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Searching for up to 100 curated homologs for GFF1992 FitnessBrowser__Phaeo:GFF1992 (474 a.a.)

Found high-coverage hits (≥70%) to 55 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hydA / A0A0A1H115 4-hydroxybenzoate 1-phenylethylidene hydrazidase from Microbacterium hydrocarbonoxydans (see paper)
    33% identity, 99% coverage of query (196 bits)

5h6sC Crystal structure of hydrazidase s179a mutant complexed with a substrate (see paper)
    33% identity, 99% coverage of query (196 bits)

AAM_RHOER / K9NBS6 Acylamidase; EC 3.5.1.13; EC 3.5.1.14; EC 3.5.1.4 from Rhodococcus erythropolis (Arthrobacter picolinophilus) (see paper)
    32% identity, 97% coverage of query (189 bits)

gatA / Q9RTA9 glutamyl-tRNAGln amidotransferase subunit A (EC 6.3.5.7; EC 6.3.5.6) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
    34% identity, 91% coverage of query (184 bits)

3kfuE / Q9LCX3 Crystal structure of the transamidosome (see paper)
    34% identity, 95% coverage of query (163 bits)

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Build an alignment for GFF1992 and 5 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

P63488 glutaminyl-tRNA synthase (glutamine-hydrolysing) (subunit 2/2) (EC 6.3.5.7) from Staphylococcus aureus (see paper)
2dqnA / P63488 Structure of tRNA-dependent amidotransferase gatcab complexed with asn (see paper)
    28% identity, 96% coverage of query (148 bits)

2f2aA Structure of tRNA-dependent amidotransferase gatcab complexed with gln
    28% identity, 96% coverage of query (148 bits)

cahA / BAC15598.1 carbaryl hydrolase from Arthrobacter sp. RC100 (see paper)
    32% identity, 94% coverage of query (147 bits)

gatA / O06491 glutamyl-tRNAGln amidotransferase subunit A (EC 6.3.5.7) from Bacillus subtilis (strain 168) (see paper)
GATA_BACSU / O06491 Glutamyl-tRNA(Gln) amidotransferase subunit A; Glu-ADT subunit A; EC 6.3.5.7 from Bacillus subtilis (strain 168) (see 2 papers)
    29% identity, 98% coverage of query (143 bits)

C3UWD1 aryl-acylamidase (EC 3.5.1.13) from bacterium CSBL00001 (see 2 papers)
    28% identity, 96% coverage of query (142 bits)

F6N111 aryl-acylamidase (EC 3.5.1.13) from Paracoccus sp. M1-1 (see paper)
G9FKH7 amidase (EC 3.5.1.4) from Paracoccus sp. (see paper)
    31% identity, 97% coverage of query (141 bits)

4yjiA / C3UWD1 The crystal structure of a bacterial aryl acylamidase belonging to the amidase signature (as) enzymes family (see paper)
    28% identity, 96% coverage of query (141 bits)

libA / G3K3F8 linuron hydrolase from Variovorax sp. SRS16 (see 2 papers)
    29% identity, 95% coverage of query (140 bits)

Q9X0Z9 glutaminyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.7) from Thermotoga maritima (see paper)
    28% identity, 96% coverage of query (136 bits)

atzE / Q936X3 1-carboxybiuret hydrolase catalytic subunit (EC 3.5.1.3; EC 3.5.1.131) from Pseudomonas sp. (strain ADP) (see 2 papers)
ATZE_PSESD / Q936X3 1-carboxybiuret hydrolase subunit AtzE; EC 3.5.1.131 from Pseudomonas sp. (strain ADP) (see 2 papers)
Q936X3 1-carboxybiuret hydrolase (EC 3.5.1.131) from Pseudomonas sp. ADP (see paper)
6c6gA / Q936X3 An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. Inhibitor bound complex. (see paper)
    33% identity, 91% coverage of query (133 bits)

nylA / P13398 6-aminohexanoate cyclic dimer hydrolase monomer (EC 3.5.2.12) from Paenarthrobacter ureafaciens (see 4 papers)
NYLA_PAEUR / P13398 6-aminohexanoate-cyclic-dimer hydrolase; Nylon oligomers-degrading enzyme EI; EC 3.5.2.12 from Paenarthrobacter ureafaciens (see paper)
    29% identity, 95% coverage of query (133 bits)

tpdC / M1X895 (Z)-N,N'-(but-2-ene-2,3-diyl)diacetamide hydrolase from Rhodococcus sp. TMP1 (see paper)
tpdC / CCN27361.1 amidase from Rhodococcus sp. TMP1 (see paper)
    28% identity, 95% coverage of query (133 bits)

B5MF68 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) from Rhodococcus sp. U-224 (see paper)
    29% identity, 95% coverage of query (132 bits)

3a2qA / P13398 Structure of 6-aminohexanoate cyclic dimer hydrolase complexed with substrate (see paper)
    29% identity, 95% coverage of query (131 bits)

B7XBZ9 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) from Cupriavidus sp. U124 (see 2 papers)
    29% identity, 95% coverage of query (131 bits)

B7XBZ7 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) from Cupriavidus sp. T7 (see 2 papers)
B7XBZ8 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) from Acidovorax sp. T31 (see 2 papers)
    29% identity, 95% coverage of query (130 bits)

A0A077JIE7 acyl-homoserine-lactone acylase (EC 3.5.1.97) from Acinetobacter sp. Ooi24 (see paper)
    27% identity, 93% coverage of query (130 bits)

B7XC00 6-aminohexanoate-cyclic-dimer hydrolase (EC 3.5.2.12) from Sphingomonas sp. U238 (see 2 papers)
    29% identity, 95% coverage of query (129 bits)

FAAH2 / Q6GMR7 fatty-acid amide hydrolase 2 (EC 3.5.1.99; EC 3.5.1.60) from Homo sapiens (see 2 papers)
FAAH2_HUMAN / Q6GMR7 Fatty-acid amide hydrolase 2; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2; EC 3.5.1.99 from Homo sapiens (Human) (see 2 papers)
B2C6G4 fatty acid amide hydrolase (EC 3.5.1.99) from Homo sapiens (see paper)
Q6GMR7 amidase (EC 3.5.1.4); fatty acid amide hydrolase (EC 3.5.1.99) from Homo sapiens (see 2 papers)
    26% identity, 94% coverage of query (126 bits)

3h0lA / O66610 Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus (see paper)
    27% identity, 83% coverage of query (126 bits)

FAAH_MEDTR / G7ISB0 Fatty acid amide hydrolase; N-acylethanolamine amidohydrolase; EC 3.5.1.- from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    28% identity, 82% coverage of query (126 bits)

3h0mA Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus
    27% identity, 83% coverage of query (126 bits)

clbL / Q0P7K2 colibactin biosynthesis amidase ClbL from Escherichia coli (see 4 papers)
    32% identity, 93% coverage of query (125 bits)

BUT78_GIBZE / I1RV18 Amidase FG08078; Butenolide biosynthesis cluster protein FG08078; EC 3.5.1.- from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
    29% identity, 83% coverage of query (123 bits)

tms2 / P0A2X0 indoleacetamide hydrolase (EC 3.5.1.4) from Rhizobium radiobacter (see paper)
    29% identity, 94% coverage of query (119 bits)

P95896 amidase (EC 3.5.1.4); nitrilase (EC 3.5.5.1) from Saccharolobus solfataricus (see 3 papers)
    27% identity, 83% coverage of query (119 bits)

P22984 amidase (EC 3.5.1.4) from Rhodococcus erythropolis (see 2 papers)
Q7DKE4 amidase (EC 3.5.1.4) from Rhodococcus sp. N-771 (see paper)
amdA / AAA62721.1 enantiomer-selective amidase from Brevibacterium sp (see paper)
CAA38009.1 amidase from Rhodococcus sp (see paper)
    30% identity, 82% coverage of query (117 bits)

GATA_ARATH / Q9LI77 Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial; Glu-AdT subunit A; EC 6.3.5.7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    27% identity, 96% coverage of query (116 bits)

Q9CZN8 glutaminyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.7) from Mus musculus (see paper)
    25% identity, 95% coverage of query (116 bits)

3a1iA / Q7DKE4 Crystal structure of rhodococcus sp. N-771 amidase complexed with benzamide (see paper)
    30% identity, 82% coverage of query (115 bits)

Q5YFS2 amidase (EC 3.5.1.4) from Achromobacter xylosoxidans (see paper)
    30% identity, 92% coverage of query (115 bits)

1m21A / Q8RJN5 Crystal structure analysis of the peptide amidase pam in complex with the competitive inhibitor chymostatin (see paper)
    32% identity, 96% coverage of query (115 bits)

pam / GI|19744118 peptide amidase from Stenotrophomonas maltophilia (see paper)
pam / CAC93616.1 peptide amidase from Stenotrophomonas maltophilia (see paper)
    32% identity, 96% coverage of query (115 bits)

6diiH / Q7XJJ7 Structure of arabidopsis fatty acid amide hydrolase in complex with methyl linolenyl fluorophosphonate (see paper)
    27% identity, 82% coverage of query (114 bits)

FAAH_ARATH / Q7XJJ7 Fatty acid amide hydrolase; AtFAAH; N-acylethanolamine amidohydrolase; EC 3.5.1.99 from Arabidopsis thaliana (Mouse-ear cress) (see 10 papers)
Q7XJJ7 fatty acid amide hydrolase (EC 3.5.1.99) from Arabidopsis thaliana (see paper)
    27% identity, 82% coverage of query (114 bits)

8ey9B Structure of arabidopsis fatty acid amide hydrolase mutant s305a in complex with 9-hydroxy-10,12-octadecadienoyl-ethanolamide
    27% identity, 82% coverage of query (113 bits)

8ey1D Structure of arabidopsis fatty acid amide hydrolase mutant s305a in complex with n-(3-oxododecanoyl)-l-homoserine lactone
    27% identity, 82% coverage of query (113 bits)

GATA_HUMAN / Q9H0R6 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Glu-AdT subunit A; Glutaminyl-tRNA synthase-like protein 1; EC 6.3.5.7 from Homo sapiens (Human) (see 3 papers)
Q9H0R6 glutaminyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.7) from Homo sapiens (see paper)
    25% identity, 96% coverage of query (112 bits)

B1GY01 nitrilase (EC 3.5.5.1) from Rhodococcus erythropolis (see paper)
    30% identity, 82% coverage of query (112 bits)

MANHY_PSEPU / Q84DC4 Mandelamide hydrolase; EC 3.5.1.86 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
    27% identity, 91% coverage of query (111 bits)

lpa / Q5XVM9 lipoamidase (EC 3.5.1.138) from Enterococcus faecalis (see 2 papers)
    28% identity, 94% coverage of query (107 bits)

FAAH_ORYSJ / Q0JFH7 Fatty acid amide hydrolase; N-acylethanolamine amidohydrolase; EC 3.5.1.- from Oryza sativa subsp. japonica (Rice) (see paper)
    27% identity, 91% coverage of query (106 bits)

amdA / P27765 nicotinamidase (EC 3.5.1.19) from Pseudomonas chlororaphis (see paper)
    27% identity, 83% coverage of query (98.2 bits)

GATA_YEAST / Q03557 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Glu-AdT subunit A; HMG2-induced ER-remodeling protein 2; Loss of respiratory capacity protein 6; EC 6.3.5.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
    23% identity, 89% coverage of query (95.9 bits)

4gysB / Q0BRB0 Granulibacter bethesdensis allophanate hydrolase co-crystallized with malonate (see paper)
    29% identity, 87% coverage of query (90.9 bits)

4n0iA / Q03557 Crystal structure of s. Cerevisiae mitochondrial gatfab in complex with glutamine (see paper)
    25% identity, 80% coverage of query (90.9 bits)

1o9oA / Q9ZIV5 Crystal structure of the s131a mutant of malonamidase e2 complexed with malonamate from bradyrhizobium japonicum (see paper)
    26% identity, 86% coverage of query (85.9 bits)

1ocmA The crystal structure of malonamidase e2 covalently complexed with pyrophosphate from bradyrhizobium japonicum
    26% identity, 86% coverage of query (84.3 bits)

atzF / Q936X2 allophanate hydrolase subunit from Pseudomonas sp. (strain ADP) (see 2 papers)
ATZF_PSESD / Q936X2 Allophanate hydrolase; EC 3.5.1.54 from Pseudomonas sp. (strain ADP) (see 2 papers)
Q936X2 allophanate hydrolase (EC 3.5.1.54) from Pseudomonas sp. ADP (see paper)
    26% identity, 91% coverage of query (73.9 bits)

TOC64_PEA / Q9MUK5 Translocon at the outer membrane of chloroplasts 64 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 4 papers)
TC 3.A.9.1.1 / Q9MUK5 Toc64 aka IAP64, component of Chloroplast envelope protein translocase (CEPT); outer membrane complex. The Tic20-like protein (acc # AUO68237.1; 413 aas, 6 TMSs in a 1 TMS (N-terminal) + 5 TMSs (C-terminal)), of the lower brown alga, Saccharina japonica, has been characterized from Pisum sativum (Garden pea) (see paper)
toc64 Toc64 from Pisum sativum
    26% identity, 80% coverage of query (62.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory