Searching for up to 100 curated homologs for GFF2170 FitnessBrowser__Marino:GFF2170 (493 a.a.)
Found high-coverage hits (≥70%) to 38 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.47.1.12 / A4QAL6 The aerobic dicarboxylate (succinate (Km, 30 μM), fumarate (Km, 79 from Corynebacterium glutamicum (strain R) (see paper)
49% identity, 87% coverage of query (394 bits)
TC 2.A.47.1.13 / Q65NC0 The Na+-coupled dicarboxylate (succinate; malate; fumarate) transporter, SdcL (transports aspartate, α-ketoglutarate and oxaloacetate with low affinity). Km for succinate, ~6 from Bacillus licheniformis (strain DSM 13 / ATCC 14580) (see 2 papers)
45% identity, 97% coverage of query (367 bits)
TC 2.A.47.1.11 / Q2FFH9 The Na+ (or Li+):dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes from Staphylococcus aureus (strain USA300) (see paper)
44% identity, 91% coverage of query (347 bits)
SDCS_STAAM / Q99SX1 Sodium-dependent dicarboxylate transporter SdcS; Na(+)/dicarboxylate symporter from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 2 papers)
44% identity, 91% coverage of query (346 bits)
7jsjA / Q86YT5 Structure of the nact-pf2 complex (see paper)
39% identity, 86% coverage of query (276 bits)
S13A2_MOUSE / Q9ES88 Solute carrier family 13 member 2; Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter from Mus musculus (Mouse) (see 2 papers)
34% identity, 88% coverage of query (264 bits)
S13A3_HUMAN / Q8WWT9 Na(+)/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; SLC13A3 from Homo sapiens (Human) (see 8 papers)
TC 2.A.47.1.15 / Q8WWT9 Solute carrier family 13 member 3 (Na+/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) from Homo sapiens (see 6 papers)
34% identity, 94% coverage of query (263 bits)
S13A3_MOUSE / Q91Y63 Na(+)/dicarboxylate cotransporter 3; NaDC-3; mNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3 from Mus musculus (Mouse) (see paper)
34% identity, 90% coverage of query (263 bits)
S13A5_HUMAN / Q86YT5 Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5 from Homo sapiens (Human) (see 7 papers)
TC 2.A.47.1.9 / Q86YT5 Na+-coupled citrate transporter (NaCT) (Km=20 μM) (also may transport dicarboxylates and other tricarboxylates with lower affinity) (Inoue et al., 2002b; Bergeron et al. 2013). Na+:citrate = 3-4:1 (Bergeron et al. 2013). Na+:citrate = 3-4:1 from Homo sapiens (Human) (see 5 papers)
34% identity, 86% coverage of query (262 bits)
S13A2_RAT / P70545 Solute carrier family 13 member 2; Intestinal sodium/dicarboxylate cotransporter; Na(+)/dicarboxylate cotransporter 1; NaDC-1 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.47.1.3 / O35055 The brush boarder intestinal and renal electrogenic, Na -dependent, low affinity (0.1-4.0mM), dicarboxylate (succinate, fumarate, malate, α-ketoglutarate, oxaloacetate, L- and D-glutamate, and citrate):H cotransporter, NaDC-1 or SDCT1. Functions in acid regulation. An acidic pH stimullates citrate uptake; acid stimulation is mediated by endothelin-1 (ET-1) and its receptor from Rattus norvegicus (Rat) (see 4 papers)
34% identity, 88% coverage of query (260 bits)
S13A3_RAT / Q9Z0Z5 Na(+)/dicarboxylate cotransporter 3; NaDC-3; rNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; SDCT2; Solute carrier family 13 member 3 from Rattus norvegicus (Rat) (see 5 papers)
TC 2.A.47.1.4 / Q9Z0Z5 The basolateral intestinal and renal electrogenic, Na+-dependent high affinity (2-50µM) dicarboxylate:(Na+)3 cotransporter (NaDC-3) (substrate range similar to that of NDC-1 except that tricarboxylates are transported with very low affinity). Na+:succinate = 3:1. Also transports N-acetyl-L-aspartate, an abundant amino acid in the nervous system from Rattus norvegicus (Rat) (see 2 papers)
33% identity, 90% coverage of query (259 bits)
TDT_ARATH / Q8LG88 Tonoplast dicarboxylate transporter; AttDT; Sodium-dicarboxylate cotransporter-like; AtSDAT; Vacuolar malate transporter from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.47.1.6 / Q8LG88 The tonoplast dicarboxylate (malate) transporter, AtDCT (see 3 papers)
TDT / GB|BAA96091.1 tonoplast dicarboxylate transporter from Arabidopsis thaliana (see paper)
33% identity, 90% coverage of query (249 bits)
S13A2_HUMAN / Q13183 Solute carrier family 13 member 2; Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.47.1.17 / Q13183 Solute carrier family 13 member 2 (Na /di- and tricarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) from Homo sapiens (see 4 papers)
35% identity, 88% coverage of query (246 bits)
TC 2.A.47.1.5 / Q9W7I2 Basolateral Na+: di- and tricarboxylate (succinate cis-aconitate, citrate, etc.) cotransporter, fNaDC-3 from Pseudopleuronecta americanus (Winter flounder) (see paper)
32% identity, 90% coverage of query (245 bits)
S13A5_RAT / Q8CJ44 Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5 from Rattus norvegicus (Rat) (see 3 papers)
34% identity, 86% coverage of query (244 bits)
S13A5_MOUSE / Q67BT3 Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5 from Mus musculus (Mouse) (see 5 papers)
32% identity, 95% coverage of query (242 bits)
S13A2_RABIT / Q28615 Solute carrier family 13 member 2; Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter from Oryctolagus cuniculus (Rabbit) (see 2 papers)
33% identity, 87% coverage of query (239 bits)
NAD3_CAEEL / Q21339 Sodium-dependent high-affinity dicarboxylate transporter 3; Na(+)/dicarboxylate cotransporter 3; NaDC-3; ceNaDC3 from Caenorhabditis elegans (see paper)
TC 2.A.47.1.8 / Q21339 High affinity dicarboxylate:Na+ symporter, NaDC2 (INDY2) (relative affinities: fumarate > malate > α-ketoglutarate > maleate > succinate > lactate) (see 2 papers)
34% identity, 88% coverage of query (238 bits)
NAD1_CAEEL / Q93655 Sodium-dependent low-affinity dicarboxylate transporter 1; Na(+)/dicarboxylate cotransporter 1; NaDC-1; ceNaDC1 from Caenorhabditis elegans (see paper)
TC 2.A.47.1.7 / Q93655 Low affinity dicarboxylate:Na+ symporter, NaDC1 (INDY1) (relative affinities: succinate > fumarate > α-ketoglutarate > malate > lactate > maleate) (see 2 papers)
33% identity, 95% coverage of query (234 bits)
S13A1_MOUSE / Q9JHI4 Solute carrier family 13 member 1; NaSi-1; Renal sodium/sulfate cotransporter; Na(+)/sulfate cotransporter from Mus musculus (Mouse) (see paper)
30% identity, 90% coverage of query (228 bits)
S13A1_RAT / Q07782 Solute carrier family 13 member 1; NaSi-1; Renal sodium/sulfate cotransporter; Na(+)/sulfate cotransporter from Rattus norvegicus (Rat) (see 5 papers)
TC 2.A.47.1.2 / Q07782 Renal sodium:sulfate cotransporter (Ssc, NaSi-1 or Nas1) (also transports tungstate, molybdate, thiosulfate and selenate) from Rattus norvegicus (Rat) (see 2 papers)
Slc13a1 / RF|NP_113839.1 solute carrier family 13 member 1 from Rattus norvegicus (see paper)
31% identity, 86% coverage of query (226 bits)
VCA0025 / Q9KNE0 dicarboxylate:Na+ symporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 6 papers)
TC 2.A.47.5.2 / Q9KNE0 Dicarboxylate (succinate, fumarate, malate) transporter, vcINDY from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
39% identity, 88% coverage of query (218 bits)
7t9gA / Q9KNE0 Structure of vcindy-na+ (see paper)
39% identity, 88% coverage of query (218 bits)
6okzB Structure of vcindy bound to fumarate
39% identity, 88% coverage of query (218 bits)
6wtxA Structure of vcindy in complex with terephthalate
39% identity, 88% coverage of query (218 bits)
TC 2.A.47.5.1 / Q58086 Hypothetical Na+ cotransporter, Orfl from Methanococcus jannaschii (see paper)
33% identity, 89% coverage of query (216 bits)
Build an alignment for GFF2170 and 26 homologs with ≥ 30% identity
Or download the sequences
S13A1_HUMAN / Q9BZW2 Solute carrier family 13 member 1; Renal sodium/sulfate cotransporter; Na(+)/sulfate cotransporter; hNaSi-1 from Homo sapiens (Human) (see paper)
TC 2.A.47.1.16 / Q9BZW2 Solute carrier family 13 member 1 (Renal and intestinal sodium/sulfate cotransporter) (Na+/sulfate cotransporter) (hNaSi-1). Also transports thiosulfate and selenium. It is inhibited by many di- and tri-valent organic and inorganic anions from Homo sapiens (see 2 papers)
29% identity, 86% coverage of query (209 bits)
4f35B / Q9KNE0 Crystal structure of a bacterial dicarboxylate/sodium symporter (see paper)
39% identity, 88% coverage of query (202 bits)
INDY1_DROME / Q9VVT2 Protein I'm not dead yet; INDY transporter protein; drIndy from Drosophila melanogaster (Fruit fly) (see 3 papers)
TC 2.A.47.1.10 / Q9VVT2 Cation-independent, electroneutral tri- and di-carboxylate transporter with a preference for tricarboxylates, Indy (I'm not dead yet) [When Indy is mutated flies live about twice as long as wild type] from Drosophila melanogaster (Fruit fly) (see 7 papers)
Indy / RF|NP_730363.2 protein I'm not dead yet from Drosophila melanogaster (see paper)
29% identity, 88% coverage of query (187 bits)
YBH4_SCHPO / O59712 Uncharacterized transporter C3B8.04c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
25% identity, 90% coverage of query (115 bits)
PHO91_YEAST / P27514 Low-affinity phosphate transporter PHO91 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
P27514 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.47.2.2 / P27514 Vacuolar low affinity phosphate transporter, Pho91 (Estrella et al., 2008) with 12 C-terminal TMSs and an N-terminal 360 hydrophilic region. Also transports selenite (Lazard et al., 2010). Pyrophosphate stimulates the phosphate-sodium symporter of Trypanosoma brucei (TC# 2.A.47.2.4) acidocalcisomes and Saccharomyces cerevisiae vacuoles (this protein) from Saccharomyces cerevisiae (Baker's yeast) (see 8 papers)
RF|NP_014410.1 uncharacterized transporter YNR013C from Saccharomyces cerevisiae (see paper)
25% identity, 96% coverage of query (104 bits)
PHO90_YEAST / P39535 Low-affinity phosphate transporter PHO90 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P39535 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.47.2.3 / P39535 Low affinity phosphate transporters (881aas). Also transports selenite from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
25% identity, 89% coverage of query (96.7 bits)
PHO87 / P25360 low-affinity phosphate transporter PHO87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 15 papers)
PHO87_YEAST / P25360 Inorganic phosphate transporter PHO87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P25360 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.47.2.1 / P25360 Inorganic phosphate transporter, Pho87. Also transports selenite from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
PHO87 / RF|NP_009966.2 inorganic phosphate transporter PHO87 from Saccharomyces cerevisiae
27% identity, 88% coverage of query (96.7 bits)
TC 2.A.47.2.4 / Q4DX24 Contractile vacuole phosphate:Na+ symporter of 727 aas and 12 TMSs, Pho91 (Pho90; Pho87) from Trypanosoma cruzi (strain CL Brener)
26% identity, 91% coverage of query (88.6 bits)
YbdS / b0612 citrate:succinate antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
citT / P0AE74 citrate:succinate antiporter from Escherichia coli (strain K12) (see 3 papers)
CITT_ECOLI / P0AE74 Citrate/succinate antiporter; Citrate carrier; Citrate transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.47.3.2 / P0AE74 Citrate:succinate antiporter from Escherichia coli (see 4 papers)
24% identity, 90% coverage of query (78.6 bits)
YgjC / b3063 L-tartrate:succinate antiporter from Escherichia coli K-12 substr. MG1655
ttdT / P39414 L-tartrate:succinate antiporter from Escherichia coli (strain K12) (see 5 papers)
TTDT_ECOLI / P39414 L-tartrate/succinate antiporter; Tartrate carrier; Tartrate transporter from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.47.3.3 / P39414 L-tartrate:succinate antiporter, TtdT (YgjE). (also takes up meso and L-tartrate and succinate; does not transport D-tartrate) from Escherichia coli (see 8 papers)
ttdT / RF|NP_417535 L-tartrate/succinate antiporter from Escherichia coli K12 (see 8 papers)
22% identity, 92% coverage of query (60.1 bits)
DIT1_ARATH / Q9LXV3 Dicarboxylate transporter 1, chloroplastic; 2-oxoglutarate/malate translocator 1; AtpOMT1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
22% identity, 73% coverage of query (53.5 bits)
YbhI / b0770 putative tricarboxylate transporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
23% identity, 91% coverage of query (48.9 bits)
Or start over
Lawrence Berkeley National Laboratory