Searching for up to 100 curated homologs for GFF2317 FitnessBrowser__psRCH2:GFF2317 (279 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_2560 ABC transporter for L-Histidine, ATPase component from Acidovorax sp. GW101-3H11
47% identity, 95% coverage of query (246 bits)
SSUB_BACSU / P97027 Aliphatic sulfonates import ATP-binding protein SsuB; EC 7.6.2.14 from Bacillus subtilis (strain 168) (see paper)
41% identity, 91% coverage of query (206 bits)
Q6RH47 taurine dehydrogenase (EC 1.4.99.2) from Paracoccus pantotrophus (see paper)
43% identity, 85% coverage of query (200 bits)
TC 3.A.1.16.2 / O05347 CynD, component of Bispecific cyanate/nitrite transporter
44% identity, 84% coverage of query (193 bits)
TC 3.A.1.17.4 / Q2BM69 Putative taurin uptake ABC transporter ATP-binding protein, component of The taurine uptake system, TauABC from Neptuniibacter caesariensis
42% identity, 85% coverage of query (192 bits)
CMPC_SYNE7 / Q55107 Bicarbonate transport ATP-binding protein CmpC; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55107 CmpC, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
43% identity, 90% coverage of query (191 bits)
NRTC_SYNE7 / P38045 Nitrate import ATP-binding protein NrtC; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see 2 papers)
TC 3.A.1.16.1 / P38045 NrtC, component of Four component nitrate/nitrite porter (see paper)
42% identity, 85% coverage of query (185 bits)
NRTD_SYNE7 / P38046 Nitrate import ATP-binding protein NrtD; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.1 / P38046 NrtD, component of Four component nitrate/nitrite porter (see paper)
40% identity, 88% coverage of query (184 bits)
CMPD_SYNE7 / Q55108 Bicarbonate transport ATP-binding protein CmpD; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55108 CmpD, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
36% identity, 91% coverage of query (173 bits)
TC 3.A.1.16.4 / Q8YRV8 Nitrate transport ATP-binding protein of ABC transporter, component of Nitrate uptake system, NrtABCD from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
36% identity, 90% coverage of query (172 bits)
AZOBR_RS18550 ABC transporter for nitrate, ATPase component from Azospirillum brasilense Sp245
39% identity, 91% coverage of query (168 bits)
TauB / b0366 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TauB / Q47538 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli (strain K12) (see 3 papers)
TAUB_ECOLI / Q47538 Taurine import ATP-binding protein TauB; EC 7.6.2.7 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.17.1 / Q47538 TauB aka SSIB aka B0366, component of Taurine (2-aminoethane sulfonate) porter from Escherichia coli (see 4 papers)
39% identity, 85% coverage of query (166 bits)
TC 3.A.1.1.5 / P54933 SmoK aka POLK, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
44% identity, 81% coverage of query (166 bits)
TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
41% identity, 78% coverage of query (164 bits)
Ac3H11_2941 ABC transporter for D-Sorbitol, ATPase component from Acidovorax sp. GW101-3H11
43% identity, 81% coverage of query (160 bits)
Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
41% identity, 80% coverage of query (159 bits)
TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
41% identity, 83% coverage of query (158 bits)
TC 3.A.1.1.28 / Q00752 MsmK aka SMU.882, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
40% identity, 77% coverage of query (158 bits)
SM_b21216 ABC transporter for D-Glucosamine, ATPase component from Sinorhizobium meliloti 1021
40% identity, 82% coverage of query (157 bits)
B9J850 pterin deaminase (EC 3.5.4.11) from Agrobacterium tumefaciens (see paper)
44% identity, 77% coverage of query (157 bits)
TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
42% identity, 81% coverage of query (157 bits)
Q70HW1 ABC-type maltose transporter (EC 7.5.2.1) from Alicyclobacillus acidocaldarius (see paper)
malK / CAE45698.1 ATP-binding MalK protein from Alicyclobacillus acidocaldarius subsp. acidocaldarius (see paper)
41% identity, 77% coverage of query (155 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
41% identity, 75% coverage of query (150 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
41% identity, 77% coverage of query (148 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
41% identity, 77% coverage of query (148 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
41% identity, 77% coverage of query (148 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
41% identity, 77% coverage of query (148 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
41% identity, 77% coverage of query (148 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
41% identity, 77% coverage of query (148 bits)
1g291 / Q9YGA6 Malk (see paper)
39% identity, 82% coverage of query (147 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
43% identity, 71% coverage of query (146 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
36% identity, 82% coverage of query (145 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
39% identity, 82% coverage of query (145 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
40% identity, 77% coverage of query (144 bits)
8hprC Lpqy-sugabc in state 4
36% identity, 82% coverage of query (139 bits)
8hprD Lpqy-sugabc in state 4
36% identity, 82% coverage of query (139 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
38% identity, 75% coverage of query (137 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
36% identity, 76% coverage of query (133 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
36% identity, 76% coverage of query (132 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
33% identity, 84% coverage of query (131 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
33% identity, 84% coverage of query (131 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
33% identity, 84% coverage of query (131 bits)
7ahhC Opua inhibited inward-facing, sbd docked
37% identity, 71% coverage of query (129 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
37% identity, 71% coverage of query (129 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
40% identity, 71% coverage of query (127 bits)
7ahdC Opua (e190q) occluded
37% identity, 71% coverage of query (127 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
38% identity, 77% coverage of query (124 bits)
5xu1B / Q8DQF8 Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
34% identity, 80% coverage of query (123 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
33% identity, 75% coverage of query (122 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
36% identity, 76% coverage of query (122 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
36% identity, 76% coverage of query (120 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
35% identity, 72% coverage of query (120 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
36% identity, 76% coverage of query (119 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
36% identity, 76% coverage of query (119 bits)
2olkA Abc protein artp in complex with adp-beta-s
36% identity, 76% coverage of query (119 bits)
2oljA Abc protein artp in complex with adp/mg2+
36% identity, 76% coverage of query (119 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
35% identity, 72% coverage of query (119 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
35% identity, 72% coverage of query (119 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
35% identity, 72% coverage of query (119 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
39% identity, 80% coverage of query (118 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
35% identity, 71% coverage of query (112 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
35% identity, 71% coverage of query (112 bits)
Build an alignment for GFF2317 and 62 homologs with ≥ 30% identity
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8g4cB / O34697 Bceabs atpgs high res tm (see paper)
27% identity, 76% coverage of query (110 bits)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
34% identity, 72% coverage of query (109 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
34% identity, 72% coverage of query (109 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
30% identity, 81% coverage of query (109 bits)
7tchB Bceab e169q variant atp-bound conformation
27% identity, 76% coverage of query (108 bits)
7mdyC Lolcde nucleotide-bound
32% identity, 73% coverage of query (108 bits)
7arlD Lolcde in complex with lipoprotein and adp
32% identity, 73% coverage of query (108 bits)
8w6iD / P0A9R7 Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
38% identity, 72% coverage of query (107 bits)
FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
38% identity, 72% coverage of query (107 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
32% identity, 73% coverage of query (107 bits)
8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
37% identity, 72% coverage of query (106 bits)
8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc
36% identity, 71% coverage of query (104 bits)
MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
35% identity, 71% coverage of query (103 bits)
FTSE_MYCTA / A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
36% identity, 71% coverage of query (103 bits)
8igqA / O05779 Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
36% identity, 71% coverage of query (103 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
34% identity, 77% coverage of query (101 bits)
8tzjA / A0A085R4L6 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
36% identity, 72% coverage of query (100 bits)
7w78A / Q6NEF2 Heme exporter hrtba in complex with mg-amppnp (see paper)
39% identity, 71% coverage of query (100 bits)
7w79A Heme exporter hrtba in complex with mn-amppnp
39% identity, 71% coverage of query (100 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
33% identity, 77% coverage of query (99.8 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
33% identity, 72% coverage of query (97.1 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
33% identity, 73% coverage of query (95.5 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
31% identity, 74% coverage of query (95.1 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
31% identity, 74% coverage of query (95.1 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
31% identity, 74% coverage of query (94.7 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
28% identity, 73% coverage of query (90.9 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
33% identity, 72% coverage of query (89.7 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
33% identity, 81% coverage of query (89.4 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
28% identity, 77% coverage of query (86.3 bits)
7chaI / Q9HVW1 Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
31% identity, 75% coverage of query (85.5 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
30% identity, 74% coverage of query (84.7 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
27% identity, 77% coverage of query (84.3 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
27% identity, 77% coverage of query (84.0 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
30% identity, 77% coverage of query (84.0 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
31% identity, 70% coverage of query (83.6 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
31% identity, 70% coverage of query (83.6 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
31% identity, 70% coverage of query (83.2 bits)
4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
33% identity, 71% coverage of query (83.2 bits)
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Lawrence Berkeley National Laboratory