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Searching for up to 100 curated homologs for GFF2397 FitnessBrowser__WCS417:GFF2397 (255 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

8ewoA / Q9I2T1 Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
    71% identity, 100% coverage of query (364 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    45% identity, 100% coverage of query (209 bits)

YafR / b0212 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gloB / P0AC84 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli (strain K12) (see 9 papers)
GLO2_ECOLI / P0AC84 Hydroxyacylglutathione hydrolase GloB; Glyoxalase II; Glx II; EC 3.1.2.6 from Escherichia coli (strain K12) (see 2 papers)
6rz0A / P0AC84 Crystal structure of escherichia coli glyoxalase ii
gloB / MB|P0AC84 hydroxyacylglutathione hydrolase; EC 3.1.2.6 from Escherichia coli K12 (see 3 papers)
    46% identity, 100% coverage of query (209 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    44% identity, 100% coverage of query (205 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    44% identity, 100% coverage of query (205 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    42% identity, 100% coverage of query (202 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    42% identity, 100% coverage of query (202 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    42% identity, 100% coverage of query (200 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 100% coverage of query (193 bits)

GLO2C_ARATH / O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    43% identity, 93% coverage of query (182 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    39% identity, 100% coverage of query (171 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    40% identity, 91% coverage of query (166 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    40% identity, 91% coverage of query (165 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    40% identity, 91% coverage of query (165 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    40% identity, 91% coverage of query (165 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    36% identity, 99% coverage of query (149 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    36% identity, 99% coverage of query (145 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    35% identity, 89% coverage of query (124 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    32% identity, 91% coverage of query (123 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    31% identity, 91% coverage of query (116 bits)

GLO21_SCHPO / Q9UT36 Probable hydroxyacylglutathione hydrolase C824.07; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    35% identity, 85% coverage of query (111 bits)

Q6KF36 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
GLXII / GI|47604513 glyoxalase II from Trypanosoma brucei brucei (see paper)
glxII / CAD37800.1 glyoxalase II from Trypanosoma brucei brucei (see paper)
    33% identity, 86% coverage of query (109 bits)

GLO2 / Q05584 glyoxalase II (cytoplasmic) (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
GLO2_YEAST / Q05584 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Glyoxalase II; Glx II; EC 3.1.2.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
GLO2 / CAA71335.1 glyoxalase-II from Saccharomyces cerevisiae (see paper)
    30% identity, 95% coverage of query (102 bits)

Build an alignment

Build an alignment for GFF2397 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q581U6 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
    28% identity, 71% coverage of query (85.1 bits)

GLO4 / Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (see paper)
GLO4 / CAA58065.1 glyoxalase-II from Saccharomyces cerevisiae (see 3 papers)
    28% identity, 95% coverage of query (81.6 bits)

GLO2_ENCCU / Q8SSH0 Probable hydroxyacylglutathione hydrolase ECU02_0580; Glyoxalase II; Glx II; EC 3.1.2.6 from Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) (see paper)
    24% identity, 99% coverage of query (67.8 bits)

GloC / b0927 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gloC / P75849 hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) from Escherichia coli (strain K12) (see 5 papers)
GLO22_ECOLI / P75849 Hydroxyacylglutathione hydrolase GloC; Accessory type II glyoxalase; Glyoxalase II 2; GlxII-2; EC 3.1.2.6 from Escherichia coli (strain K12) (see paper)
    28% identity, 71% coverage of query (66.6 bits)

ETHE1_MOUSE / Q9DCM0 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1 homolog; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Mus musculus (Mouse) (see paper)
    24% identity, 80% coverage of query (55.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory