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Searching for up to 100 curated homologs for GFF2157 FitnessBrowser__WCS417:GFF2157 (440 a.a.)

Found high-coverage hits (≥70%) to 34 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    72% identity, 96% coverage of query (618 bits)

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    41% identity, 94% coverage of query (297 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    41% identity, 94% coverage of query (291 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    40% identity, 88% coverage of query (288 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    41% identity, 94% coverage of query (288 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    36% identity, 95% coverage of query (280 bits)

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    38% identity, 90% coverage of query (259 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    35% identity, 94% coverage of query (257 bits)

Build an alignment

Build an alignment for GFF2157 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

orf19.3232 putative transporter from Candida albicans (see paper)
    27% identity, 85% coverage of query (165 bits)

CH_124132 transporter of Nicotinic Acid from Magnaporthe grisea 70-15 (see paper)
    26% identity, 85% coverage of query (157 bits)

CH_124318 MFS transporter from Magnaporthe grisea 70-15 (see 2 papers)
    28% identity, 72% coverage of query (153 bits)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    26% identity, 96% coverage of query (150 bits)

CH_124029 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    28% identity, 73% coverage of query (147 bits)

CH_124319 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    28% identity, 86% coverage of query (142 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    26% identity, 87% coverage of query (136 bits)

CH_124317 phthalate transporter from Magnaporthe grisea 70-15 (see paper)
    27% identity, 96% coverage of query (132 bits)

YIZG_SCHPO / Q9US44 Uncharacterized transporter C1002.16c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    27% identity, 72% coverage of query (120 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    29% identity, 85% coverage of query (111 bits)

orf19.2397.3 putative uncharacterized protein VHT1 from Candida albicans (see paper)
    23% identity, 87% coverage of query (111 bits)

HXNP_EMENI / C8VJW1 Major facilitator-type transporter hxnP; Nicotinate catabolism cluster protein hxnP from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    25% identity, 74% coverage of query (101 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    24% identity, 94% coverage of query (98.6 bits)

CH_124323 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see 2 papers)
    24% identity, 72% coverage of query (97.4 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    27% identity, 87% coverage of query (96.3 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    26% identity, 91% coverage of query (90.9 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    26% identity, 91% coverage of query (90.5 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    26% identity, 93% coverage of query (90.5 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    23% identity, 88% coverage of query (86.7 bits)

TC 2.A.1.14.11 / P53322 Plasma membrane, high affinity nicotinate permease, Tna1 from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
TNA1 / RF|NP_011776.1 high-affinity nicotinic acid transporter from Saccharomyces cerevisiae
    23% identity, 95% coverage of query (85.9 bits)

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    23% identity, 95% coverage of query (85.9 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    26% identity, 91% coverage of query (77.4 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    23% identity, 89% coverage of query (76.6 bits)

PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
    21% identity, 85% coverage of query (53.9 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    21% identity, 81% coverage of query (52.4 bits)

GLCP_STAES / A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) (see paper)
    20% identity, 94% coverage of query (44.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory