Sites on a Tree

 

Searching for up to 100 curated homologs for GFF2306 FitnessBrowser__psRCH2:GFF2306 (323 a.a.)

Found high-coverage hits (≥70%) to 72 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS34225 L-fucose dehydrogenase (EC 1.1.1.122) from Burkholderia phytofirmans PsJN
    41% identity, 98% coverage of query (235 bits)

SMc02775 D-arabinose 1-dehydrogenase from Sinorhizobium meliloti 1021
    42% identity, 89% coverage of query (216 bits)

PLD_MICLT / Q76KC2 Pyridoxal 4-dehydrogenase; EC 1.1.1.107 from Microbacterium luteolum (Aureobacterium luteolum) (see paper)
    39% identity, 97% coverage of query (212 bits)

FCDH_PSESP / Q52472 D-threo-aldose 1-dehydrogenase; L-fucose dehydrogenase; EC 1.1.1.122 from Pseudomonas sp.
Q52472 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Pseudomonas sp. (see paper)
    37% identity, 95% coverage of query (201 bits)

Build an alignment

Build an alignment for GFF2306 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

E9M5S4 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Citrus unshiu (see paper)
    29% identity, 87% coverage of query (122 bits)

C0LVA5 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Actinidia eriantha (see paper)
    29% identity, 87% coverage of query (122 bits)

Q6BDJ2 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Spinacia oleracea (see paper)
GDH / BAD32687.1 L-galactose dehydrogenase from Spinacia oleracea (see paper)
    29% identity, 87% coverage of query (122 bits)

Q84L20 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Malus domestica (see paper)
    29% identity, 98% coverage of query (122 bits)

7svqA / Q6BDJ2 Crystal structure of l-galactose dehydrogenase from spinacia oleracea in complex with NAD+ (see paper)
    29% identity, 87% coverage of query (122 bits)

LGALDH / O81884 L-galactose dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
GALDH_ARATH / O81884 L-galactose dehydrogenase; At-GalDH; L-GalDH; EC 1.1.1.316 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O81884 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
L-GalDH / CAD10386.1 L-galactose dehydrogenase from Arabidopsis thaliana (see paper)
    28% identity, 86% coverage of query (117 bits)

7eziA / Q2QQV2 Rice l-galactose dehydrogenase (apo form)
    27% identity, 88% coverage of query (110 bits)

7ezlA Rice l-galactose dehydrogenase (holo form)
    27% identity, 88% coverage of query (110 bits)

lgaA / A6KWY2 L-galactose dehydrogenase from Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) (see paper)
    26% identity, 92% coverage of query (107 bits)

IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
    28% identity, 90% coverage of query (94.4 bits)

1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
    28% identity, 90% coverage of query (94.4 bits)

1ynpB / Q9KE47 Aldo-keto reductase akr11c1 from bacillus halodurans (apo form) (see paper)
    26% identity, 89% coverage of query (84.0 bits)

1ynqB Aldo-keto reductase akr11c1 from bacillus halodurans (holo form)
    26% identity, 89% coverage of query (84.0 bits)

1ynpA Aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
    26% identity, 89% coverage of query (80.1 bits)

YdjG / b1771 NADH-dependent methylglyoxal reductase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydjG / P77256 NADH-dependent methylglyoxal reductase from Escherichia coli (strain K12) (see 4 papers)
AKRMG_ECOLI / P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
ydjG / RF|NP_416285 uncharacterized oxidoreductase ydjG from Escherichia coli K12 (see paper)
    23% identity, 96% coverage of query (75.5 bits)

6ow0B / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    27% identity, 89% coverage of query (72.4 bits)

6ow0A / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    26% identity, 89% coverage of query (70.5 bits)

3n6qD Crystal structure of yghz from e. Coli
    26% identity, 92% coverage of query (69.7 bits)

mtmW / Q194Q1 mithramycin dehydrogenase from Streptomyces argillaceus (see 2 papers)
    26% identity, 89% coverage of query (68.9 bits)

4aubE The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate
    25% identity, 92% coverage of query (68.9 bits)

YAKC_SCHPO / Q09923 Aldo-keto reductase yakc [NADP(+)]; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
yak3 aldose reductase YakC from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 71% coverage of query (68.2 bits)

5t79A / Q8ZNA1 X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
    27% identity, 89% coverage of query (67.4 bits)

4aubB / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    25% identity, 92% coverage of query (67.0 bits)

Q5FQJ0 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans (see paper)
    29% identity, 71% coverage of query (67.0 bits)

F2YCN5 D-xylose reductase (EC 1.1.1.307) from Zymomonas mobilis subsp. mobilis (see paper)
    25% identity, 98% coverage of query (66.2 bits)

Gpr / b3001 L-glyceraldehyde 3-phosphate reductase from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gpr / Q46851 L-glyceraldehyde 3-phosphate reductase (EC 1.1.1.21) from Escherichia coli (strain K12) (see 7 papers)
GPR_ECOLI / Q46851 L-glyceraldehyde 3-phosphate reductase; GAP reductase; EC 1.1.1.- from Escherichia coli (strain K12) (see 4 papers)
    25% identity, 92% coverage of query (65.5 bits)

3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium
    27% identity, 89% coverage of query (64.7 bits)

1exbA Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels
    22% identity, 83% coverage of query (63.9 bits)

KCAB2_MOUSE / P62482 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5; EC 1.1.1.- from Mus musculus (Mouse) (see 8 papers)
KCAB2_RAT / P62483 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Rattus norvegicus (Rat) (see 19 papers)
    22% identity, 83% coverage of query (63.5 bits)

8hw0A / A0A6B8QIS5 The structure of akr6d1
    25% identity, 80% coverage of query (63.5 bits)

YajO / b0419 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli K-12 substr. MG1655 (see 7 papers)
yajO / P77735 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli (strain K12) (see 6 papers)
YAJO_ECOLI / P77735 1-deoxyxylulose-5-phosphate synthase YajO; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
P77735 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (see paper)
    24% identity, 94% coverage of query (63.5 bits)

4aubF / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    25% identity, 92% coverage of query (63.5 bits)

KCAB3_XENLA / Q9PTM4 Voltage-gated potassium channel subunit beta-3; K(+) channel subunit beta-3; Kv-beta-3; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
    22% identity, 92% coverage of query (63.5 bits)

3eauA Voltage-dependent k+ channel beta subunit in complex with cortisone
    22% identity, 83% coverage of query (63.5 bits)

PR / Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 2 papers)
PERR_RAUSE / Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see 2 papers)
Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 3 papers)
    28% identity, 71% coverage of query (63.2 bits)

KCAB2_HUMAN / Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 4 papers)
    22% identity, 83% coverage of query (62.8 bits)

7wf3C / Q13303 Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
    22% identity, 83% coverage of query (62.8 bits)

3v0sA / Q3L181 Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
    26% identity, 94% coverage of query (62.8 bits)

KCAB2_XENLA / Q9PTM5 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
    22% identity, 83% coverage of query (62.4 bits)

8hnqA / A0A6B8QJ47 The structure of a alcohol dehydrogenase akr13b2 with NADP
    26% identity, 88% coverage of query (60.1 bits)

KCAB2_BOVIN / Q27955 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Bos taurus (Bovine) (see paper)
    22% identity, 83% coverage of query (60.1 bits)

KCAB_ORYSJ / Q40648 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Oryza sativa subsp. japonica (Rice) (see paper)
    26% identity, 85% coverage of query (59.7 bits)

KCAB1_MUSPU / Q28528 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mustela putorius (European polecat) (see paper)
    22% identity, 83% coverage of query (58.5 bits)

GME68_PESMI / A0A5B8YXI2 Aryl-alcohol dehydrogenase GME11368; Dibenzodioxocinones biosynthesis cluster protein GME11368; EC 1.1.1.- from Pestalotiopsis microspora (see 2 papers)
    23% identity, 93% coverage of query (58.2 bits)

KCAB1_RAT / P63144 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Rattus norvegicus (Rat) (see 9 papers)
    22% identity, 83% coverage of query (58.2 bits)

GS69_BACSU / P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
    26% identity, 73% coverage of query (57.8 bits)

KCAB1_RABIT / Q9XT31 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Oryctolagus cuniculus (Rabbit) (see paper)
    22% identity, 83% coverage of query (57.8 bits)

KCAB1_HUMAN / Q14722 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Homo sapiens (Human) (see 13 papers)
    22% identity, 83% coverage of query (57.8 bits)

KCAB1_MOUSE / P63143 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mus musculus (Mouse) (see 5 papers)
    22% identity, 83% coverage of query (57.8 bits)

AMT2_ALTAL / Q75ZG2 Aldo-keto reductase AMT2; AM-toxin biosynthesis protein 2; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    25% identity, 85% coverage of query (57.4 bits)

1pz1A / P80874 Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
    25% identity, 73% coverage of query (57.4 bits)

DTXS3_METRA / E9FCP6 Aldo-keto reductase dtxS3; Destruxin synthesis protein 3; EC 1.1.1.- from Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23)) (see paper)
    28% identity, 72% coverage of query (57.0 bits)

eryBII / A4F7P4 dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-α-D-allose-forming) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
    27% identity, 80% coverage of query (56.2 bits)

megBIIb / Q9F833 MegBIIb from Micromonospora megalomicea subsp. nigra (see paper)
    26% identity, 85% coverage of query (56.2 bits)

AFTS1_ALTAL / Q75ZG3 Aldo-keto reductase AFTS1; AF-toxin biosynthesis protein S1; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    25% identity, 91% coverage of query (55.5 bits)

A0QV10 Aldo-keto reductase MSMEG_2408/MSMEI_2347; EC 1.1.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    25% identity, 92% coverage of query (55.5 bits)

Y2407_MYCS2 / A0QV09 Aldo-keto reductase MSMEG_2407/MSMEI_2346; AKR; AKR5H1; EC 1.1.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    25% identity, 95% coverage of query (54.7 bits)

smoB / A9CEY6 6-dehydroglucose reductase monomer (EC 1.1.1.432) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
DHGRD_AGRFC / A9CEY6 6-dehydroglucose reductase; SQ monooxygenase cluster protein B; EC 1.1.1.432 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    25% identity, 90% coverage of query (54.7 bits)

2wzmA / A0QV09 Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form (see paper)
    25% identity, 95% coverage of query (54.3 bits)

5c7hA / Q92NR7 Crystal structure of aldo-keto reductase from sinorhizobium meliloti 1021 in complex with NADPH
    25% identity, 95% coverage of query (54.3 bits)

4pmjA Crystal structure of a putative oxidoreductase from sinorhizobium meliloti 1021 in complex with NADP
    25% identity, 95% coverage of query (54.3 bits)

KCAB3_HUMAN / O43448 Voltage-gated potassium channel subunit beta-3; K(+) channel subunit beta-3; Kv-beta-3; EC 1.1.1.- from Homo sapiens (Human) (see paper)
    22% identity, 85% coverage of query (52.8 bits)

7bc1A / A9CEY6 Crystal structure of aldo-keto reductase from agrobacterium tumefaciens in a ternary complex with NADPH and glucose (see paper)
    24% identity, 90% coverage of query (52.4 bits)

FDB38_GIBM7 / W7N2Q9 Aldo-keto reductase FVEG_12638; Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12638; FDB2 cluster protein FVEG_12638; EC 1.1.1.- from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 4 papers)
    25% identity, 85% coverage of query (52.4 bits)

AKR1_SOYBN / C6TBN2 Probable aldo-keto reductase 1; GmAKR1; EC 1.1.1.- from Glycine max (Soybean) (Glycine hispida) (see paper)
    23% identity, 71% coverage of query (52.0 bits)

KCAB_ARATH / O23016 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; Potassium voltage beta 1; KV-beta1; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 85% coverage of query (50.8 bits)

KCAB3_RAT / Q63494 Voltage-gated potassium channel subunit beta-3; K(+) channel subunit beta-3; Kv-beta-3; RCK beta3; EC 1.1.1.- from Rattus norvegicus (Rat) (see paper)
    21% identity, 85% coverage of query (50.4 bits)

STCV_EMENI / Q00727 Norsolorinic acid reductase stcV; Sterigmatocystin biosynthesis cluster protein V; EC 1.1.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 8 papers)
stcV putative sterigmatocystin biosynthesis dehydrogenase stcV; EC 1.1.1.- from Emericella nidulans (see paper)
    23% identity, 74% coverage of query (45.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory