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Searching for up to 100 curated homologs for GFF1984 FitnessBrowser__Phaeo:GFF1984 (360 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5cm6A Crystal structure of a trap periplasmic solute binding protein from pseudoalteromonas atlantica t6c(patl_2292, target efi-510180) with bound sodium and pyruvate
    39% identity, 88% coverage of query (216 bits)

4petA / Q48AL6 Crystal structure of a trap periplasmic solute binding protein from colwellia psychrerythraea (cps_0129, target efi-510097) with bound calcium and pyruvate (see paper)
    37% identity, 88% coverage of query (214 bits)

TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
    39% identity, 79% coverage of query (211 bits)

7ug8B / Q0I6F8 Crystal structure of a solute receptor from synechococcus cc9311 in complex with alpha-ketovaleric and calcium
    39% identity, 79% coverage of query (209 bits)

TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    35% identity, 93% coverage of query (194 bits)

TAKP_CERS4 / Q3J1R2 Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
    34% identity, 98% coverage of query (194 bits)

2hzlB / Q3J1R2 Crystal structures of a sodium-alpha-keto acid binding subunit from a trap transporter in its closed forms (see paper)
    32% identity, 89% coverage of query (186 bits)

4yicA / A0A0J9X284 Crystal structure of a trap transporter solute binding protein (ipr025997) from bordetella bronchiseptica rb50 (bb0280, target efi- 500035) with bound picolinic acid
    33% identity, 88% coverage of query (182 bits)

Build an alignment

Build an alignment for GFF1984 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TLBP_THET8 / Q5SK82 Lactate-binding periplasmic protein TTHA0766; ABC transporter, solute-binding protein; Extracytoplasmic solute receptor protein TTHA0766; TRAP transporter lactate-binding subunit P from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    28% identity, 84% coverage of query (104 bits)

2zzvA / Q5SK82 Crystal structure of a periplasmic substrate binding protein in complex with calcium and lactate (see paper)
    27% identity, 73% coverage of query (92.4 bits)

2zzwA Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
    27% identity, 73% coverage of query (92.4 bits)

4p8bA / Q0KC03 Crystal structure of a trap periplasmic solute binding protein from ralstonia eutropha h16 (h16_a1328), target efi-510189, with bound (s)-2-hydroxy-2-methyl-3-oxobutanoate ((s)-2-acetolactate) (see paper)
    23% identity, 82% coverage of query (60.8 bits)

Psest_2125 D-gluconate TRAP transporter, periplasmic component from Pseudomonas stutzeri RCH2
    24% identity, 80% coverage of query (57.8 bits)

4xf5A / Q1QZR9 Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound (s)-(+)-2-amino-1-propanol.
    22% identity, 86% coverage of query (57.4 bits)

4uabA Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound ethanolamine
    22% identity, 86% coverage of query (57.4 bits)

7nrrBBB / Q1R0W5 7nrrBBB (see paper)
    26% identity, 74% coverage of query (55.8 bits)

7nrrAAA / Q1R0W5 7nrrAAA (see paper)
    26% identity, 74% coverage of query (55.8 bits)

7nswBBB TRAP dicarboxylate transporter-DctP subunit
    26% identity, 74% coverage of query (55.8 bits)

7ntdAAA TRAP dicarboxylate transporter-DctP subunit
    26% identity, 74% coverage of query (55.8 bits)

DCTP2_POLSJ / Q122C7 Solute-binding protein Bpro_4736 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
    24% identity, 84% coverage of query (55.1 bits)

4mncA / Q122C7 Crystal structure of a trap periplasmic solute binding protein from polaromonas sp. Js666 (bpro_4736), target efi-510156, with bound benzoyl formate, space group p21 (see paper)
    24% identity, 79% coverage of query (53.1 bits)

TEAA_HALED / E1VBK1 Ectoine-binding periplasmic protein TeaA from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) (see 3 papers)
    22% identity, 78% coverage of query (53.1 bits)

AZOBR_RS15915 gluconate TRAP transporter, periplasmic solute-binding component from Azospirillum brasilense Sp245
    22% identity, 80% coverage of query (52.4 bits)

DCTP_RHOCA / P37735 C4-dicarboxylate-binding periplasmic protein DctP from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see 3 papers)
TC 2.A.56.1.1 / P37735 DctP, component of Tripartite dicarboxylate:H+ symporter (substrates include: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate and mesaconate) from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
    25% identity, 90% coverage of query (52.0 bits)

Ac3H11_3226 gluconate TRAP transporter, periplasmic solute-binding component from Acidovorax sp. GW101-3H11
    23% identity, 93% coverage of query (52.0 bits)

3gyyD / E1VBK1 The ectoine binding protein of the teaabc trap transporter teaa in the apo-state (see paper)
    22% identity, 76% coverage of query (51.2 bits)

2vpnB High-resolution structure of the periplasmic ectoine- binding protein from teaabc trap-transporter of halomonas elongata
    22% identity, 76% coverage of query (51.2 bits)

TC 2.A.56.1.7 / Q930W1 ABC transporter, periplasmic solute-binding protein, component of The malonate uptake transporter, MatPQM. Regulated by the GtrA transcriptional activator (Chen et al. 2010). MatM is fused in a single protein C-terminal to MatA (malonyl-CoA decarboxylase) from Rhizobium meliloti (strain 1021)
    23% identity, 85% coverage of query (47.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory