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Searching for up to 100 curated homologs for GFF2482 FitnessBrowser__Phaeo:GFF2482 (257 a.a.)

Found high-coverage hits (≥70%) to 29 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    44% identity, 98% coverage of query (236 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    44% identity, 98% coverage of query (235 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    43% identity, 98% coverage of query (234 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 100% coverage of query (220 bits)

8ewoA / Q9I2T1 Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
    44% identity, 98% coverage of query (190 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    42% identity, 98% coverage of query (186 bits)

GLO2C_ARATH / O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    38% identity, 98% coverage of query (177 bits)

YafR / b0212 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gloB / P0AC84 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli (strain K12) (see 9 papers)
GLO2_ECOLI / P0AC84 Hydroxyacylglutathione hydrolase GloB; Glyoxalase II; Glx II; EC 3.1.2.6 from Escherichia coli (strain K12) (see 2 papers)
6rz0A / P0AC84 Crystal structure of escherichia coli glyoxalase ii
gloB / MB|P0AC84 hydroxyacylglutathione hydrolase; EC 3.1.2.6 from Escherichia coli K12 (see 3 papers)
    37% identity, 98% coverage of query (153 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    35% identity, 98% coverage of query (150 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    35% identity, 100% coverage of query (150 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    34% identity, 98% coverage of query (150 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    34% identity, 98% coverage of query (150 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    34% identity, 98% coverage of query (150 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    35% identity, 98% coverage of query (149 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    35% identity, 98% coverage of query (149 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    33% identity, 98% coverage of query (149 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    33% identity, 98% coverage of query (146 bits)

GLO21_SCHPO / Q9UT36 Probable hydroxyacylglutathione hydrolase C824.07; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    33% identity, 94% coverage of query (118 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 99% coverage of query (110 bits)

GLO2 / Q05584 glyoxalase II (cytoplasmic) (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
GLO2_YEAST / Q05584 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Glyoxalase II; Glx II; EC 3.1.2.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
GLO2 / CAA71335.1 glyoxalase-II from Saccharomyces cerevisiae (see paper)
    30% identity, 94% coverage of query (108 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    30% identity, 86% coverage of query (107 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    31% identity, 86% coverage of query (105 bits)

Q6KF36 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
GLXII / GI|47604513 glyoxalase II from Trypanosoma brucei brucei (see paper)
glxII / CAD37800.1 glyoxalase II from Trypanosoma brucei brucei (see paper)
    30% identity, 86% coverage of query (99.0 bits)

Build an alignment

Build an alignment for GFF2482 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

GLO4 / Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (see paper)
GLO4 / CAA58065.1 glyoxalase-II from Saccharomyces cerevisiae (see 3 papers)
    28% identity, 93% coverage of query (87.4 bits)

GLO2_ENCCU / Q8SSH0 Probable hydroxyacylglutathione hydrolase ECU02_0580; Glyoxalase II; Glx II; EC 3.1.2.6 from Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) (see paper)
    26% identity, 89% coverage of query (76.6 bits)

Q581U6 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
    26% identity, 70% coverage of query (71.2 bits)

BAEB_BACVZ / A7Z4X7 Probable polyketide biosynthesis zinc-dependent hydrolase BaeB; EC 3.-.-.- from Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum) (see paper)
    24% identity, 74% coverage of query (58.5 bits)

NOTP_ASPSM / E1ACR1 Lactamase-like protein notP; Notoamide biosynthesis cluster protein P; EC 3.1.-.- from Aspergillus sp. (strain MF297-2) (see 3 papers)
    28% identity, 84% coverage of query (53.5 bits)

GME57_PESMI / A0A5B8YUX5 Lactamase-like protein GME11357; Dibenzodioxocinones biosynthesis cluster protein GME11357; EC 3.1.2.- from Pestalotiopsis microspora (see 2 papers)
    28% identity, 70% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory