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Searching for up to 100 curated homologs for GFF2442 FitnessBrowser__Marino:GFF2442 (318 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
    43% identity, 99% coverage of query (228 bits)

wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
    38% identity, 99% coverage of query (195 bits)

ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
    35% identity, 93% coverage of query (181 bits)

wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
    37% identity, 96% coverage of query (179 bits)

wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
    37% identity, 98% coverage of query (176 bits)

Build an alignment

Build an alignment for GFF2442 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

cpsG polysaccharide capsule synthesis protein CpsG from Streptococcus iniae (see paper)
    26% identity, 83% coverage of query (94.4 bits)

gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
    26% identity, 86% coverage of query (80.9 bits)

6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
    30% identity, 77% coverage of query (78.6 bits)

6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
    30% identity, 77% coverage of query (78.6 bits)

6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
    27% identity, 70% coverage of query (69.3 bits)

6kvcA Moee5 in complex with udp-glucose and NAD
    33% identity, 75% coverage of query (68.6 bits)

6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
    26% identity, 93% coverage of query (67.0 bits)

6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
    33% identity, 75% coverage of query (67.0 bits)

O73960 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrococcus horikoshii (see paper)
    25% identity, 80% coverage of query (66.6 bits)

1z45A / P04397 Crystal structure of the gal10 fusion protein galactose mutarotase/udp-galactose 4-epimerase from saccharomyces cerevisiae complexed with NAD, udp-glucose, and galactose (see paper)
    30% identity, 70% coverage of query (65.9 bits)

P04397 UDP-glucose 4-epimerase (EC 5.1.3.2) from Saccharomyces cerevisiae (see paper)
    29% identity, 70% coverage of query (63.5 bits)

GALE_NEIGO / Q05026 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Neisseria gonorrhoeae (see paper)
galE / CAA79721.1 UDP-glucose 4-epimerase from Neisseria gonorrhoeae (see 2 papers)
    29% identity, 80% coverage of query (63.2 bits)

6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
    25% identity, 79% coverage of query (62.8 bits)

6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
    25% identity, 79% coverage of query (62.8 bits)

GALE_NEIMC / P56986 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Neisseria meningitidis serogroup C (see paper)
galE / AAA86716.1 UDP-glucose 4-epimerase from Neisseria meningitidis (see paper)
    28% identity, 76% coverage of query (62.4 bits)

6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
    25% identity, 79% coverage of query (62.4 bits)

3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
    29% identity, 80% coverage of query (62.0 bits)

A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
    30% identity, 80% coverage of query (61.2 bits)

6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
    25% identity, 79% coverage of query (60.8 bits)

rmd / AAK53475.1 putative NDP-hexose epimerase/oxydoreductase from Xanthomonas campestris pv. campestris (see 4 papers)
    31% identity, 76% coverage of query (60.5 bits)

GALE_NEIMB / P56985 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
galE1 / AAA65535.1 UDP-glucose 4-epimerase from Neisseria meningitidis (see paper)
    28% identity, 76% coverage of query (60.5 bits)

galE / AAA63156.1 UPD-glucose-4-epimerase from Neisseria meningitidis (see paper)
    28% identity, 81% coverage of query (59.3 bits)

6pnlA / O26475 Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
    26% identity, 98% coverage of query (59.3 bits)

6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
    26% identity, 98% coverage of query (59.3 bits)

Q7MH46 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Vibrio vulnificus (see paper)
    24% identity, 81% coverage of query (58.9 bits)

bciA / Q8KDI7 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) (EC 1.3.1.75) from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (see 5 papers)
Q8KDI7 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) (EC 1.3.1.75) from Chlorobaculum tepidum (see 3 papers)
    26% identity, 85% coverage of query (58.2 bits)

galE / P21977 UDP-glucose-4-epimerase (EC 5.1.3.2) from Streptococcus thermophilus (see paper)
GALE_STRTR / P21977 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Streptococcus thermophilus (see paper)
P21977 UDP-glucose 4-epimerase (EC 5.1.3.2) from Streptococcus thermophilus (see paper)
    24% identity, 93% coverage of query (57.8 bits)

rhsB / AAC44074.1 dTDP-D-glucose-4,6-dehydratase from Sphingomonas sp. S88 (see paper)
    26% identity, 77% coverage of query (57.8 bits)

RHM2 / Q9LPG6 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM2 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM2_ARATH / Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    24% identity, 92% coverage of query (57.4 bits)

8b9zP / Q9VPE2 Drosophila melanogaster complex i in the active state (dm1) (see paper)
    22% identity, 78% coverage of query (55.5 bits)

5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
    23% identity, 85% coverage of query (55.1 bits)

RHM1 / Q9SYM5 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM1 (EC 4.2.1.76) from Arabidopsis thaliana (see 3 papers)
RHM1_ARATH / Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    24% identity, 92% coverage of query (53.5 bits)

3enkA / Q3JPI3 1.9a crystal structure of udp-glucose 4-epimerase from burkholderia pseudomallei
    27% identity, 82% coverage of query (52.0 bits)

DCVR_ORYSI / D5L1S4 Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic; EC 1.3.1.75 from Oryza sativa subsp. indica (Rice) (see 2 papers)
D5L1S4 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) (EC 1.3.1.75) from Oryza sativa (see paper)
Q10LH0 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) (EC 1.3.1.75) from Oryza sativa (see 2 papers)
    27% identity, 85% coverage of query (48.5 bits)

2cnbA Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose
    25% identity, 82% coverage of query (47.8 bits)

auaH / H1ZZB0 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide 3-reductase (EC 1.1.1.394) from Stigmatella aurantiaca (see 2 papers)
AUAH_STIAU / H1ZZB0 Aurachin B dehydrogenase; EC 1.1.1.394 from Stigmatella aurantiaca (see 2 papers)
H1ZZB0 aurachin B dehydrogenase (EC 1.1.1.394) from Stigmatella aurantiaca (see paper)
    25% identity, 93% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory