Searching for up to 100 curated homologs for GFF2427 PGA1_c24580 putative serine hydroxymethyltransferase (435 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GLYA_SACS2 / Q9UWT5 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q9UWT5 glycine hydroxymethyltransferase (EC 2.1.2.1) from Saccharolobus solfataricus (see paper)
33% identity, 91% coverage of query (236 bits)
GLYA_METJA / Q58992 Serine hydroxymethyltransferase; SHMT; Serine methylase; L-allo-threonine aldolase; EC 2.1.2.-; EC 4.1.2.49 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58992 glycine hydroxymethyltransferase (EC 2.1.2.1) from Methanocaldococcus jannaschii (see paper)
4uqvG / Q58992 Methanococcus jannaschii serine hydroxymethyl-transferase in complex with plp (see paper)
32% identity, 88% coverage of query (208 bits)
GLYA_METTH / O27433 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.- from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
32% identity, 89% coverage of query (204 bits)
4bhdB / Q58992 Methanococcus jannaschii serine hydroxymethyl-transferase, apo form (see paper)
32% identity, 80% coverage of query (170 bits)
4-FTase / B6VP39 4-fluorothreonine transaldolase monomer (EC 2.2.1.8) from Streptantibioticus cattleyicolor (see 2 papers)
4FTAS_STRCT / B6VP39 Fluorothreonine transaldolase; 4-fluorothreonine transaldolase; 4-FTase; EC 2.2.1.8 from Streptantibioticus cattleyicolor (Streptomyces cattleya) (see paper)
B6VP39 fluorothreonine transaldolase (EC 2.2.1.8) from Streptomyces cattleya (see paper)
F8JMF0 fluorothreonine transaldolase (EC 2.2.1.8) from Streptomyces cattleya (see paper)
33% identity, 86% coverage of query (166 bits)
GLYA_THET8 / Q5SI56 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SI56 glycine hydroxymethyltransferase (EC 2.1.2.1) from Thermus thermophilus (see paper)
31% identity, 86% coverage of query (155 bits)
2dkjA / Q5SI56 Crystal structure of t.Th.Hb8 serine hydroxymethyltransferase
31% identity, 86% coverage of query (154 bits)
8suiB Joint x-ray/neutron structure of thermus thermophilus serine hydroxymethyltransferase (tthshmt) in internal aldimine state with l- ser bound in a pre-michalis complex
31% identity, 86% coverage of query (154 bits)
8ssyA Room-temperature x-ray structure of thermus thermophilus serine hydroxymethyltransferase (shmt) bound with d-ser in a pseudo- michaelis complex
31% identity, 86% coverage of query (154 bits)
GLYA2_BURP1 / Q3JGP5 Serine hydroxymethyltransferase 2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Burkholderia pseudomallei (strain 1710b)
32% identity, 78% coverage of query (149 bits)
6ymfA Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the plp-serine external aldimine state
30% identity, 86% coverage of query (148 bits)
Build an alignment for GFF2427 and 11 homologs with ≥ 30% identity
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I7H6W6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Aphanothece halophytica (see paper)
29% identity, 88% coverage of query (147 bits)
6ymdA / I7H6W6 Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the covalent complex with malonate (see paper)
30% identity, 86% coverage of query (147 bits)
A8GTI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Rickettsia rickettsii (see paper)
28% identity, 89% coverage of query (146 bits)
GLYA_CAMJE / P24531 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Campylobacter jejuni (see 2 papers)
30% identity, 85% coverage of query (144 bits)
2vmyA Crystal structure of f351gbsshmt in complex with gly and fthf
31% identity, 79% coverage of query (143 bits)
2vmxA Crystal structure of f351gbsshmt in complex with l-allo-thr
31% identity, 79% coverage of query (143 bits)
GLYA_HYDTT / D3DKC4 Serine hydroxymethyltransferase; SHMT; Serine methylase; L-threonine/L-allo-threonine aldolase; EC 2.1.2.1; EC 4.1.2.48 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see paper)
32% identity, 81% coverage of query (142 bits)
6ti4A Shmt from streptococcus thermophilus tyr55ser variant in complex with plp/d-serine/lys230 gem diamine complex
29% identity, 86% coverage of query (142 bits)
6ti3A Apo-shmt from streptococcus thermophilus tyr55ser variant in complex with d-threonine
29% identity, 86% coverage of query (142 bits)
6tghA / Q5M0B4 Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
29% identity, 86% coverage of query (141 bits)
7x5oB / I3U4H4 Crystal structure of e. Faecium shmt in complex with me-thf and plp- gly (see paper)
30% identity, 89% coverage of query (141 bits)
6tghC Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
29% identity, 86% coverage of query (141 bits)
7x5nA Crystal structure of e. Faecium shmt in complex with (+)-shin-1 and plp-ser
30% identity, 89% coverage of query (141 bits)
7v3dA Complex structure of serine hydroxymethyltransferase from enterococcus faecium and its inhibitor
30% identity, 89% coverage of query (141 bits)
4wxgA Crystal structure of l-serine hydroxymethyltransferase in complex with a mixture of l-threonine and glycine
29% identity, 86% coverage of query (141 bits)
4wxfA Crystal structure of l-serine hydroxymethyltransferase in complex with glycine
29% identity, 86% coverage of query (141 bits)
Q5M0B4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Streptococcus thermophilus (see paper)
29% identity, 86% coverage of query (140 bits)
1kkjA / Q7SIB6 Crystal structure of serine hydroxymethyltransferase from b.Stearothermophilus (see paper)
31% identity, 79% coverage of query (140 bits)
U5TRK6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Glutamicibacter nicotianae (see paper)
31% identity, 81% coverage of query (140 bits)
1kl2A Crystal structure of serine hydroxymethyltransferase complexed with glycine and 5-formyl tetrahydrofolate
31% identity, 79% coverage of query (140 bits)
1kl1A Crystal structure of serine hydroxymethyltransferase complexed with glycine
31% identity, 79% coverage of query (140 bits)
1kkpA Crystal structure of serine hydroxymethyltransferase complexed with serine
31% identity, 79% coverage of query (140 bits)
R9YJZ9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Shewanella algae (see paper)
30% identity, 88% coverage of query (139 bits)
A1SUU0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Psychromonas ingrahamii (see 2 papers)
30% identity, 83% coverage of query (137 bits)
B4ECY9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia cenocepacia (see paper)
30% identity, 89% coverage of query (135 bits)
4n0wA / B4ECY9 X-ray crystal structure of a serine hydroxymethyltransferase from burkholderia cenocepacia with covalently attached pyridoxal phosphate
30% identity, 89% coverage of query (135 bits)
glyA / P34895 serine hydroxymethyltransferase subunit (EC 2.1.2.1) from Hyphomicrobium methylovorum (see paper)
31% identity, 80% coverage of query (135 bits)
A0A069BAT4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia pseudomallei (see paper)
30% identity, 88% coverage of query (135 bits)
4otlA X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and glycine
30% identity, 89% coverage of query (135 bits)
4ot8A X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and serine
30% identity, 89% coverage of query (135 bits)
GLYA2_MYCTU / P9WGI7 Serine hydroxymethyltransferase 2; SHM2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WGI7 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see paper)
32% identity, 83% coverage of query (134 bits)
GLYA_BACSU / P39148 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Bacillus subtilis (strain 168) (see 2 papers)
31% identity, 82% coverage of query (134 bits)
GLYA_STAAC / Q5HE87 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Staphylococcus aureus (strain COL)
Q5HE87 glycine hydroxymethyltransferase (EC 2.1.2.1) from Staphylococcus aureus (see paper)
29% identity, 83% coverage of query (133 bits)
MSHMT_PARSX / B2DEU7 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Paracoccus sp.
27% identity, 88% coverage of query (131 bits)
glyA / P77962 glycine hydroxymethyltransferase (EC 2.1.2.1) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
30% identity, 79% coverage of query (130 bits)
L7Y8B0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas plecoglossicida (see paper)
29% identity, 85% coverage of query (130 bits)
MSHMT_AMISX / B2DEU8 2-methylserine hydroxymethyltransferase; MSHMT; AHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Aminobacter sp. (see paper)
B2DEU8 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Aminobacter sp. AJ110403 (see paper)
28% identity, 86% coverage of query (129 bits)
P56089 glycine hydroxymethyltransferase (EC 2.1.2.1) from Helicobacter pylori (see paper)
29% identity, 79% coverage of query (127 bits)
GLYA_SALTY / P0A2E1 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P0A2E1 glycine hydroxymethyltransferase (EC 2.1.2.1) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Salmonella enterica subsp. enterica serovar Typhimurium (see 3 papers)
29% identity, 88% coverage of query (127 bits)
PfGW456L13_2685 Glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas fluorescens GW456-L13
28% identity, 83% coverage of query (124 bits)
3pgyB / Q5HE87 Serine hydroxymethyltransferase from staphylococcus aureus, s95p mutant.
28% identity, 83% coverage of query (123 bits)
MSHMT_ENSSX / B2DEV1 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EHMT; EC 2.1.2.7 from Ensifer sp. (see paper)
B2DEV1 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Ensifer sp. AJ110404 (see paper)
28% identity, 85% coverage of query (122 bits)
GlyA / b2551 serine hydroxymethyltransferase (EC 2.1.2.1) from Escherichia coli K-12 substr. MG1655 (see 27 papers)
glyA / P0A825 serine hydroxymethyltransferase (EC 2.1.2.1) from Escherichia coli (strain K12) (see 25 papers)
GLYA_ECOLI / P0A825 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Escherichia coli (strain K12) (see 11 papers)
P0A825 low-specificity L-threonine aldolase (EC 4.1.2.48) from Escherichia coli (see paper)
1dfoB / P0A825 Crystal structure at 2.4 angstrom resolution of e. Coli serine hydroxymethyltransferase in complex with glycine and 5-formyl tetrahydrofolate (see paper)
glyA / RF|NP_417046 serine hydroxymethyltransferase; EC 2.1.2.1 from Escherichia coli K12 (see 12 papers)
29% identity, 88% coverage of query (122 bits)
1eqbA X-ray crystal structure at 2.7 angstroms resolution of ternary complex between the y65f mutant of e-coli serine hydroxymethyltransferase, glycine and 5-formyl tetrahydrofolate
29% identity, 88% coverage of query (121 bits)
6cczA Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3) soaked with selenourea
29% identity, 84% coverage of query (115 bits)
GLYA_METBF / Q46A52 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
Q46A52 glycine hydroxymethyltransferase (EC 2.1.2.1) from Methanosarcina barkeri (see 2 papers)
25% identity, 88% coverage of query (113 bits)
Q86LS9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Leishmania donovani (see paper)
28% identity, 83% coverage of query (111 bits)
6cd1A / G7ILW0 Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates (see paper)
29% identity, 84% coverage of query (111 bits)
G7ILW0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Medicago truncatula (see paper)
29% identity, 84% coverage of query (111 bits)
6cd1E Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates
29% identity, 84% coverage of query (111 bits)
GLYP3_ARATH / Q94JQ3 Serine hydroxymethyltransferase 3, chloroplastic; AtSHM3; AtSHMT3; Glycine hydroxymethyltransferase 3; Serine methylase 3; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q94JQ3 glycine hydroxymethyltransferase (EC 2.1.2.1) from Arabidopsis thaliana (see paper)
28% identity, 78% coverage of query (110 bits)
6uldA Crystal structure of serine hydroxymethyltransferase from mycobacterium tuberculosis with bound plp forming a schiff base with substrate serine in one monomer and plp forming a schiff base with product glycine in the other monomer
30% identity, 88% coverage of query (110 bits)
GLYA1_MYCTU / P9WGI9 Serine hydroxymethyltransferase 1; SHM1; SHMT 1; Serine methylase 1; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WGI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see 2 papers)
30% identity, 88% coverage of query (109 bits)
6smrA / O23254 A. Thaliana serine hydroxymethyltransferase isoform 4 (atshmt4) in complex with methotrexate (see paper)
29% identity, 79% coverage of query (107 bits)
GLYC4_ARATH / O23254 Serine hydroxymethyltransferase 4; AtSHMT4; Glycine hydroxymethyltransferase 4; Serine methylase 4; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
29% identity, 79% coverage of query (107 bits)
SHMT / Q8W4V3 serine hydroxymethyltransferase (EC 2.1.2.1) from Chlamydomonas reinhardtii (see paper)
27% identity, 86% coverage of query (102 bits)
8dskA / A0A0R0IK90 Structure of the n358y variant of serine hydroxymethyltransferase 8 in complex with plp, glycine, and formyl tetrahydrofolate (see paper)
28% identity, 79% coverage of query (101 bits)
GLYC_SHEEP / P35623 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Ovis aries (Sheep) (see paper)
29% identity, 78% coverage of query (99.8 bits)
GLYA_PLAF7 / Q8I566 Serine hydroxymethyltransferase; PfSHMTc; EC 2.1.2.1 from Plasmodium falciparum (isolate 3D7) (see 4 papers)
26% identity, 86% coverage of query (98.2 bits)
4o6zA / Q8I566 Crystal structure of serine hydroxymethyltransferase with covalently bound plp schiff-base from plasmodium falciparum (see paper)
26% identity, 86% coverage of query (98.2 bits)
A5K8L9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Plasmodium vivax (see 3 papers)
5gvkA / A5K8L9 Plasmodium vivax shmt bound with plp-glycine and gs256 (see paper)
25% identity, 86% coverage of query (94.7 bits)
5yg4A Plasmodium vivax shmt bound with plp-glycine and s-gs849
25% identity, 86% coverage of query (94.7 bits)
5yg3A Plasmodium vivax shmt bound with plp-glycine and s-gs834
25% identity, 86% coverage of query (94.7 bits)
5yg2A Plasmodium vivax shmt bound with plp-glycine and gs705
25% identity, 86% coverage of query (94.7 bits)
5yg1A Plasmodium vivax shmt bound with plp-glycine and gs704
25% identity, 86% coverage of query (94.7 bits)
5yg0A Plasmodium vivax shmt bound with plp-glycine and gs657
25% identity, 86% coverage of query (94.7 bits)
5yfzA Plasmodium vivax shmt bound with plp-glycine and s-gs626
25% identity, 86% coverage of query (94.7 bits)
5yfyA Plasmodium vivax shmt bound with plp-glycine and gs625
25% identity, 86% coverage of query (94.7 bits)
5xmvA Plasmodium vivax shmt bound with plp-glycine and gs362
25% identity, 86% coverage of query (94.7 bits)
5xmuA Plasmodium vivax shmt bound with plp-glycine and gs363
25% identity, 86% coverage of query (94.7 bits)
5xmtA Plasmodium vivax shmt bound with plp-glycine and gs380
25% identity, 86% coverage of query (94.7 bits)
5xmsA Plasmodium vivax shmt bound with plp-glycine and gs498
25% identity, 86% coverage of query (94.7 bits)
5gvpA Plasmodium vivax shmt bound with plp-glycine and gs654
25% identity, 86% coverage of query (94.7 bits)
5gvnA Plasmodium vivax shmt bound with plp-glycine and gs653
25% identity, 86% coverage of query (94.7 bits)
5gvmA Plasmodium vivax shmt bound with plp-glycine and gs557
25% identity, 86% coverage of query (94.7 bits)
5gvlA Plasmodium vivax shmt bound with plp-glycine and gs182
25% identity, 86% coverage of query (94.7 bits)
4tn4A Crystal structure of ternary complex of plasmodium vivax shmt with glycine and a novel pyrazolopyran 33g: (4s)-6-amino-4-(5-cyano-3'- fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3- c]pyrazole-5-carbonitrile
25% identity, 86% coverage of query (94.7 bits)
4tmrA Crystal structure of ternary complex of plasmodium vivax shmt with glycine and a novel pyrazolopyran 99s: methyl 5-{3-[(4s)-6-amino-5- cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]- 5-cyanophenyl}thiophene-2-carboxylate .
25% identity, 86% coverage of query (94.7 bits)
4pfnA Crystal structure of plasmodium vivax shmt with l-serine schiff base
25% identity, 86% coverage of query (94.7 bits)
4pffA Crystal structure of plasmodium vivax shmt with plp schiff base
25% identity, 86% coverage of query (94.7 bits)
4oytA Crystal structure of ternary complex of plasmodium vivax shmt with d- serine and folinic acid
25% identity, 86% coverage of query (94.7 bits)
5xmrA Plasmodium vivax shmt(c346a) bound with plp-glycine and gs395
25% identity, 86% coverage of query (94.7 bits)
5xmqA Plasmodium vivax shmt(c346a) bound with plp-glycine and mf011
25% identity, 86% coverage of query (94.7 bits)
5xmpA Plasmodium vivax shmt(c346a) bound with plp-glycine and mf057
25% identity, 86% coverage of query (94.7 bits)
SHM1 / P37292 serine hydroxymethyltransferase, mitochondrial (EC 2.1.2.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
GLYM_YEAST / P37292 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
26% identity, 84% coverage of query (94.0 bits)
6smwC A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
26% identity, 89% coverage of query (92.8 bits)
6smwB A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
26% identity, 89% coverage of query (92.8 bits)
6smnD / Q94C74 A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with methotrexate (see paper)
26% identity, 89% coverage of query (92.4 bits)
7e13A Caprylic acid targets a serine hydroxymethyltransferase to kill horseweed
27% identity, 83% coverage of query (92.4 bits)
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