lyase; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see paper)
66% identity, 98% coverage of query (394 bits)
RR42_RS11260 Methylisocitrate lyase (EC 4.1.3.30) from Cupriavidus basilensis FW507-4G11
66% identity, 98% coverage of query (391 bits)
YahQ / b0331 2-methylisocitrate lyase (EC 4.1.3.30) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
prpB / P77541 2-methylisocitrate lyase (EC 4.1.3.30) from Escherichia coli (strain K12) (see 6 papers)
PRPB_ECOLI / P77541 2-methylisocitrate lyase; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Escherichia coli (strain K12) (see 3 papers)
62% identity, 98% coverage of query (376 bits)
1mumA / P77541 Structure of the 2-methylisocitrate lyase (prpb) from escherichia coli (see paper)
63% identity, 97% coverage of query (374 bits)
prpB / Q56062 2-methylisocitrate lyase subunit (EC 4.1.3.30) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
PRPB_SALTY / Q56062 2-methylisocitrate lyase; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
61% identity, 98% coverage of query (371 bits)
6t4vC / Q9I5E2 Crystal structure of 2-methylisocitrate lyase (prpb) from pseudomonas aeruginosa in apo form.
64% identity, 97% coverage of query (367 bits)
1o5qA Crystal structure of pyruvate and mg2+ bound 2-methylisocitrate lyase (prpb) from salmonella typhimurium
59% identity, 95% coverage of query (334 bits)
4iqdA / A0A6L7HJ56 Crystal structure of carboxyvinyl-carboxyphosphonate phosphorylmutase from bacillus anthracis
49% identity, 93% coverage of query (257 bits)
MMGF_BACSU / P54528 2-methylisocitrate lyase; 2-MIC; MICL; EC 4.1.3.- from Bacillus subtilis (strain 168) (see paper)
P54528 Methylisocitrate lyase (EC 4.1.3.30) from Bacillus subtilis (see paper)
47% identity, 93% coverage of query (240 bits)
PRPB2_CORGL / Q8NSL2 Probable 2-methylisocitrate lyase 2; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
44% identity, 91% coverage of query (217 bits)
PRPB1_CORGL / Q8NSH8 Probable 2-methylisocitrate lyase 1; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
42% identity, 100% coverage of query (214 bits)
bcpA / P11435 carboxyphosphonoenolpyruvate phosphonomutase monomer (EC 2.7.8.23) from Streptomyces hygroscopicus (see 3 papers)
38% identity, 93% coverage of query (207 bits)
phpI / A0A0M3WPI5 carboxyphosphonoenolpyruvate phosphonomutase (EC 2.7.8.23) from Kitasatospora phosalacinea (see 4 papers)
38% identity, 96% coverage of query (202 bits)
dml / Q0QLE4 2,3-dimethylmalate lyase subunit (EC 4.1.3.32) from Eubacterium barkeri (see 2 papers)
DML_EUBBA / Q0QLE4 2,3-dimethylmalate lyase; EC 4.1.3.32 from Eubacterium barkeri (Clostridium barkeri) (see 3 papers)
38% identity, 95% coverage of query (194 bits)
Q2L8W6 Methylisocitrate lyase (EC 4.1.3.30) from Toxoplasma gondii (see paper)
37% identity, 92% coverage of query (175 bits)
Q2L886 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see paper)
37% identity, 85% coverage of query (166 bits)
CPPM_ARATH / O49290 Carboxyvinyl-carboxyphosphonate phosphorylmutase, chloroplastic; Carboxyphosphonoenolpyruvate phosphonomutase; CPEP phosphonomutase; EC 2.7.8.23 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
33% identity, 95% coverage of query (164 bits)
PDP_DIACA / Q05957 Petal death protein; (R)-2-methylmalate lyase; D-citramalate lyase; Oxalacetic hydrolase; PSR132; EC 3.7.1.1; EC 4.1.3.- from Dianthus caryophyllus (Carnation) (Clove pink) (see 3 papers)
Q05957 isocitrate lyase (EC 4.1.3.1) from Dianthus caryophyllus (see paper)
38% identity, 94% coverage of query (162 bits)
1zlpB / Q05957 Petal death protein psr132 with cysteine-linked glutaraldehyde forming a thiohemiacetal adduct (see paper)
38% identity, 93% coverage of query (162 bits)
1zlpA Petal death protein psr132 with cysteine-linked glutaraldehyde forming a thiohemiacetal adduct
38% identity, 93% coverage of query (162 bits)
A2QP68 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see paper)
Q2L887 2,3-Dimethylmalate lyase (EC 4.1.3.32) from Aspergillus niger (see paper)
37% identity, 78% coverage of query (152 bits)
3fa3B / Q2L887 Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, trigonal crystal form (see paper)
37% identity, 78% coverage of query (151 bits)
OAHA / Q6PNM8 oxaloacetate acetylhydrolase monomer (EC 3.7.1.1) from Botryotinia fuckeliana (see 4 papers)
Q6PNM8 oxaloacetase (EC 3.7.1.1) from Botrytis cinerea (see 2 papers)
35% identity, 85% coverage of query (142 bits)
A7ESB3 oxaloacetase (EC 3.7.1.1) from Sclerotinia sclerotiorum (see paper)
34% identity, 83% coverage of query (137 bits)
Q7Z986 oxaloacetase (EC 3.7.1.1) from Aspergillus niger (see 2 papers)
32% identity, 81% coverage of query (133 bits)
3fa4A Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, triclinic crystal form
35% identity, 78% coverage of query (132 bits)
3fa3J Crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate lyase superfamily member, trigonal crystal form
35% identity, 78% coverage of query (132 bits)
3m0jA Structure of oxaloacetate acetylhydrolase in complex with the inhibitor 3,3-difluorooxalacetate (see paper)
32% identity, 80% coverage of query (128 bits)
D5LIR7 oxaloacetase (EC 3.7.1.1) from Cryphonectria parasitica (see paper)
33% identity, 79% coverage of query (128 bits)
Build an alignment for GFF1975 and 32 homologs with ≥ 30% identity
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rhiH / D4HRI5 phosphoenolpyruvate mutase (EC 5.4.2.9) from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
29% identity, 94% coverage of query (123 bits)
3b8iA / Q9HUU1 Crystal structure of oxaloacetate decarboxylase from pseudomonas aeruginosa (pa4872) in complex with oxalate and mg2+. (see paper)
33% identity, 81% coverage of query (119 bits)
OADC_PSEAE / Q9HUU1 Oxaloacetate decarboxylase; EC 4.1.1.112 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
33% identity, 81% coverage of query (119 bits)
3m0kA Structure of oxaloacetate acetylhydrolase in complex with the product oxalate
31% identity, 80% coverage of query (118 bits)
5uncA / A0A0A0V023 The crystal structure of phosphoenolpyruvate phosphomutase from streptomyces platensis subsp. Rosaceus
31% identity, 94% coverage of query (105 bits)
dhpE / D7PC17 phosphoenolpyruvate phosphomutase (EC 5.4.2.9) from Streptomyces luridus (see paper)
28% identity, 95% coverage of query (104 bits)
PEMT / P56839 phosphoenolpyruvate mutase subunit (EC 5.4.2.9) from Mytilus edulis (see paper)
PEPM_MYTED / P56839 Phosphoenolpyruvate phosphomutase; PEP mutase; PEP phosphomutase; Phosphoenolpyruvate mutase; EC 5.4.2.9 from Mytilus edulis (Blue mussel) (see 2 papers)
28% identity, 99% coverage of query (98.2 bits)
frbD / Q0ZQ45 phosphoenolpyruvate mutase (EC 5.4.2.9) from Streptomyces rubellomurinus (strain ATCC 31215) (see 2 papers)
33% identity, 74% coverage of query (97.8 bits)
1m1bA / P56839 Crystal structure of phosphoenolpyruvate mutase complexed with sulfopyruvate (see paper)
29% identity, 89% coverage of query (95.5 bits)
1pymA Phosphoenolpyruvate mutase from mollusk in with bound mg2-oxalate
29% identity, 89% coverage of query (95.5 bits)
ppm / P33182 phosphoenolpyruvate mutase subunit (EC 5.4.2.9) from Tetrahymena pyriformis (see paper)
pepm / AAA30123.1 phosphoenolpyruvate mutase from Tetrahymena pyriformis (see paper)
30% identity, 78% coverage of query (92.8 bits)
pphA / Q84G06 phosphonopyruvate hydrolase subunit (EC 3.11.1.3) from Variovorax sp. (strain Pal2) (see 6 papers)
PPHA_VARSP / Q84G06 Phosphonopyruvate hydrolase; PPH; EC 3.11.1.3 from Variovorax sp. (strain Pal2) (see 3 papers)
Q84G06 phosphonopyruvate hydrolase (EC 3.11.1.3) from Variovorax sp. (see 2 papers)
32% identity, 86% coverage of query (90.1 bits)
2duaA / Q84G06 Crystal structure of phosphonopyruvate hydrolase complex with oxalate and mg++ (see paper)
32% identity, 86% coverage of query (87.8 bits)
2hjpA Crystal structure of phosphonopyruvate hydrolase complex with phosphonopyruvate and mg++
32% identity, 86% coverage of query (87.8 bits)
ppm / A0A0M3WNK3 phosphoenolpyruvate phosphomutase (EC 5.4.2.9) from Kitasatospora phosalacinea (see 2 papers)
30% identity, 94% coverage of query (87.4 bits)
Q8T8D9 phosphoenolpyruvate mutase (EC 5.4.2.9) from Trypanosoma cruzi (see paper)
27% identity, 86% coverage of query (85.9 bits)
ppm / Q5IW38 phosphoenolpyruvate phosphomutase (EC 5.4.2.9) from Streptomyces viridochromogenes (see paper)
30% identity, 97% coverage of query (83.2 bits)
icl / CAA82555.1 isocitrate lyase from Rhodococcus fascians (see paper)
29% identity, 75% coverage of query (80.9 bits)
fom1 / P96074 phosphoenolpyruvate phosphomutase/2-hydroxyethylphosphonate cytidylyltransferase monomer (EC 2.7.7.104; EC 5.4.2.9) from Streptomyces wedmorensis (see 6 papers)
FOM1_STRWE / P96074 Fosfomycin biosynthesis bifunctional protein Fom1; EC 2.7.7.104; EC 5.4.2.9 from Streptomyces wedmorensis (see paper)
30% identity, 72% coverage of query (80.5 bits)
6c4aA / P9WKK7 Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis with pyruvate (see paper)
28% identity, 78% coverage of query (80.5 bits)
icl / P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) (see paper)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see 3 papers)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis (see 4 papers)
28% identity, 78% coverage of query (80.5 bits)
7rb1A Isocitrate lyase-1 from mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-d-isocitric acid
28% identity, 78% coverage of query (80.1 bits)
6wsiA Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium tuberculosis
28% identity, 78% coverage of query (80.1 bits)
6vb9A Covalent adduct of cis-2,3-epoxysuccinic acid with isocitrate lyase-1 from mycobacterium tuberculosis
28% identity, 78% coverage of query (80.1 bits)
5dqlA Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis
28% identity, 78% coverage of query (80.1 bits)
6xppA Crystal structure of itaconate modified mycobaterium tuberculosis isocitrate lyase
28% identity, 78% coverage of query (80.1 bits)
ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
27% identity, 75% coverage of query (78.2 bits)
bcpB / BAA00905.1 phosphoenolpyruvate phosphomutase from Streptomyces hygroscopicus (see paper)
31% identity, 95% coverage of query (76.6 bits)
A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii (see paper)
27% identity, 75% coverage of query (75.9 bits)
1f8iA Crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
27% identity, 78% coverage of query (75.9 bits)
7cmyC / Q81GQ9 Isocitrate lyase from bacillus cereus atcc 14579 in complex with magnessium ion, glyoxylate, and succinate
25% identity, 84% coverage of query (74.7 bits)
Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus (see paper)
25% identity, 84% coverage of query (73.9 bits)
6lrtA / A9WDE7 Crystal structure of isocitrate lyase (caur_3889) from chloroflexus aurantiacus in complex with isocitrate and manganese ion
26% identity, 84% coverage of query (73.2 bits)
Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus (see paper)
25% identity, 78% coverage of query (67.0 bits)
1igwA / P0A9G6 Crystal structure of the isocitrate lyase from the a219c mutant of escherichia coli (see paper)
26% identity, 75% coverage of query (58.9 bits)
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Lawrence Berkeley National Laboratory