Searching for up to 100 curated homologs for GFF2283 FitnessBrowser__Phaeo:GFF2283 (331 a.a.)
Found high-coverage hits (≥70%) to 74 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q9HWN0 acetoin dehydrogenase system (subunit 1/2) (EC 2.3.1.190) from Pseudomonas aeruginosa (see paper)
50% identity, 98% coverage of query (308 bits)
Q46143 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoB TPP-dependent acetoin dehydrogenase complex, E1 component, beta subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21745.1 TPP-dependent acetoin dehydrogenase beta-subunit from Clostridium magnum (see paper)
47% identity, 98% coverage of query (307 bits)
Q97YF5 acetoin dehydrogenase system (EC 2.3.1.190) from Saccharolobus solfataricus (see paper)
47% identity, 96% coverage of query (300 bits)
PDHB / P11177 pyruvate dehydrogenase E1 component β subunit from Homo sapiens (see 7 papers)
ODPB_HUMAN / P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
P11177 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Homo sapiens (see 2 papers)
47% identity, 93% coverage of query (291 bits)
6cerD / P11177 Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
45% identity, 97% coverage of query (291 bits)
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
45% identity, 97% coverage of query (291 bits)
Q9D051 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104) from Mus musculus (see paper)
46% identity, 97% coverage of query (290 bits)
ODPB_SCHPO / Q09171 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
pdb1 / RF|NP_596272.1 pyruvate dehydrogenase e1 component beta subunit Pdb1; EC 1.2.4.1 from Schizosaccharomyces pombe (see paper)
46% identity, 98% coverage of query (290 bits)
A2Z2Z0 pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
45% identity, 97% coverage of query (290 bits)
ODPB_DROME / Q7K5K3 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; EC 1.2.4.1 from Drosophila melanogaster (Fruit fly) (see paper)
45% identity, 100% coverage of query (289 bits)
ODPB1_ARATH / Q38799 Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; PDHE1-B; Protein MACCI-BOU; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q38799 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Arabidopsis thaliana (see paper)
44% identity, 97% coverage of query (288 bits)
P21874 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Geobacillus stearothermophilus (see paper)
46% identity, 98% coverage of query (285 bits)
3dufD / P21874 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
46% identity, 97% coverage of query (283 bits)
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
46% identity, 97% coverage of query (283 bits)
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
46% identity, 97% coverage of query (283 bits)
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
46% identity, 97% coverage of query (283 bits)
P52904 pyruvate dehydrogenase system (subunit 3/3) (EC 1.2.1.104) from Pisum sativum (see paper)
45% identity, 97% coverage of query (279 bits)
ODPB_YEAST / P32473 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Pyruvate dehydrogenase complex component E1 beta; PDHE1-B; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 98% coverage of query (278 bits)
bfmBAB / P37941 2-keto-isovalerate dehydrogenase component β subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
43% identity, 97% coverage of query (278 bits)
P73405 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Synechocystis sp. PCC 6803 (see 2 papers)
45% identity, 95% coverage of query (277 bits)
pdhC pyruvate dehydrogenase (lipoamide) from Emericella nidulans (see paper)
44% identity, 97% coverage of query (277 bits)
PDHB / P26269 pyruvate dehydrogenase β subunit from Ascaris suum (see paper)
42% identity, 97% coverage of query (274 bits)
Q52015 acetoin dehydrogenase system (EC 2.3.1.190) from Pseudomonas putida (see paper)
45% identity, 97% coverage of query (268 bits)
acoB / Q3A7P0 acetoin:DCPIP oxidoreductase β subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
43% identity, 97% coverage of query (266 bits)
acoB / AAA18916.1 acetoin:DCPIP oxidoreductase beta subunit from Pelobacter carbinolicus (see paper)
43% identity, 97% coverage of query (264 bits)
ODPB_STAAU / P0A0A3 Pyruvate dehydrogenase E1 component subunit beta; EC 1.2.4.1 from Staphylococcus aureus (see paper)
41% identity, 98% coverage of query (264 bits)
pdhB / AAC24933.1 pyruvate decarboxylase E-1 beta subunit from Bacillus subtilis (see 3 papers)
44% identity, 98% coverage of query (263 bits)
ODPB_CHATD / G0RYE0 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Pyruvate dehydrogenase complex component E1 beta; PDHE1-B; EC 1.2.4.1 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 2 papers)
G0RYE0 pyruvate dehydrogenase system (subunit 1/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 1/2) (EC 1.2.4.1) from Chaetomium thermophilum (see paper)
45% identity, 98% coverage of query (263 bits)
Q9HIA4 branched-chain-2-oxoacid decarboxylase (subunit 2/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
42% identity, 97% coverage of query (261 bits)
P27746 acetoin dehydrogenase system (EC 2.3.1.190) from Alcaligenes eutrophus H16 (see paper)
acoB / AAA21949.1 acetoin:DCPIP oxidoreductase-beta from Cupriavidus necator (see paper)
44% identity, 98% coverage of query (259 bits)
SMc03202 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Sinorhizobium meliloti 1021
40% identity, 98% coverage of query (250 bits)
Q1KSF0 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Toxoplasma gondii (see paper)
41% identity, 97% coverage of query (246 bits)
ODBB_THET8 / Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
43% identity, 94% coverage of query (239 bits)
1umbD / Q5SLR3 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
44% identity, 93% coverage of query (239 bits)
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
44% identity, 93% coverage of query (239 bits)
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
44% identity, 93% coverage of query (239 bits)
AO356_22985 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
37% identity, 95% coverage of query (234 bits)
Pf6N2E2_480 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
37% identity, 95% coverage of query (234 bits)
ODBB2_ARATH / Q9LDY2 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; Protein DARK INDUCIBLE 4; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
38% identity, 95% coverage of query (233 bits)
PfGW456L13_3541 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
37% identity, 95% coverage of query (231 bits)
PS417_17550 branched-chain alpha-ketoacid dehydrogenase, E1 component beta subunit (EC 1.2.4.4) from Pseudomonas simiae WCS417
36% identity, 95% coverage of query (230 bits)
1qs0B / P09061 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
37% identity, 97% coverage of query (229 bits)
bkdA2 / GI|790516 2-oxoisovalerate dehydrogenase subunit beta; EC 1.2.4.4 from Pseudomonas putida (see 2 papers)
37% identity, 97% coverage of query (229 bits)
2j9fD / P21953 Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
37% identity, 98% coverage of query (223 bits)
BCKDHB / P21953 branched-chain α-keto acid dehydrogenase E1 component β subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBB_HUMAN / P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 5 papers)
P21953 branched-chain alpha-keto acid dehydrogenase system (subunit 1/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
37% identity, 98% coverage of query (223 bits)
ODBB_BOVIN / P21839 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
37% identity, 98% coverage of query (223 bits)
1dtwB Human branched-chain alpha-keto acid dehydrogenase
37% identity, 98% coverage of query (223 bits)
Q6P3A8 branched-chain alpha-keto acid dehydrogenase system (subunit 1/2) (EC 1.2.1.25) from Mus musculus (see paper)
36% identity, 98% coverage of query (221 bits)
P35738 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (subunit 1/2) (EC 1.2.4.4) from Rattus norvegicus (see paper)
36% identity, 98% coverage of query (220 bits)
ppdcβ / G1UHX5 phenylpyruvate decarboxylase β subunit (EC 4.1.1.43) from Streptomyces virginiae (see paper)
41% identity, 94% coverage of query (217 bits)
Build an alignment for GFF2283 and 50 homologs with ≥ 30% identity
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DXS_DEIRA / Q9RUB5 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
Q9RUB5 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Deinococcus radiodurans (see 2 papers)
26% identity, 82% coverage of query (72.4 bits)
6xxgAAA / Q9RUB5 6xxgAAA (see paper)
25% identity, 90% coverage of query (72.0 bits)
2o1xA 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from deinococcus radiodurans
26% identity, 82% coverage of query (72.0 bits)
6ouvA / Q9RUB5 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with methylacetylphosphonate (map) bound (see paper)
26% identity, 82% coverage of query (72.0 bits)
6ouwA 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with enamine intermediate bound
26% identity, 82% coverage of query (72.0 bits)
6xxgBBB / Q9RUB5 6xxgBBB (see paper)
25% identity, 90% coverage of query (72.0 bits)
6yakDDD 6yakDDD (see paper)
25% identity, 89% coverage of query (68.6 bits)
6rjbB / P29401 Human transketolase variant t382e (see paper)
24% identity, 81% coverage of query (57.0 bits)
6ha3A Human transketolase variant e160q in covalent complex with donor ketose d-fructose-6-phosphate
24% identity, 81% coverage of query (56.6 bits)
8waaA Human transketolase soaked with donor ketose d-xylulose
24% identity, 81% coverage of query (56.6 bits)
8wa9A Human transketolase soaked with donor ketose d-fructose
24% identity, 81% coverage of query (56.6 bits)
4kxyA Human transketolase in complex with thdp analogue (r)-2-(1,2- dihydroxyethyl)-3-deaza-thdp
24% identity, 81% coverage of query (56.6 bits)
4kxvA Human transketolase in covalent complex with donor ketose d-xylulose- 5-phosphate, crystal 1
24% identity, 81% coverage of query (56.6 bits)
4kxuA Human transketolase in covalent complex with donor ketose d-fructose- 6-phosphate
24% identity, 81% coverage of query (56.6 bits)
4kxxA Human transketolase in covalent complex with donor ketose d- sedoheptulose-7-phosphate
24% identity, 81% coverage of query (56.6 bits)
2o1sB / P77488 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
23% identity, 89% coverage of query (51.2 bits)
2o1sA / P77488 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
23% identity, 89% coverage of query (50.8 bits)
YajP / b0420 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dxs / P77488 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (strain K12) (see 26 papers)
DXS_ECOLI / P77488 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Escherichia coli (strain K12) (see 3 papers)
23% identity, 89% coverage of query (50.8 bits)
8a4dA 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa with a thiamine analog inhibitor
27% identity, 75% coverage of query (47.8 bits)
8a45F / B7V7R4 Structural analysis of 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa with 2-acetyl thiamine diphosphate (see paper)
27% identity, 75% coverage of query (47.4 bits)
8a5kA Structural analysis of 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa and klebsiella pneumoniae reveals conformational changes upon cofactor binding
27% identity, 75% coverage of query (47.4 bits)
8bzxA / A6T5F3 1-deoxy-d-xylulose 5-phosphate synthase from klebsiella pneumoniae (kpdxps),co-crystal with thiamine monophosphate analog (see paper)
23% identity, 89% coverage of query (46.2 bits)
8bzxB / A6T5F3 1-deoxy-d-xylulose 5-phosphate synthase from klebsiella pneumoniae (kpdxps),co-crystal with thiamine monophosphate analog (see paper)
23% identity, 89% coverage of query (46.2 bits)
8a9cB / A6T5F3 Structure of truncated 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from klebsiella pneumoniae in complex with cofactor tpp
23% identity, 89% coverage of query (46.2 bits)
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